Steffen Mueller

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. pmc Putting synthesis into biology: a viral view of genetic engineering through de novo gene and genome synthesis
    Steffen Mueller
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794 5222, USA
    Chem Biol 16:337-47. 2009
  2. pmc Live attenuated influenza virus vaccines by computer-aided rational design
    Steffen Mueller
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
    Nat Biotechnol 28:723-6. 2010
  3. pmc Reduction of the rate of poliovirus protein synthesis through large-scale codon deoptimization causes attenuation of viral virulence by lowering specific infectivity
    Steffen Mueller
    Department of Molecular Genetics and Microbiology, Life Sciences Building, Stony Brook University, Stony Brook, NY 11794 5222, USA
    J Virol 80:9687-96. 2006
  4. pmc Virus attenuation by genome-scale changes in codon pair bias
    J Robert Coleman
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA
    Science 320:1784-7. 2008
  5. pmc Identification of two functionally redundant RNA elements in the coding sequence of poliovirus using computer-generated design
    Yutong Song
    Department of Molecular Genetics and Microbiology and Computer Science, Stony Brook University, Stony Brook, NY 11794, USA
    Proc Natl Acad Sci U S A 109:14301-7. 2012
  6. pmc Direct interaction between two viral proteins, the nonstructural protein 2C and the capsid protein VP3, is required for enterovirus morphogenesis
    Ying Liu
    Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, New York, United States of America
    PLoS Pathog 6:e1001066. 2010
  7. ncbi request reprint Oncolytic treatment and cure of neuroblastoma by a novel attenuated poliovirus in a novel poliovirus-susceptible animal model
    Hidemi Toyoda
    Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, New York 11794 5222, USA
    Cancer Res 67:2857-64. 2007
  8. pmc Deliberate reduction of hemagglutinin and neuraminidase expression of influenza virus leads to an ultraprotective live vaccine in mice
    Chen Yang
    Departments of Molecular Genetics and Microbiology and Computer Science, Stony Brook University, Stony Brook, NY 11794
    Proc Natl Acad Sci U S A 110:9481-6. 2013
  9. ncbi request reprint Poliovirus and poliomyelitis: a tale of guts, brains, and an accidental event
    Steffen Mueller
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA
    Virus Res 111:175-93. 2005
  10. pmc Computationally designed adeno-associated virus (AAV) Rep 78 is efficiently maintained within an adenovirus vector
    Varsha Sitaraman
    Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA
    Proc Natl Acad Sci U S A 108:14294-9. 2011

Collaborators

Detail Information

Publications19

  1. pmc Putting synthesis into biology: a viral view of genetic engineering through de novo gene and genome synthesis
    Steffen Mueller
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794 5222, USA
    Chem Biol 16:337-47. 2009
    ..For this reason viruses are once again poised to lead the way in the budding field of synthetic biology--for better or worse...
  2. pmc Live attenuated influenza virus vaccines by computer-aided rational design
    Steffen Mueller
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
    Nat Biotechnol 28:723-6. 2010
    ..The method can be applied rapidly to any emerging influenza virus in its entirety, an advantage that is especially relevant when dealing with seasonal epidemics and pandemic threats, such as H5N1- or 2009-H1N1 influenza...
  3. pmc Reduction of the rate of poliovirus protein synthesis through large-scale codon deoptimization causes attenuation of viral virulence by lowering specific infectivity
    Steffen Mueller
    Department of Molecular Genetics and Microbiology, Life Sciences Building, Stony Brook University, Stony Brook, NY 11794 5222, USA
    J Virol 80:9687-96. 2006
    ....
  4. pmc Virus attenuation by genome-scale changes in codon pair bias
    J Robert Coleman
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA
    Science 320:1784-7. 2008
    ..Polioviruses thus customized were used to immunize mice and provided protective immunity after challenge. This "death by a thousand cuts" strategy could be generally applicable to attenuating many kinds of viruses...
  5. pmc Identification of two functionally redundant RNA elements in the coding sequence of poliovirus using computer-generated design
    Yutong Song
    Department of Molecular Genetics and Microbiology and Computer Science, Stony Brook University, Stony Brook, NY 11794, USA
    Proc Natl Acad Sci U S A 109:14301-7. 2012
    ..Recoding offers a unique and effective method to search for unknown functional RNA elements in coding sequences of RNA viruses, particularly if the signals are redundant in function...
  6. pmc Direct interaction between two viral proteins, the nonstructural protein 2C and the capsid protein VP3, is required for enterovirus morphogenesis
    Ying Liu
    Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, New York, United States of America
    PLoS Pathog 6:e1001066. 2010
    ..These conditions lead to morphogenesis at the site where newly synthesized genomes emerge from the replication complex...
  7. ncbi request reprint Oncolytic treatment and cure of neuroblastoma by a novel attenuated poliovirus in a novel poliovirus-susceptible animal model
    Hidemi Toyoda
    Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, New York 11794 5222, USA
    Cancer Res 67:2857-64. 2007
    ..We suggest that our novel attenuated oncolytic poliovirus is a promising candidate for effective oncolytic treatment of human neuroblastoma or other cancer even in the presence of present or induced antipolio immunity...
  8. pmc Deliberate reduction of hemagglutinin and neuraminidase expression of influenza virus leads to an ultraprotective live vaccine in mice
    Chen Yang
    Departments of Molecular Genetics and Microbiology and Computer Science, Stony Brook University, Stony Brook, NY 11794
    Proc Natl Acad Sci U S A 110:9481-6. 2013
    ..We conclude that the suppression of HA and NA is a unique strategy in live vaccine development...
  9. ncbi request reprint Poliovirus and poliomyelitis: a tale of guts, brains, and an accidental event
    Steffen Mueller
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA
    Virus Res 111:175-93. 2005
    ..This review will attempt to summarize our current knowledge of the molecular biology of poliovirus, its pathogenesis, as well as recent advances in the areas of cell and tissue tropism and mechanisms of central nervous system invasion...
  10. pmc Computationally designed adeno-associated virus (AAV) Rep 78 is efficiently maintained within an adenovirus vector
    Varsha Sitaraman
    Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA
    Proc Natl Acad Sci U S A 108:14294-9. 2011
    ..These data provide insights into the molecular relationships of AAV Rep and Ad replication, while expanding the applicability of synonymous codon pair reengineering as a strategy to effect phenotypic endpoints...
  11. pmc A host-specific, temperature-sensitive translation defect determines the attenuation phenotype of a human rhinovirus/poliovirus chimera, PV1(RIPO)
    Nusrat Jahan
    Department of Molecular Genetics and Microbiology, Life Sciences Building, Stony Brook University, Stony Brook, NY 11794 5222, USA
    J Virol 85:7225-35. 2011
    ..Thus, novel poliovirus variants in line for possible development of human vaccines must be tested in nonhuman primates...
  12. ncbi request reprint Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains
    Steffen Mueller
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794, USA
    J Biol Chem 278:31251-60. 2003
    ....
  13. ncbi request reprint Expression of the human poliovirus receptor/CD155 gene is activated by sonic hedgehog
    David J Solecki
    Department of Molecular Genetics and Microbiology, School of Medicine, State University of New York at Stony Brook, 11794, USA
    J Biol Chem 277:25697-702. 2002
    ..These data identify the CD155 gene as a transcriptional target of Shh, a finding that has significance for the normal function of CD155 during development and the expression of CD155 in neuroectodermal tumors...
  14. doi request reprint Production of infectious poliovirus from synthetic viral genomes
    Jeronimo Cello
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY, USA
    Methods Mol Biol 852:181-93. 2012
    ..Our work shows that it is possible to synthesize an infectious agent in test tube by solely following instructions from a written sequence...
  15. ncbi request reprint Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis
    Steffen Mueller
    Department of Molecular Genetics and Microbiology, State University of New York, Stony Brook, New York 11794, USA
    J Biol Chem 277:7897-904. 2002
    ..Association with Tctex-1 and, hence, with the dynein motor complex may offer an explanation for how poliovirus hijacks the cellular transport machinery to retrogradely ascend along the axon to the neuronal cell body...
  16. pmc Polypyrimidine tract binding protein-1 (PTB1) is a determinant of the tissue and host tropism of a human rhinovirus/poliovirus chimera PV1(RIPO)
    Nusrat Jahan
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, New York, United States of America
    PLoS ONE 8:e60791. 2013
    ..All three mechanisms can conceivably modulate the thermodynamics of RNA folding, and thus facilitate and stabilize the functional IRES structure...
  17. pmc Synthetic viruses: a new opportunity to understand and prevent viral disease
    Eckard Wimmer
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
    Nat Biotechnol 27:1163-72. 2009
    ..Although only a few applications of virus synthesis have been described as yet, key recent findings have been the resurrection of the 1918 influenza virus and the generation of codon- and codon pair-deoptimized polioviruses...
  18. pmc Complexes of poliovirus serotypes with their common cellular receptor, CD155
    Yongning He
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Virol 77:4827-35. 2003
    ..Many of these are likely to have lost their ability to bind CD155, resulting in there being only three PV serotypes...
  19. ncbi request reprint Immunofluorescence analysis of poliovirus receptor expression in Peyer's patches of humans, primates, and CD155 transgenic mice: implications for poliovirus infection
    Akiko Iwasaki
    Department of Epidemiology and Public Health, School of Medicine, Yale University, New Haven, Connecticut, USA
    J Infect Dis 186:585-92. 2002
    ..This suggests that productive poliovirus infection of the gut is dependent on the expression of CD155 within the FAE, including the M cells, and on cells within Peyer's patches, most likely within germinal centers...