KATHLYN PARKER

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. ncbi Heterocycle annulation of enolizable vinyl quinone imides. Dihydroquinolines and quinolines from thermal 6pi-electrocyclizations and indoles from photochemical cyclizations
    Kathlyn A Parker
    Department of Chemistry, SUNY Stony Brook, Stony Brook, New York 11794 3400, USA
    Org Lett 4:4265-8. 2002
  2. ncbi Asymmetric catalysis route to anti,anti stereotriads, illustrated by applications
    Kathlyn A Parker
    Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    Org Lett 10:1349-52. 2008
  3. ncbi Deconstruction-reconstruction strategy for accessing valuable polyketides. Preparation of the C15-C24 stereopentad of discodermolide
    Kathlyn A Parker
    Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Org Lett 9:4793-6. 2007
  4. ncbi Cleavable chiral auxiliaries in 8pi (8pi, 6pi) electrocyclizations
    Kathlyn A Parker
    Department of Chemistry, Stony Brook University, Stony Brook, New York 11794 3400, USA
    Org Lett 8:3553-6. 2006
  5. ncbi Scalable, catalytic asymmetric synthesis of syn, anti stereotriad building blocks for polypropionate antibiotics
    Kathlyn A Parker
    Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794 3400, USA
    Org Lett 8:3541-4. 2006
  6. ncbi TESOTf-induced rearrangement of quinols. Efficient construction of the fully functionalized carbon skeleton of the griseusins by a divergent-reconvergent approach
    Kathlyn A Parker
    Department of Chemistry, SUNY Stony Brook, Stony Brook, New York 11794 3400, USA
    Org Lett 8:1759-62. 2006
  7. ncbi A synthesis of L-vancosamine derivatives from non-carbohydrate precursors by a short sequence based on the Marshall, McDonald, and Du Bois reactions
    Kathlyn A Parker
    Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794 3400, USA
    Org Lett 5:3891-3. 2003
  8. ncbi The total synthesis of (-)-SNF4435 C and (+)-SNF4435 D
    Kathlyn A Parker
    Department of Chemistry, State University of New York at Stony Brook, Stoney Brook, New York 11794 3400, USA
    J Am Chem Soc 126:15968-9. 2004
  9. ncbi A strategy for exploiting the pseudosymmetry of the C1-C13 stretch of discodermolide
    Kathlyn A Parker
    Department of Chemistry, State University of New York at Stony Brook Stony Brook, New York 11794 3400, USA
    Org Lett 6:1413-6. 2004
  10. ncbi "Endo" and "exo" bicyclo[4.2.0]-octadiene isomers from the electrocyclization of fully substituted tetraene models for SNF 4435C and D. control of stereochemistry by choice of a functionalized substituent
    Kathlyn A Parker
    Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York, 11794 3400, USA
    Org Lett 6:161-4. 2004

Research Grants

  1. Natural Product Leads for Drug Development
    KATHLYN PARKER; Fiscal Year: 2007
  2. Natural Product Leads for Drug Development
    KATHLYN PARKER; Fiscal Year: 2009
  3. Natural Product Leads for Drug Development
    KATHLYN PARKER; Fiscal Year: 2007
  4. STRATEGIES AND METHODS IN SYNTHESIS OF NATURAL PRODUCTS
    KATHLYN PARKER; Fiscal Year: 2003

Collaborators

Detail Information

Publications18

  1. ncbi Heterocycle annulation of enolizable vinyl quinone imides. Dihydroquinolines and quinolines from thermal 6pi-electrocyclizations and indoles from photochemical cyclizations
    Kathlyn A Parker
    Department of Chemistry, SUNY Stony Brook, Stony Brook, New York 11794 3400, USA
    Org Lett 4:4265-8. 2002
    ..Aromatization provides the corresponding quinolines in quantitative yields. The quinone monoimide substrates undergo clean photochemical conversion to 5-hydroxy indoles...
  2. ncbi Asymmetric catalysis route to anti,anti stereotriads, illustrated by applications
    Kathlyn A Parker
    Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    Org Lett 10:1349-52. 2008
    ....
  3. ncbi Deconstruction-reconstruction strategy for accessing valuable polyketides. Preparation of the C15-C24 stereopentad of discodermolide
    Kathlyn A Parker
    Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Org Lett 9:4793-6. 2007
    ..This synthesis illustrates a new strategy, "deconstruction-reconstruction", for accessing stereochemically complex polyketide building blocks...
  4. ncbi Cleavable chiral auxiliaries in 8pi (8pi, 6pi) electrocyclizations
    Kathlyn A Parker
    Department of Chemistry, Stony Brook University, Stony Brook, New York 11794 3400, USA
    Org Lett 8:3553-6. 2006
    ..In the 8-arylmenthyl series, diastereomeric products were separated by chromatography...
  5. ncbi Scalable, catalytic asymmetric synthesis of syn, anti stereotriad building blocks for polypropionate antibiotics
    Kathlyn A Parker
    Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794 3400, USA
    Org Lett 8:3541-4. 2006
    ..Development of this compound, a versatile intermediate for polypropionate synthesis, gave known building blocks for discodermolide...
  6. ncbi TESOTf-induced rearrangement of quinols. Efficient construction of the fully functionalized carbon skeleton of the griseusins by a divergent-reconvergent approach
    Kathlyn A Parker
    Department of Chemistry, SUNY Stony Brook, Stony Brook, New York 11794 3400, USA
    Org Lett 8:1759-62. 2006
    ....
  7. ncbi A synthesis of L-vancosamine derivatives from non-carbohydrate precursors by a short sequence based on the Marshall, McDonald, and Du Bois reactions
    Kathlyn A Parker
    Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794 3400, USA
    Org Lett 5:3891-3. 2003
    ..This sequence is a prototype for a new and efficient strategy for the synthesis of 3-amino sugar derivatives. The key intermediate was elaborated to the silyl ether of N,N-dimethyl vancosamine glycal...
  8. ncbi The total synthesis of (-)-SNF4435 C and (+)-SNF4435 D
    Kathlyn A Parker
    Department of Chemistry, State University of New York at Stony Brook, Stoney Brook, New York 11794 3400, USA
    J Am Chem Soc 126:15968-9. 2004
    ..A biomimetic synthesis of (-)-SNF4435 C and (+)-SNF4435 D exploits these steric effects and allows confirmation of the predicted absolute stereochemistry of the natural products...
  9. ncbi A strategy for exploiting the pseudosymmetry of the C1-C13 stretch of discodermolide
    Kathlyn A Parker
    Department of Chemistry, State University of New York at Stony Brook Stony Brook, New York 11794 3400, USA
    Org Lett 6:1413-6. 2004
    ..Two approaches based on this recognition were devised, and one was shown to be effective in a model series...
  10. ncbi "Endo" and "exo" bicyclo[4.2.0]-octadiene isomers from the electrocyclization of fully substituted tetraene models for SNF 4435C and D. control of stereochemistry by choice of a functionalized substituent
    Kathlyn A Parker
    Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York, 11794 3400, USA
    Org Lett 6:161-4. 2004
    ..The ratio of endo:exo products could be controlled by the choice of the RZ substituent at C-1. On the basis of these results, a short stereoselective route to an advanced SNF 4435 intermediate was devised...
  11. ncbi Short synthesis of the C1-C14 stretch of discodermolide from building blocks prepared by asymmetric catalysis
    Huanyan Cao
    Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794 3400, USA
    Org Lett 10:1353-6. 2008
    ..The preparation of this complex synthon requires 15 steps in the longest linear sequence and 19 steps total from inexpensive materials...
  12. ncbi Cyclic alternating ring-opening metathesis polymerization (CAROMP). Rapid access to functionalized cyclic polymers
    Airong Song
    Department of Chemistry, Stony Brook University, Stony Brook, New York 11794 3400, USA
    Org Lett 12:3729-31. 2010
    ..Conditions for the cyclic AROMP were used to prepare a polymer in which one of the repeat units bore a primary alkyl chloride that was used for further elaboration...
  13. ncbi Regioselectivity of rhodium nitrene insertion. Syntheses of protected glycals of l-daunosamine, d-saccharosamine, and l-ristosamine
    Kathlyn A Parker
    Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794 3400, USA sunysb edu
    Org Lett 7:1785-8. 2005
    ..The short, high-yield syntheses are based on the chemoselective insertion of a rhodium nitrene in an allylic C-H bond rather than in a C-H bond that is alpha to an oxygen substituent...
  14. ncbi Functional group compatibility. Propargyl alcohol reduction in the presence of a vinyl iodide
    Richard W Denton
    Department of Chemistry, SUNY Stony Brook, Stony Brook, New York 11794 3400, USA
    Org Lett 11:2722-3. 2009
    ..They are also stable to the reduction of propargyl alcohols to saturated alcohols by hydrogen over Crabtree's iridium catalyst in CH(2)Cl(2)...
  15. ncbi Amino acid-bearing ROMP polymers with a stereoregular backbone
    Jae Chul Lee
    Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, USA
    J Am Chem Soc 128:4578-9. 2006
    ..6 and suggests that they are the products of a "living" polymerization. 1-Cyclobutenecarboxamide-derived ROMP polymers are excellent prospects for applications that require stereoregular chains functionalized with polar ligands...
  16. ncbi Enantioselective synthesis of (-)-dihydrocodeinone: a short formal synthesis of (-)-morphine
    Kathlyn A Parker
    Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA
    J Org Chem 71:449-55. 2006
    ....
  17. ncbi Synthesis of copolymers by alternating ROMP (AROMP)
    Airong Song
    Department of Chemistry, Stony Brook University, Stony Brook, New York 11794 3400, USA
    J Am Chem Soc 131:3444-5. 2009
    ..The regiocontrol of heteropolymer formation derives from the inability of the cyclobutene ester and cyclohexene monomers to undergo homopolymerization in combination with the favorable kinetics of cross polymerization...
  18. ncbi Structures of the phosphorylated and VO(3)-bound 2H-phosphatase domain of Sts-2
    Yunting Chen
    Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York 11794 8661, USA
    Biochemistry 48:8129-35. 2009
    ..In both structures, the conformation of the active site is remarkably similar to the one seen in apo-Sts-2(PGM) suggesting that the spatial arrangement of the catalytic residues does not change during the dephosphorylation reaction...

Research Grants10

  1. Natural Product Leads for Drug Development
    KATHLYN PARKER; Fiscal Year: 2007
    ..Candidates will be evaluated in the squalene synthase assay. Collaborations for the medicinal chemistry components of the project have beenarranged. ..
  2. Natural Product Leads for Drug Development
    KATHLYN PARKER; Fiscal Year: 2009
    ..Molecular modeling will allow the design of candidates for more active drugs. Candidates will be evaluated in the squalene synthase assay. Collaborations for the medicinal chemistry components of the project have been arranged. ..
  3. Natural Product Leads for Drug Development
    KATHLYN PARKER; Fiscal Year: 2007
    ..Molecular modeling will allow the design of candidates for more active drugs. Candidates will be evaluated in the squalene synthase assay. Collaborations for the medicinal chemistry components of the project have been arranged. ..
  4. STRATEGIES AND METHODS IN SYNTHESIS OF NATURAL PRODUCTS
    KATHLYN PARKER; Fiscal Year: 2003
    ..During the period which corresponds to this proposal, we plan to apply our new methodology to the synthesis of deacetylravidomycin and kidamycin, representatives of the remaining two major classes. ..