Research Topics
| Subodh KumarSummaryAffiliation: State University of New York College at Buffalo Country: USA Publications
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Publications
Mutagenicity of benzo[b]phenanthro[2,3-d]thiophene (BPT) and its metabolites in TA100 and base-specific tester strains (TA7001-TA7006) of Salmonella typhimurium: evidence of multiple pathways for the bioactivation of BPTSubodh Kumar
Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, NY 14222, USA
Mutat Res 545:11-21. 2004....- Metabolism of phenanthrene by brown bullhead liver microsomesJyotsna Pangrekar
Great Lakes Center for Environmental Research and Education, State University of New York College at Buffalo, Buffalo, NY 14222, USA
Aquat Toxicol 64:407-18. 2003..Phenanthrene, compared with benzo[a]pyrene and chrysene, is metabolized by bullhead liver microsomal enzymes to its benzo-ring dihydrodiols with a relatively low degree of stereoselectivity... - Comparative metabolism of the aza polynuclear aromatic hydrocarbon dibenz[a,h]acridine by recombinant human and rat cytochrome P450sZhi-Xin Yuan
Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, 1300 Elmwood Avenue, Buffalo, New York 14222, USA
Chem Res Toxicol 17:672-8. 2004..However, human and rat P450 1A1 do not differ with respect to their stereoselectivity in the metabolism of DB[a,h]ACR to the diols... - Metabolism of the polynuclear sulfur heterocycle benzo[b]phenanthro[2,3-d]thiophene by rodent liver microsomes: evidence for multiple pathways in the bioactivation of benzo[b]phenanthro[2,3-d]thiopheneZhi-Xin Yuan
Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, 1300 Elmwood Avenue, Buffalo, New York 14222, USA
Chem Res Toxicol 16:1581-8. 2003.... - Comparative metabolism of chrysene and 5-methylchrysene by rat and rainbow trout liver microsomesNancy W Shappell
Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, 1300 Elmwood Avenue, Buffalo, New York 14222, USA
Toxicol Sci 72:260-6. 2003..In contrast the reverse is true in the case of 5-MeCHR, indicating that a non-benzo ring methyl substituent alters the regioselectivity of the enzymes involved in the oxidative metabolism of PAHs... 
Phenolic fraction of tobacco smoke inhibits BPDE-induced apoptosis response and potentiates cell transformation: role of attenuation of p53 responseJagat J Mukherjee
Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, United States
Chem Res Toxicol 24:698-705. 2011..Although p53-mediated NF-κB activation has a role in apoptosis induction, the role of NF-κB in TSCPhFr-mediated potentiation of PAH-induced cell transformation is not clear from our studies...
Inhibition of benzopyrene-diol-epoxide (BPDE)-induced bax and caspase-9 by cadmium: role of mitogen activated protein kinaseJagat J Mukherjee
State University of New York College at Buffalo, Environ Toxicol and Chem, Great Lakes Center, 1300 Elmwood Avenue, Buffalo, NY 14222, United States
Mutat Res 661:41-6. 2009..Our results suggest that cadmium inhibits BPDE-induced apoptosis by modulating apoptotic signaling through up-regulation of ERK, which is known to promote cell survival...- Phenolic fraction of tobacco smoke condensate potentiates benzo[a]pyerene diol epoxide-induced cell transformation: role of protein kinase CJagat J Mukherjee
Great Lakes Center, State University of New York College, Buffalo, NY 14222, USA
Mutat Res 696:89-94. 2010..Our data suggest a possible role of PKC down-regulation in potentiation of BPDE-induced tumorogenicity by TSC phenolic fraction... - Inhibition of benzopyrene diol epoxide-induced apoptosis by cadmium(II) is AP-1-independent: role of extracelluler signal related kinaseJagat J Mukherjee
Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, Buffalo, NY 14222, USA
Chem Biol Interact 172:72-80. 2008..We suggest that cadmium inhibits BPDE-induced apoptosis not involving AP-1 but probably through a different mechanism by up-regulating ERK which is known to promote cell survival... - Effects of cadmium(II) on (+/-)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide-induced DNA damage response in human fibroblasts and DNA repair: a possible mechanism of cadmium's cogenotoxicityJagat J Mukherjee
Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, 1300 Elmwood Avenue, Buffalo, New York 14222, USA
Chem Res Toxicol 17:287-93. 2004..The effect of cadmium on these processes may explain, at least partly, the potentiating effect of the metal on the genotoxicity of BP... - Metabolism of chrysene by brown bullhead liver microsomesJyotsna Pangrekar
Environmental Toxicology and Chemistry Laboratory, Great Lakes Center for Environmental Research and Education, State University of New York College at Buffalo, 1300 Elmwood Avenue, Buffalo, New York 14222, USA
Toxicol Sci 71:67-73. 2003.... - Synthesis of dihydrodiol metabolites implicated in the mechanism of carcinogenesis of phenanthro[4,3-b][1]benzothiophene and phenanthro[3,4-b][1]benzothiophene, the polycyclic sulfur heterocycles with a "Fjord" structureSubodh Kumar
Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, 1300 Elmwood Avenue, 14222, USA
J Org Chem 67:8842-6. 2002..The trans-stereochemistry of the dihydrodiols was established by (1)H NMR, which indicated a large coupling constant between vicinal carbinol protons. The UV spectra of the dihydrodiols 5 and 6 are presented... - Evaluation of genotoxicity of medicinal plant extracts by the comet and VITOTOX testsSaroj Arora
Department of Botanical Sciences, Guru Nanak Dev University, Amritsar 143 005, Punjab, India
J Environ Pathol Toxicol Oncol 24:193-200. 2005..1 mL. A literature survey also showed that plant extracts can be mutagenic as well as antimutagenic depending on the test system used. This indicates that a battery of assays is needed before any conclusion can be reached... - Electrophilic chemistry of thia-PAHs: stable carbocations (NMR and DFT), S-alkylated onium salts, model electrophilic substitutions (nitration and bromination), and mutagenicity assayKenneth K Laali
Department of Chemistry, Kent State University, Kent, Ohio 44242, USA
J Org Chem 72:8383-93. 2007..Bromination of 4 and 6 is also reported. Comparative mutagenicity assays (Ames test) were performed on 1 versus 1NO2, 5 versus 5NO2, and 11 versus 11NO2. Compound 5NO2 was found to be a potent direct acting mutagen... - 3'-Intercalation of a N2-dG 1R-trans-anti-benzo[c]phenanthrene DNA adduct in an iterated (CG)3 repeatYazhen Wang
Department of Chemistry, Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37235, USA
Chem Res Toxicol 21:1348-58. 2008..The aromatic rings of the B[ c]Ph moiety were below the Watson-Crick hydrogen-bonding face of the modified base pair X (4) x C (19). The B[c]Ph moiety was stacked above nucleotide G (18), in the complementary strand... - Modulatory effect of phenolic fractions of Terminalia arjuna on the mutagenicity in Ames assayKamaljit Kaur
Department of Botanical Sciences, Guru Nanak Dev University, Amritsar, India
J Environ Pathol Toxicol Oncol 21:45-56. 2002..The fraction insoluble in chloroform showed more inhibition than the soluble one, which corresponds to a higher polyphenol content in the insoluble fraction than in the soluble extract... - In vitro protective effects of Terminalia arjuna bark extracts against the 4-nitroquinoline-N-oxide genotoxicityRossana Pasquini
Department of Hygiene, University of Perugia, Italy
J Environ Pathol Toxicol Oncol 21:33-44. 2002..arjuna bark contains some nonpolar as well as polar compounds with antimutagenic activity against 4-NQO. Several explanations can be suggested, but further investigations are necessary to definitely identify the active compounds... - A correlative study on antimutagenic and chemopreventive activity of Acacia auriculiformis A. Cunn. and Acacia nilotica (L.) Willd. Ex DelKamaljit Kaur
Department of Botanical Sciences, Guru Nanak Dev University, Amritsar 143 005, India
Drug Chem Toxicol 25:39-64. 2002..nilotica > A. auriculiformis. These results exhibited a good correlation between the antimutagenesis assay and the MMOC model, suggesting that these plants may contain active chemopreventive agents...