Joseph Lachance

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. ncbi A fundamental relationship between genotype frequencies and fitnesses
    Joseph Lachance
    Department of Ecology and Evolution, State University of New York, Stony Brook, New York 11794 5222, USA
    Genetics 180:1087-93. 2008
  2. ncbi Detecting selection-induced departures from Hardy-Weinberg proportions
    Joseph Lachance
    Graduate Program in Genetics, Department of Ecology and Evolution, State University of New York at Stony Brook, Stony Brook, NY 11794 5222, USA
    Genet Sel Evol 41:15. 2009
  3. ncbi Inbreeding, pedigree size, and the most recent common ancestor of humanity
    Joseph Lachance
    Graduate Program in Genetics, Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY 11794 5222, USA
    J Theor Biol 261:238-47. 2009
  4. ncbi X-autosome incompatibilities in Drosophila melanogaster: tests of Haldane's rule and geographic patterns within species
    Joseph Lachance
    Graduate Program in Genetics, Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York 11794, USA
    Evolution 64:3035-46. 2010
  5. ncbi The population genetics of X-autosome synthetic lethals and steriles
    Joseph Lachance
    Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York 11794 5222, USA
    Genetics 189:1011-27. 2011
  6. ncbi Long-term adaptation of epistatic genetic networks
    Roman Yukilevich
    Department of Ecology and Evolution, State University of New York, Stony Brook, New York 11794, USA
    Evolution 62:2215-35. 2008
  7. ncbi Disease-associated alleles in genome-wide association studies are enriched for derived low frequency alleles relative to HapMap and neutral expectations
    Joseph Lachance
    Graduate Program in Genetics, Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY 11794 5222, USA
    BMC Med Genomics 3:57. 2010

Detail Information

Publications7

  1. ncbi A fundamental relationship between genotype frequencies and fitnesses
    Joseph Lachance
    Department of Ecology and Evolution, State University of New York, Stony Brook, New York 11794 5222, USA
    Genetics 180:1087-93. 2008
    ..When this ratio does not equal two, either selection or population structure is present. Within-population HapMap data show population-specific patterns, while pooled data show an excess of homozygotes...
  2. ncbi Detecting selection-induced departures from Hardy-Weinberg proportions
    Joseph Lachance
    Graduate Program in Genetics, Department of Ecology and Evolution, State University of New York at Stony Brook, Stony Brook, NY 11794 5222, USA
    Genet Sel Evol 41:15. 2009
    ....
  3. ncbi Inbreeding, pedigree size, and the most recent common ancestor of humanity
    Joseph Lachance
    Graduate Program in Genetics, Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY 11794 5222, USA
    J Theor Biol 261:238-47. 2009
    ..Inbreeding reduces the number of ancestors in a pedigree, pushing back global common ancestry times. These results are consistent with the remarkable findings of previous studies: all humanity shares common ancestry in the recent past...
  4. ncbi X-autosome incompatibilities in Drosophila melanogaster: tests of Haldane's rule and geographic patterns within species
    Joseph Lachance
    Graduate Program in Genetics, Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York 11794, USA
    Evolution 64:3035-46. 2010
    ..These findings are consistent with the view that genomes are coadapted gene complexes and that geography affects the likelihood of epistatic fitness interactions...
  5. ncbi The population genetics of X-autosome synthetic lethals and steriles
    Joseph Lachance
    Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York 11794 5222, USA
    Genetics 189:1011-27. 2011
    ..We also discuss the implications of these findings with respect to standing genetic variation and the origins of Haldane's rule...
  6. ncbi Long-term adaptation of epistatic genetic networks
    Roman Yukilevich
    Department of Ecology and Evolution, State University of New York, Stony Brook, New York 11794, USA
    Evolution 62:2215-35. 2008
    ..These results provide testable predictions for adaptation of traits governed by epistatic networks and the evolution of epistasis within networks...
  7. ncbi Disease-associated alleles in genome-wide association studies are enriched for derived low frequency alleles relative to HapMap and neutral expectations
    Joseph Lachance
    Graduate Program in Genetics, Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY 11794 5222, USA
    BMC Med Genomics 3:57. 2010
    ..derived states of disease-associated alleles differ from the rest of the genome. Characteristics of disease-associated alleles can be used to increase the yield of future studies...