Xian Cheng Jiang

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. ncbi request reprint Role of hepatic lipase and scavenger receptor BI in clearing phospholipid/free cholesterol-rich lipoproteins in PLTP-deficient mice
    Koichi Kawano
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Biochim Biophys Acta 1583:133-40. 2002
  2. ncbi request reprint Phospholipid transfer protein deficiency impairs apolipoprotein-B secretion from hepatocytes by stimulating a proteolytic pathway through a relative deficiency of vitamin E and an increase in intracellular oxidants
    Xian Cheng Jiang
    State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
    J Biol Chem 280:18336-40. 2005
  3. pmc Sphingomyelin synthase 2 is one of the determinants for plasma and liver sphingomyelin levels in mice
    Jing Liu
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, 450 Clarkson Ave, Box 5, Brooklyn, NY 11203, USA
    Arterioscler Thromb Vasc Biol 29:850-6. 2009
  4. ncbi request reprint Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice
    Mohammad Reza Hojjati
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, 450 Clarkson Ave, Brooklyn, New York 11203, USA
    J Biol Chem 280:10284-9. 2005
  5. pmc Liver-specific deficiency of serine palmitoyltransferase subunit 2 decreases plasma sphingomyelin and increases apolipoprotein E levels
    Zhiqiang Li
    State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
    J Biol Chem 284:27010-9. 2009
  6. doi request reprint Sphingomyelin synthase 2 deficiency attenuates NFkappaB activation
    Tiruneh K Hailemariam
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    Arterioscler Thromb Vasc Biol 28:1519-26. 2008
  7. ncbi request reprint Increased atherosclerotic lesions in apoE mice with plasma phospholipid transfer protein overexpression
    Xiao Ping Yang
    Department of Anatomy and Cell Biology, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA
    Arterioscler Thromb Vasc Biol 23:1601-7. 2003
  8. ncbi request reprint Phospholipid transfer protein deficiency protects circulating lipoproteins from oxidation due to the enhanced accumulation of vitamin E
    Xian Cheng Jiang
    Downstate Medical Center, State University of New York, New York, New York 11203, USA
    J Biol Chem 277:31850-6. 2002
  9. pmc Myeloid cell-specific serine palmitoyltransferase subunit 2 haploinsufficiency reduces murine atherosclerosis
    Mahua Chakraborty
    Department of Cell Biology, State University of New York Downstate Medical Center, New York, New York, USA
    J Clin Invest 123:1784-97. 2013
  10. ncbi request reprint PLTP deficiency improves the anti-inflammatory properties of HDL and reduces the ability of LDL to induce monocyte chemotactic activity
    Daoguang Yan
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 10032, USA
    J Lipid Res 45:1852-8. 2004

Collaborators

Detail Information

Publications70

  1. ncbi request reprint Role of hepatic lipase and scavenger receptor BI in clearing phospholipid/free cholesterol-rich lipoproteins in PLTP-deficient mice
    Koichi Kawano
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Biochim Biophys Acta 1583:133-40. 2002
    ..SRBI appears to be dysfunctional in coconut oil diet-fed animals, possibly related to changes in hepatocyte membrane fatty acid composition...
  2. ncbi request reprint Phospholipid transfer protein deficiency impairs apolipoprotein-B secretion from hepatocytes by stimulating a proteolytic pathway through a relative deficiency of vitamin E and an increase in intracellular oxidants
    Xian Cheng Jiang
    State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
    J Biol Chem 280:18336-40. 2005
    ..These findings are likely to be broadly relevant to hepatic apoB secretory control in vivo...
  3. pmc Sphingomyelin synthase 2 is one of the determinants for plasma and liver sphingomyelin levels in mice
    Jing Liu
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, 450 Clarkson Ave, Box 5, Brooklyn, NY 11203, USA
    Arterioscler Thromb Vasc Biol 29:850-6. 2009
    ..Sphingomyelin synthase (SMS) is the last enzyme for SM de novo biosynthesis. Two SMS genes, SMS1 and SMS2, have been cloned and characterized...
  4. ncbi request reprint Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice
    Mohammad Reza Hojjati
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, 450 Clarkson Ave, Brooklyn, New York 11203, USA
    J Biol Chem 280:10284-9. 2005
    ..Thus, inhibition of SPT activity could be an alternative treatment for atherosclerosis...
  5. pmc Liver-specific deficiency of serine palmitoyltransferase subunit 2 decreases plasma sphingomyelin and increases apolipoprotein E levels
    Zhiqiang Li
    State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
    J Biol Chem 284:27010-9. 2009
    ..As a result of these findings, we believe that the ability to control liver SPT activity could result in regulation of lipoprotein metabolism and might have an impact on the development of atherosclerosis...
  6. doi request reprint Sphingomyelin synthase 2 deficiency attenuates NFkappaB activation
    Tiruneh K Hailemariam
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    Arterioscler Thromb Vasc Biol 28:1519-26. 2008
    ..SMS2 regulates SM levels in cell plasma membrane and lipid rafts and has a potential to regulate NFkappaB activation...
  7. ncbi request reprint Increased atherosclerotic lesions in apoE mice with plasma phospholipid transfer protein overexpression
    Xiao Ping Yang
    Department of Anatomy and Cell Biology, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA
    Arterioscler Thromb Vasc Biol 23:1601-7. 2003
    ..To investigate additionally the effect of PLTP on the development of atherosclerosis, we overexpressed PLTP in mice...
  8. ncbi request reprint Phospholipid transfer protein deficiency protects circulating lipoproteins from oxidation due to the enhanced accumulation of vitamin E
    Xian Cheng Jiang
    Downstate Medical Center, State University of New York, New York, New York 11203, USA
    J Biol Chem 277:31850-6. 2002
    ....
  9. pmc Myeloid cell-specific serine palmitoyltransferase subunit 2 haploinsufficiency reduces murine atherosclerosis
    Mahua Chakraborty
    Department of Cell Biology, State University of New York Downstate Medical Center, New York, New York, USA
    J Clin Invest 123:1784-97. 2013
    ..Additionally, Ldlr(-/-) mice with myeloid cell-specific Sptlc2 haploinsufficiency exhibited significantly less atherosclerosis than controls. These findings suggest that SPT could be a novel therapeutic target in atherosclerosis...
  10. ncbi request reprint PLTP deficiency improves the anti-inflammatory properties of HDL and reduces the ability of LDL to induce monocyte chemotactic activity
    Daoguang Yan
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 10032, USA
    J Lipid Res 45:1852-8. 2004
    ..We conclude that PLTP deficiency improves the anti-inflammatory properties of HDL in mice and reduces the ability of LDL to induce monocyte chemotactic activity...
  11. doi request reprint Magnesium deficiency upregulates serine palmitoyl transferase (SPT 1 and SPT 2) in cardiovascular tissues: relationship to serum ionized Mg and cytochrome c
    Burton M Altura
    Department of Physiology and Pharmacology, SUNY Downstate Medical Ctr, 450 Clarkson Ave, Brooklyn, NY, 11203 2098, USA
    Am J Physiol Heart Circ Physiol 299:H932-8. 2010
    ..Low levels of drinking water Mg were cardio- and vasculoprotective...
  12. pmc Sphingomyelin synthase 2 activity and liver steatosis: an effect of ceramide-mediated peroxisome proliferator-activated receptor γ2 suppression
    Yue Li
    Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Arterioscler Thromb Vasc Biol 33:1513-20. 2013
    ..Sphingomyelin synthase (SMS), using ceramide as one of the substrates to produce sphingomyelin, sits at the crossroads of sphingolipid biosynthesis. SMS has 2 isoforms: SMS1 and SMS2. SMS2 is the major isoform in liver...
  13. pmc Lysophosphatidylcholine acyltransferase 3 knockdown-mediated liver lysophosphatidylcholine accumulation promotes very low density lipoprotein production by enhancing microsomal triglyceride transfer protein expression
    Zhiqiang Li
    Molecular and Cellular Cardiology Program, Veterans Affairs New York Harbor Healthcare System, Brooklyn, New York 11209, USA
    J Biol Chem 287:20122-31. 2012
    ..Moreover, LysoPC increased MTP mRNA, protein, and activity. In short, these results indicate that hepatic LPCAT3 modulates VLDL production by regulating LysoPC levels and MTP expression...
  14. pmc Impact of sphingomyelin synthase 1 deficiency on sphingolipid metabolism and atherosclerosis in mice
    Zhiqiang Li
    Molecular and Cellular Cardiology Program, VA New York Harbor Healthcare System, Brooklyn, NY, USA
    Arterioscler Thromb Vasc Biol 32:1577-84. 2012
    ..It is conceivable that these differences could yield different consequences, in terms of sphingolipid metabolism and its related atherogenesis...
  15. pmc Reducing plasma membrane sphingomyelin increases insulin sensitivity
    Zhiqiang Li
    Department of Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave Box 5, Brooklyn, NY 11203, USA
    Mol Cell Biol 31:4205-18. 2011
    ..We have concluded that Sptlc2 heterozygous deficiency- or Sms2 deficiency-mediated reduction of SM in the plasma membranes leads to an improvement in tissue and whole-body insulin sensitivity...
  16. ncbi request reprint The effect of dietary sphingolipids on plasma sphingomyelin metabolism and atherosclerosis
    Zhiqiang Li
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Avenue Box 5, Brooklyn, NY 11203, USA
    Biochim Biophys Acta 1735:130-4. 2005
    ..9670+/-2370 microm(2), P<0.001; 5.9+/-3.1% vs. 1.1+/-0.9%, P<0.001). These results indicate that the enrichment of sphingolipids in diet has proatherogenic properties...
  17. ncbi request reprint Macrophage phospholipid transfer protein deficiency and ApoE secretion: impact on mouse plasma cholesterol levels and atherosclerosis
    Ruijie Liu
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Arterioscler Thromb Vasc Biol 27:190-6. 2007
    ..We investigated the relationship between PLTP and apoE in macrophages and the atherogenic relevance in a mouse model...
  18. ncbi request reprint Phospholipid transfer protein-deficient mice absorb less cholesterol
    Ruijie Liu
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave, Box 5, Brooklyn, NY 11203, USA
    Arterioscler Thromb Vasc Biol 27:2014-21. 2007
    ..Because small intestine is one of the major tissue expressing PLTP, we hypothesize that PLTP deficient small intestine absorbs less cholesterol, thus contributing to the diminishing of cholesterol levels in the plasma...
  19. doi request reprint Liver-specific phospholipid transfer protein deficiency reduces high-density lipoprotein and non-high-density lipoprotein production in mice
    Amirfarbod Yazdanyar
    Department of Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    Arterioscler Thromb Vasc Biol 33:2058-64. 2013
    ..The effect of liver-specific PLTP deficiency on plasma lipoprotein production and metabolism in mice was investigated...
  20. ncbi request reprint SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis
    Tinbo Ding
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    J Lipid Res 49:376-85. 2008
    ..These results indicate that SMS1 and SMS2 are key factors in the control of SM and DAG levels within the cell and thus influence apoptosis...
  21. pmc Short-term magnesium deficiency upregulates sphingomyelin synthase and p53 in cardiovascular tissues and cells: relevance to the de novo synthesis of ceramide
    Burton M Altura
    Department of Physiology and Pharmacology, State University of New York, Brooklyn, New York, USA
    Am J Physiol Heart Circ Physiol 299:H2046-55. 2010
    ..In addition, the data indicated that inhibition of either SMS, p53, SPT, or CS in VSMCs exposed to low [Mg(2+)](o) resulted in marked reductions in the de novo synthesis of ceramide...
  22. pmc Diet-induced lipid accumulation in phospholipid transfer protein-deficient mice: its atherogenicity and potential mechanism
    Calvin Yeang
    Department of Cell Biology, State University of New York SUNY Downstate Medical Center, Brooklyn, NY, USA
    J Lipid Res 51:2993-3002. 2010
    ..In conclusion, COD-fed, Pltp-deficient mice are no longer protected from atherosclerosis and have impaired biliary lipid secretion, which is associated with free cholesterol and phospholipid accumulation...
  23. doi request reprint Sphingomyelin and its role in cellular signaling
    Mahua Chakraborty
    Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Adv Exp Med Biol 991:1-14. 2013
    ..So, sphingomyelin has important impact in cell -signaling through its structural role in lipid rafts or its catabolic inter-mediators, such as ceramide and glycoceramide. In this chapter, we will discuss both aspects...
  24. ncbi request reprint Anti-inflammatory effects of phospholipid transfer protein (PLTP) deficiency in mice
    Axel Schlitt
    Department of Anatomy and Cell Biology, State University of New York, Downstate Medical Center, Brooklyn, 11203, USA
    Biochim Biophys Acta 1733:187-91. 2005
    ..The results of our experiments demonstrated an anti-inflammatory effect of PLTP deficiency as a further aspect of its proatherogenic potency...
  25. pmc Increased intestinal lipid absorption caused by Ire1β deficiency contributes to hyperlipidemia and atherosclerosis in apolipoprotein E-deficient mice
    Jahangir Iqbal
    Department of Cell Biology, Box 5, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Circ Res 110:1575-84. 2012
    ..High fasting serum lipid levels are significant risk factors for atherosclerosis. However, the contributions of postprandial excursions in serum lipoproteins to atherogenesis are less well-characterized...
  26. pmc Liver phospholipid transfer protein (PLTP) expression with a PLTP-null background promotes very low-density lipoprotein production in mice
    Amirfarbod Yazdanyar
    Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Hepatology 56:576-84. 2012
    ....
  27. ncbi request reprint Serum sphingomyelin levels are related to the clearance of postprandial remnant-like particles
    Axel Schlitt
    Department of Anatomy and Cell Biology and Scientific Computing Center, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
    J Lipid Res 46:196-200. 2005
    ..Serum SM was positively correlated with serum TG (P <0.001), RLP SM (P <0.001), RLP TG (P <0.001), and RLP cholesterol (P <0.001) levels. It is our conclusion that serum SM is a marker for the clearance of RLPs...
  28. ncbi request reprint Serine palmitoyl-CoA transferase (SPT) deficiency and sphingolipid levels in mice
    Mohammad Reza Hojjati
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave Box 5, Brooklyn, NY 11203, USA
    Biochim Biophys Acta 1737:44-51. 2005
    ..Furthermore, manipulation of SPT activity might well influence the course of such diseases as atherosclerosis...
  29. pmc Role of phospholipid transfer protein in high-density lipoprotein- mediated reverse cholesterol transport
    Amirfarbod Yazdanyar
    Department of Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave Box 5, Brooklyn, NY 11203, USA
    Curr Atheroscler Rep 13:242-8. 2011
    ..In this review, we focus on the potential role of PLTP in RCT through its impact on HDL homeostasis. The relationship between PLTP and RCT is expected to be an important area in finding novel therapies for atherosclerosis...
  30. ncbi request reprint The effect of phospholipid transfer protein on lipoprotein metabolism and atherosclerosis
    Xian Cheng Jiang
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Front Biosci 7:d1634-41. 2002
    ..Human studies indicated that PLTP activity positively correlated with aging, obesity, diabetes and coronary artery disease. A challenge for the future will be the inhibition of PLTP for therapeutic benefit...
  31. pmc Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization
    Zhiqiang Li
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, 450 Clarkson Ave Box 5, Brooklyn, NY 11203, USA
    Biochim Biophys Acta 1771:1186-94. 2007
    ....
  32. doi request reprint Sphingolipids and cardiovascular diseases: lipoprotein metabolism, atherosclerosis and cardiomyopathy
    Xian Cheng Jiang
    Department of Cell Biology, Downstate Medical Center, State University of New York, Brooklyn, New York, USA
    Adv Exp Med Biol 721:19-39. 2011
    ..In this chapter, we will focus on the relationship between de novo synthesis of sphingolipids and lipid metabolism, atherosclerosis, and cardiomyopathy...
  33. doi request reprint Serine palmitoyltransferase (SPT) deficient mice absorb less cholesterol
    Zhiqiang Li
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, USA
    Biochim Biophys Acta 1791:297-306. 2009
    ..This may be also true for ABCA1 which locates on basal membrane of enterocytes. Manipulation of SPT activity could thus provide a novel alternative treatment for dyslipidemia...
  34. ncbi request reprint The F11 receptor (F11R/JAM-A) in atherothrombosis: overexpression of F11R in atherosclerotic plaques
    Anna Babinska
    Department of Anatomy Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Thromb Haemost 97:272-81. 2007
    ....
  35. ncbi request reprint A simple, rapid, and sensitive fluorescence assay for microsomal triglyceride transfer protein
    Humra Athar
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    J Lipid Res 45:764-72. 2004
    ..Furthermore, the assay was useful in studying the inhibition of the cellular as well as purified MTP by its antagonists. This new method is amenable to automation and can be easily adopted for large-scale, high-throughput screening...
  36. doi request reprint Generation of adipose tissue-specific transgenic mouse models
    Xian Cheng Jiang
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY, USA
    Methods Mol Biol 456:55-64. 2008
    ..Here, we report the preparation of adipose tissue-specific cholesteryl ester transfer protein transgenic mice. The general principle might apply to the establishment of other adipose tissue-specific transgenic mice models...
  37. ncbi request reprint Enlargement of high density lipoprotein in mice via liver X receptor activation requires apolipoprotein E and is abolished by cholesteryl ester transfer protein expression
    Xian Cheng Jiang
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 278:49072-8. 2003
    ..Our studies provide direct evidence that apoE and CETP are intimately involved in the accumulation of the enlarged HDL (HDL1 or HDLc) particles in mice...
  38. pmc Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in mice
    Jing Liu
    Department of Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    Circ Res 105:295-303. 2009
    ..SMS2 deficiency in macrophages diminishes nuclear factor kappaB and mitogen-activated protein kinase activation induced by inflammatory stimuli...
  39. ncbi request reprint Rapid, specific, and sensitive measurements of plasma sphingomyelin and phosphatidylcholine
    Mohammad Reza Hojjati
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    J Lipid Res 47:673-6. 2006
    ..6 +/- 3.8% for PC. The interassay coefficient of variation of the assay was 1.7 +/- 0.05% for SM and 3.1 +/- 0.13% for PC. These two new methods are amenable to automation and can be adapted for large-scale, high-throughput assays...
  40. doi request reprint Short-term magnesium deficiency results in decreased levels of serum sphingomyelin, lipid peroxidation, and apoptosis in cardiovascular tissues
    Burton M Altura
    Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, NY 11203 2098, USA
    Am J Physiol Heart Circ Physiol 297:H86-92. 2009
    ..e., 15 parts.million(-1).day(-1)) were cardio- and vascular protective. In addition, we demonstrate that short-term dietary deficiency of Mg probably results in a downregulation of SM synthase and a decreased synthesis of PC...
  41. ncbi request reprint Adipose tissue-specific CETP expression in mice: impact on plasma lipoprotein metabolism
    Hongwen Zhou
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    J Lipid Res 47:2011-9. 2006
    ..Moreover, adipose tissue CETP expression changes triglyceride and cholesterol content and the size of adipocytes...
  42. doi request reprint Sphingolipid metabolism and atherosclerosis
    Xian Cheng Jiang
    Department of Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave Box 5, Brooklyn, NY, 11203, USA
    Handb Exp Pharmacol 216:133-46. 2013
    ..Recent researches indicated that these lipids play important roles in the development of atherosclerosis. In this chapter, we summarized the major findings in the field...
  43. pmc HEXIM1 controls satellite cell expansion after injury to regulate skeletal muscle regeneration
    Peng Hong
    Department of Cell Biology, State University of New York Downstate Medical Center, New York, New York, USA
    J Clin Invest 122:3873-87. 2012
    ..These findings suggest a crucial role for the HEXIM1/P-TEFb pathway in the regulation of satellite cell–mediated muscle regeneration and identify HEXIM1 as a potential therapeutic target for degenerative muscular diseases...
  44. pmc Mechanisms involved in cellular ceramide homeostasis
    M Mahmood Hussain
    Department of Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Nutr Metab (Lond) 9:71. 2012
    ..All these pathways might have evolved to ensure steady cellular ceramide levels...
  45. pmc The impact of phospholipid transfer protein (PLTP) on lipoprotein metabolism
    Xian Cheng Jiang
    Department of Cell Biology, Downstate Medical Center, State University of New York, 450 Clarkson Ave, Box 5, Brooklyn, NY, 11203, USA
    Nutr Metab (Lond) 9:75. 2012
    ..In this review, we summarized the recent progresses made in the PLTP research field and focused on its effect on apoB-containing- triglyceride-rich particle and HDL metabolism...
  46. pmc Subcellular targeting domains of sphingomyelin synthase 1 and 2
    Calvin Yeang
    Department of Cell Biology, State University of New York Downstate Medical Center, 450 Clarkson Ave, Brooklyn, New York, 11203 USA
    Nutr Metab (Lond) 8:89. 2011
    ..We created truncations and chimeras of SMS1 and SMS2 to define their targeting signals. We found that SMS1 contains a C-terminal Golgi targeting signal and that SMS2 contains a C-terminal plasma membrane targeting signal...
  47. ncbi request reprint Plasma lipid transfer proteins
    Xian Cheng Jiang
    Department of Anatomy and Cell Biology, State University of New York, Downstate Medical Center, Brooklyn, New York, USA
    Curr Opin Lipidol 17:302-8. 2006
    ..Plasma cholesteryl ester transfer protein and phospholipid transfer protein are involved in lipoprotein metabolism. Conceivably, manipulation of either transfer protein could impact atherosclerosis and other lipid-driven diseases...
  48. ncbi request reprint Relation of baseline plasma phospholipid levels to cardiovascular outcomes at two years in men with acute coronary syndrome referred for coronary angiography
    Erdal Cavusoglu
    Department of Medicine, SUNY Downstate Medical Center, Brooklyn, New York, USA
    Am J Cardiol 100:1739-43. 2007
    ..In conclusion, these data demonstrate that low baseline levels of total choline-containing phospholipid are a strong and independent predictor of cardiovascular outcomes (including mortality) in patients with acute coronary syndromes...
  49. ncbi request reprint A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes
    Yu Liang
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurochem 88:623-34. 2004
    ..LXR/RXR agonists may have significant impact on the pathogenesis of multiple neurological diseases, including AD...
  50. ncbi request reprint Cholesteryl ester transfer protein modulates the effect of liver X receptor agonists on cholesterol transport and excretion in the mouse
    David Masson
    Institut National de la Santé et de la Recherche Médicale U498, Faculte de Medecine, BP87900, 21079 Dijon Cedex, France
    J Lipid Res 45:543-50. 2004
    ..In conclusion, induction of CETP constitutes a major determinant of the effect of LXR agonists on cholesterol transport and excretion...
  51. ncbi request reprint High plasma phospholipid transfer protein levels as a risk factor for coronary artery disease
    Axel Schlitt
    Department of Medicine II, Johannes Gutenberg University, Mainz, Germany
    Arterioscler Thromb Vasc Biol 23:1857-62. 2003
    ..PLTP-deficient mice have demonstrated increased antioxidation potential as well as a decrease in apolipoprotein B secretion and atherosclerotic lesions. In humans, high PLTP is associated with type II diabetes and obesity...
  52. ncbi request reprint Phospholipid transfer protein is regulated by liver X receptors in vivo
    Guoqing Cao
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 277:39561-5. 2002
    ..We conclude that PLTP is a direct target gene of LXRs in vivo and plays an important role in LXR agonist-mediated HDL cholesterol and size increase in mice...
  53. ncbi request reprint Apolipoprotein CI deficiency markedly augments plasma lipoprotein changes mediated by human cholesteryl ester transfer protein (CETP) in CETP transgenic/ApoCI-knocked out mice
    Thomas Gautier
    Laboratoire de Biochimie des Lipoproteines, INSERM U498, Faculte de Medecine, BP87900, 21079 Dijon Cedex, France
    J Biol Chem 277:31354-63. 2002
    ..Overall, the present observations provide direct support for a potent specific inhibition of CETP by plasma apoCI in vivo...
  54. ncbi request reprint Coadministration of a liver X receptor agonist and a peroxisome proliferator activator receptor-alpha agonist in Mice: effects of nuclear receptor interplay on high-density lipoprotein and triglyceride metabolism in vivo
    Thomas P Beyer
    Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
    J Pharmacol Exp Ther 309:861-8. 2004
    ..Liver lipoprotein lipase expression was additively increased upon LXR agonist and PPARalpha agonist coadministration. Our studies mark the first exploration of nuclear receptor interplay on lipid homeostasis in vivo...
  55. ncbi request reprint Liver X receptors (LXRs) regulate apolipoprotein AIV-implications of the antiatherosclerotic effect of LXR agonists
    Yu Liang
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Mol Endocrinol 18:2000-10. 2004
    ..In addition, we identified a functional LXR-responsive element at 3' end enhancer region of mouse ApoAIV gene. We conclude that ApoAIV is a direct target gene of LXRs that may contribute to the antiatherogenic effect of LXR activation...
  56. pmc Cholesteryl ester transfer protein (CETP) expression enhances HDL cholesteryl ester liver delivery, which is independent of scavenger receptor BI, LDL receptor related protein and possibly LDL receptor
    Hongwen Zhou
    Department of Endocrinology, 1st Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    Biochim Biophys Acta 1761:1482-8. 2006
    ..01, respectively). These results suggest that CETP expression in mouse increases direct removal of HDL CE in the liver and this process is independent of SR-BI, LRP, and possibly LDLR...
  57. ncbi request reprint Alpha-tocopherol modulates phosphatidylserine externalization in erythrocytes: relevance in phospholipid transfer protein-deficient mice
    Alexis Klein
    INSERM U498, IFR100, Universite de Bourgogne, Dijon, France
    Arterioscler Thromb Vasc Biol 26:2160-7. 2006
    ..The aim of the present study was to assess the effect of alpha-tocopherol, the main vitamin E isomer on phosphatidylserine (PS) exposure at the surface of circulating erythrocytes, and to determine consequences on erythrocyte properties...
  58. pmc HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway
    Fumihiko Matsuura
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York, USA
    J Clin Invest 116:1435-42. 2006
    ..Thus, CETP-D HDL has enhanced ability to promote cholesterol efflux from foam cells in an ABCG1-dependent pathway due to an increased content of LCAT and apoE...
  59. ncbi request reprint Phospholipid transfer protein (PLTP) deficiency reduces brain vitamin E content and increases anxiety in mice
    Catherine Desrumaux
    Laboratoire de Biochimie des Lipoproteines, INSERM, Dijon, France
    FASEB J 19:296-7. 2005
    ....
  60. pmc Apolipoprotein CI overexpression is not a relevant strategy to block cholesteryl ester transfer protein (CETP) activity in CETP transgenic mice
    Thomas Gautier
    Laboratoire de Biochimie des Lipoproteines, INSERM U498, Faculte de Medecine, BP87900, 21079 Dijon Cedex, France
    Biochem J 385:189-95. 2005
    ....
  61. doi request reprint Effect of plasma phospholipid transfer protein deficiency on lethal endotoxemia in mice
    Thomas Gautier
    INSERM, Centre de Recherche UMR866, Faculte de Medecine, Institut Fédératif de Recherche Santé STIC, Universitéde Bourgogne, 21079 Dijon, France
    J Biol Chem 283:18702-10. 2008
    ..Finally, PLTP deficiency in mice led to a significant increase in LPS-induced mortality. It is concluded that increasing circulating levels of PLTP may constitute a new and promising strategy in preventing endotoxic shock...
  62. ncbi request reprint Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis
    Guoqing Cao
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 278:1131-6. 2003
    ..These data not only suggest that LXRs are novel targets for diabetes but also reveal an unanticipated role for these receptors, further linking lipid and glucose metabolism...
  63. ncbi request reprint A single intravenous dose of endotoxin rapidly alters serum lipoproteins and lipid transfer proteins in normal volunteers
    Lisa C Hudgins
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Lipid Res 44:1489-98. 2003
    ..The selective loss of phospholipid from HDL may have been mediated by LBP and, after more intense or prolonged inflammation, could result in increased HDL clearance and reduced HDL levels...
  64. ncbi request reprint Phospholipid transfer protein in hemodialysis patients
    Axel Schlitt
    Department of Medicine III, Martin Luther University, Halle Wittenberg, Germany
    Am J Nephrol 27:138-43. 2007
    ..The role of PLTP in atherogenesis is still controversial. We aimed to investigate PLTP activity in hemodialysis (HD) patients, a population which has an increased risk for the development of atherosclerosis...
  65. ncbi request reprint Common genetic variation of the cholesteryl ester transfer protein gene strongly predicts future cardiovascular death in patients with coronary artery disease
    Stefan Blankenberg
    Department of Medicine II, Johannes Gutenberg University Mainz, Mainz, Germany
    J Am Coll Cardiol 41:1983-9. 2003
    ..We sought to evaluate the association between cholesteryl ester transfer protein (CETP) genotypes and the risk of future cardiovascular mortality in patients with coronary artery disease (CAD)...
  66. pmc Ceramide is a cardiotoxin in lipotoxic cardiomyopathy
    Tae Sik Park
    Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    J Lipid Res 49:2101-12. 2008
    ..Our results suggest a critical role for ceramide accumulation in the pathogenesis of lipotoxic cardiomyopathy...
  67. ncbi request reprint Liver X receptors as potential therapeutic targets for multiple diseases
    Guoqing Cao
    Division of Cardiovascular Discovery, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Drug News Perspect 17:35-41. 2004
    ..This review intends to summarize the most recent progress in the field and provide an assessment of LXRs as potential therapeutic targets...
  68. ncbi request reprint Adenovirus-mediated overexpression of sphingomyelin synthases 1 and 2 increases the atherogenic potential in mice
    Jibin Dong
    School of Pharmacy, Fudan University, Shanghai, People s Republic of China
    J Lipid Res 47:1307-14. 2006
    ..Such an effect may contribute to the increased plasma SM levels observed in animal models of atherosclerosis and in human patients with coronary artery disease...
  69. ncbi request reprint Prognostic value of lipoproteins and their relation to inflammatory markers among patients with coronary artery disease
    Axel Schlitt
    Department of Medicine II, Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, 55101 Mainz, Germany
    Int J Cardiol 102:477-85. 2005
    ..There is growing evidence indicating that those lipoprotein factors are related to the inflammatory process in atherogenesis...
  70. ncbi request reprint Inhibition of cholesteryl ester transfer protein by torcetrapib modestly increases macrophage cholesterol efflux to HDL
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, 630 West 168 St, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 27:1132-8. 2007
    ..This study examines the effects of pharmacological inhibition of cholesteryl ester transfer protein (CETP) on the ability of high-density lipoprotein particles (HDL) to promote net cholesterol efflux from human THP-1 macrophage foam cells...