Makoto Kanzaki

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. ncbi request reprint Insulin signaling: GLUT4 vesicles exit via the exocyst
    Makoto Kanzaki
    The Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    Curr Biol 13:R574-6. 2003
  2. ncbi request reprint Phosphatidylinositol 4,5-bisphosphate regulates adipocyte actin dynamics and GLUT4 vesicle recycling
    Makoto Kanzaki
    Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    J Biol Chem 279:30622-33. 2004
  3. pmc Entry of newly synthesized GLUT4 into the insulin-responsive storage compartment is GGA dependent
    Robert T Watson
    Department of Pharmacological Sciences, SUNY Stony Brook, Stony Brook, NY 11794 8651, USA
    EMBO J 23:2059-70. 2004
  4. ncbi request reprint Regulated membrane trafficking of the insulin-responsive glucose transporter 4 in adipocytes
    Robert T Watson
    Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Endocr Rev 25:177-204. 2004
  5. pmc Atypical protein kinase C (PKCzeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways
    Makoto Kanzaki
    Dept of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Cell Biol 164:279-90. 2004
  6. ncbi request reprint Intracellular insulin-responsive glucose transporter (GLUT4) distribution but not insulin-stimulated GLUT4 exocytosis and recycling are microtubule dependent
    Satoshi Shigematsu
    Department of Physiology and Biophysics, The University of Iowa, Iowa City, Iowa 52242, USA
    Mol Endocrinol 16:1060-8. 2002
  7. pmc The exocytotic trafficking of TC10 occurs through both classical and nonclassical secretory transport pathways in 3T3L1 adipocytes
    Robert T Watson
    Department of Physiology and Biophysics, The University of Iowa, Iowa City, Iowa 52242, USA
    Mol Cell Biol 23:961-74. 2003
  8. ncbi request reprint A Crk-II/TC10 signaling pathway is required for osmotic shock-stimulated glucose transport
    Philippe Gual
    INSERM U 568 and IFR 50, Faculte de Medecine, Avenue de Valombrose, 06107 Nice, Cedex 02, France
    J Biol Chem 277:43980-6. 2002
  9. pmc Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes
    Makoto Kanzaki
    Department of Physiology and Biophysics, The University of Iowa, Iowa City, Iowa 52242, USA
    Mol Biol Cell 13:2334-46. 2002
  10. ncbi request reprint Insulin receptor signals regulating GLUT4 translocation and actin dynamics
    Makoto Kanzaki
    TUBERO Tohoku University Biomedical Engineering Research Organization, Tohoku University, Sendai, Japan
    Endocr J 53:267-93. 2006

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Insulin signaling: GLUT4 vesicles exit via the exocyst
    Makoto Kanzaki
    The Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    Curr Biol 13:R574-6. 2003
    ..The exocyst has now been identified as a downstream target for TC10, directing GLUT4-containing vesicles to the site of fusion...
  2. ncbi request reprint Phosphatidylinositol 4,5-bisphosphate regulates adipocyte actin dynamics and GLUT4 vesicle recycling
    Makoto Kanzaki
    Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    J Biol Chem 279:30622-33. 2004
    ..In adipocytes, altered PI(4,5)P2 metabolism has marked effects on GLUT4 endocytosis and intracellular vesicle trafficking due to the derangement of actin dynamics...
  3. pmc Entry of newly synthesized GLUT4 into the insulin-responsive storage compartment is GGA dependent
    Robert T Watson
    Department of Pharmacological Sciences, SUNY Stony Brook, Stony Brook, NY 11794 8651, USA
    EMBO J 23:2059-70. 2004
    ..Together, these data demonstrate that following biosynthesis, GLUT4 directly sorts and traffics to the insulin-responsive storage compartment through a specific GGA-sensitive process...
  4. ncbi request reprint Regulated membrane trafficking of the insulin-responsive glucose transporter 4 in adipocytes
    Robert T Watson
    Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Endocr Rev 25:177-204. 2004
    ..To this end, the combined efforts of numerous research groups employing a range of experimental approaches has led to a clearer molecular picture of how insulin regulates the membrane trafficking of GLUT4...
  5. pmc Atypical protein kinase C (PKCzeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways
    Makoto Kanzaki
    Dept of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Cell Biol 164:279-90. 2004
    ....
  6. ncbi request reprint Intracellular insulin-responsive glucose transporter (GLUT4) distribution but not insulin-stimulated GLUT4 exocytosis and recycling are microtubule dependent
    Satoshi Shigematsu
    Department of Physiology and Biophysics, The University of Iowa, Iowa City, Iowa 52242, USA
    Mol Endocrinol 16:1060-8. 2002
    ....
  7. pmc The exocytotic trafficking of TC10 occurs through both classical and nonclassical secretory transport pathways in 3T3L1 adipocytes
    Robert T Watson
    Department of Physiology and Biophysics, The University of Iowa, Iowa City, Iowa 52242, USA
    Mol Cell Biol 23:961-74. 2003
    ..Moreover, the transport through the secretory pathway is necessary for the localization of TC10 to lipid raft microdomains at the plasma membrane...
  8. ncbi request reprint A Crk-II/TC10 signaling pathway is required for osmotic shock-stimulated glucose transport
    Philippe Gual
    INSERM U 568 and IFR 50, Faculte de Medecine, Avenue de Valombrose, 06107 Nice, Cedex 02, France
    J Biol Chem 277:43980-6. 2002
    ..These data provide the first evidence that activation of TC10 and remodeling of cortical actin, which could occur through the TC10 signaling, are required for osmotic shock-mediated Glut 4 translocation and glucose uptake...
  9. pmc Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes
    Makoto Kanzaki
    Department of Physiology and Biophysics, The University of Iowa, Iowa City, Iowa 52242, USA
    Mol Biol Cell 13:2334-46. 2002
    ..Together, these data demonstrate that TC10 can differentially regulate two types of filamentous actin in adipocytes dependent on distinct functional domains and its subcellular compartmentalization...
  10. ncbi request reprint Insulin receptor signals regulating GLUT4 translocation and actin dynamics
    Makoto Kanzaki
    TUBERO Tohoku University Biomedical Engineering Research Organization, Tohoku University, Sendai, Japan
    Endocr J 53:267-93. 2006
    ..Thus, both spatial and temporal regulations of actin dynamics, both beneath the plasma membrane and around endomembranes, by insulin receptor signals are also involved in the process of GLUT4 translocation...
  11. ncbi request reprint Regulation of glucose transporters by insulin and extracellular glucose in C2C12 myotubes
    Taku Nedachi
    TUBERO Tohoku University Biomedical Engineering Research Organization, Tohoku University 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Am J Physiol Endocrinol Metab 291:E817-28. 2006
    ..We herein also describe several methods of monitoring insulin-dependent glucose uptake in C(2)C(12) myotubes and propose this cell line to be a useful model for analyzing GLUT4 translocation in skeletal muscle...
  12. doi request reprint Ambient glucose levels qualify the potency of insulin myogenic actions by regulating SIRT1 and FoxO3a in C2C12 myocytes
    Taku Nedachi
    Division of Biomaterials, Tohoku University Biomedical Engineering Research Organization, Tohoku University, Sendai, Japan
    Am J Physiol Endocrinol Metab 294:E668-78. 2008
    ....
  13. doi request reprint Functional role of sortilin in myogenesis and development of insulin-responsive glucose transport system in C2C12 myocytes
    Miyako Ariga
    21st Century COE Program Comprehensive Research and Education Center for Planning of Drug Development and Clinical Evaluation, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    J Biol Chem 283:10208-20. 2008
    ....