Subodh Kumar

Summary

Affiliation: State University of New York College at Buffalo
Country: USA

Publications

  1. ncbi request reprint Mutagenicity of benzo[b]phenanthro[2,3-d]thiophene (BPT) and its metabolites in TA100 and base-specific tester strains (TA7001-TA7006) of Salmonella typhimurium: evidence of multiple pathways for the bioactivation of BPT
    Subodh Kumar
    Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, NY 14222, USA
    Mutat Res 545:11-21. 2004
  2. ncbi request reprint Metabolism of phenanthrene by brown bullhead liver microsomes
    Jyotsna Pangrekar
    Great Lakes Center for Environmental Research and Education, State University of New York College at Buffalo, Buffalo, NY 14222, USA
    Aquat Toxicol 64:407-18. 2003
  3. ncbi request reprint Comparative metabolism of the aza polynuclear aromatic hydrocarbon dibenz[a,h]acridine by recombinant human and rat cytochrome P450s
    Zhi Xin Yuan
    Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, 1300 Elmwood Avenue, Buffalo, New York 14222, USA
    Chem Res Toxicol 17:672-8. 2004
  4. ncbi request reprint Metabolism of the polynuclear sulfur heterocycle benzo[b]phenanthro[2,3-d]thiophene by rodent liver microsomes: evidence for multiple pathways in the bioactivation of benzo[b]phenanthro[2,3-d]thiophene
    Zhi Xin Yuan
    Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, 1300 Elmwood Avenue, Buffalo, New York 14222, USA
    Chem Res Toxicol 16:1581-8. 2003
  5. ncbi request reprint Comparative metabolism of chrysene and 5-methylchrysene by rat and rainbow trout liver microsomes
    Nancy W Shappell
    Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, 1300 Elmwood Avenue, Buffalo, New York 14222, USA
    Toxicol Sci 72:260-6. 2003
  6. pmc DNA synthesis inhibition in response to benzo[a]pyrene dihydrodiol epoxide is associated with attenuation of p(34)cdc2: Role of p53
    Jagat J Mukherjee
    State University of New York College, Buffalo, NY 14222, USA
    Mutat Res 755:61-7. 2013
  7. doi request reprint Inhibition of benzopyrene-diol-epoxide (BPDE)-induced bax and caspase-9 by cadmium: role of mitogen activated protein kinase
    Jagat J Mukherjee
    State University of New York College at Buffalo, Environ Toxicol and Chem, Great Lakes Center, 1300 Elmwood Avenue, Buffalo, NY 14222, United States
    Mutat Res 661:41-6. 2009
  8. pmc Phenolic fraction of tobacco smoke inhibits BPDE-induced apoptosis response and potentiates cell transformation: role of attenuation of p53 response
    Jagat J Mukherjee
    Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, United States
    Chem Res Toxicol 24:698-705. 2011
  9. pmc Inhibition of benzopyrene diol epoxide-induced apoptosis by cadmium(II) is AP-1-independent: role of extracelluler signal related kinase
    Jagat J Mukherjee
    Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, Buffalo, NY 14222, USA
    Chem Biol Interact 172:72-80. 2008
  10. pmc Phenolic fraction of tobacco smoke condensate potentiates benzo[a]pyerene diol epoxide-induced cell transformation: role of protein kinase C
    Jagat J Mukherjee
    Great Lakes Center, State University of New York College, Buffalo, NY 14222, USA
    Mutat Res 696:89-94. 2010

Collaborators

  • Jagat J Mukherjee
  • Shantu Amin
  • Jyh Ming Lin
  • Atul Kumar
  • Nancy W Shappell
  • J Whysner
  • Ethel Brits
  • Luc Verschaeve
  • Zhi Xin Yuan
  • Saroj Arora
  • Harish C Sikka
  • Jyotsna Pangrekar
  • Kamaljit Kaur
  • Yazhen Wang
  • Kenneth K Laali
  • Swayamjot Kaur
  • Sangeet A Honey
  • Panna L Kole
  • Rossana Pasquini
  • Michael P Stone
  • Heiko Kroth
  • Nathalie C Schnetz-Boutaud
  • Donald M Jerina
  • Jane M Sayer
  • Haruhiko Yagi
  • Takao Okazaki
  • Gabriela L Borosky
  • Carol Swartz
  • Joong Hyun Chun
  • Kamaljeet Kaur
  • Rajbir S Sohi
  • A V Muruganandam
  • Sumaira Munir
  • Michael E Hawthorne
  • Satwinderjeet Kaur
  • Rajendra G Mehta
  • Massimo Moretti
  • Cristina Fatigoni
  • Avinash Nagpal
  • Milena Villarini
  • Massimiliano Marcarelli
  • Giuseppina Scassellati-Sforzolini
  • Iqbal Sing Grover

Detail Information

Publications19

  1. ncbi request reprint Mutagenicity of benzo[b]phenanthro[2,3-d]thiophene (BPT) and its metabolites in TA100 and base-specific tester strains (TA7001-TA7006) of Salmonella typhimurium: evidence of multiple pathways for the bioactivation of BPT
    Subodh Kumar
    Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, NY 14222, USA
    Mutat Res 545:11-21. 2004
    ....
  2. ncbi request reprint Metabolism of phenanthrene by brown bullhead liver microsomes
    Jyotsna Pangrekar
    Great Lakes Center for Environmental Research and Education, State University of New York College at Buffalo, Buffalo, NY 14222, USA
    Aquat Toxicol 64:407-18. 2003
    ..Phenanthrene, compared with benzo[a]pyrene and chrysene, is metabolized by bullhead liver microsomal enzymes to its benzo-ring dihydrodiols with a relatively low degree of stereoselectivity...
  3. ncbi request reprint Comparative metabolism of the aza polynuclear aromatic hydrocarbon dibenz[a,h]acridine by recombinant human and rat cytochrome P450s
    Zhi Xin Yuan
    Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, 1300 Elmwood Avenue, Buffalo, New York 14222, USA
    Chem Res Toxicol 17:672-8. 2004
    ..However, human and rat P450 1A1 do not differ with respect to their stereoselectivity in the metabolism of DB[a,h]ACR to the diols...
  4. ncbi request reprint Metabolism of the polynuclear sulfur heterocycle benzo[b]phenanthro[2,3-d]thiophene by rodent liver microsomes: evidence for multiple pathways in the bioactivation of benzo[b]phenanthro[2,3-d]thiophene
    Zhi Xin Yuan
    Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, 1300 Elmwood Avenue, Buffalo, New York 14222, USA
    Chem Res Toxicol 16:1581-8. 2003
    ....
  5. ncbi request reprint Comparative metabolism of chrysene and 5-methylchrysene by rat and rainbow trout liver microsomes
    Nancy W Shappell
    Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, 1300 Elmwood Avenue, Buffalo, New York 14222, USA
    Toxicol Sci 72:260-6. 2003
    ..In contrast the reverse is true in the case of 5-MeCHR, indicating that a non-benzo ring methyl substituent alters the regioselectivity of the enzymes involved in the oxidative metabolism of PAHs...
  6. pmc DNA synthesis inhibition in response to benzo[a]pyrene dihydrodiol epoxide is associated with attenuation of p(34)cdc2: Role of p53
    Jagat J Mukherjee
    State University of New York College, Buffalo, NY 14222, USA
    Mutat Res 755:61-7. 2013
    ....
  7. doi request reprint Inhibition of benzopyrene-diol-epoxide (BPDE)-induced bax and caspase-9 by cadmium: role of mitogen activated protein kinase
    Jagat J Mukherjee
    State University of New York College at Buffalo, Environ Toxicol and Chem, Great Lakes Center, 1300 Elmwood Avenue, Buffalo, NY 14222, United States
    Mutat Res 661:41-6. 2009
    ..Our results suggest that cadmium inhibits BPDE-induced apoptosis by modulating apoptotic signaling through up-regulation of ERK, which is known to promote cell survival...
  8. pmc Phenolic fraction of tobacco smoke inhibits BPDE-induced apoptosis response and potentiates cell transformation: role of attenuation of p53 response
    Jagat J Mukherjee
    Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, United States
    Chem Res Toxicol 24:698-705. 2011
    ..Although p53-mediated NF-κB activation has a role in apoptosis induction, the role of NF-κB in TSCPhFr-mediated potentiation of PAH-induced cell transformation is not clear from our studies...
  9. pmc Inhibition of benzopyrene diol epoxide-induced apoptosis by cadmium(II) is AP-1-independent: role of extracelluler signal related kinase
    Jagat J Mukherjee
    Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, Buffalo, NY 14222, USA
    Chem Biol Interact 172:72-80. 2008
    ..We suggest that cadmium inhibits BPDE-induced apoptosis not involving AP-1 but probably through a different mechanism by up-regulating ERK which is known to promote cell survival...
  10. pmc Phenolic fraction of tobacco smoke condensate potentiates benzo[a]pyerene diol epoxide-induced cell transformation: role of protein kinase C
    Jagat J Mukherjee
    Great Lakes Center, State University of New York College, Buffalo, NY 14222, USA
    Mutat Res 696:89-94. 2010
    ..Our data suggest a possible role of PKC down-regulation in potentiation of BPDE-induced tumorogenicity by TSC phenolic fraction...
  11. ncbi request reprint Effects of cadmium(II) on (+/-)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide-induced DNA damage response in human fibroblasts and DNA repair: a possible mechanism of cadmium's cogenotoxicity
    Jagat J Mukherjee
    Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, 1300 Elmwood Avenue, Buffalo, New York 14222, USA
    Chem Res Toxicol 17:287-93. 2004
    ..The effect of cadmium on these processes may explain, at least partly, the potentiating effect of the metal on the genotoxicity of BP...
  12. ncbi request reprint Metabolism of chrysene by brown bullhead liver microsomes
    Jyotsna Pangrekar
    Environmental Toxicology and Chemistry Laboratory, Great Lakes Center for Environmental Research and Education, State University of New York College at Buffalo, 1300 Elmwood Avenue, Buffalo, New York 14222, USA
    Toxicol Sci 71:67-73. 2003
    ....
  13. ncbi request reprint Synthesis of dihydrodiol metabolites implicated in the mechanism of carcinogenesis of phenanthro[4,3-b][1]benzothiophene and phenanthro[3,4-b][1]benzothiophene, the polycyclic sulfur heterocycles with a "Fjord" structure
    Subodh Kumar
    Environmental Toxicology and Chemistry Laboratory, Great Lakes Center, State University of New York College at Buffalo, 1300 Elmwood Avenue, 14222, USA
    J Org Chem 67:8842-6. 2002
    ..The trans-stereochemistry of the dihydrodiols was established by (1)H NMR, which indicated a large coupling constant between vicinal carbinol protons. The UV spectra of the dihydrodiols 5 and 6 are presented...
  14. ncbi request reprint Evaluation of genotoxicity of medicinal plant extracts by the comet and VITOTOX tests
    Saroj Arora
    Department of Botanical Sciences, Guru Nanak Dev University, Amritsar 143 005, Punjab, India
    J Environ Pathol Toxicol Oncol 24:193-200. 2005
    ..1 mL. A literature survey also showed that plant extracts can be mutagenic as well as antimutagenic depending on the test system used. This indicates that a battery of assays is needed before any conclusion can be reached...
  15. pmc Electrophilic chemistry of thia-PAHs: stable carbocations (NMR and DFT), S-alkylated onium salts, model electrophilic substitutions (nitration and bromination), and mutagenicity assay
    Kenneth K Laali
    Department of Chemistry, Kent State University, Kent, Ohio 44242, USA
    J Org Chem 72:8383-93. 2007
    ..Bromination of 4 and 6 is also reported. Comparative mutagenicity assays (Ames test) were performed on 1 versus 1NO2, 5 versus 5NO2, and 11 versus 11NO2. Compound 5NO2 was found to be a potent direct acting mutagen...
  16. pmc 3'-Intercalation of a N2-dG 1R-trans-anti-benzo[c]phenanthrene DNA adduct in an iterated (CG)3 repeat
    Yazhen Wang
    Department of Chemistry, Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37235, USA
    Chem Res Toxicol 21:1348-58. 2008
    ..The aromatic rings of the B[ c]Ph moiety were below the Watson-Crick hydrogen-bonding face of the modified base pair X (4) x C (19). The B[c]Ph moiety was stacked above nucleotide G (18), in the complementary strand...
  17. ncbi request reprint Modulatory effect of phenolic fractions of Terminalia arjuna on the mutagenicity in Ames assay
    Kamaljit Kaur
    Department of Botanical Sciences, Guru Nanak Dev University, Amritsar, India
    J Environ Pathol Toxicol Oncol 21:45-56. 2002
    ..The fraction insoluble in chloroform showed more inhibition than the soluble one, which corresponds to a higher polyphenol content in the insoluble fraction than in the soluble extract...
  18. ncbi request reprint In vitro protective effects of Terminalia arjuna bark extracts against the 4-nitroquinoline-N-oxide genotoxicity
    Rossana Pasquini
    Department of Hygiene, University of Perugia, Italy
    J Environ Pathol Toxicol Oncol 21:33-44. 2002
    ..arjuna bark contains some nonpolar as well as polar compounds with antimutagenic activity against 4-NQO. Several explanations can be suggested, but further investigations are necessary to definitely identify the active compounds...
  19. ncbi request reprint A correlative study on antimutagenic and chemopreventive activity of Acacia auriculiformis A. Cunn. and Acacia nilotica (L.) Willd. Ex Del
    Kamaljit Kaur
    Department of Botanical Sciences, Guru Nanak Dev University, Amritsar 143 005, India
    Drug Chem Toxicol 25:39-64. 2002
    ..nilotica > A. auriculiformis. These results exhibited a good correlation between the antimutagenesis assay and the MMOC model, suggesting that these plants may contain active chemopreventive agents...