Research Topics
| John G KralSummaryAffiliation: State University of New York Country: USA Publications
| Collaborators
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Detail Information
Publications
Binge eating as a major phenotype of melanocortin 4 receptor gene mutationsRuth Branson
Klinik Hirslanden, Zurich, Switzerland
N Engl J Med 348:1096-103. 2003..A few mutations in these genes, such as in the leptin receptor (LEPR) gene and melanocortin 4 receptor (MC4R) gene, have been identified as causes of monogenic obesity...- Swedish Obese Subjects study--best available data to support antiobesity surgery?John G Kral
Surg Obes Relat Dis 2:561-4. 2006 - Studies show reduction in mortality after bariatric surgeryJohn G Kral
Surg Obes Relat Dis 2:564. 2006 
Characterization of arterial wave reflection in healthy bonnet macaques: feasibility of applanation tonometryJason Lazar
Division of Cardiovascular Medicine, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
J Biomed Biotechnol 2009:876093. 2009..001 and P = .03). In conclusion, applanation tonometry is feasible for determining AI. Reference values are provided for AI in bonnet macaques, in whom higher AI is related to HR and CRL, and in turn contributes to higher LV mass...
Subarachnoid pharmacodialysis for central nervous system disordersJohn G Kral
Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY, United States
Med Hypotheses 80:105-11. 2013....
Physiological models of body composition and human obesityDavid G Levitt
Department of Integrative Biology and Physiology, University of Minnesota, 321 Church St, S, E, Minneapolis, MN 55455, USA
Nutr Metab (Lond) 4:19. 2007..We attempt to develop regression relations that are based on realistic models of body composition changes in obesity. These models, if valid, can then be extrapolated to the high fat fraction of the morbidly obese...- Physiological models of body composition and human obesityDavid G Levitt
Department of Integrative Biology and Physiology, University of Minnesota, 321 Church Street SE, Minneapolis, MN 55455, USA
Nutr Metab (Lond) 6:7. 2009..ABSTRACT: Correction to Levitt DG, Heymsfield SB, Pierson Jr RN, Shapses SA, Kral JG: Physiological models of body composition and human obesity. Nutrition & Metabolism 2007, 4:19... - Vagal nerve function in obesity: therapeutic implicationsJohn G Kral
Department of Surgery, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Box 40, Brooklyn, NY, 11203, USA
World J Surg 33:1995-2006. 2009.... - Surgery for obesity in older womenMegan E Miller
Department of Surgery, SUNY Downstate Medical Center, 450 Clarkson Avenue, Box 40, Brooklyn, NY 11203, USA
Menopause Int 14:155-62. 2008.... - Preventing and treating the accelerated ageing of obesityJohn G Kral
Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
Maturitas 66:223-30. 2010.... - Surgical treatment of obesityJohn G Kral
Department of Surgery, State University of New York Downstate Medical Center, Brooklyn, NY 11203 2098, USA
Nat Clin Pract Endocrinol Metab 3:574-83. 2007..In the absence of effective societal changes to restore a healthy energy balance, bariatric surgery is an important tool for treating a very serious disease... - Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 yearsJohn G Kral
Department of Surgery, Box 40, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
Pediatrics 118:e1644-9. 2006.... - Research considerations in obesity surgeryJohn G Kral
American Society for Bariatric Surgery, Gainesville, Florida, USA
Obes Res 10:63-4. 2002 - Patient selection for treatment of obesityJohn G Kral
Department of Surgery, State University of New York Downstate Medical Center, Brooklyn, New York 11203-2098, USA
Surg Obes Relat Dis 1:126-32. 2005 - The pathogenesis of obesity: Stress and the brain-gut axisJohn G Kral
Department of Surgery, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
Surg Obes Relat Dis 1:25-34. 2005 - Preventing and treating obesity in girls and young women to curb the epidemicJohn G Kral
Department of Surgery, Box 40, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
Obes Res 12:1539-46. 2004.... - Metabolic syndrome and neurometabolic asymmetry of hippocampus in adult bonnet monkeysJeremy D Coplan
SUNY Downstate Medical Center, Primate Behavior Laboratory, Department of Psychiatry, Brooklyn, NY 11203 2098, USA
Physiol Behav 103:535-9. 2011.... - Maternal-infant response to variable foraging demand in nonhuman primates: effects of timing of stressor on cerebrospinal fluid corticotropin-releasing factor and circulating glucocorticoid concentrationsJeremy D Coplan
State University of New York SUNY, Downstate Medical Center Box 120, 450 Clarkson Ave, Brooklyn, NY 11203, USA
Ann N Y Acad Sci 1071:525-33. 2006..However, absolute cortisol change was greater in early versus late VFD. Timing of the VFD stressor differentially affects maternal neuroendocrine response, with potential implications for the offspring's developmental trajectory... - Early-life stress and the development of obesity and insulin resistance in juvenile bonnet macaquesDaniel Kaufman
Department of Surgery, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
Diabetes 56:1382-6. 2007..Our data suggest that early-life stress during a critical period of neuro development can result in the peripubertal emergence of obesity and insulin resistance... - Echocardiographic determination of epicardial adipose tissue in healthy bonnet macaquesAther Mansoor
Division of Cardiovascular Medicine, State University of New York Downstate Medical Center, Brooklyn, New York 11203 2098, USA
Echocardiography 27:180-5. 2010..The objective of the present study was to determine EAT thickness in apparently healthy bonnet macaques and assess its relations with anthropometric and CV variables... - Effects of surgical treatment of the metabolic syndrome on liver fibrosis and cirrhosisJohn G Kral
Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
Surgery 135:48-58. 2004..CONCLUSIONS: The metabolic syndrome of obesity is a determinant of liver fibrosis and cirrhosis, treatable by substantial weight loss after malabsorptive surgery... - Medicare and bariatric surgeryJohn G Kral
American Society for Bariatric Surgery, Gainesville, Florida 32607, USA
Surg Obes Relat Dis 1:35-63. 2005 - Correlations between hippocampal neurogenesis and metabolic indices in adult nonhuman primatesTarique D Perera
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Neural Plast 2011:1-6. 2011..This study demonstrates that markers of dentate gyrus neuroplasticity correlate with metabolic parameters in primates... - Early-life stress and neurometabolites of the hippocampusJeremy D Coplan
SUNY Downstate Medical Center, Nonhuman Primate Facility, Department of Psychiatry, Brooklyn, NY 11203, USA
Brain Res 1358:191-9. 2010..Given the importance of the hippocampus in stress-mediated toxicity, validation of these data using absolute quantification is suggested and correlative neurohistological studies of hippocampus are warranted... - Ghrelin: integrative neuroendocrine peptide in health and diseaseJames T Wu
Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
Ann Surg 239:464-74. 2004..Newly discovered biologic roles of ghrelin imply that it may have other important physiological functions as well. This is a review of recent clinically relevant, yet less well-known, physiologic actions of ghrelin... - ABC of obesity. Management: Part III--surgeryJohn G Kral
Department of Surgery, SUNY Downstate Medical Center, New York, USA
BMJ 333:900-3. 2006 - Early appearance of the metabolic syndrome in socially reared bonnet macaquesDaniel Kaufman
Department of Surgery, Primate Behavior Laboratory, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York 11203, USA
J Clin Endocrinol Metab 90:404-8. 2005..Socially reared and housed bonnet macaques may provide a useful model for studying the pathogenesis, prevention, and treatment of the metabolic syndrome... - Left ventricular systolic and diastolic function in healthy adult bonnet macaques (Macaca radiata). New echocardiographic indices in Old World monkeysJason M Lazar
Division of Cardiovascular Medicine, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Box 1199 Brooklyn, NY 11203 2098, USA
Cardiology 113:116-21. 2009..Macaques are used in cardiovascular and metabolic research. We determined echocardiographic-derived reference values of left ventricular (LV) systolic and diastolic function in healthy adult bonnet macaques (Macaca radiata)... - Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demandJeremy D Coplan
Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
CNS Spectr 10:530-6. 2005..Environmental contribution to the neurobiology of psychopathology is perhaps most relevant during infancy, where vulnerability to early-life stressors is particularly evident... - The NF-kappaB/IkappaB signaling system: a molecular target in breast cancer therapyJames T Wu
Department of Surgery, SUNY Downstate Medical Center, Brooklyn, New York, USA
J Surg Res 123:158-69. 2005..In this review, we discuss the regulatory mechanisms and physiological significance of NF-kappaB activation, and highlight recent advances in the development of NF-kappaB as an integral mediator of mammary carcinogenesis... - Adipose tissue quantification by imaging methods: a proposed classificationWei Shen
Obesity Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, New York 10025, USA
Obes Res 11:5-16. 2003..This analysis leads us to propose an updated classification of total body and regional adipose tissue, providing a well-defined basis for correlating imaging studies of specific adipose tissue depots with molecular processes... - Outcome of pregnancies after biliopancreatic diversionPicard Marceau
Department of Surgery, Laval University, 2725 Chemin Sainte Foy, Quebec G1V 4G5, Canada
Obes Surg 14:318-24. 2004..This is a follow-up report of our initial findings regarding pregnancy and neonatal outcomes in biliopancreatic diversion (BPD) patients, with addition of a new cohort of children born to mothers after BPD... - Effect of circulatory congestion on the components of pulmonary diffusing capacity in morbid obesityBeno W Oppenheimer
Division of Pulmonary and Critical Care Medicine and Bellevue Hospital Chest Service, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
Obesity (Silver Spring) 14:1172-80. 2006..We examined DLCO and its partition into Vc and Dm in 13 severely obese subjects (BMI = 51 +/- 14 kg/m2) without manifest cardiopulmonary disease before and after surgically induced weight loss... - Gene variants and binge eating as predictors of comorbidity and outcome of treatment in severe obesityNatascha Potoczna
Klinik Hirslanden, Witellikerstrasse, Zurich, Switzerland
J Gastrointest Surg 8:971-81; discussion 981-2. 2004..Overall outcome was poorest in MC4R variant carriers, better in noncarriers with BED (P < 0.05), and best in noncarriers without BED (P < 0.001). MC4R variants influence comorbidities and treatment outcomes in severe obesity... - "Tastes worse"--"more filling": surgical controversy, but who decides?John G Kral
Surg Obes Relat Dis 2:4-5. 2006 - Leptin reduces the development of the initial precancerous lesions induced by azoxymethane in the rat colonic mucosaDavid E Stein
Gastroenterology 127:1866-7; author reply 1867-8. 2004 - Poverty, food insecurity, and obesity in childrenAlan F Meyers
Pediatrics 118:2265-6. 2006 - A stitch in time versus a life in miseryJohn G Kral
Surg Obes Relat Dis 3:2-5. 2007 - Patient selection and the physiology of gastrointestinal antiobesity operationsErik Naslund
Division of Surgery, Karolinska Institutet, Danderyd Hospital, SE 182 88 Stockholm, Sweden
Surg Clin North Am 85:725-40, vi. 2005..The balance between physiologic mechanisms that promote weight loss and motivational factors that cause maladaptive eating is the greatest challenge to effective surgical treatment of obesity... - Eating fast leads to insulin resistance: findings in middle-aged Japanese men and womenRei Otsuka
Department of Public Health Health Information Dynamics, Field of Social Life Science, Nagoya University Graduate School of Medicine, Aichi, Japan
Prev Med 46:154-9. 2008..To examine relationships between speed of eating and insulin resistance...