John G Kral

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. ncbi request reprint Binge eating as a major phenotype of melanocortin 4 receptor gene mutations
    Ruth Branson
    Klinik Hirslanden, Zurich, Switzerland
    N Engl J Med 348:1096-103. 2003
  2. ncbi request reprint Swedish Obese Subjects study--best available data to support antiobesity surgery?
    John G Kral
    Surg Obes Relat Dis 2:561-4. 2006
  3. ncbi request reprint Studies show reduction in mortality after bariatric surgery
    John G Kral
    Surg Obes Relat Dis 2:564. 2006
  4. pmc Characterization of arterial wave reflection in healthy bonnet macaques: feasibility of applanation tonometry
    Jason Lazar
    Division of Cardiovascular Medicine, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    J Biomed Biotechnol 2009:876093. 2009
  5. doi request reprint Diabesity: palliating, curing or preventing the dysmetabolic diathesis
    John G Kral
    Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY, USA Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA Electronic address
    Maturitas 77:243-8. 2014
  6. doi request reprint Subarachnoid pharmacodialysis for central nervous system disorders
    John G Kral
    Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY, United States
    Med Hypotheses 80:105-11. 2013
  7. pmc Physiological models of body composition and human obesity
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 321 Church St, S, E, Minneapolis, MN 55455, USA
    Nutr Metab (Lond) 4:19. 2007
  8. pmc Physiological models of body composition and human obesity
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 321 Church Street SE, Minneapolis, MN 55455, USA
    Nutr Metab (Lond) 6:7. 2009
  9. doi request reprint Surgery for obesity in older women
    Megan E Miller
    Department of Surgery, SUNY Downstate Medical Center, 450 Clarkson Avenue, Box 40, Brooklyn, NY 11203, USA
    Menopause Int 14:155-62. 2008
  10. ncbi request reprint The pathogenesis of obesity: Stress and the brain-gut axis
    John G Kral
    Department of Surgery, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    Surg Obes Relat Dis 1:25-34. 2005

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Binge eating as a major phenotype of melanocortin 4 receptor gene mutations
    Ruth Branson
    Klinik Hirslanden, Zurich, Switzerland
    N Engl J Med 348:1096-103. 2003
    ..A few mutations in these genes, such as in the leptin receptor (LEPR) gene and melanocortin 4 receptor (MC4R) gene, have been identified as causes of monogenic obesity...
  2. ncbi request reprint Swedish Obese Subjects study--best available data to support antiobesity surgery?
    John G Kral
    Surg Obes Relat Dis 2:561-4. 2006
  3. ncbi request reprint Studies show reduction in mortality after bariatric surgery
    John G Kral
    Surg Obes Relat Dis 2:564. 2006
  4. pmc Characterization of arterial wave reflection in healthy bonnet macaques: feasibility of applanation tonometry
    Jason Lazar
    Division of Cardiovascular Medicine, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    J Biomed Biotechnol 2009:876093. 2009
    ..001 and P = .03). In conclusion, applanation tonometry is feasible for determining AI. Reference values are provided for AI in bonnet macaques, in whom higher AI is related to HR and CRL, and in turn contributes to higher LV mass...
  5. doi request reprint Diabesity: palliating, curing or preventing the dysmetabolic diathesis
    John G Kral
    Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY, USA Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA Electronic address
    Maturitas 77:243-8. 2014
    ..Readers can expect new knowledge and enhanced understanding of a global health problem: "diabesity". ..
  6. doi request reprint Subarachnoid pharmacodialysis for central nervous system disorders
    John G Kral
    Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY, United States
    Med Hypotheses 80:105-11. 2013
    ....
  7. pmc Physiological models of body composition and human obesity
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 321 Church St, S, E, Minneapolis, MN 55455, USA
    Nutr Metab (Lond) 4:19. 2007
    ..We attempt to develop regression relations that are based on realistic models of body composition changes in obesity. These models, if valid, can then be extrapolated to the high fat fraction of the morbidly obese...
  8. pmc Physiological models of body composition and human obesity
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 321 Church Street SE, Minneapolis, MN 55455, USA
    Nutr Metab (Lond) 6:7. 2009
    ..ABSTRACT: Correction to Levitt DG, Heymsfield SB, Pierson Jr RN, Shapses SA, Kral JG: Physiological models of body composition and human obesity. Nutrition & Metabolism 2007, 4:19...
  9. doi request reprint Surgery for obesity in older women
    Megan E Miller
    Department of Surgery, SUNY Downstate Medical Center, 450 Clarkson Avenue, Box 40, Brooklyn, NY 11203, USA
    Menopause Int 14:155-62. 2008
    ....
  10. ncbi request reprint The pathogenesis of obesity: Stress and the brain-gut axis
    John G Kral
    Department of Surgery, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    Surg Obes Relat Dis 1:25-34. 2005
  11. ncbi request reprint Surgical treatment of obesity
    John G Kral
    Department of Surgery, State University of New York Downstate Medical Center, Brooklyn, NY 11203 2098, USA
    Nat Clin Pract Endocrinol Metab 3:574-83. 2007
    ..In the absence of effective societal changes to restore a healthy energy balance, bariatric surgery is an important tool for treating a very serious disease...
  12. ncbi request reprint Patient selection for treatment of obesity
    John G Kral
    Department of Surgery, State University of New York Downstate Medical Center, Brooklyn, New York 11203 2098, USA
    Surg Obes Relat Dis 1:126-32. 2005
  13. ncbi request reprint Research considerations in obesity surgery
    John G Kral
    American Society for Bariatric Surgery, Gainesville, Florida, USA
    Obes Res 10:63-4. 2002
  14. doi request reprint Vagal nerve function in obesity: therapeutic implications
    John G Kral
    Department of Surgery, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Box 40, Brooklyn, NY, 11203, USA
    World J Surg 33:1995-2006. 2009
    ....
  15. ncbi request reprint Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years
    John G Kral
    Department of Surgery, Box 40, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Pediatrics 118:e1644-9. 2006
    ....
  16. ncbi request reprint Preventing and treating obesity in girls and young women to curb the epidemic
    John G Kral
    Department of Surgery, Box 40, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Obes Res 12:1539-46. 2004
    ....
  17. doi request reprint Preventing and treating the accelerated ageing of obesity
    John G Kral
    Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Maturitas 66:223-30. 2010
    ....
  18. pmc Metabolic syndrome and neurometabolic asymmetry of hippocampus in adult bonnet monkeys
    Jeremy D Coplan
    SUNY Downstate Medical Center, Primate Behavior Laboratory, Department of Psychiatry, Brooklyn, NY 11203 2098, USA
    Physiol Behav 103:535-9. 2011
    ....
  19. ncbi request reprint Maternal-infant response to variable foraging demand in nonhuman primates: effects of timing of stressor on cerebrospinal fluid corticotropin-releasing factor and circulating glucocorticoid concentrations
    Jeremy D Coplan
    State University of New York SUNY, Downstate Medical Center Box 120, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Ann N Y Acad Sci 1071:525-33. 2006
    ..However, absolute cortisol change was greater in early versus late VFD. Timing of the VFD stressor differentially affects maternal neuroendocrine response, with potential implications for the offspring's developmental trajectory...
  20. ncbi request reprint Early-life stress and the development of obesity and insulin resistance in juvenile bonnet macaques
    Daniel Kaufman
    Department of Surgery, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    Diabetes 56:1382-6. 2007
    ..Our data suggest that early-life stress during a critical period of neuro development can result in the peripubertal emergence of obesity and insulin resistance...
  21. ncbi request reprint Effects of surgical treatment of the metabolic syndrome on liver fibrosis and cirrhosis
    John G Kral
    Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Surgery 135:48-58. 2004
    ..Both weight loss and gastrointestinal surgery for obesity can cause liver disease, making their role in the treatment of obesity-related liver disease controversial...
  22. doi request reprint Echocardiographic determination of epicardial adipose tissue in healthy bonnet macaques
    Ather Mansoor
    Division of Cardiovascular Medicine, State University of New York Downstate Medical Center, Brooklyn, New York 11203 2098, USA
    Echocardiography 27:180-5. 2010
    ..The objective of the present study was to determine EAT thickness in apparently healthy bonnet macaques and assess its relations with anthropometric and CV variables...
  23. pmc Correlations between hippocampal neurogenesis and metabolic indices in adult nonhuman primates
    Tarique D Perera
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neural Plast 2011:1-6. 2011
    ..This study demonstrates that markers of dentate gyrus neuroplasticity correlate with metabolic parameters in primates...
  24. ncbi request reprint Medicare and bariatric surgery
    John G Kral
    American Society for Bariatric Surgery, Gainesville, Florida 32607, USA
    Surg Obes Relat Dis 1:35-63. 2005
  25. pmc Early-life stress and neurometabolites of the hippocampus
    Jeremy D Coplan
    SUNY Downstate Medical Center, Nonhuman Primate Facility, Department of Psychiatry, Brooklyn, NY 11203, USA
    Brain Res 1358:191-9. 2010
    ..Given the importance of the hippocampus in stress-mediated toxicity, validation of these data using absolute quantification is suggested and correlative neurohistological studies of hippocampus are warranted...
  26. pmc ABC of obesity. Management: Part III--surgery
    John G Kral
    Department of Surgery, SUNY Downstate Medical Center, New York, USA
    BMJ 333:900-3. 2006
  27. pmc Ghrelin: integrative neuroendocrine peptide in health and disease
    James T Wu
    Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Ann Surg 239:464-74. 2004
    ..Newly discovered biologic roles of ghrelin imply that it may have other important physiological functions as well. This is a review of recent clinically relevant, yet less well-known, physiologic actions of ghrelin...
  28. ncbi request reprint Early appearance of the metabolic syndrome in socially reared bonnet macaques
    Daniel Kaufman
    Department of Surgery, Primate Behavior Laboratory, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York 11203, USA
    J Clin Endocrinol Metab 90:404-8. 2005
    ..Socially reared and housed bonnet macaques may provide a useful model for studying the pathogenesis, prevention, and treatment of the metabolic syndrome...
  29. ncbi request reprint Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demand
    Jeremy D Coplan
    Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    CNS Spectr 10:530-6. 2005
    ..Environmental contribution to the neurobiology of psychopathology is perhaps most relevant during infancy, where vulnerability to early-life stressors is particularly evident...
  30. doi request reprint Left ventricular systolic and diastolic function in healthy adult bonnet macaques (Macaca radiata). New echocardiographic indices in Old World monkeys
    Jason M Lazar
    Division of Cardiovascular Medicine, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Box 1199 Brooklyn, NY 11203 2098, USA
    Cardiology 113:116-21. 2009
    ..Macaques are used in cardiovascular and metabolic research. We determined echocardiographic-derived reference values of left ventricular (LV) systolic and diastolic function in healthy adult bonnet macaques (Macaca radiata)...
  31. ncbi request reprint The effect of lower body weight support on arterial wave reflection in healthy adults
    Atif Afzal
    Division of Cardiovascular Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
    J Am Soc Hypertens 8:388-93. 2014
    ..In normal men, WS acutely decreases the PP amplification ratio, increases the amplitude and duration of the reflected aortic pressure wave, and increases measures of wasted left ventricular pressure energy and oxygen demand. ..
  32. ncbi request reprint The NF-kappaB/IkappaB signaling system: a molecular target in breast cancer therapy
    James T Wu
    Department of Surgery, SUNY Downstate Medical Center, Brooklyn, New York, USA
    J Surg Res 123:158-69. 2005
    ..In this review, we discuss the regulatory mechanisms and physiological significance of NF-kappaB activation, and highlight recent advances in the development of NF-kappaB as an integral mediator of mammary carcinogenesis...
  33. pmc Adipose tissue quantification by imaging methods: a proposed classification
    Wei Shen
    Obesity Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, New York 10025, USA
    Obes Res 11:5-16. 2003
    ..This analysis leads us to propose an updated classification of total body and regional adipose tissue, providing a well-defined basis for correlating imaging studies of specific adipose tissue depots with molecular processes...
  34. ncbi request reprint Leptin reduces the development of the initial precancerous lesions induced by azoxymethane in the rat colonic mucosa
    David E Stein
    Gastroenterology 127:1866-7; author reply 1867-8. 2004
  35. ncbi request reprint Gene variants and binge eating as predictors of comorbidity and outcome of treatment in severe obesity
    Natascha Potoczna
    Klinik Hirslanden, Witellikerstrasse, Zurich, Switzerland
    J Gastrointest Surg 8:971-81; discussion 981-2. 2004
    ..Overall outcome was poorest in MC4R variant carriers, better in noncarriers with BED (P < 0.05), and best in noncarriers without BED (P < 0.001). MC4R variants influence comorbidities and treatment outcomes in severe obesity...
  36. ncbi request reprint Outcome of pregnancies after biliopancreatic diversion
    Picard Marceau
    Department of Surgery, Laval University, 2725 Chemin Sainte Foy, Quebec G1V 4G5, Canada
    Obes Surg 14:318-24. 2004
    ..This is a follow-up report of our initial findings regarding pregnancy and neonatal outcomes in biliopancreatic diversion (BPD) patients, with addition of a new cohort of children born to mothers after BPD...
  37. ncbi request reprint Patient selection and the physiology of gastrointestinal antiobesity operations
    Erik Naslund
    Division of Surgery, Karolinska Institutet, Danderyd Hospital, SE 182 88 Stockholm, Sweden
    Surg Clin North Am 85:725-40, vi. 2005
    ..The balance between physiologic mechanisms that promote weight loss and motivational factors that cause maladaptive eating is the greatest challenge to effective surgical treatment of obesity...
  38. ncbi request reprint Effect of circulatory congestion on the components of pulmonary diffusing capacity in morbid obesity
    Beno W Oppenheimer
    Division of Pulmonary and Critical Care Medicine and Bellevue Hospital Chest Service, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Obesity (Silver Spring) 14:1172-80. 2006
    ..We examined DLCO and its partition into Vc and Dm in 13 severely obese subjects (BMI = 51 +/- 14 kg/m2) without manifest cardiopulmonary disease before and after surgically induced weight loss...
  39. ncbi request reprint "Tastes worse"--"more filling": surgical controversy, but who decides?
    John G Kral
    Surg Obes Relat Dis 2:4-5. 2006
  40. ncbi request reprint Eating fast leads to insulin resistance: findings in middle-aged Japanese men and women
    Rei Otsuka
    Department of Public Health Health Information Dynamics, Field of Social Life Science, Nagoya University Graduate School of Medicine, Aichi, Japan
    Prev Med 46:154-9. 2008
    ..To examine relationships between speed of eating and insulin resistance...
  41. ncbi request reprint A stitch in time versus a life in misery
    John G Kral
    Surg Obes Relat Dis 3:2-5. 2007
  42. ncbi request reprint Poverty, food insecurity, and obesity in children
    Alan F Meyers
    Pediatrics 118:2265-6. 2006