Research Topics
Species | Wilfred LieberthalSummaryAffiliation: State University of New York Country: USA Publications
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Detail Information
Publications
The role of the mammalian target of rapamycin (mTOR) in renal diseaseWilfred Lieberthal
Stony Brook Medical Center, Health Sciences Center, 16 081B Nicholls Road, Stony Brook, NY 11794 8166, USA
J Am Soc Nephrol 20:2493-502. 2009..Finally, inhibitors of mTOR improve survival in patients with metastatic renal cell carcinoma...- Macroautophagy: a mechanism for mediating cell death or for promoting cell survival?Wilfred Lieberthal
Stony Brook University Hospital, Department of Medicine, Stony Brook, New York, USA
Kidney Int 74:555-7. 2008..This finding provides novel evidence that autophagy may play a role in ameliorating the effects of acute injury on the kidney... 
Rapamycin delays but does not prevent recovery from acute renal failure: role of acquired tubular resistanceWilfred Lieberthal
Department of Nephrology, Health Science Center, Stony Brook University Hospital, Stony Brook, NY 11794 0001, USA
Transplantation 82:17-22. 2006..We reported that rapamycin impairs recovery after acute renal failure (ARF) in rats. The objective of this study was to determine if recovery will eventually occur after ARF despite continued rapamycin treatment...
Recognition-dependent signaling events in response to apoptotic targets inhibit epithelial cell viability by multiple mechanisms: implications for non-immune tissue homeostasisVimal A Patel
Section of Nephrology, Department of Medicine, University of Illinois, Chicago, Illinois 60612, USA
J Biol Chem 287:13761-77. 2012..g. breast-derived) show increased viability. By acting as sentinels of environmental change, apoptotic targets allow neighboring cells, especially non-migratory epithelial cells, to monitor and potentially adapt to local stresses...- Recognition of apoptotic cells by epithelial cells: conserved versus tissue-specific signaling responsesVimal A Patel
Section of Nephrology, Department of Medicine, University of Illinois, Chicago, Illinois 60612, USA
J Biol Chem 285:1829-40. 2010..By acting as sentinels of environmental change, apoptotic and necrotic targets may permit neighboring viable cells, especially non-migratory epithelial cells, to monitor and adapt to local stresses... - Mammalian target of rapamycin and the kidney. II. Pathophysiology and therapeutic implicationsWilfred Lieberthal
Stony Brook Univ Medical Center, Health Sciences Center, Stony Brook, NY 11794 8166, USA
Am J Physiol Renal Physiol 303:F180-91. 2012.... - AMPK protects proximal tubular cells from stress-induced apoptosis by an ATP-independent mechanism: potential role of Akt activationWilfred Lieberthal
Dept of Medicine, Stony Brook Medical Center, 101 Nicholls Rd, Stony Brook, NY 11794 8166, USA
Am J Physiol Renal Physiol 301:F1177-92. 2011..Protection by AMPK appears to be due not to AMPK-mediated conservation of cell energy stores, but rather, at least in part, to AMPK-mediated activation of Akt... - Mammalian target of rapamycin and the kidney. I. The signaling pathwayWilfred Lieberthal
Department of Medicine, Stony Brook University Medical Center, Stony Brook, NY, USA
Am J Physiol Renal Physiol 303:F1-10. 2012..Rapamycin and its analogs inhibit the activity of mTORC1 only, and not that of mTORC2, while the newer "catalytic" mTOR inhibitors affect both complexes... - Phagocytosis of apoptotic cells by macrophages induces novel signaling events leading to cytokine-independent survival and inhibition of proliferation: activation of Akt and inhibition of extracellular signal-regulated kinases 1 and 2Suman M Reddy
Renal Section, Evans Memorial Department of Clinical Research, Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
J Immunol 169:702-13. 2002..These signaling differences may underlie the opposing tendencies of apoptotic cells and danger signals in promoting tolerance vs immunity... - Apoptotic and necrotic cells as sentinels of local tissue stress and inflammation: response pathways initiated in nearby viable cellsVimal A Patel
Section of Nephrology, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA
Autoimmunity 42:317-21. 2009..We propose that dead cells (apo and nec) act as sentinels to alert nearby viable cells to local environmental change or stress... - Role of apoptosis in the pathogenesis of acute renal failureRamon Bonegio
Renal Section, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Curr Opin Nephrol Hypertens 11:301-8. 2002..In addition to caspase inhibition, the apoptotic pathway offers many potential targets for therapeutic interventions to prevent renal tubular cell apoptosis... - Chemical anoxia of tubular cells induces activation of c-Src and its translocation to the zonula adherensDiviya Sinha
Renal Section, Evans Biomedical Research Center, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts 02118, USA
Am J Physiol Renal Physiol 284:F488-97. 2003..Our findings suggest that these events contribute to the loss of the epithelial barrier function associated with chemical anoxia... - Primary prevention of acute renal failure in the critically illJohn A Kellum
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Curr Opin Crit Care 11:537-41. 2005..To date, no therapy apart from renal replacement therapy has been shown to improve survival or enhance recover. Thus, efforts to prevent acute renal failure are eagerly sought... - Risk factors for acute renal failure: inherent and modifiable risksMartine Leblanc
Department of Nephrology, University of Montreal, Montreal, Canada
Curr Opin Crit Care 11:533-6. 2005..Our purpose is to discuss established risk factors in the development of acute renal failure and briefly overview clinical markers and preventive measures... - Rapamycin ameliorates proteinuria-associated tubulointerstitial inflammation and fibrosis in experimental membranous nephropathyRamon G B Bonegio
Evans Biomedical Research Center, Room X530, Boston University Medical Center, 650 Albany Street, Boston, MA 02129, USA
J Am Soc Nephrol 16:2063-72. 2005..Rapamycin also completely inhibited compensatory renal hypertrophy. In summary, rapamycin ameliorates the tubulointerstitial disease associated with chronic proteinuria and loss of renal mass... - Lithium activates the Wnt and phosphatidylinositol 3-kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factorsDiviya Sinha
Renal Section, Evans Biomedical Research Center, Rm. 546, 650 Albany St, Boston, MA 02118, USA
Am J Physiol Renal Physiol 288:F703-13. 2005..Extracellular IGF-II serves as an autocrine survival factor that is responsible, in part, for activating the anti-apoptotic phosphatidylinositol-3-kinase-Akt pathway during serum deprivation... - Inhibition of ligand-independent ERK1/2 activity in kidney proximal tubular cells deprived of soluble survival factors up-regulates Akt and prevents apoptosisDiviya Sinha
Renal Section, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Biol Chem 279:10962-72. 2004.... - Acute renal failure in the critically ill patientVivian E Abernethy
Boston University School of Medicine, Renal Section, Evans Biomedical Research Center, 5th Floor, Room 537, 650 Albany Street, Boston, MA 02118, USA
Crit Care Clin 18:203-22, v. 2002..In addition, some unusual causes of acute renal failure that occur predominantly in the intensive care unit are briefly discussed... - Comparison of the effects of a 50% exchange-transfusion with albumin, hetastarch, and modified hemoglobin solutionsWilfred Lieberthal
Evans Department of Clinical Research, Boston University Medical Center, Massachusetts, USA
Shock 17:61-9. 2002..We conclude, that of all solutions tested, both the short- and long-term effects of an exchange-transfusion with whole blood are most closely reproduced by an exchange with o-raffinose-crosslinked hemoglobin...