Research Topics
Genomes and Genes | Xian Cheng JiangSummaryAffiliation: State University of New York Country: USA Publications
| Collaborators
|
Detail Information
Publications
Phospholipid transfer protein deficiency impairs apolipoprotein-B secretion from hepatocytes by stimulating a proteolytic pathway through a relative deficiency of vitamin E and an increase in intracellular oxidantsXian Cheng Jiang
State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
J Biol Chem 280:18336-40. 2005..These findings are likely to be broadly relevant to hepatic apoB secretory control in vivo...
Sphingomyelin synthase 2 is one of the determinants for plasma and liver sphingomyelin levels in miceJing Liu
Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, 450 Clarkson Ave, Box 5, Brooklyn, NY 11203, USA
Arterioscler Thromb Vasc Biol 29:850-6. 2009..Sphingomyelin synthase (SMS) is the last enzyme for SM de novo biosynthesis. Two SMS genes, SMS1 and SMS2, have been cloned and characterized...- Liver-specific deficiency of serine palmitoyltransferase subunit 2 decreases plasma sphingomyelin and increases apolipoprotein E levelsZhiqiang Li
State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
J Biol Chem 284:27010-9. 2009..As a result of these findings, we believe that the ability to control liver SPT activity could result in regulation of lipoprotein metabolism and might have an impact on the development of atherosclerosis... 
Sphingomyelin synthase 2 deficiency attenuates NFkappaB activationTiruneh K Hailemariam
Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
Arterioscler Thromb Vasc Biol 28:1519-26. 2008..SMS2 regulates SM levels in cell plasma membrane and lipid rafts and has a potential to regulate NFkappaB activation...- Phospholipid transfer protein deficiency protects circulating lipoproteins from oxidation due to the enhanced accumulation of vitamin EXian Cheng Jiang
Downstate Medical Center, State University of New York, New York, New York 11203, USA
J Biol Chem 277:31850-6. 2002.... - Increased atherosclerotic lesions in apoE mice with plasma phospholipid transfer protein overexpressionXiao Ping Yang
Department of Anatomy and Cell Biology, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA
Arterioscler Thromb Vasc Biol 23:1601-7. 2003..To investigate additionally the effect of PLTP on the development of atherosclerosis, we overexpressed PLTP in mice... - Macrophage phospholipid transfer protein deficiency and ApoE secretion: impact on mouse plasma cholesterol levels and atherosclerosisRuijie Liu
Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
Arterioscler Thromb Vasc Biol 27:190-6. 2007..We investigated the relationship between PLTP and apoE in macrophages and the atherogenic relevance in a mouse model... - PLTP deficiency improves the anti-inflammatory properties of HDL and reduces the ability of LDL to induce monocyte chemotactic activityDaoguang Yan
Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 10032, USA
J Lipid Res 45:1852-8. 2004..We conclude that PLTP deficiency improves the anti-inflammatory properties of HDL in mice and reduces the ability of LDL to induce monocyte chemotactic activity... - Magnesium deficiency upregulates serine palmitoyl transferase (SPT 1 and SPT 2) in cardiovascular tissues: relationship to serum ionized Mg and cytochrome cBurton M Altura
Department of Physiology and Pharmacology, SUNY Downstate Medical Ctr, 450 Clarkson Ave, Brooklyn, NY, 11203 2098, USA
Am J Physiol Heart Circ Physiol 299:H932-8. 2010..Low levels of drinking water Mg were cardio- and vasculoprotective... - Role of hepatic lipase and scavenger receptor BI in clearing phospholipid/free cholesterol-rich lipoproteins in PLTP-deficient miceKoichi Kawano
Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
Biochim Biophys Acta 1583:133-40. 2002..SRBI appears to be dysfunctional in coconut oil diet-fed animals, possibly related to changes in hepatocyte membrane fatty acid composition... - Lysophosphatidylcholine acyltransferase 3 knockdown-mediated liver lysophosphatidylcholine accumulation promotes very low density lipoprotein production by enhancing microsomal triglyceride transfer protein expressionZhiqiang Li
Molecular and Cellular Cardiology Program, Veterans Affairs New York Harbor Healthcare System, Brooklyn, New York 11209, USA
J Biol Chem 287:20122-31. 2012..Moreover, LysoPC increased MTP mRNA, protein, and activity. In short, these results indicate that hepatic LPCAT3 modulates VLDL production by regulating LysoPC levels and MTP expression... - Impact of sphingomyelin synthase 1 deficiency on sphingolipid metabolism and atherosclerosis in miceZhiqiang Li
Molecular and Cellular Cardiology Program, VA New York Harbor Healthcare System, Brooklyn, NY, USA
Arterioscler Thromb Vasc Biol 32:1577-84. 2012..It is conceivable that these differences could yield different consequences, in terms of sphingolipid metabolism and its related atherogenesis... - Reducing plasma membrane sphingomyelin increases insulin sensitivityZhiqiang Li
Department of Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave Box 5, Brooklyn, NY 11203, USA
Mol Cell Biol 31:4205-18. 2011..We have concluded that Sptlc2 heterozygous deficiency- or Sms2 deficiency-mediated reduction of SM in the plasma membranes leads to an improvement in tissue and whole-body insulin sensitivity... - The effect of dietary sphingolipids on plasma sphingomyelin metabolism and atherosclerosisZhiqiang Li
Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Avenue Box 5, Brooklyn, NY 11203, USA
Biochim Biophys Acta 1735:130-4. 2005..9670+/-2370 microm(2), P<0.001; 5.9+/-3.1% vs. 1.1+/-0.9%, P<0.001). These results indicate that the enrichment of sphingolipids in diet has proatherogenic properties... - Phospholipid transfer protein-deficient mice absorb less cholesterolRuijie Liu
Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave, Box 5, Brooklyn, NY 11203, USA
Arterioscler Thromb Vasc Biol 27:2014-21. 2007..Because small intestine is one of the major tissue expressing PLTP, we hypothesize that PLTP deficient small intestine absorbs less cholesterol, thus contributing to the diminishing of cholesterol levels in the plasma... - SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosisTinbo Ding
Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
J Lipid Res 49:376-85. 2008..These results indicate that SMS1 and SMS2 are key factors in the control of SM and DAG levels within the cell and thus influence apoptosis... - Diet-induced lipid accumulation in phospholipid transfer protein-deficient mice: its atherogenicity and potential mechanismCalvin Yeang
Department of Cell Biology, State University of New York SUNY Downstate Medical Center, Brooklyn, NY, USA
J Lipid Res 51:2993-3002. 2010..In conclusion, COD-fed, Pltp-deficient mice are no longer protected from atherosclerosis and have impaired biliary lipid secretion, which is associated with free cholesterol and phospholipid accumulation... - Short-term magnesium deficiency upregulates sphingomyelin synthase and p53 in cardiovascular tissues and cells: relevance to the de novo synthesis of ceramideBurton M Altura
Department of Physiology and Pharmacology, State University of New York, Brooklyn, New York, USA
Am J Physiol Heart Circ Physiol 299:H2046-55. 2010..In addition, the data indicated that inhibition of either SMS, p53, SPT, or CS in VSMCs exposed to low [Mg(2+)](o) resulted in marked reductions in the de novo synthesis of ceramide... - Anti-inflammatory effects of phospholipid transfer protein (PLTP) deficiency in miceAxel Schlitt
Department of Anatomy and Cell Biology, State University of New York, Downstate Medical Center, Brooklyn, 11203, USA
Biochim Biophys Acta 1733:187-91. 2005..The results of our experiments demonstrated an anti-inflammatory effect of PLTP deficiency as a further aspect of its proatherogenic potency... - Liver phospholipid transfer protein (PLTP) expression with a PLTP-null background promotes very low-density lipoprotein production in miceAmirfarbod Yazdanyar
Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
Hepatology 56:576-84. 2012..Our results suggest, for the first time, that the major function of liver PLTP is to drive VLDL production and makes a small contribution to plasma PLTP activity... - Increased intestinal lipid absorption caused by Ire1β deficiency contributes to hyperlipidemia and atherosclerosis in apolipoprotein E-deficient miceJahangir Iqbal
Department of Cell Biology, Box 5, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
Circ Res 110:1575-84. 2012..High fasting serum lipid levels are significant risk factors for atherosclerosis. However, the contributions of postprandial excursions in serum lipoproteins to atherogenesis are less well-characterized... - Serum sphingomyelin levels are related to the clearance of postprandial remnant-like particlesAxel Schlitt
Department of Anatomy and Cell Biology and Scientific Computing Center, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
J Lipid Res 46:196-200. 2005..Serum SM was positively correlated with serum TG (P <0.001), RLP SM (P <0.001), RLP TG (P <0.001), and RLP cholesterol (P <0.001) levels. It is our conclusion that serum SM is a marker for the clearance of RLPs... - Serine palmitoyl-CoA transferase (SPT) deficiency and sphingolipid levels in miceMohammad Reza Hojjati
Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave Box 5, Brooklyn, NY 11203, USA
Biochim Biophys Acta 1737:44-51. 2005..Furthermore, manipulation of SPT activity might well influence the course of such diseases as atherosclerosis... - Role of phospholipid transfer protein in high-density lipoprotein- mediated reverse cholesterol transportAmirfarbod Yazdanyar
Department of Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave Box 5, Brooklyn, NY 11203, USA
Curr Atheroscler Rep 13:242-8. 2011..In this review, we focus on the potential role of PLTP in RCT through its impact on HDL homeostasis. The relationship between PLTP and RCT is expected to be an important area in finding novel therapies for atherosclerosis... - The effect of phospholipid transfer protein on lipoprotein metabolism and atherosclerosisXian Cheng Jiang
Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
Front Biosci 7:d1634-41. 2002..Human studies indicated that PLTP activity positively correlated with aging, obesity, diabetes and coronary artery disease. A challenge for the future will be the inhibition of PLTP for therapeutic benefit... - The F11 receptor (F11R/JAM-A) in atherothrombosis: overexpression of F11R in atherosclerotic plaquesAnna Babinska
Department of Anatomy Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
Thromb Haemost 97:272-81. 2007.... - Sphingolipids and cardiovascular diseases: lipoprotein metabolism, atherosclerosis and cardiomyopathyXian Cheng Jiang
Department of Cell Biology, Downstate Medical Center, State University of New York, Brooklyn, New York, USA
Adv Exp Med Biol 721:19-39. 2011..In this chapter, we will focus on the relationship between de novo synthesis of sphingolipids and lipid metabolism, atherosclerosis, and cardiomyopathy... - Serine palmitoyltransferase (SPT) deficient mice absorb less cholesterolZhiqiang Li
Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, USA
Biochim Biophys Acta 1791:297-306. 2009..This may be also true for ABCA1 which locates on basal membrane of enterocytes. Manipulation of SPT activity could thus provide a novel alternative treatment for dyslipidemia... - Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organizationZhiqiang Li
Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, 450 Clarkson Ave Box 5, Brooklyn, NY 11203, USA
Biochim Biophys Acta 1771:1186-94. 2007.... - Enlargement of high density lipoprotein in mice via liver X receptor activation requires apolipoprotein E and is abolished by cholesteryl ester transfer protein expressionXian Cheng Jiang
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Biol Chem 278:49072-8. 2003..Our studies provide direct evidence that apoE and CETP are intimately involved in the accumulation of the enlarged HDL (HDL1 or HDLc) particles in mice... - Generation of adipose tissue-specific transgenic mouse modelsXian Cheng Jiang
Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY, USA
Methods Mol Biol 456:55-64. 2008..Here, we report the preparation of adipose tissue-specific cholesteryl ester transfer protein transgenic mice. The general principle might apply to the establishment of other adipose tissue-specific transgenic mice models... - HEXIM1 controls satellite cell expansion after injury to regulate skeletal muscle regenerationPeng Hong
Department of Cell Biology, State University of New York Downstate Medical Center, New York, New York, USA
J Clin Invest 122:3873-87. 2012..These findings suggest a crucial role for the HEXIM1/P-TEFb pathway in the regulation of satellite cell–mediated muscle regeneration and identify HEXIM1 as a potential therapeutic target for degenerative muscular diseases... - The impact of phospholipid transfer protein (PLTP) on lipoprotein metabolismXian Cheng Jiang
Department of Cell Biology, Downstate Medical Center, State University of New York, 450 Clarkson Ave, Box 5, Brooklyn, NY, 11203, USA
Nutr Metab (Lond) 9:75. 2012..In this review, we summarized the recent progresses made in the PLTP research field and focused on its effect on apoB-containing- triglyceride-rich particle and HDL metabolism... - Mechanisms involved in cellular ceramide homeostasisM Mahmood Hussain
Department of Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
Nutr Metab (Lond) 9:71. 2012..All these pathways might have evolved to ensure steady cellular ceramide levels... - Subcellular targeting domains of sphingomyelin synthase 1 and 2Calvin Yeang
Department of Cell Biology, State University of New York Downstate Medical Center, 450 Clarkson Ave, Brooklyn, New York, 11203 USA
Nutr Metab (Lond) 8:89. 2011..We created truncations and chimeras of SMS1 and SMS2 to define their targeting signals. We found that SMS1 contains a C-terminal Golgi targeting signal and that SMS2 contains a C-terminal plasma membrane targeting signal... - Short-term magnesium deficiency results in decreased levels of serum sphingomyelin, lipid peroxidation, and apoptosis in cardiovascular tissuesBurton M Altura
Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, NY 11203 2098, USA
Am J Physiol Heart Circ Physiol 297:H86-92. 2009..e., 15 parts.million(-1).day(-1)) were cardio- and vascular protective. In addition, we demonstrate that short-term dietary deficiency of Mg probably results in a downregulation of SM synthase and a decreased synthesis of PC... - Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in miceJing Liu
Department of Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
Circ Res 105:295-303. 2009..SMS2 deficiency in macrophages diminishes nuclear factor kappaB and mitogen-activated protein kinase activation induced by inflammatory stimuli... - Relation of baseline plasma phospholipid levels to cardiovascular outcomes at two years in men with acute coronary syndrome referred for coronary angiographyErdal Cavusoglu
Department of Medicine, SUNY Downstate Medical Center, Brooklyn, New York, USA
Am J Cardiol 100:1739-43. 2007..In conclusion, these data demonstrate that low baseline levels of total choline-containing phospholipid are a strong and independent predictor of cardiovascular outcomes (including mortality) in patients with acute coronary syndromes... - Plasma lipid transfer proteinsXian Cheng Jiang
Department of Anatomy and Cell Biology, State University of New York, Downstate Medical Center, Brooklyn, New York, USA
Curr Opin Lipidol 17:302-8. 2006..Plasma cholesteryl ester transfer protein and phospholipid transfer protein are involved in lipoprotein metabolism. Conceivably, manipulation of either transfer protein could impact atherosclerosis and other lipid-driven diseases... - HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathwayFumihiko Matsuura
Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York, USA
J Clin Invest 116:1435-42. 2006..Thus, CETP-D HDL has enhanced ability to promote cholesterol efflux from foam cells in an ABCG1-dependent pathway due to an increased content of LCAT and apoE... - Alpha-tocopherol modulates phosphatidylserine externalization in erythrocytes: relevance in phospholipid transfer protein-deficient miceAlexis Klein
INSERM U498, IFR100, Universite de Bourgogne, Dijon, France
Arterioscler Thromb Vasc Biol 26:2160-7. 2006..The aim of the present study was to assess the effect of alpha-tocopherol, the main vitamin E isomer on phosphatidylserine (PS) exposure at the surface of circulating erythrocytes, and to determine consequences on erythrocyte properties... - A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytesYu Liang
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Neurochem 88:623-34. 2004..LXR/RXR agonists may have significant impact on the pathogenesis of multiple neurological diseases, including AD... - Cholesteryl ester transfer protein modulates the effect of liver X receptor agonists on cholesterol transport and excretion in the mouseDavid Masson
Institut National de la Santé et de la Recherche Médicale U498, Faculte de Medecine, BP87900, 21079 Dijon Cedex, France
J Lipid Res 45:543-50. 2004..In conclusion, induction of CETP constitutes a major determinant of the effect of LXR agonists on cholesterol transport and excretion... - High plasma phospholipid transfer protein levels as a risk factor for coronary artery diseaseAxel Schlitt
Department of Medicine II, Johannes Gutenberg-University, Mainz, Germany
Arterioscler Thromb Vasc Biol 23:1857-62. 2003.... - Apolipoprotein CI deficiency markedly augments plasma lipoprotein changes mediated by human cholesteryl ester transfer protein (CETP) in CETP transgenic/ApoCI-knocked out miceThomas Gautier
Laboratoire de Biochimie des Lipoproteines, INSERM U498, Faculte de Medecine, BP87900, 21079 Dijon Cedex, France
J Biol Chem 277:31354-63. 2002..Overall, the present observations provide direct support for a potent specific inhibition of CETP by plasma apoCI in vivo... - Phospholipid transfer protein is regulated by liver X receptors in vivoGuoqing Cao
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Biol Chem 277:39561-5. 2002..We conclude that PLTP is a direct target gene of LXRs in vivo and plays an important role in LXR agonist-mediated HDL cholesterol and size increase in mice... - Adipose tissue-specific CETP expression in mice: impact on plasma lipoprotein metabolismHongwen Zhou
Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
J Lipid Res 47:2011-9. 2006..Moreover, adipose tissue CETP expression changes triglyceride and cholesterol content and the size of adipocytes... - Cholesteryl ester transfer protein (CETP) expression enhances HDL cholesteryl ester liver delivery, which is independent of scavenger receptor BI, LDL receptor related protein and possibly LDL receptorHongwen Zhou
Department of Endocrinology, 1st Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
Biochim Biophys Acta 1761:1482-8. 2006..01, respectively). These results suggest that CETP expression in mouse increases direct removal of HDL CE in the liver and this process is independent of SR-BI, LRP, and possibly LDLR... - Coadministration of a liver X receptor agonist and a peroxisome proliferator activator receptor-alpha agonist in Mice: effects of nuclear receptor interplay on high-density lipoprotein and triglyceride metabolism in vivoThomas P Beyer
Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
J Pharmacol Exp Ther 309:861-8. 2004..Liver lipoprotein lipase expression was additively increased upon LXR agonist and PPARalpha agonist coadministration. Our studies mark the first exploration of nuclear receptor interplay on lipid homeostasis in vivo... - Liver X receptors (LXRs) regulate apolipoprotein AIV-implications of the antiatherosclerotic effect of LXR agonistsYu Liang
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
Mol Endocrinol 18:2000-10. 2004..In addition, we identified a functional LXR-responsive element at 3' end enhancer region of mouse ApoAIV gene. We conclude that ApoAIV is a direct target gene of LXRs that may contribute to the antiatherogenic effect of LXR activation... - Apolipoprotein CI overexpression is not a relevant strategy to block cholesteryl ester transfer protein (CETP) activity in CETP transgenic miceThomas Gautier
Laboratoire de Biochimie des Lipoproteines, INSERM U498, Faculte de Medecine, BP87900, 21079 Dijon Cedex, France
Biochem J 385:189-95. 2005.... - Phospholipid transfer protein (PLTP) deficiency reduces brain vitamin E content and increases anxiety in miceCatherine Desrumaux
Laboratoire de Biochimie des Lipoproteines, INSERM, Dijon, France
FASEB J 19:296-7. 2005.... - Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient miceMohammad Reza Hojjati
Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, 450 Clarkson Ave, Brooklyn, New York 11203, USA
J Biol Chem 280:10284-9. 2005..Thus, inhibition of SPT activity could be an alternative treatment for atherosclerosis... - Effect of plasma phospholipid transfer protein deficiency on lethal endotoxemia in miceThomas Gautier
INSERM, Centre de Recherche UMR866, Faculte de Medecine, Institut Fédératif de Recherche Santé STIC, Universitéde Bourgogne, 21079 Dijon, France
J Biol Chem 283:18702-10. 2008..Finally, PLTP deficiency in mice led to a significant increase in LPS-induced mortality. It is concluded that increasing circulating levels of PLTP may constitute a new and promising strategy in preventing endotoxic shock... - Liver X receptors as potential therapeutic targets for multiple diseasesGuoqing Cao
Division of Cardiovascular Discovery, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
Drug News Perspect 17:35-41. 2004..This review intends to summarize the most recent progress in the field and provide an assessment of LXRs as potential therapeutic targets... - Adenovirus-mediated overexpression of sphingomyelin synthases 1 and 2 increases the atherogenic potential in miceJibin Dong
School of Pharmacy, Fudan University, Shanghai, People s Republic of China
J Lipid Res 47:1307-14. 2006..Such an effect may contribute to the increased plasma SM levels observed in animal models of atherosclerosis and in human patients with coronary artery disease... - Ceramide is a cardiotoxin in lipotoxic cardiomyopathyTae Sik Park
Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
J Lipid Res 49:2101-12. 2008..Our results suggest a critical role for ceramide accumulation in the pathogenesis of lipotoxic cardiomyopathy... - Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesisGuoqing Cao
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Biol Chem 278:1131-6. 2003..These data not only suggest that LXRs are novel targets for diabetes but also reveal an unanticipated role for these receptors, further linking lipid and glucose metabolism... - A single intravenous dose of endotoxin rapidly alters serum lipoproteins and lipid transfer proteins in normal volunteersLisa C Hudgins
The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
J Lipid Res 44:1489-98. 2003..The selective loss of phospholipid from HDL may have been mediated by LBP and, after more intense or prolonged inflammation, could result in increased HDL clearance and reduced HDL levels... - Common genetic variation of the cholesteryl ester transfer protein gene strongly predicts future cardiovascular death in patients with coronary artery diseaseStefan Blankenberg
Department of Medicine II, Johannes Gutenberg University Mainz, Mainz, Germany
J Am Coll Cardiol 41:1983-9. 2003..We sought to evaluate the association between cholesteryl ester transfer protein (CETP) genotypes and the risk of future cardiovascular mortality in patients with coronary artery disease (CAD)... - Phospholipid transfer protein in hemodialysis patientsAxel Schlitt
Department of Medicine III, Martin Luther University, Halle Wittenberg, Germany
Am J Nephrol 27:138-43. 2007..The role of PLTP in atherogenesis is still controversial. We aimed to investigate PLTP activity in hemodialysis (HD) patients, a population which has an increased risk for the development of atherosclerosis... - Prognostic value of lipoproteins and their relation to inflammatory markers among patients with coronary artery diseaseAxel Schlitt
Department of Medicine II, Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, 55101 Mainz, Germany
Int J Cardiol 102:477-85. 2005..There is growing evidence indicating that those lipoprotein factors are related to the inflammatory process in atherogenesis... - Inhibition of cholesteryl ester transfer protein by torcetrapib modestly increases macrophage cholesterol efflux to HDLLaurent Yvan-Charvet
Division of Molecular Medicine, Department of Medicine, Columbia University, 630 West 168 St, New York, NY 10032, USA
Arterioscler Thromb Vasc Biol 27:1132-8. 2007..This study examines the effects of pharmacological inhibition of cholesteryl ester transfer protein (CETP) on the ability of high-density lipoprotein particles (HDL) to promote net cholesterol efflux from human THP-1 macrophage foam cells... - A simple, rapid, and sensitive fluorescence assay for microsomal triglyceride transfer proteinHumra Athar
Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
J Lipid Res 45:764-72. 2004..Furthermore, the assay was useful in studying the inhibition of the cellular as well as purified MTP by its antagonists. This new method is amenable to automation and can be easily adopted for large-scale, high-throughput screening...