S Judex

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. pmc Small oscillatory accelerations, independent of matrix deformations, increase osteoblast activity and enhance bone morphology
    Russell Garman
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York, United States of America
    PLoS ONE 2:e653. 2007
  2. ncbi request reprint Adaptations of trabecular bone to low magnitude vibrations result in more uniform stress and strain under load
    Stefan Judex
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    Ann Biomed Eng 31:12-20. 2003
  3. ncbi request reprint Is bone's response to mechanical signals dominated by gravitational loading?
    Stefan Judex
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    Med Sci Sports Exerc 41:2037-43. 2009
  4. ncbi request reprint Low-magnitude mechanical signals that stimulate bone formation in the ovariectomized rat are dependent on the applied frequency but not on the strain magnitude
    Stefan Judex
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY, USA
    J Biomech 40:1333-9. 2007
  5. ncbi request reprint Combining high-resolution micro-computed tomography with material composition to define the quality of bone tissue
    Stefan Judex
    Department of Biomedical Engineering, Psychology A Building, 3rd Floor, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    Curr Osteoporos Rep 1:11-9. 2003
  6. ncbi request reprint Mechanical modulation of molecular signals which regulate anabolic and catabolic activity in bone tissue
    Stefan Judex
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    J Cell Biochem 94:982-94. 2005
  7. pmc Is bone formation induced by high-frequency mechanical signals modulated by muscle activity?
    S Judex
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 2580, USA
    J Musculoskelet Neuronal Interact 10:3-11. 2010
  8. ncbi request reprint Genetically linked site-specificity of disuse osteoporosis
    Stefan Judex
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794 2580, USA
    J Bone Miner Res 19:607-13. 2004
  9. ncbi request reprint Genetically based influences on the site-specific regulation of trabecular and cortical bone morphology
    Stefan Judex
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794 2580, USA
    J Bone Miner Res 19:600-6. 2004
  10. ncbi request reprint Genetic predisposition to low bone mass is paralleled by an enhanced sensitivity to signals anabolic to the skeleton
    Stefan Judex
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794 2580, USA
    FASEB J 16:1280-2. 2002

Collaborators

Detail Information

Publications47

  1. pmc Small oscillatory accelerations, independent of matrix deformations, increase osteoblast activity and enhance bone morphology
    Russell Garman
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York, United States of America
    PLoS ONE 2:e653. 2007
    ..In retrospect, acceleration, as opposed to direct mechanical distortion, represents a more generic and safe, and perhaps more fundamental means of transducing physical challenges to the cells and tissues of an organism...
  2. ncbi request reprint Adaptations of trabecular bone to low magnitude vibrations result in more uniform stress and strain under load
    Stefan Judex
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    Ann Biomed Eng 31:12-20. 2003
    ....
  3. ncbi request reprint Is bone's response to mechanical signals dominated by gravitational loading?
    Stefan Judex
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    Med Sci Sports Exerc 41:2037-43. 2009
    ....
  4. ncbi request reprint Low-magnitude mechanical signals that stimulate bone formation in the ovariectomized rat are dependent on the applied frequency but not on the strain magnitude
    Stefan Judex
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY, USA
    J Biomech 40:1333-9. 2007
    ..Ideally, such mechanical signals represent a non-pharmacologic means of controlling bone mass and morphology in spite of systemic pressures for bone resorption...
  5. ncbi request reprint Combining high-resolution micro-computed tomography with material composition to define the quality of bone tissue
    Stefan Judex
    Department of Biomedical Engineering, Psychology A Building, 3rd Floor, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    Curr Osteoporos Rep 1:11-9. 2003
    ....
  6. ncbi request reprint Mechanical modulation of molecular signals which regulate anabolic and catabolic activity in bone tissue
    Stefan Judex
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    J Cell Biochem 94:982-94. 2005
    ..More detailed spatial and temporal correlations between altered mRNA levels and tissue plasticity may further delineate the molecules responsible for the control of bone mass and morphology...
  7. pmc Is bone formation induced by high-frequency mechanical signals modulated by muscle activity?
    S Judex
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 2580, USA
    J Musculoskelet Neuronal Interact 10:3-11. 2010
    ..This independence of cells on large strains suggests that mechanical interventions can be designed that are both safe and effective...
  8. ncbi request reprint Genetically linked site-specificity of disuse osteoporosis
    Stefan Judex
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794 2580, USA
    J Bone Miner Res 19:607-13. 2004
    ..One mouse strain failed to lose bone after removal of function, whereas osteopenia was evident in multiple regions of the remaining two strains but in different areas of the bone...
  9. ncbi request reprint Genetically based influences on the site-specific regulation of trabecular and cortical bone morphology
    Stefan Judex
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794 2580, USA
    J Bone Miner Res 19:600-6. 2004
    ..Morphological indices were highly dependent on both genetic makeup as well as anatomical location showing that the assessment of bone structure from a single site cannot be extrapolated to other sites even within a single bone...
  10. ncbi request reprint Genetic predisposition to low bone mass is paralleled by an enhanced sensitivity to signals anabolic to the skeleton
    Stefan Judex
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794 2580, USA
    FASEB J 16:1280-2. 2002
    ....
  11. ncbi request reprint High-impact exercise and growing bone: relation between high strain rates and enhanced bone formation
    S Judex
    McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, Alberta, Canada
    J Appl Physiol (1985) 88:2183-91. 2000
    ..Comparing the mechanical milieus produced by running and drop jumps revealed that jumping significantly elevated only peak strain rates. This further emphasized the sensitivity of immature bone to high strain rates...
  12. ncbi request reprint Does the mechanical milieu associated with high-speed running lead to adaptive changes in diaphyseal growing bone?
    S Judex
    McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, AB, Canada
    Bone 26:153-9. 2000
    ..This study also supports the tenet that the exercise-generated mechanical milieu must differ substantially from the habitual milieu to induce significant adaptations...
  13. pmc Quantification of adiposity in small rodents using micro-CT
    S Judex
    Department of Biomedical Engineering, Stony Brook University, NY 11794, USA
    Methods 50:14-9. 2010
    ....
  14. pmc Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signals
    C T Rubin
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA
    Proc Natl Acad Sci U S A 104:17879-84. 2007
    ..Translated to the human, this may represent the basis for the nonpharmacologic prevention of obesity and its sequelae, achieved through developmental, rather than metabolic, pathways...
  15. ncbi request reprint Physical activity engendering loads from diverse directions augments the growing skeleton
    I J Wallace
    Interdepartmental Doctoral Program in Anthropological Sciences, Stony Brook University, Stony Brook, NY 11794, USA
    J Musculoskelet Neuronal Interact 13:283-8. 2013
    ..An experiment was conducted to determine if modifying habitual activities to involve mechanical loading from more diverse directions can enhance the growing skeleton...
  16. doi request reprint Regulation of mechanical signals in bone
    S Judex
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    Orthod Craniofac Res 12:94-104. 2009
    ..Anabolic effects of high-frequency, low-magnitude vibrations, a mechanical intervention with a favorable safety profile, as well as the modulation of bone loss by genetic and epigenetic factors during disuse are highlighted...
  17. pmc In vivo quantification of subcutaneous and visceral adiposity by micro-computed tomography in a small animal model
    Y K Luu
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA
    Med Eng Phys 31:34-41. 2009
    ..Compared to current imaging techniques with similar capabilities, such as microMRI or the combination of DEXA with NMR, it may also be more cost-effective and offer higher spatial resolutions...
  18. pmc Development of diet-induced fatty liver disease in the aging mouse is suppressed by brief daily exposure to low-magnitude mechanical signals
    Y K Luu
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 2580, USA
    Int J Obes (Lond) 34:401-5. 2010
    ....
  19. ncbi request reprint Devastation of bone tissue in the appendicular skeleton parallels the progression of neuromuscular disease
    B J Lee
    Department of Biomedical Engineering, State University of New York, Stony Brook, New York 11794 2580, USA
    J Musculoskelet Neuronal Interact 9:215-24. 2009
    ....
  20. ncbi request reprint Low-level accelerations applied in the absence of weight bearing can enhance trabecular bone formation
    Russell Garman
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    J Orthop Res 25:732-40. 2007
    ....
  21. ncbi request reprint Rapid establishment of chemical and mechanical properties during lamellar bone formation
    B Busa
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY, USA
    Calcif Tissue Int 77:386-94. 2005
    ..83. These data indicate that lamellar bone has the ability to quickly establish its mechanical and chemical tissue properties during primary and secondary mineralization even when the skeleton experiences rapid growth...
  22. ncbi request reprint The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low-magnitude mechanical stimuli
    C Rubin
    Musculo Skeletal Research Laboratory, Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794 2580 USA
    FASEB J 15:2225-9. 2001
    ..This work indicates that this noninvasive, extremely low-level stimulus may provide an effective biomechanical intervention for the bone loss that plagues long-term space flight, bed rest, or immobilization caused by paralysis...
  23. ncbi request reprint An automated algorithm to detect the trabecular-cortical bone interface in micro-computed tomographic images
    Svetlana Lublinsky
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    Calcif Tissue Int 81:285-93. 2007
    ....
  24. ncbi request reprint Bone hyperemia precedes disuse-induced intracortical bone resorption
    T S Gross
    McCaig Centre for Joint Injury and Arthritis Research, Department of Surgery, University of Calgary, Calgary, Canada T2N 4N1
    J Appl Physiol (1985) 86:230-5. 1999
    ..02 vs. 0. 002 +/- 0.002 mm2; P = 0.03). We conclude that disuse induces bone hyperemia before an increase in intracortical porosity. The potential interaction between bone vasoregulation and bone cell dynamics remains to be studied...
  25. ncbi request reprint Low-level mechanical signals and their potential as a non-pharmacological intervention for osteoporosis
    Clinton Rubin
    Department of Biomedical Engineering, State University of New York, Stony Brook, NY 11794 2580, USA
    Age Ageing 35:ii32-ii36. 2006
    ..Recent data indicate that extremely low-level mechanical signals are anabolic to bone, and thus may be used, non-invasively, as a form of 'passive' exercise to positively influence skeletal status...
  26. pmc Postural instability caused by extended bed rest is alleviated by brief daily exposure to low magnitude mechanical signals
    Jesse Muir
    Department of Biomedical Engineering, State University of New York, Stony Brook, NY 11794 2580, USA
    Gait Posture 33:429-35. 2011
    ....
  27. pmc Low-level vibrations retain bone marrow's osteogenic potential and augment recovery of trabecular bone during reambulation
    Engin Ozcivici
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA
    PLoS ONE 5:e11178. 2010
    ..These data indicate that the osteogenic potential of bone marrow cells is retained by low-magnitude vibrations during disuse, an attribute which may have contributed to an enhanced recovery of bone morphology during reambulation...
  28. doi request reprint Enhancement of the adolescent murine musculoskeletal system using low-level mechanical vibrations
    Liqin Xie
    Dept of Biomedical Engineering, Psychology A, 3rd Floor, State Univ of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    J Appl Physiol (1985) 104:1056-62. 2008
    ..If maintained into adulthood, the beneficial structural changes in trabecular bone, cortical bone, and muscle may serve to decrease the incidence of osteoporotic fractures and sarcopenia later in life...
  29. ncbi request reprint Low-level mechanical vibrations can influence bone resorption and bone formation in the growing skeleton
    Liqin Xie
    Department of Biomedical Engineering, Psychology A, 3rd Floor, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    Bone 39:1059-66. 2006
    ....
  30. pmc Mechanical signals as anabolic agents in bone
    Engin Ozcivici
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, NY 11794 2580, USA
    Nat Rev Rheumatol 6:50-9. 2010
    ..Mechanical targeting of the bone marrow stem-cell pool might, therefore, represent a novel, drug-free means of slowing the age-related decline of the musculoskeletal system...
  31. ncbi request reprint Physical activity engendering loads from diverse directions augments the growing skeleton
    I J Wallace
    Interdepartmental Doctoral Program in Anthropological Sciences, Stony Brook University, Stony Brook, NY 11794, USA
    J Musculoskelet Neuronal Interact 13:283-8. 2013
    ..An experiment was conducted to determine if modifying habitual activities to involve mechanical loading from more diverse directions can enhance the growing skeleton...
  32. pmc Mechanical stimulation of mesenchymal stem cell proliferation and differentiation promotes osteogenesis while preventing dietary-induced obesity
    Yen Kim Luu
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York 11794 2580, USA
    J Bone Miner Res 24:50-61. 2009
    ....
  33. ncbi request reprint Determination of bone's mechanical matrix properties by nanoindentation
    Engin Ozcivici
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY, USA
    Methods Mol Biol 455:323-34. 2008
    ....
  34. ncbi request reprint High-frequency oscillatory motions enhance the simulated mechanical properties of non-weight bearing trabecular bone
    Engin Ozcivici
    Department of Biomedical Engineering, Psychology A Building, 3rd Floor, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    J Biomech 40:3404-11. 2007
    ....
  35. doi request reprint Short applications of very low-magnitude vibrations attenuate expansion of the intervertebral disc during extended bed rest
    Nilsson Holguin
    Department of Biomedical Engineering, State University of New York at Stony Brook, Psychology A, 3rd Floor, Stony Brook, NY 11794 2580, USA
    Spine J 9:470-7. 2009
    ..Effective interventions for the negative effects of unloading are critical but not yet available...
  36. doi request reprint Craniofacial biomechanics and functional and dietary inferences in hominin paleontology
    Frederick E Grine
    Department of Anthropology, Stony Brook University, Stony Brook, NY 11794 4364, USA
    J Hum Evol 58:293-308. 2010
    ....
  37. pmc Automated separation of visceral and subcutaneous adiposity in in vivo microcomputed tomographies of mice
    Svetlana Lublinsky
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 2580, USA
    J Digit Imaging 22:222-31. 2009
    ....
  38. ncbi request reprint Integrative metabolic regulation of peripheral tissue fatty acid oxidation by the SRC kinase family member Fyn
    Claire C Bastie
    Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, USA
    Cell Metab 5:371-81. 2007
    ....
  39. pmc Functional significance of genetic variation underlying limb bone diaphyseal structure
    Ian J Wallace
    Interdepartmental Doctoral Program in Anthropological Sciences, Stony Brook University, Stony Brook, NY 11794 4364, USA
    Am J Phys Anthropol 143:21-30. 2010
    ....
  40. ncbi request reprint Baseline bone morphometry and cellular activity modulate the degree of bone loss in the appendicular skeleton during disuse
    Maria Squire
    Department of Biology, Loyola Hall, The University of Scranton, Scranton, PA 18510, USA
    Bone 42:341-9. 2008
    ....
  41. ncbi request reprint Increased non-linear locomotion alters diaphyseal bone shape
    Kristian J Carlson
    Department of Anatomy, New York College of Osteopathic Medicine, Northern Boulevard, Old Westbury, NY 11568 8000, USA
    J Exp Biol 210:3117-25. 2007
    ..These data indicate that increased turning can alter distribution of bone mass in the femoral diaphysis, and that turning should be considered in efforts to understand form-function relationships in vertebrates...
  42. ncbi request reprint Genetic variations that regulate bone morphology in the male mouse skeleton do not define its susceptibility to mechanical unloading
    Maria Squire
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    Bone 35:1353-60. 2004
    ..Cross-gender comparisons with previous data from female BALB and C3H mice further suggest strong interactions by which gender, genotype, and anatomical location define the response of the skeleton to the removal of weight bearing...
  43. ncbi request reprint Accretion of bone quantity and quality in the developing mouse skeleton
    Lisa M Miller
    National Synchrotron Light Source, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    J Bone Miner Res 22:1037-45. 2007
    ....
  44. ncbi request reprint High-frequency, low-magnitude vibrations suppress the number of blood vessels per muscle fiber in mouse soleus muscle
    Walter L Murfee
    Dept of Biomedical Engineering, Box 800759, UVA Health System, Charlottesville, VA 22908, USA
    J Appl Physiol (1985) 98:2376-80. 2005
    ..These results demonstrate the sensitivity of the vasculature in mouse skeletal muscle to whole body, low-level mechanical signals...
  45. ncbi request reprint Gene expression patterns in bone after 4 days of hind-limb unloading in two inbred strains of mice
    Nan Zhong
    Department of Biomedical Engineering, State University of New York, Stony Brook, NY 11794 2580, USA
    Aviat Space Environ Med 76:530-5. 2005
    ....
  46. ncbi request reprint Low-level, high-frequency mechanical signals enhance musculoskeletal development of young women with low BMD
    Vicente Gilsanz
    Department of Radiology, Childrens Hospital of Los Angeles, University of Southern California, Keck School of Medicine, Los Angeles, California 90027, USA
    J Bone Miner Res 21:1464-74. 2006
    ..Twelve months of this noninvasive signal, induced as whole body vibration for at least 2 minutes each day, increased bone and muscle mass in the axial skeleton and lower extremities compared with controls...
  47. pmc Mechanical regulation of PTHrP expression in entheses
    Xuesong Chen
    Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8020, USA
    Bone 41:752-9. 2007
    ..In these surface sites, mechanical force seems to be an important regulator of PTHrP expression. In selected sites and/or at specific times, PTHrP may influence the recruitment and/or activities of underlying bone cell populations...

Research Grants4

  1. Modulation of Bone's Mechanical Behavior by Bone Quality
    Stefan Judex; Fiscal Year: 2007
    ..Identification of these potential chemical targets will provide critical information for improved diagnostic, prophylactic, and therapeutic means of addressing bone quality defects in disease. ..
  2. Modulation of Bone's Mechanical Behavior by Bone Quality
    Stefan Judex; Fiscal Year: 2009
    ..Identification of these potential chemical targets will provide critical information for improved diagnostic, prophylactic, and therapeutic means of addressing bone quality defects in disease. ..
  3. Modulation of Bone's Mechanical Behavior by Bone Quality
    Stefan Judex; Fiscal Year: 2010
    ..Identification of these potential chemical targets will provide critical information for improved diagnostic, prophylactic, and therapeutic means of addressing bone quality defects in disease. ..