Research Topics
Species | S JudexSummaryAffiliation: State University of New York Country: USA Publications
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Publications
Adaptations of trabecular bone to low magnitude vibrations result in more uniform stress and strain under loadStefan Judex
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
Ann Biomed Eng 31:12-20. 2003....
Quantification of adiposity in small rodents using micro-CTS Judex
Department of Biomedical Engineering, Stony Brook University, NY 11794, USA
Methods 50:14-9. 2010....
Is bone's response to mechanical signals dominated by gravitational loading?Stefan Judex
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
Med Sci Sports Exerc 41:2037-43. 2009....- Low-magnitude mechanical signals that stimulate bone formation in the ovariectomized rat are dependent on the applied frequency but not on the strain magnitudeStefan Judex
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY, USA
J Biomech 40:1333-9. 2007..Ideally, such mechanical signals represent a non-pharmacologic means of controlling bone mass and morphology in spite of systemic pressures for bone resorption... - Combining high-resolution micro-computed tomography with material composition to define the quality of bone tissueStefan Judex
Department of Biomedical Engineering, Psychology A Building, 3rd Floor, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
Curr Osteoporos Rep 1:11-9. 2003.... - Is bone formation induced by high-frequency mechanical signals modulated by muscle activity?S Judex
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 2580, USA
J Musculoskelet Neuronal Interact 10:3-11. 2010..This independence of cells on large strains suggests that mechanical interventions can be designed that are both safe and effective... - Mechanical modulation of molecular signals which regulate anabolic and catabolic activity in bone tissueStefan Judex
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
J Cell Biochem 94:982-94. 2005..More detailed spatial and temporal correlations between altered mRNA levels and tissue plasticity may further delineate the molecules responsible for the control of bone mass and morphology... - Genetically linked site-specificity of disuse osteoporosisStefan Judex
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794 2580, USA
J Bone Miner Res 19:607-13. 2004..One mouse strain failed to lose bone after removal of function, whereas osteopenia was evident in multiple regions of the remaining two strains but in different areas of the bone... - Does the mechanical milieu associated with high-speed running lead to adaptive changes in diaphyseal growing bone?S Judex
McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, AB, Canada
Bone 26:153-9. 2000..This study also supports the tenet that the exercise-generated mechanical milieu must differ substantially from the habitual milieu to induce significant adaptations... - Genetically based influences on the site-specific regulation of trabecular and cortical bone morphologyStefan Judex
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794 2580, USA
J Bone Miner Res 19:600-6. 2004..Morphological indices were highly dependent on both genetic makeup as well as anatomical location showing that the assessment of bone structure from a single site cannot be extrapolated to other sites even within a single bone... - Genetic predisposition to low bone mass is paralleled by an enhanced sensitivity to signals anabolic to the skeletonStefan Judex
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794 2580, USA
FASEB J 16:1280-2. 2002.... - High-impact exercise and growing bone: relation between high strain rates and enhanced bone formationS Judex
McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, Alberta, Canada
J Appl Physiol 88:2183-91. 2000..Comparing the mechanical milieus produced by running and drop jumps revealed that jumping significantly elevated only peak strain rates. This further emphasized the sensitivity of immature bone to high strain rates... - Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signalsC T Rubin
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA
Proc Natl Acad Sci U S A 104:17879-84. 2007..Translated to the human, this may represent the basis for the nonpharmacologic prevention of obesity and its sequelae, achieved through developmental, rather than metabolic, pathways... - In vivo quantification of subcutaneous and visceral adiposity by micro-computed tomography in a small animal modelY K Luu
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA
Med Eng Phys 31:34-41. 2009..Compared to current imaging techniques with similar capabilities, such as microMRI or the combination of DEXA with NMR, it may also be more cost-effective and offer higher spatial resolutions... - Regulation of mechanical signals in boneS Judex
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
Orthod Craniofac Res 12:94-104. 2009..Anabolic effects of high-frequency, low-magnitude vibrations, a mechanical intervention with a favorable safety profile, as well as the modulation of bone loss by genetic and epigenetic factors during disuse are highlighted... - Development of diet-induced fatty liver disease in the aging mouse is suppressed by brief daily exposure to low-magnitude mechanical signalsY K Luu
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 2580, USA
Int J Obes (Lond) 34:401-5. 2010.... - Devastation of bone tissue in the appendicular skeleton parallels the progression of neuromuscular diseaseB J Lee
Department of Biomedical Engineering, State University of New York, Stony Brook, New York 11794 2580, USA
J Musculoskelet Neuronal Interact 9:215-24. 2009.... - Low-level accelerations applied in the absence of weight bearing can enhance trabecular bone formationRussell Garman
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
J Orthop Res 25:732-40. 2007.... - Rapid establishment of chemical and mechanical properties during lamellar bone formationB Busa
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY, USA
Calcif Tissue Int 77:386-94. 2005..83. These data indicate that lamellar bone has the ability to quickly establish its mechanical and chemical tissue properties during primary and secondary mineralization even when the skeleton experiences rapid growth... - The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low-magnitude mechanical stimuliC Rubin
Musculo Skeletal Research Laboratory, Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794 2580 USA
FASEB J 15:2225-9. 2001..This work indicates that this noninvasive, extremely low-level stimulus may provide an effective biomechanical intervention for the bone loss that plagues long-term space flight, bed rest, or immobilization caused by paralysis... - An automated algorithm to detect the trabecular-cortical bone interface in micro-computed tomographic imagesSvetlana Lublinsky
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
Calcif Tissue Int 81:285-93. 2007.... - Bone hyperemia precedes disuse-induced intracortical bone resorptionT S Gross
McCaig Centre for Joint Injury and Arthritis Research, Department of Surgery, University of Calgary, Calgary, Canada T2N 4N1
J Appl Physiol 86:230-5. 1999..02 vs. 0. 002 +/- 0.002 mm2; P = 0.03). We conclude that disuse induces bone hyperemia before an increase in intracortical porosity. The potential interaction between bone vasoregulation and bone cell dynamics remains to be studied... - Enhancement of the adolescent murine musculoskeletal system using low-level mechanical vibrationsLiqin Xie
Dept of Biomedical Engineering, Psychology A, 3rd Floor, State Univ of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
J Appl Physiol 104:1056-62. 2008..If maintained into adulthood, the beneficial structural changes in trabecular bone, cortical bone, and muscle may serve to decrease the incidence of osteoporotic fractures and sarcopenia later in life... - Low-level vibrations retain bone marrow's osteogenic potential and augment recovery of trabecular bone during reambulationEngin Ozcivici
Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA
PLoS ONE 5:e11178. 2010..These data indicate that the osteogenic potential of bone marrow cells is retained by low-magnitude vibrations during disuse, an attribute which may have contributed to an enhanced recovery of bone morphology during reambulation... - Postural instability caused by extended bed rest is alleviated by brief daily exposure to low magnitude mechanical signalsJesse Muir
Department of Biomedical Engineering, State University of New York, Stony Brook, NY 11794 2580, USA
Gait Posture 33:429-35. 2011.... - Low-level mechanical vibrations can influence bone resorption and bone formation in the growing skeletonLiqin Xie
Department of Biomedical Engineering, Psychology A, 3rd Floor, State University of New York at Stony Brook, Stony Brook, NY 11794-2580, USA
Bone 39:1059-66. 2006.... - Mechanical signals as anabolic agents in boneEngin Ozcivici
Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, NY 11794 2580, USA
Nat Rev Rheumatol 6:50-9. 2010..Mechanical targeting of the bone marrow stem-cell pool might, therefore, represent a novel, drug-free means of slowing the age-related decline of the musculoskeletal system... - Low-level mechanical signals and their potential as a non-pharmacological intervention for osteoporosisClinton Rubin
Department of Biomedical Engineering, State University of New York, Stony Brook, NY 11794 2580, USA
Age Ageing 35:ii32-ii36. 2006..Recent data indicate that extremely low-level mechanical signals are anabolic to bone, and thus may be used, non-invasively, as a form of 'passive' exercise to positively influence skeletal status... - Mechanical stimulation of mesenchymal stem cell proliferation and differentiation promotes osteogenesis while preventing dietary-induced obesityYen Kim Luu
Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York 11794 2580, USA
J Bone Miner Res 24:50-61. 2009.... - Determination of bone's mechanical matrix properties by nanoindentationEngin Ozcivici
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY, USA
Methods Mol Biol 455:323-34. 2008.... - Small oscillatory accelerations, independent of matrix deformations, increase osteoblast activity and enhance bone morphologyRussell Garman
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York, United States of America
PLoS ONE 2:e653. 2007..In retrospect, acceleration, as opposed to direct mechanical distortion, represents a more generic and safe, and perhaps more fundamental means of transducing physical challenges to the cells and tissues of an organism... - Short applications of very low-magnitude vibrations attenuate expansion of the intervertebral disc during extended bed restNilsson Holguin
Department of Biomedical Engineering, State University of New York at Stony Brook, Psychology A, 3rd Floor, Stony Brook, NY 11794 2580, USA
Spine J 9:470-7. 2009..Effective interventions for the negative effects of unloading are critical but not yet available... - High-frequency oscillatory motions enhance the simulated mechanical properties of non-weight bearing trabecular boneEngin Ozcivici
Department of Biomedical Engineering, Psychology A Building, 3rd Floor, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
J Biomech 40:3404-11. 2007.... - Craniofacial biomechanics and functional and dietary inferences in hominin paleontologyFrederick E Grine
Department of Anthropology, Stony Brook University, Stony Brook, NY 11794 4364, USA
J Hum Evol 58:293-308. 2010.... - Functional significance of genetic variation underlying limb bone diaphyseal structureIan J Wallace
Interdepartmental Doctoral Program in Anthropological Sciences, Stony Brook University, Stony Brook, NY 11794 4364, USA
Am J Phys Anthropol 143:21-30. 2010.... - Integrative metabolic regulation of peripheral tissue fatty acid oxidation by the SRC kinase family member FynClaire C Bastie
Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, USA
Cell Metab 5:371-81. 2007.... - Automated separation of visceral and subcutaneous adiposity in in vivo microcomputed tomographies of miceSvetlana Lublinsky
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 2580, USA
J Digit Imaging 22:222-31. 2009.... - Genetic variations that regulate bone morphology in the male mouse skeleton do not define its susceptibility to mechanical unloadingMaria Squire
SUNY, Stony Brook
Bone 35:1353-60. 2004..Cross-gender comparisons with previous data from female BALB and C3H mice further suggest strong interactions by which gender, genotype, and anatomical location define the response of the skeleton to the removal of weight bearing... - High-frequency, low-magnitude vibrations suppress the number of blood vessels per muscle fiber in mouse soleus muscleWalter L Murfee
Dept of Biomedical Engineering, Box 800759, UVA Health System, Charlottesville, VA 22908, USA
J Appl Physiol 98:2376-80. 2005..These results demonstrate the sensitivity of the vasculature in mouse skeletal muscle to whole body, low-level mechanical signals... - Gene expression patterns in bone after 4 days of hind-limb unloading in two inbred strains of miceNan Zhong
SUNY Stony Brook, NY
Aviat Space Environ Med 76:530-5. 2005.... - Low-level, high-frequency mechanical signals enhance musculoskeletal development of young women with low BMDVicente Gilsanz
Department of Radiology, Childrens Hospital of Los Angeles, University of Southern California, Keck School of Medicine, Los Angeles, California 90027, USA
J Bone Miner Res 21:1464-74. 2006..Twelve months of this noninvasive signal, induced as whole body vibration for at least 2 minutes each day, increased bone and muscle mass in the axial skeleton and lower extremities compared with controls... - Accretion of bone quantity and quality in the developing mouse skeletonLisa M Miller
National Synchrotron Light Source, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
J Bone Miner Res 22:1037-45. 2007.... - Baseline bone morphometry and cellular activity modulate the degree of bone loss in the appendicular skeleton during disuseMaria Squire
Department of Biology, Loyola Hall, The University of Scranton, Scranton, PA 18510, USA
Bone 42:341-9. 2008.... - Increased non-linear locomotion alters diaphyseal bone shapeKristian J Carlson
Department of Anatomy, New York College of Osteopathic Medicine, Northern Boulevard, Old Westbury, NY 11568 8000, USA
J Exp Biol 210:3117-25. 2007..These data indicate that increased turning can alter distribution of bone mass in the femoral diaphysis, and that turning should be considered in efforts to understand form-function relationships in vertebrates... - Mechanical regulation of PTHrP expression in enthesesXuesong Chen
Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8020, USA
Bone 41:752-9. 2007..In these surface sites, mechanical force seems to be an important regulator of PTHrP expression. In selected sites and/or at specific times, PTHrP may influence the recruitment and/or activities of underlying bone cell populations...
Research Grants
- Modulation of Bone's Mechanical Behavior by Bone QualityStefan Judex; Fiscal Year: 2007..Identification of these potential chemical targets will provide critical information for improved diagnostic, prophylactic, and therapeutic means of addressing bone quality defects in disease. ..
- Modulation of Bone's Mechanical Behavior by Bone QualityStefan Judex; Fiscal Year: 2010..Identification of these potential chemical targets will provide critical information for improved diagnostic, prophylactic, and therapeutic means of addressing bone quality defects in disease. ..