D N Klein

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. ncbi request reprint Mental health service use by patients with dysthymic disorder: treatment use and dropout in a 7 1/2-year naturalistic follow-up study
    Brian R McFarland
    Psychology Department, Stony Brook University, Stony Brook, NY 11794 2500, USA
    Compr Psychiatry 46:246-53. 2005
  2. pmc Classification of depressive disorders in the DSM-V: proposal for a two-dimension system
    Daniel N Klein
    Department of Psychology, Stony Brook University, Stony Brook, NY 11794 2500, USA
    J Abnorm Psychol 117:552-60. 2008
  3. ncbi request reprint Clinical features of major depressive disorder in adolescents and their relatives: impact on familial aggregation, implications for phenotype definition, and specificity of transmission
    Daniel N Klein
    Department of Psychology, State University of New York at Stony Brook, 11794 2500, USA
    J Abnorm Psychol 111:98-106. 2002
  4. ncbi request reprint Family study of chronic depression in a community sample of young adults
    Daniel N Klein
    Department of Psychology, Stony Brook University, NY 11794 2500, USA
    Am J Psychiatry 161:646-53. 2004
  5. ncbi request reprint Dysthymia and chronic depression: introduction, classification, risk factors, and course
    Daniel N Klein
    Department of Psychology, State University of New York at Stony Brook, 11794 2500, USA
    J Clin Psychol 59:807-16. 2003
  6. ncbi request reprint Patients' versus informants' reports of personality disorders in predicting 7 1/2-year outcome in outpatients with depressive disorders
    Daniel N Klein
    Department of Psychology, Stony Brook University, Stony Brook, New York 11794 2500, USA
    Psychol Assess 15:216-22. 2003
  7. ncbi request reprint Cognitive-behavioral analysis system of psychotherapy as a maintenance treatment for chronic depression
    Daniel N Klein
    Department of Psychology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    J Consult Clin Psychol 72:681-8. 2004
  8. ncbi request reprint The relation between depressive symptoms and borderline personality disorder features over time in dysthymic disorder
    Daniel N Klein
    Departments of Psychology and Psychiatry and Behavioral Science, State University of New York at Stony Brook, USA
    J Pers Disord 16:523-35. 2002
  9. pmc Dysthymic disorder and double depression: prediction of 10-year course trajectories and outcomes
    Daniel N Klein
    Department of Psychology, Stony Brook University, Stony Brook, NY 11794 2500, USA
    J Psychiatr Res 42:408-15. 2008
  10. ncbi request reprint Toward guidelines for evidence-based assessment of depression in children and adolescents
    Daniel N Klein
    Department of Psychology, University at Stony Brook, NY 11794 2500, USA
    J Clin Child Adolesc Psychol 34:412-32. 2005

Research Grants

  1. MDD in Adolescents & Young Adults: Pathways & Processes
    Daniel Klein; Fiscal Year: 2004
  2. REVAMP Follow-Up Study
    Daniel Klein; Fiscal Year: 2007
  3. Temperamental Emotionality in Preschoolers and Depression Risk
    Daniel N Klein; Fiscal Year: 2010
  4. CLASSIFICATION OF EARLY ONSET DYSTHMIA
    Daniel Klein; Fiscal Year: 2003
  5. CLASSIFICATION OF EARLY-ONSET DYSTHYMIA
    Daniel Klein; Fiscal Year: 1993
  6. Temperamental Low PE in Preschoolers and Depression Risk
    Daniel Klein; Fiscal Year: 2009

Detail Information

Publications82

  1. ncbi request reprint Mental health service use by patients with dysthymic disorder: treatment use and dropout in a 7 1/2-year naturalistic follow-up study
    Brian R McFarland
    Psychology Department, Stony Brook University, Stony Brook, NY 11794 2500, USA
    Compr Psychiatry 46:246-53. 2005
    ..Younger patients, ethnic minority patients, and patients with personality disorders may be at increased risk of dropping out from treatment for depression. Combination treatments may increase treatment retention...
  2. pmc Classification of depressive disorders in the DSM-V: proposal for a two-dimension system
    Daniel N Klein
    Department of Psychology, Stony Brook University, Stony Brook, NY 11794 2500, USA
    J Abnorm Psychol 117:552-60. 2008
    ....
  3. ncbi request reprint Clinical features of major depressive disorder in adolescents and their relatives: impact on familial aggregation, implications for phenotype definition, and specificity of transmission
    Daniel N Klein
    Department of Psychology, State University of New York at Stony Brook, 11794 2500, USA
    J Abnorm Psychol 111:98-106. 2002
    ..Depression severity best distinguished the relatives of depressed adolescents from relatives of controls. Specific clinical features did not aggregate in families...
  4. ncbi request reprint Family study of chronic depression in a community sample of young adults
    Daniel N Klein
    Department of Psychology, Stony Brook University, NY 11794 2500, USA
    Am J Psychiatry 161:646-53. 2004
    ..The validity of the distinctions between dysthymic disorder, chronic major depressive disorder, and episodic major depressive disorder was examined in a family study of a large community sample of young adults...
  5. ncbi request reprint Dysthymia and chronic depression: introduction, classification, risk factors, and course
    Daniel N Klein
    Department of Psychology, State University of New York at Stony Brook, 11794 2500, USA
    J Clin Psychol 59:807-16. 2003
    ..First, we discuss nosological issues, followed by a summary of potential risk factors. Finally, the naturalistic course of chronic depression is described and implications for clinical practice are discussed...
  6. ncbi request reprint Patients' versus informants' reports of personality disorders in predicting 7 1/2-year outcome in outpatients with depressive disorders
    Daniel N Klein
    Department of Psychology, Stony Brook University, Stony Brook, New York 11794 2500, USA
    Psychol Assess 15:216-22. 2003
    ..This finding indicates that both patients and informants provide unique information on Axis II psychopathology and argues for the use of both sources in the assessment of PDs...
  7. ncbi request reprint Cognitive-behavioral analysis system of psychotherapy as a maintenance treatment for chronic depression
    Daniel N Klein
    Department of Psychology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    J Consult Clin Psychol 72:681-8. 2004
    ..The 2 conditions also differed significantly on change in depressive symptoms over time. These findings support the use of CBASP as a maintenance treatment for chronic forms of MDD...
  8. ncbi request reprint The relation between depressive symptoms and borderline personality disorder features over time in dysthymic disorder
    Daniel N Klein
    Departments of Psychology and Psychiatry and Behavioral Science, State University of New York at Stony Brook, USA
    J Pers Disord 16:523-35. 2002
    ..The fixed common factor model was the best fitting of the models, providing an excellent fit to the data. These results suggest that depressive symptoms and BPD features in DD arise from partially overlapping processes...
  9. pmc Dysthymic disorder and double depression: prediction of 10-year course trajectories and outcomes
    Daniel N Klein
    Department of Psychology, Stony Brook University, Stony Brook, NY 11794 2500, USA
    J Psychiatr Res 42:408-15. 2008
    ..These variables should be routinely assessed in clinical evaluations and can provide clinicians with valuable prognostic information...
  10. ncbi request reprint Toward guidelines for evidence-based assessment of depression in children and adolescents
    Daniel N Klein
    Department of Psychology, University at Stony Brook, NY 11794 2500, USA
    J Clin Child Adolesc Psychol 34:412-32. 2005
    ..Last, we highlight areas in which further research is necessary and conclude with some broad recommendations for clinical practice given the current state of the knowledge...
  11. ncbi request reprint Five-year course and outcome of dysthymic disorder: A prospective, naturalistic follow-up study
    D N Klein
    Department of Psychology, State University of New York at Stony Brook, 11794 2500, USA
    Am J Psychiatry 157:931-9. 2000
    ..There have been few naturalistic follow-up studies of dysthymic disorder. This study describes the 5-year course and outcome of dysthymic disorder...
  12. ncbi request reprint Age of onset in chronic major depression: relation to demographic and clinical variables, family history, and treatment response
    D N Klein
    Department of Psychology, State University of New York at Stony Brook, NY 11794 2500, USA
    J Affect Disord 55:149-57. 1999
    ..The clinical and etiological significance of the early-late onset distinction in chronic major depressive disorder was explored...
  13. ncbi request reprint Thirty-month naturalistic follow-up study of early-onset dysthymic disorder: course, diagnostic stability, and prediction of outcome
    D N Klein
    Department of Psychology, State University of New York, Stony Brook 11794 2500, USA
    J Abnorm Psychol 107:338-48. 1998
    ..The diagnosis of DD was fairly stable, with 52% of the EOD group meeting full criteria for DD at follow-up. These data provide prospective confirmation of the chronic course of DD...
  14. pmc Subthreshold depressive disorder in adolescents: predictors of escalation to full-syndrome depressive disorders
    Daniel N Klein
    Department of Psychology, State University of New York Stony Brook, Stony Brook, NY 11794 2500, USA
    J Am Acad Child Adolesc Psychiatry 48:703-10. 2009
    ..We examined predictors of escalation to full-syndrome depressive disorders in a community sample of 225 adolescents with subthreshold depressive disorder...
  15. ncbi request reprint Ten-year stability of depressive personality disorder in depressed outpatients
    Rebecca S Laptook
    Department of Psychology, Stony Brook University, Stony Brook, NY 11794 2500, USA
    Am J Psychiatry 163:865-71. 2006
    ..The purpose of this study was to examine the long-term stability of depressive personality disorder...
  16. ncbi request reprint Long-term stability of parental representations in depressed outpatients utilizing the Parental Bonding Instrument
    Humberto Lizardi
    Department of Psychology, City University of New York at Lehman College, Bronx, New York 10468 1589, USA
    J Nerv Ment Dis 193:183-8. 2005
    ..Thus, the present study provides evidence for the long-term stability of parental representations, as measured by the PBI, in depressed outpatients...
  17. pmc Latent trajectory classes of depressive and anxiety disorders from adolescence to adulthood: descriptions of classes and associations with risk factors
    Thomas M Olino
    Department of Psychology, Stony Brook University, Stony Brook, NY, USA
    Compr Psychiatry 51:224-35. 2010
    ..The findings indicate that several subgroups of adolescents exist with distinct longitudinal trajectories of depressive and anxiety disorders, and these trajectory classes are associated with different risk factors...
  18. ncbi request reprint A construct validation study of the Response Styles Questionnaire Rumination Scale in participants with a recent-onset major depressive episode
    K L Kasch
    Department of Psychology, State University of New York at Stony Brook, USA
    Psychol Assess 13:375-83. 2001
    ..Finally, rumination appeared to be closely associated with the severity of the depressive episode, rather than defining a distinct clinical subtype...
  19. ncbi request reprint A family study of outpatients with borderline personality disorder and no history of mood disorder
    L P Riso
    Department of Psychology, Georgia State University, Atlanta 30303, USA
    J Pers Disord 14:208-17. 2000
    ..The results suggest there may be common etiological factors between borderline personality disorder and mood disorders...
  20. ncbi request reprint Temperamental emotionality in preschoolers and parental mood disorders
    C Emily Durbin
    Department of Psychology, State University of New York at Stony Brook, Stoney Brook, NY, USA
    J Abnorm Psychol 114:28-37. 2005
    ..The low PE-maternal depression link was relatively specific, as there were few associations between low PE and other forms of parental psychopathology or between NE and BI and parental mood disorders...
  21. ncbi request reprint Ten-year prospective follow-up study of the naturalistic course of dysthymic disorder and double depression
    Daniel N Klein
    Department of Psychology, Stony Brook University, Stony Brook, NY 11794 2500, USA
    Am J Psychiatry 163:872-80. 2006
    ..The purpose of this study was to describe the 10-year course and outcome of dysthymic disorder...
  22. ncbi request reprint Early- versus late-onset dythymic disorder: comparison in out-patients with superimposed major depressive episodes
    D N Klein
    Department of Psychology, State University of New York at Stony Brook, 11794 2500, USA
    J Affect Disord 52:187-96. 1999
    ..This study examined the validity of the early-late onset subtyping distinction in dysthymic disorder...
  23. ncbi request reprint Outcome of dysthymic disorder at 5-year follow-up: the effect of familial psychopathology, early adversity, personality, comorbidity, and chronic stress
    E P Hayden
    Department of Psychology, State University of New York at Stony Brook, 11794-2500, USA
    Am J Psychiatry 158:1864-70. 2001
    ....
  24. ncbi request reprint Depressive personality: associations with DSM-III-R mood and personality disorders and negative and positive affectivity, 30-month stability, and prediction of course of Axis I depressive disorders
    D N Klein
    Department of Psychology, State University of New York at Stony Brook 11794 2500, USA
    J Abnorm Psychol 107:319-27. 1998
    ..Finally, DPD was moderately stable over a 30-month period and was associated with a poorer course of depression...
  25. pmc Early adversity in chronic depression: clinical correlates and response to pharmacotherapy
    Daniel N Klein
    Department of Psychology, State University of New York at Stony Brook, Stony Brook, New York 11794 2500, USA
    Depress Anxiety 26:701-10. 2009
    ..We examined associations between childhood adversity and a broad variety of clinical characteristics and response to pharmacotherapy in a large sample of patients with chronic forms of MDD...
  26. ncbi request reprint Reward sensitivity in depression: a biobehavioral study
    Stewart A Shankman
    Department of Psychology, Stony Brook University, Stony Brook, NY, USA
    J Abnorm Psychol 116:95-104. 2007
    ..This suggests that early-onset depression may be associated with a deficit in the hypothesized approach motivation system...
  27. ncbi request reprint Dimensional diagnosis of depression: adding the dimension of course to severity, and comparison to the DSM
    Stewart A Shankman
    Department of Psychology, State University of New York at Stony Brook, Stony Brook, NY 11794 2500, USA
    Compr Psychiatry 43:420-6. 2002
    ..However, the linear combination of symptom severity and prior course provided only a minimal increase in predictive power over and above the DSM diagnoses of major depressive disorder (MDD) and dysthymia...
  28. ncbi request reprint Evidence of increased sensitivity using a three-factor version of the Parental Bonding Instrument
    Humberto Lizardi
    Department of Psychology, City University of New York at Lehman College, 250 Bedford Park Boulevard West, Bronx, New York 10468 1589, USA
    J Nerv Ment Dis 190:619-23. 2002
    ..The results indicated that the three-factor model revealed associations between parenting behaviors and different types of depression that were not evident using the two-factor structure's original dimensions...
  29. ncbi request reprint Family history assessment of personality disorders: II. Association with measures of psychosocial functioning in direct evaluations with relatives
    M E Lara
    Department of Psychology, State University of New York at Stony Brook 11794-2500, USA
    J Pers Disord 11:137-45. 1997
    ..These results support the convergent validity of the FHIPD, and suggest that informants may provide important information on Axis II psychopathology that is not obtained from direct interviews with the subjects themselves...
  30. ncbi request reprint Psychosocial processes underlying the maintenance and persistence of depression: implications for understanding chronic depression
    M E Lara
    State University of New York at Stony Brook, USA
    Clin Psychol Rev 19:553-70. 1999
    ..We conclude by suggesting a number of ways in which cognitive and interpersonal factors and early adversity may interact to maintain and prolong depressive episodes...
  31. ncbi request reprint Family study of subthreshold psychopathology in a community sample
    S A Shankman
    Department of Psychology, University of Illinois at Chicago, Chicago, IL 60607, USA
    Psychol Med 38:187-98. 2008
    ..However, most of these studies examined a single subthreshold condition and thus fail to take into account the high co-morbidity among subthreshold conditions and between subthreshold conditions and FS disorders...
  32. ncbi request reprint Chronic depression: update on classification and treatment
    Dana C Torpey
    Department of Psychology, Stony Brook University, Stony Brook, NY 11794 2500, USA
    Curr Psychiatry Rep 10:458-64. 2008
    ..An important direction for future research is to elucidate the multiple pathways to chronic depression and to tailor treatments to specific etiopathogenetic subgroups...
  33. ncbi request reprint Group comparisons of DSM-IV subtypes of chronic depression: validity of the distinctions, part 2
    James P McCullough
    Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284 2018, USA
    J Abnorm Psychol 112:614-22. 2003
    ..The authors suggest that chronic depression should be viewed as a single, broad condition that can assume a variety of clinical course configurations...
  34. ncbi request reprint A growth curve analysis of the course of dysthymic disorder: the effects of chronic stress and moderation by adverse parent-child relationships and family history
    Lea R Dougherty
    Department of Psychology, State University of New York at Stony Brook, Stony Brook, NY 11794 2500, USA
    J Consult Clin Psychol 72:1012-21. 2004
    ....
  35. ncbi request reprint Ten-year stability of personality disorders among outpatients with mood disorders
    C Emily Durbin
    Department of Psychology, Northwestern University, Evanston, IL 60208, USA
    J Abnorm Psychol 115:75-84. 2006
    ..Growth curve analyses revealed complex patterns of change in absolute scores for PD traits across the 10-year interval. Stability of PDs was generally comparable to that of anxiety disorder diagnoses and normal personality traits...
  36. ncbi request reprint Psychopathology in the adolescent and young adult offspring of parents with dysthymic disorder and major depressive disorder
    Humberto Lizardi
    Department of Psychology, City University of New York at Lehman College, Bronx, NY, USA
    J Nerv Ment Dis 192:193-9. 2004
    ..These results support the importance of early-onset DD in parents as a risk factor for psychopathology in their offspring...
  37. pmc Longitudinal associations between depressive and anxiety disorders: a comparison of two trait models
    Thomas M Olino
    Department of Psychology, Stony Brook University, Stony Brook, NY 11794 2500, USA
    Psychol Med 38:353-63. 2008
    ....
  38. ncbi request reprint The impact of comorbid anxiety disorders on the course of dysthymic disorder: a 5-year prospective longitudinal study
    Stewart A Shankman
    Department of Psychology, State University of New York at Stony Brook, Stony Brook, NY 11794 2500, USA
    J Affect Disord 70:211-7. 2002
    ..This research prospectively examines the naturalistic course of dysthymic disorder in patients with and without a comorbid anxiety disorder over a 5-year period...
  39. ncbi request reprint Behavioral activation system deficits predict the six-month course of depression
    Brian R McFarland
    Psychology Department, Stony Brook University, NY 11794 2500, USA
    J Affect Disord 91:229-34. 2006
    ..This study tested the hypothesis that BAS deficits, measured with both self-report and electrophysiological methods, would predict the six-month course of depression...
  40. pmc Exploring depressive personality traits in youth: origins, correlates, and developmental consequences
    Karen D Rudolph
    Department of Psychology, University of Illinois, 603 East Daniel Street, Champaign, IL 61820, USA
    Dev Psychopathol 21:1155-80. 2009
    ..These findings support the construct of DP traits in youth, and suggest that these traits may be a useful addition to developmental models of risk for youth depression...
  41. ncbi request reprint Positive emotionality at age 3 predicts cognitive styles in 7-year-old children
    Elizabeth P Hayden
    State University of New York at Stony Brook, NY, USA
    Dev Psychopathol 18:409-23. 2006
    ..Our findings are consistent with the hypothesis that some portion of cognitive vulnerability to depression may stem from early-emerging differences in the expression of positive emotions...
  42. ncbi request reprint Development and validation of a Q-sort procedure to assess temperament and behavior in preschool-age children
    Maureen E Buckley
    State University of New York at Stony Brook, Psychology Department, Stony Brook, NY 11794 2500, USA
    J Clin Child Adolesc Psychol 31:525-39. 2002
    ..The CTBQ-Set shows promise as an observer-reated measure of preschoolers' behavior and temperament in their natural home environment...
  43. ncbi request reprint The relation between depression and anxiety: an evaluation of the tripartite, approach-withdrawal and valence-arousal models
    Stewart A Shankman
    Department of Psychology, SUNY Stony Brook, Stony Brook, NY 11794 2500, USA
    Clin Psychol Rev 23:605-37. 2003
    ..Because of the heterogeneity of depression and anxiety disorders, a model with 2-4 factors or dimensions may not be sufficient to explain the relation between the two conditions...
  44. doi request reprint Emotional reactivity in depression: diminished responsiveness to anticipated reward but not to anticipated punishment or to nonreward or avoidance
    Brian R McFarland
    Department of Psychology, Stony Brook University, Stony Brook, New York, USA
    Depress Anxiety 26:117-22. 2009
    ..This study compared depressed and nondepressed participants' emotional reactivity to anticipated reward, anticipated punishment, failure to obtain a reward, and successful avoidance of punishment...
  45. ncbi request reprint Retrospective reports of parenting in depressed adults with and without comorbid panic disorder and social anxiety disorder
    Dana C Torpey
    Department of Psychology, Stony Brook University, Stony Brook, New York, USA
    J Nerv Ment Dis 195:738-44. 2007
    ....
  46. pmc Influence of parental and grandparental major depressive disorder on behavior problems in early childhood: a three-generation study
    Thomas M Olino
    Department of Psychology, State University of New York at Stony Brook, NY 11794 2500, USA
    J Am Acad Child Adolesc Psychiatry 47:53-60. 2008
    ..This aim of this study was to examine the influence of grandparental (G1) and parental (G2) major depressive disorder (MDD) and other forms of psychopathology on behavior problems in very young offspring (G3)...
  47. ncbi request reprint Sibling similarity for MDD: evidence for shared familial factors
    Thomas M Olino
    Department of Psychology, Stony Brook University, Stony Brook, NY 11794 2500, United States
    J Affect Disord 94:211-8. 2006
    ..Sibling designs have the potential to identify familial factors that are shared and unshared between siblings. Unfortunately, this methodology has rarely been applied to mood disorders...
  48. ncbi request reprint The relationship between EEG asymmetry and positive emotionality in young children
    Stewart A Shankman
    Department of Psychology, Stony Brook University, Stony Brook, New York 11794 2500, USA
    Ann N Y Acad Sci 1000:389-92. 2003
  49. ncbi request reprint Psychosocial predictors of the short-term course and outcome of major depression: a longitudinal study of a nonclinical sample with recent-onset episodes
    M E Lara
    State University of New York at Stony Brook, USA
    J Abnorm Psychol 109:644-50. 2000
    ..Harsh discipline was also significantly associated with relapse but not with recovery. After controlling for baseline severity, rumination and the interpersonal variables did not predict the outcome of MDD...
  50. ncbi request reprint Family study of co-morbidity between major depressive disorder and anxiety disorders
    D N Klein
    Department of Psychology, State University of New York at Stony Brook, Stony Brook, NY 11794 2500, USA
    Psychol Med 33:703-14. 2003
    ..However, the reason for this is unclear. Family studies provide one potentially useful approach for addressing this issue...
  51. ncbi request reprint Stability of laboratory-assessed temperamental emotionality traits from ages 3 to 7
    C Emily Durbin
    Department of Psychology, Northwestern University, Evanston, IL 60208 2710, USA
    Emotion 7:388-99. 2007
    ..Measures of emotional expressions exhibited levels of stability comparable to or higher than traits defined by other behavioral patterns (e.g., sociability and engagement)...
  52. ncbi request reprint Low positive emotionality in young children: association with EEG asymmetry
    Stewart A Shankman
    Stony Brook University, NY 11794 2500, USA
    Dev Psychopathol 17:85-98. 2005
    ..These findings support the construct validity of the hypothesis that low PE may be a temperamental precursor or risk factor for depression...
  53. pmc Multifinality in the development of personality disorders: a Biology x Sex x Environment interaction model of antisocial and borderline traits
    Theodore P Beauchaine
    Department of Psychology, University of Washington, Seattle, WA 98195 1525, USA
    Dev Psychopathol 21:735-70. 2009
    ....
  54. ncbi request reprint Therapeutic alliance in depression treatment: controlling for prior change and patient characteristics
    Daniel N Klein
    Department of Psychology and Psychiatry, State University of New York at Stony Brook, 11794 2500, USA
    J Consult Clin Psychol 71:997-1006. 2003
    ..Patients receiving combination treatment reported stronger alliances with their psychotherapists than patients receiving CBASP alone. However, the impact of the alliance on outcome was similar for both treatment conditions...
  55. doi request reprint Additive effects of the dopamine D2 receptor and dopamine transporter genes on the error-related negativity in young children
    A Meyer
    Department of Psychology, Stony Brook University, Stony Brook, NY, USA
    Genes Brain Behav 11:695-703. 2012
    ..e. more negative) ERN. These results provide further support for the involvement of dopamine in the generation of the ERN...
  56. ncbi request reprint Family history assessment of personality disorders: I. Concordance with direct interview and between pairs of informants
    T Ferro
    Department of Psychology, State University of New York at Stony Brook, USA
    J Pers Disord 11:123-36. 1997
    ..Kappa for a diagnosis of any personality disorder was .36. These data suggest that subjects and informants provide different perspectives on Axis II psychopathology, and support the use of both sources of information whenever possible...
  57. ncbi request reprint Converging evidence for a cognitive anomaly in early psychopathology
    L O Fernandes
    Department of Psychology, University of Illinois at Urbana Champaign, USA
    Psychophysiology 36:511-21. 1999
    ..Results suggested abnormal voluntary cognitive processing, perhaps reflecting compensatory efforts in subjects at risk for or manifesting psychopathology, particularly those showing negative symptoms...
  58. ncbi request reprint Psychopathology in the adolescent and young adult offspring of a community sample of mothers and fathers with major depression
    Daniel N Klein
    Department of Psychology, Stony Brook University, Stony Brook, NY 11794 2500, USA
    Psychol Med 35:353-65. 2005
    ..There is a large literature indicating that the offspring of mothers with Major Depressive Disorder (MDD) are at increased risk for depression. However, much less is known about the effects of paternal MDD on offspring psychopathology...
  59. pmc Interaction between 5-HTTLPR and BDNF Val66Met polymorphisms on HPA axis reactivity in preschoolers
    Lea R Dougherty
    Department of Psychology, Stony Brook University, NY, United States
    Biol Psychol 83:93-100. 2010
    ....
  60. pmc Chronic forms of major depression are still undertreated in the 21st century: systematic assessment of 801 patients presenting for treatment
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA
    J Affect Disord 110:55-61. 2008
    ..These results and the consistency of similar results over time point to the dire need for patient and provider education regarding the signs and symptoms of depression and its treatment...
  61. pmc Psychosocial functioning of adults who experienced substance use disorders as adolescents
    Paul Rohde
    Oregon Research Institute, Eugene, OR 97403 1983, USA
    Psychol Addict Behav 21:155-64. 2007
    ..Adolescent SUD is associated with numerous functioning difficulties at age 30, some of which appear to be related to recurrent SUD, comorbid adolescent disorders, or functioning problems already evident in adolescence...
  62. pmc Early-emerging cognitive vulnerability to depression and the serotonin transporter promoter region polymorphism
    Elizabeth P Hayden
    University of Western Ontario, Department of Psychology, London, Ontario Canada N6A 5C2
    J Affect Disord 107:227-30. 2008
    ..However, the effects of this genotype on measures of stress sensitivity are poorly understood. Therefore, this study examined whether 5-HTTLPR genotype was associated with negative information processing biases in early childhood...
  63. pmc Faster remission of chronic depression with combined psychotherapy and medication than with each therapy alone
    Rachel Manber
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Consult Clin Psychol 76:459-67. 2008
    ..The authors conclude that combined antidepressant medications and psychotherapy result in faster full remission of chronic forms of major depressive disorder...
  64. ncbi request reprint Dropouts versus completers among chronically depressed outpatients
    Bruce A Arnow
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5722, United States
    J Affect Disord 97:197-202. 2007
    ..Premature termination is common among patients treated for depression with either pharmacotherapy or psychotherapy. Yet little is known about factors associated with premature treatment termination among depressed patients...
  65. ncbi request reprint Does psychosocial functioning improve independent of depressive symptoms? A comparison of nefazodone, psychotherapy, and their combination
    Robert M A Hirschfeld
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, Texas 77555 0188, USA
    Biol Psychiatry 51:123-33. 2002
    ..This study compared efficacy of nefazodone, psychotherapy, and their combination in improving psychosocial functioning in chronically depressed outpatients...
  66. ncbi request reprint Differential effects of nefazodone and cognitive behavioral analysis system of psychotherapy on insomnia associated with chronic forms of major depression
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213 2593, USA
    J Clin Psychiatry 63:493-500. 2002
    ..As nefazodone-mediated blockade of serotonin-2 receptors may directly relieve insomnia associated with depression, we examined the more specific effects of CBASP and nefazodone, singly and in combination, on sleep disturbances...
  67. ncbi request reprint Psychosocial outcomes following long-term, double-blind treatment of chronic depression with sertraline vs placebo
    James H Kocsis
    Cornell University School of Medicine, New York, New York, USA
    Arch Gen Psychiatry 59:723-8. 2002
    ..To date, no study has measured psychosocial functioning in this population during long-term maintenance antidepressant treatment or following the double-blind discontinuation of treatment...
  68. ncbi request reprint Psychosocial functioning of young adults who have experienced and recovered from major depressive disorder during adolescence
    Peter M Lewinsohn
    Oregon Research Institute, Eugene 97403 1983, USA
    J Abnorm Psychol 112:353-63. 2003
    ..Accounting for levels of functioning in adolescence or for current depression at age 24 eliminated the remaining associations. The implications of these findings for efforts to prevent MDD in adolescence are discussed...
  69. ncbi request reprint The 16-Item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
    Biol Psychiatry 54:573-83. 2003
    ..The QIDS-SR(16) has highly acceptable psychometric properties, which supports the usefulness of this brief rating of depressive symptom severity in both clinical and research settings...
  70. ncbi request reprint Randomized, placebo-controlled trial of nefazodone maintenance treatment in preventing recurrence in chronic depression
    Alan J Gelenberg
    Department of Psychiatry, Health Sciences Center, University of Arizona, PO Box 245002, Tucson, AZ 85724 5002, USA
    Biol Psychiatry 54:806-17. 2003
    ..This randomized, placebo-controlled study of the efficacy and safety of nefazodone in preventing recurrence was conducted for patients with chronic MDD...
  71. pmc Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322
    Proc Natl Acad Sci U S A 100:14293-6. 2003
    ..Our results suggest that psychotherapy may be an essential element in the treatment of patients with chronic forms of major depression and a history of childhood trauma...
  72. ncbi request reprint Therapeutic reactance as a predictor of outcome in the treatment of chronic depression
    Bruce A Arnow
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305 5722, USA
    J Consult Clin Psychol 71:1025-35. 2003
    ..Results support the importance of Aptitude * Treatment interactions in psychotherapy outcome. The direction and significance of such interactions may vary with different forms of psychopathology...
  73. ncbi request reprint The prevalence and co-morbidity of subthreshold psychiatric conditions
    Peter M Lewinsohn
    Oregon Research Institute, 1715 Franklin Blvd, Eugene, Oregon 97403 1983, USA
    Psychol Med 34:613-22. 2004
    ..The purpose was to examine rates of co-morbidity among subthreshold disorders and between subthreshold and full-syndrome disorders for the major non-psychotic classes of disorders from DSM-IV...
  74. pmc Association of parental depression with psychiatric course from adolescence to young adulthood among formerly depressed individuals
    Paul Rohde
    Oregon Research Institute, Eugene, OR 97403 1983, USA
    J Abnorm Psychol 114:409-20. 2005
    ..Recurrent paternal MDD was associated with depression recurrence in daughters but not sons. The impact of parental MDD on offspring could not be attributed to characteristics of the offspring's depression prior to age 19...
  75. ncbi request reprint Chronic depression: medication (nefazodone) or psychotherapy (CBASP) is effective when the other is not
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5717, USA
    Arch Gen Psychiatry 62:513-20. 2005
    ..Although various strategies are available to manage nonresponders to an initial treatment for depression, no controlled trials address the utility of switching from an antidepressant medication to psychotherapy or vice versa...
  76. ncbi request reprint Self-reported depressive symptom measures: sensitivity to detecting change in a randomized, controlled trial of chronically depressed, nonpsychotic outpatients
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9086, USA
    Neuropsychopharmacology 30:405-16. 2005
    ..Global patient ratings such as the PGI-I, as opposed to specific item-based ratings, provide less valid findings...
  77. pmc Psychosocial impairment in offspring of depressed parents
    Peter M Lewinsohn
    Oregon Research Institute, Eugene, OR 97403 1983, USA
    Psychol Med 35:1493-503. 2005
    ..Offspring of depressed parents experience impairment in a number of domains of functioning. Few studies have examined the impact of both maternal and paternal depression and co-morbid psychopathology on offspring functioning...
  78. ncbi request reprint Continuation treatment of chronic depression: a comparison of nefazodone, cognitive behavioral analysis system of psychotherapy, and their combination
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10021, USA
    Psychopharmacol Bull 37:73-87. 2003
    ..COMB was associated with less symptom re-emergence during the continuation phase than either monotherapy, particularly for partial remitters...
  79. ncbi request reprint Bipolar disorder in adolescence and young adulthood
    Peter M Lewinsohn
    Oregon Research Institute, 1715 Franklin Boulevard, Eugene, OR 97403 1983, USA
    Child Adolesc Psychiatr Clin N Am 11:461-75, vii. 2002
    ..Adolescent BD showed significant continuity across developmental periods and was associated with adverse outcomes during young adulthood. Subthreshold BD results provide partial support for a bipolar spectrum...
  80. ncbi request reprint Double-blind switch study of imipramine or sertraline treatment of antidepressant-resistant chronic depression
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 59:233-9. 2002
    ..Although various strategies have been proposed to treat antidepressant nonresponders, little controlled research has been published that examines prospectively the use of switching to an alternate antidepressant...
  81. ncbi request reprint Family study of subthreshold depressive symptoms: risk factor for MDD?
    Peter M Lewinsohn
    Oregon Research Institute, 1715 Franklin Boulevard, Eugene, OR 97403 1983, USA
    J Affect Disord 77:149-57. 2003
    ..MDD): (a) is there an elevated rate of MDD in the relatives of probands with SubD? (b) does SubD aggregate in the families of probands with MDD and SubD? (c) is the relationship between SubD and familial psychopathology specific to MDD?..
  82. ncbi request reprint Temperamental fearfulness in childhood and the serotonin transporter promoter region polymorphism: a multimethod association study
    Elizabeth P Hayden
    Department of Psychology, University of Western Ontario, London, Ontario, Canada
    Psychiatr Genet 17:135-42. 2007
    ..Previous research indicates that the serotonin transporter promoter region polymorphism is a candidate gene for such traits...

Research Grants25

  1. MDD in Adolescents & Young Adults: Pathways & Processes
    Daniel Klein; Fiscal Year: 2004
    ..We will use latent growth curve modeling to identify distinct groups of developmental trajectories of psychopathology in offspring, and examine grandparental, parental, and familial predictors of these trajectories. ..
  2. REVAMP Follow-Up Study
    Daniel Klein; Fiscal Year: 2007
    ....
  3. Temperamental Emotionality in Preschoolers and Depression Risk
    Daniel N Klein; Fiscal Year: 2010
    ..This will contribute to understanding when and how to intervene in order to prevent the disorder and/or its progression. ..
  4. CLASSIFICATION OF EARLY ONSET DYSTHMIA
    Daniel Klein; Fiscal Year: 2003
    ..abstract_text> ..
  5. CLASSIFICATION OF EARLY-ONSET DYSTHYMIA
    Daniel Klein; Fiscal Year: 1993
    ..Which of five models of the relationships between PEOD and the major affective and Axis II disorders best explains the pattern of mood and personality disorders in relatives of PEOD, EMD, and normal probands?..
  6. Temperamental Low PE in Preschoolers and Depression Risk
    Daniel Klein; Fiscal Year: 2009
    ....