Aaron Neiman

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. pmc A screen for spore wall permeability mutants identifies a secreted protease required for proper spore wall assembly
    Yasuyuki Suda
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York, United States of America
    PLoS ONE 4:e7184. 2009
  2. pmc The yeast spore wall enables spores to survive passage through the digestive tract of Drosophila
    Alison E Coluccio
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York, United States of America
    PLoS ONE 3:e2873. 2008
  3. pmc A Gip1p-Glc7p phosphatase complex regulates septin organization and spore wall formation
    H Tachikawa
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    J Cell Biol 155:797-808. 2001
  4. pmc Vesicle docking to the spindle pole body is necessary to recruit the exocyst during membrane formation in Saccharomyces cerevisiae
    Erin M Mathieson
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794 5215, USA
    Mol Biol Cell 21:3693-707. 2010
  5. pmc Septins localize to microtubules during nutritional limitation in Saccharomyces cerevisiae
    M Evangelina Pablo-Hernando
    Instituto de Microbiologia Bioquimica, Departamento de Microbiologia y Genetica, CSIC Universidad de Salamanca, 37007, Salamanca, Spain
    BMC Cell Biol 9:55. 2008
  6. pmc Ascospore formation in the yeast Saccharomyces cerevisiae
    Aaron M Neiman
    Department of Biochemistry and Cell Biology, SUNY Stony Brook, Stony Brook, New York 11794 5215, USA
    Microbiol Mol Biol Rev 69:565-84. 2005
  7. pmc Morphogenetic pathway of spore wall assembly in Saccharomyces cerevisiae
    Alison Coluccio
    Life Sciences, SUNY Stony Brook, Stony Brook, NY 11794 5215, USA
    Eukaryot Cell 3:1464-75. 2004
  8. ncbi request reprint Erv14 family cargo receptors are necessary for ER exit during sporulation in Saccharomyces cerevisiae
    Hideki Nakanishi
    Department of Biochemistry and Cell Biology and Institute for Cell and Developmental Biology, SUNY Stony Brook, Stony Brook, NY 11794 5215, USA
    J Cell Sci 120:908-16. 2007
  9. pmc The anaphase promoting complex targeting subunit Ama1 links meiotic exit to cytokinesis during sporulation in Saccharomyces cerevisiae
    Aviva E Diamond
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794 5215, USA
    Mol Biol Cell 20:134-45. 2009
  10. pmc Membrane assembly modulates the stability of the meiotic spindle-pole body
    Erin M Mathieson
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794 5215, USA
    J Cell Sci 123:2481-90. 2010

Research Grants

Collaborators

  • JoAnne Engebrecht
  • Javier Arroyo
  • Hideki Nakanishi
  • Alison Coluccio
  • Yasuyuki Suda
  • Erin M Mathieson
  • Mark E Nickas
  • Hui Ju Yang
  • M Evangelina Pablo-Hernando
  • David Shapiro
  • Johanna Nelson
  • Xiaojing Huang
  • Alison E Coluccio
  • Janos Kirz
  • Chris Jacobsen
  • Song Liu
  • Aviva E Diamond
  • Jan Steinbrener
  • Stefano Marchesini
  • Joshua J Turner
  • Hiroyuki Tachikawa
  • Rachael K Rodriguez
  • Yolanda Arnaiz-Pita
  • Francisco del Rey
  • James A McNew
  • Carlos R Vazquez de Aldana
  • Enrico Ragni
  • Maria Zeniou-Meyer
  • Enju Lima
  • Huijie Miao
  • Cindi Schwartz
  • Matthew J Winters
  • H Tachikawa
  • Trisha N Davis
  • Brian Snydsman
  • Eric G D Muller
  • Mark Nickas
  • Jae Sook Park
  • Ichiro Inoue
  • Andrew Stewart
  • Maurice J Kernan
  • José Manuel Rodriguez-Peña
  • Kirilee A Wilson
  • Gaia Colasante
  • Guangwei Du
  • Nicolas Vitale
  • Dean Dawson
  • Eleonora Rolli
  • Irit Gottfried
  • Uri Ashery
  • Travis Rice-Stitt
  • Sylvette Chasserot-Golaz
  • Laura Popolo
  • Valérie Demais
  • Yannick Bailly
  • Naama Zabari
  • Michael A Frohman
  • Marie France Bader
  • Anne Marie Haeberle
  • Cindi L Schwartz
  • Masayo Morishita
  • Rachel E Lamson
  • Veit Elser
  • David Sayre
  • Tobias Beetz
  • Malcolm Howells
  • Peter M Pryciak
  • Pierre Thibault
  • Edith Bogengruber
  • Michael E Dresser
  • Pablo de los Santos
  • Min Jay Yang
  • Michael N Conrad
  • Maria Malzone
  • Peter Briza
  • A Bloecher
  • K Tatchell

Detail Information

Publications28

  1. pmc A screen for spore wall permeability mutants identifies a secreted protease required for proper spore wall assembly
    Yasuyuki Suda
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York, United States of America
    PLoS ONE 4:e7184. 2009
    ..OSW3 and other OSW genes identified in this screen are strong candidates to encode enzymes involved in assembly of this protective dityrosine coat...
  2. pmc The yeast spore wall enables spores to survive passage through the digestive tract of Drosophila
    Alison E Coluccio
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York, United States of America
    PLoS ONE 3:e2873. 2008
    ..melanogaster. These results suggest that the primary function of the yeast ascospore is as a cell type specialized for dispersion by insect vectors...
  3. pmc A Gip1p-Glc7p phosphatase complex regulates septin organization and spore wall formation
    H Tachikawa
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    J Cell Biol 155:797-808. 2001
    ..These results indicate that a Gip1p-Glc7p phosphatase complex is required for proper septin organization and initiation of spore wall formation during sporulation...
  4. pmc Vesicle docking to the spindle pole body is necessary to recruit the exocyst during membrane formation in Saccharomyces cerevisiae
    Erin M Mathieson
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794 5215, USA
    Mol Biol Cell 21:3693-707. 2010
    ..This suggests that the MOP promotes membrane formation both by localization of precursor vesicles to a particular site and by recruitment of a second tethering complex, the exocyst, that stimulates downstream events of fusion...
  5. pmc Septins localize to microtubules during nutritional limitation in Saccharomyces cerevisiae
    M Evangelina Pablo-Hernando
    Instituto de Microbiologia Bioquimica, Departamento de Microbiologia y Genetica, CSIC Universidad de Salamanca, 37007, Salamanca, Spain
    BMC Cell Biol 9:55. 2008
    ..In sporulating cells, the septin ring disassembles and septins relocalize to the prospore membrane...
  6. pmc Ascospore formation in the yeast Saccharomyces cerevisiae
    Aaron M Neiman
    Department of Biochemistry and Cell Biology, SUNY Stony Brook, Stony Brook, New York 11794 5215, USA
    Microbiol Mol Biol Rev 69:565-84. 2005
    ..This review focuses on our current understanding of the cellular rearrangements and the genes required in each of these phases to give rise to a wild-type spore...
  7. pmc Morphogenetic pathway of spore wall assembly in Saccharomyces cerevisiae
    Alison Coluccio
    Life Sciences, SUNY Stony Brook, Stony Brook, NY 11794 5215, USA
    Eukaryot Cell 3:1464-75. 2004
    ..The results demonstrate that spore wall construction involves a series of dependent steps and provide the outline of a morphogenetic pathway for assembly of a complex extracellular structure...
  8. ncbi request reprint Erv14 family cargo receptors are necessary for ER exit during sporulation in Saccharomyces cerevisiae
    Hideki Nakanishi
    Department of Biochemistry and Cell Biology and Institute for Cell and Developmental Biology, SUNY Stony Brook, Stony Brook, NY 11794 5215, USA
    J Cell Sci 120:908-16. 2007
    ..These results reveal a developmentally regulated change in the requirements for ER export in S. cerevisiae...
  9. pmc The anaphase promoting complex targeting subunit Ama1 links meiotic exit to cytokinesis during sporulation in Saccharomyces cerevisiae
    Aviva E Diamond
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794 5215, USA
    Mol Biol Cell 20:134-45. 2009
    ..These results demonstrate that APC(Ama1) functions to coordinate the exit from meiosis II with cytokinesis...
  10. pmc Membrane assembly modulates the stability of the meiotic spindle-pole body
    Erin M Mathieson
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794 5215, USA
    J Cell Sci 123:2481-90. 2010
    ..These results suggest an architectural rearrangement of the MOP coincident with vesicle fusion...
  11. pmc Alternative modes of organellar segregation during sporulation in Saccharomyces cerevisiae
    Yasuyuki Suda
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794 5215, USA
    Eukaryot Cell 6:2009-17. 2007
    ..These results reveal that organellar segregation into spores is achieved by mechanisms distinct from those in mitotic cells...
  12. pmc Ady3p links spindle pole body function to spore wall synthesis in Saccharomyces cerevisiae
    Mark E Nickas
    Department of Biochemistry and Cell Biology and Institute for Cell and Developmental Biology, State University of New York, Stony Brook, New York 11794 5215, USA
    Genetics 160:1439-50. 2002
    ..Our results suggest that Ady3p mediates assembly of the Don1p-containing structure at the leading edge of the prospore membrane via interaction with components of the SPB and that this structure is involved in spore wall formation...
  13. pmc Ady4p and Spo74p are components of the meiotic spindle pole body that promote growth of the prospore membrane in Saccharomyces cerevisiae
    Mark E Nickas
    Department of Biochemistry and Cell Biology and Institute for Cell and Developmental Biology, State University of New York at Stony Brook, Stony Brook, New York 11794 5215, USA
    Eukaryot Cell 2:431-45. 2003
    ....
  14. pmc Positive and negative regulation of a SNARE protein by control of intracellular localization
    Hideki Nakanishi
    Department of Biochemistry and Cell Biology and Institute for Cell and Developmental Biology, SUNY Stony Brook, Stony Brook, New York 11794 5215, USA
    Mol Biol Cell 15:1802-15. 2004
    ..Thus, the SNARE Spo20p is both positively and negatively regulated by control of its intracellular localization...
  15. pmc Binding interactions control SNARE specificity in vivo
    Hui Ju Yang
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794, USA
    J Cell Biol 183:1089-100. 2008
    ..These results demonstrate that differences within the SNARE helices can discriminate between closely related SNAREs for function in vivo...
  16. ncbi request reprint Phospholipase D and the SNARE Sso1p are necessary for vesicle fusion during sporulation in yeast
    Hideki Nakanishi
    Department of Biochemistry and Cell Biology, SUNY Stony Brook, Stony Brook, NY 4 5215, USA
    J Cell Sci 119:1406-15. 2006
    ..These results demonstrate a role for phospholipase D in vesicle fusion and suggest that phospholipase D-generated phosphatidic acid plays multiple roles in the fusion process...
  17. ncbi request reprint Interspore bridges: a new feature of the Saccharomyces cerevisiae spore wall
    Alison Coluccio
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York, Stony Brook, 332 Life Sciences, Stony Brook, NY 11794 5215, USA
    Microbiology 150:3189-96. 2004
    ..Interspore bridges are shown to be necessary to hold spores together after release from the ascus. A function for these bridges in the maintenance of heterozygous markers in a homothallic yeast population is proposed...
  18. pmc Regulation of spindle pole function by an intermediary metabolite
    Mark E Nickas
    Department of Biochemistry and Cell Biology and Institute for Cell and Developmental Biology, State University of New York at Stony Brook, Stony Brook, New York 11794 5215, USA
    Mol Biol Cell 15:2606-16. 2004
    ..These results define a cellular response in which the accumulation of an intermediary metabolite serves as a measure of biosynthetic capacity to regulate the number of daughter cells formed...
  19. pmc A guaninine nucleotide exchange factor is a component of the meiotic spindle pole body in Schizosaccharomyces pombe
    Hui Ju Yang
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794 5215, USA
    Mol Biol Cell 21:1272-81. 2010
    ..These results demonstrate that stimulation of Rab-GTPase activity is a property of the S. pombe MOP essential for the initiation of membrane formation...
  20. ncbi request reprint In vitro fusion catalyzed by the sporulation-specific t-SNARE light-chain Spo20p is stimulated by phosphatidic acid
    Song Liu
    Department of Biochemistry and Cell Biology, Rice University, 6100 Main Street MS 140, Houston, TX 77251 1892, USA
    Traffic 8:1630-43. 2007
    ..Our results suggest that the fusion strength of SNAREs, the composition of organelle lipids and lipid-SNARE interactions may be coordinately regulated to control the rate and specificity of membrane fusion...
  21. pmc Soft X-ray diffraction microscopy of a frozen hydrated yeast cell
    Xiaojing Huang
    Department of Physics and Astronomy, Stony Brook University, Stony Brook, New York 11794 3800, USA
    Phys Rev Lett 103:198101. 2009
    ..This demonstration represents an important step towards high resolution imaging of cells in their natural, hydrated state, without limitations imposed by x-ray optics...
  22. pmc High-resolution x-ray diffraction microscopy of specifically labeled yeast cells
    Johanna Nelson
    Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY 11794 3800, USA
    Proc Natl Acad Sci U S A 107:7235-9. 2010
    ..Cells were plunge-frozen in liquid ethane and freeze-dried, after which they were imaged whole using x-ray diffraction microscopy at 750 eV photon energy...
  23. pmc Genetic evidence of a role for membrane lipid composition in the regulation of soluble NEM-sensitive factor receptor function in Saccharomyces cerevisiae
    Alison Coluccio
    Department of Biochemistry and Cell Biology and Institute for Cell and Developmental Biology, State University of New York, Stony Brook, New York 11794 5215, USA
    Genetics 166:89-97. 2004
    ..These results indicate that elevated levels of phosphatidic acid in the membrane may be required specifically for the function of SNARE complexes containing Spo20p...
  24. pmc Biological imaging by soft x-ray diffraction microscopy
    David Shapiro
    Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY 11794 3800, USA
    Proc Natl Acad Sci U S A 102:15343-6. 2005
    ....
  25. pmc GAS2 and GAS4, a pair of developmentally regulated genes required for spore wall assembly in Saccharomyces cerevisiae
    Enrico Ragni
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy
    Eukaryot Cell 6:302-16. 2007
    ..The ectopic expression of GAS2 and GAS4 genes in a gas1 null mutant revealed that these proteins are redundant versions of Gas1p specialized to function in a compartment at a pH value close to neutral...
  26. pmc Cdc15 is required for spore morphogenesis independently of Cdc14 in Saccharomyces cerevisiae
    M Evangelina Pablo-Hernando
    Instituto de Microbiologia Bioquimica, Departamento de Microbiologia y Genetica, CSIC Universidad de Salamanca, 37007 Salamanca, Spain
    Genetics 177:281-93. 2007
    ....
  27. ncbi request reprint A membrane binding domain in the ste5 scaffold synergizes with gbetagamma binding to control localization and signaling in pheromone response
    Matthew J Winters
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 20:21-32. 2005
    ..Therefore, weak membrane affinity is advantageous, ensuring a normal level of signaling quiescence in the absence of stimulus and imposing a requirement for Gbetagamma binding...
  28. ncbi request reprint Phospholipase D1 production of phosphatidic acid at the plasma membrane promotes exocytosis of large dense-core granules at a late stage
    Maria Zeniou-Meyer
    Département Neurotransmission and Sécrétion Neuroendocrine, Institut des Neurosciences Cellulaires et Integratives, CNRS and Université Louis Pasteur, 5 rue Blaise Pascal, Strasbourg, France
    J Biol Chem 282:21746-57. 2007
    ..We propose that the underlying mechanism is related to the ability of PA to alter membrane curvature and promote hemi-fusion...

Research Grants16

  1. Assembly and Function of the Yeast Spore Wall
    Aaron M Neiman; Fiscal Year: 2010
    ..Experiments are targeted towards understanding the regulation, assembly pathways, and structure of wall components. ..
  2. REGULATION OF THE SECRETORY PATHWAY IN YEAST
    Aaron Neiman; Fiscal Year: 2001
    ..The model that Spo2lp is a sporulation-specific component of the SPB will be tested and the role of Spo2 Ip in SPB modification examined. ..
  3. Assembly and Function of the Yeast Spore Wall
    Aaron Neiman; Fiscal Year: 2009
    ..In sum, these studies should deepen our understanding of the molecular mechanisms of spore wall construction, which will in turn provide insight into the strategies of extracellular matrix assembly in other organisms. ..
  4. Developmental Regulation of the Secretory Pathway in Yeast
    Aaron Neiman; Fiscal Year: 2009
    ..The basis for this change is also under investigation. Together these studies will provide insight into how the cell modifies its basic architecture during differentiation. ..
  5. Assembly and Function of the Yeast Spore Wall
    Aaron Neiman; Fiscal Year: 2007
    ..In sum, these studies should deepen our understanding of the molecular mechanisms of spore wall construction, which will in turn provide insight into the strategies of extracellular matrix assembly in other organisms. ..
  6. Developmental Regulation of the Secretory Pathway in Yeast
    Aaron Neiman; Fiscal Year: 2007
    ..The basis for this change is also under investigation. Together these studies will provide insight into how the cell modifies its basic architecture during differentiation. ..
  7. Assembly and Function of the Yeast Spore Wall
    Aaron Neiman; Fiscal Year: 2006
    ..In sum, these studies should deepen our understanding of the molecular mechanisms of spore wall construction, which will in turn provide insight into the strategies of extracellular matrix assembly in other organisms. ..
  8. Developmental Regulation of the Secretory Pathway in Yeast
    Aaron Neiman; Fiscal Year: 2006
    ..The basis for this change is also under investigation. Together these studies will provide insight into how the cell modifies its basic architecture during differentiation. ..
  9. Assembly and Function of the Yeast Spore Wall
    Aaron Neiman; Fiscal Year: 2005
    ..In sum, these studies should deepen our understanding of the molecular mechanisms of spore wall construction, which will in turn provide insight into the strategies of extracellular matrix assembly in other organisms. ..
  10. REGULATION OF THE SECRETORY PATHWAY IN YEAST
    Aaron Neiman; Fiscal Year: 2005
    ..The model that Spo2lp is a sporulation-specific component of the SPB will be tested and the role of Spo2 Ip in SPB modification examined. ..
  11. REGULATION OF THE SECRETORY PATHWAY IN YEAST
    Aaron Neiman; Fiscal Year: 2004
    ..The model that Spo2lp is a sporulation-specific component of the SPB will be tested and the role of Spo2 Ip in SPB modification examined. ..
  12. REGULATION OF THE SECRETORY PATHWAY IN YEAST
    Aaron Neiman; Fiscal Year: 2003
    ..The model that Spo2lp is a sporulation-specific component of the SPB will be tested and the role of Spo2 Ip in SPB modification examined. ..
  13. REGULATION OF THE SECRETORY PATHWAY IN YEAST
    Aaron Neiman; Fiscal Year: 2002
    ..The model that Spo2lp is a sporulation-specific component of the SPB will be tested and the role of Spo2 Ip in SPB modification examined. ..
  14. Developmental Regulation of the Secretory Pathway in Yeast
    Aaron Neiman; Fiscal Year: 2009
    ..The basis for this change is also under investigation. Together these studies will provide insight into how the cell modifies its basic architecture during differentiation. ..