Research Topics
Genomes and GenesSpecies | Makoto KanzakiSummaryAffiliation: State University of New York Country: USA Publications
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Publications
Insulin signaling: GLUT4 vesicles exit via the exocystMakoto Kanzaki
The Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
Curr Biol 13:R574-6. 2003..The exocyst has now been identified as a downstream target for TC10, directing GLUT4-containing vesicles to the site of fusion...- Phosphatidylinositol 4,5-bisphosphate regulates adipocyte actin dynamics and GLUT4 vesicle recyclingMakoto Kanzaki
Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
J Biol Chem 279:30622-33. 2004..In adipocytes, altered PI(4,5)P2 metabolism has marked effects on GLUT4 endocytosis and intracellular vesicle trafficking due to the derangement of actin dynamics... 
Entry of newly synthesized GLUT4 into the insulin-responsive storage compartment is GGA dependentRobert T Watson
Department of Pharmacological Sciences, SUNY-Stony Brook, Stony Brook, NY 11794-8651, USA
EMBO J 23:2059-70. 2004..Together, these data demonstrate that following biosynthesis, GLUT4 directly sorts and traffics to the insulin-responsive storage compartment through a specific GGA-sensitive process...- Regulated membrane trafficking of the insulin-responsive glucose transporter 4 in adipocytesRobert T Watson
Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
Endocr Rev 25:177-204. 2004..To this end, the combined efforts of numerous research groups employing a range of experimental approaches has led to a clearer molecular picture of how insulin regulates the membrane trafficking of GLUT4... 
Atypical protein kinase C (PKCzeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathwaysMakoto Kanzaki
Dept of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
J Cell Biol 164:279-90. 2004....- Intracellular insulin-responsive glucose transporter (GLUT4) distribution but not insulin-stimulated GLUT4 exocytosis and recycling are microtubule dependentSatoshi Shigematsu
Department of Physiology and Biophysics, The University of Iowa, Iowa City, Iowa 52242, USA
Mol Endocrinol 16:1060-8. 2002.... - The exocytotic trafficking of TC10 occurs through both classical and nonclassical secretory transport pathways in 3T3L1 adipocytesRobert T Watson
Department of Physiology and Biophysics, The University of Iowa, Iowa City, Iowa 52242, USA
Mol Cell Biol 23:961-74. 2003..Moreover, the transport through the secretory pathway is necessary for the localization of TC10 to lipid raft microdomains at the plasma membrane... - A Crk-II/TC10 signaling pathway is required for osmotic shock-stimulated glucose transportPhilippe Gual
INSERM U 568 and IFR 50, Faculte de Medecine, Avenue de Valombrose, 06107 Nice, Cedex 02, France
J Biol Chem 277:43980-6. 2002..These data provide the first evidence that activation of TC10 and remodeling of cortical actin, which could occur through the TC10 signaling, are required for osmotic shock-mediated Glut 4 translocation and glucose uptake... - Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytesMakoto Kanzaki
Department of Physiology and Biophysics, The University of Iowa, Iowa City, Iowa 52242, USA
Mol Biol Cell 13:2334-46. 2002..Together, these data demonstrate that TC10 can differentially regulate two types of filamentous actin in adipocytes dependent on distinct functional domains and its subcellular compartmentalization... - Insulin receptor signals regulating GLUT4 translocation and actin dynamicsMakoto Kanzaki
TUBERO/Tohoku University Biomedical Engineering Research Organization, Tohoku University, Sendai, Japan
Endocr J 53:267-93. 2006..Thus, both spatial and temporal regulations of actin dynamics, both beneath the plasma membrane and around endomembranes, by insulin receptor signals are also involved in the process of GLUT4 translocation... - Regulation of glucose transporters by insulin and extracellular glucose in C2C12 myotubesTaku Nedachi
TUBERO/Tohoku University Biomedical Engineering Research Organization, Tohoku University 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
Am J Physiol Endocrinol Metab 291:E817-28. 2006..We herein also describe several methods of monitoring insulin-dependent glucose uptake in C(2)C(12) myotubes and propose this cell line to be a useful model for analyzing GLUT4 translocation in skeletal muscle... 
Ambient glucose levels qualify the potency of insulin myogenic actions by regulating SIRT1 and FoxO3a in C2C12 myocytesTaku Nedachi
Division of Biomaterials, Tohoku University Biomedical Engineering Research Organization, Tohoku University, Sendai, Japan
Am J Physiol Endocrinol Metab 294:E668-78. 2008....- Functional role of sortilin in myogenesis and development of insulin-responsive glucose transport system in C2C12 myocytesMiyako Ariga
21st Century COE Program Comprehensive Research and Education Center for Planning of Drug Development and Clinical Evaluation, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
J Biol Chem 283:10208-20. 2008....