Mahmood M Hussain

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. doi request reprint Clock genes, intestinal transport and plasma lipid homeostasis
    M Mahmood Hussain
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Trends Endocrinol Metab 20:177-85. 2009
  2. pmc Acknowledgement of manuscript reviewers, the underappreciated contributors
    Lucy Abel
    Department of Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave, 11203, Brooklyn, NY, USA
    Nutr Metab (Lond) 10:17. 2013
  3. doi request reprint Clock regulation of dietary lipid absorption
    M Mahmood Hussain
    Departments of Cell Biology and Pediatrics, SUNY Downstate Medical Center, Brooklyn, New York, USA
    Curr Opin Clin Nutr Metab Care 15:336-41. 2012
  4. ncbi request reprint Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly
    M Mahmood Hussain
    Department of Anatomy, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    J Lipid Res 44:22-32. 2003
  5. ncbi request reprint Microsomal triglyceride transfer protein: a multifunctional protein
    Mohammed Mahmood Hussain
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave, Box 5, Brooklyn, NY 11203, USA
    Front Biosci 8:s500-6. 2003
  6. pmc Hepatic steatosis in hepatitis C is a storage disease due to HCV interaction with microsomal triglyceride transfer protein (MTP)
    Silvia Mirandola
    VIMM Venetian Institute of Molecular Medicine, Padova, Italy
    Nutr Metab (Lond) 7:13. 2010
  7. ncbi request reprint Intestinal lipoprotein assembly
    M Mahmood Hussain
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York, USA
    Curr Opin Lipidol 16:281-5. 2005
  8. ncbi request reprint Phospholipid transfer activity of microsomal triacylglycerol transfer protein is sufficient for the assembly and secretion of apolipoprotein B lipoproteins
    Paul Rava
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    J Biol Chem 281:11019-27. 2006
  9. pmc Intestinal lipid absorption
    Jahangir Iqbal
    Dept of Anatomy, 450 Clarkson Ave, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    Am J Physiol Endocrinol Metab 296:E1183-94. 2009
  10. ncbi request reprint Diurnal regulation of microsomal triglyceride transfer protein and plasma lipid levels
    Xiaoyue Pan
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
    J Biol Chem 282:24707-19. 2007

Collaborators

Detail Information

Publications33

  1. doi request reprint Clock genes, intestinal transport and plasma lipid homeostasis
    M Mahmood Hussain
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Trends Endocrinol Metab 20:177-85. 2009
    ..This review highlights recent studies examining light- and food-entrained regulation of plasma lipids and of various intestinal activities and offers insight into the role of the intestine in food entrainment...
  2. pmc Acknowledgement of manuscript reviewers, the underappreciated contributors
    Lucy Abel
    Department of Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave, 11203, Brooklyn, NY, USA
    Nutr Metab (Lond) 10:17. 2013
    ..It is largely due to their support and expertise that we have been able to publish high-standard manuscripts. We would also like to thank authors for choosing Nutrition & Metabolism and contributing their cherished work...
  3. doi request reprint Clock regulation of dietary lipid absorption
    M Mahmood Hussain
    Departments of Cell Biology and Pediatrics, SUNY Downstate Medical Center, Brooklyn, New York, USA
    Curr Opin Clin Nutr Metab Care 15:336-41. 2012
    ..To summarize the new knowledge about the regulation of dietary lipid absorption by circadian locomotor output cycles kaput (Clock) and Nocturnin...
  4. ncbi request reprint Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly
    M Mahmood Hussain
    Department of Anatomy, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    J Lipid Res 44:22-32. 2003
    ..However, specific steps in lipoprotein assembly that require apoB-MTP binding have not been identified. ApoB-MTP binding may be important for the prevention of degradation and lipidation of nascent apoB...
  5. ncbi request reprint Microsomal triglyceride transfer protein: a multifunctional protein
    Mohammed Mahmood Hussain
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave, Box 5, Brooklyn, NY 11203, USA
    Front Biosci 8:s500-6. 2003
    ..It is also speculated that MTP may function in physiologic processes beyond lipoprotein assembly...
  6. pmc Hepatic steatosis in hepatitis C is a storage disease due to HCV interaction with microsomal triglyceride transfer protein (MTP)
    Silvia Mirandola
    VIMM Venetian Institute of Molecular Medicine, Padova, Italy
    Nutr Metab (Lond) 7:13. 2010
    ....
  7. ncbi request reprint Intestinal lipoprotein assembly
    M Mahmood Hussain
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York, USA
    Curr Opin Lipidol 16:281-5. 2005
    ..In this review we propose a nomenclature for these lipoproteins and have summarized recent data about their intracellular assembly and factors that modulate their secretion...
  8. ncbi request reprint Phospholipid transfer activity of microsomal triacylglycerol transfer protein is sufficient for the assembly and secretion of apolipoprotein B lipoproteins
    Paul Rava
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    J Biol Chem 281:11019-27. 2006
    ..Identification of MTP inhibitors, which selectively affect transfer of a specific lipid class, may have therapeutic potential...
  9. pmc Intestinal lipid absorption
    Jahangir Iqbal
    Dept of Anatomy, 450 Clarkson Ave, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    Am J Physiol Endocrinol Metab 296:E1183-94. 2009
    ....
  10. ncbi request reprint Diurnal regulation of microsomal triglyceride transfer protein and plasma lipid levels
    Xiaoyue Pan
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
    J Biol Chem 282:24707-19. 2007
    ..Furthermore, environmental factors, such as food and light, play an important role in MTP regulation...
  11. doi request reprint Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism
    M Mahmood Hussain
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    Curr Opin Lipidol 19:277-84. 2008
    ..This review summarizes recent advances about the role of microsomal triglyceride transfer protein in plasma and tissue lipid homeostasis...
  12. pmc Clock is important for food and circadian regulation of macronutrient absorption in mice
    Xiaoyue Pan
    Departments of Anatomy and Cell Biology, and Pediatrics, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    J Lipid Res 50:1800-13. 2009
    ..Clock plays an important role in light and food entrainment of intestinal functions by regulating nutrient transport proteins. Disruptions in intestinal circadian activity may contribute to hyperlipidemia and hyperglycemia...
  13. pmc IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA
    Jahangir Iqbal
    Department of Anatomy and Cell Biology and Department of Pediatrics, The State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    Cell Metab 7:445-55. 2008
    ..Conversely, knockdown of IRE1beta enhanced MTP expression. These studies show that IRE1beta plays a role in regulating MTP and in chylomicron production...
  14. pmc An intrinsic gut leptin-melanocortin pathway modulates intestinal microsomal triglyceride transfer protein and lipid absorption
    Jahangir Iqbal
    Department of Cell Biology and Pediatrics, State University of New York Health Science Center at Brooklyn SUNY Downstate Medical Center, Brooklyn, NY, USA
    J Lipid Res 51:1929-42. 2010
    ..Instead, we found that enterocytes express LEPR, POMC, AGRP, and MC4R. We propose that a peripheral, local gut signaling mechanism involving LEPR B and MC4R regulates intestinal MTP and controls intestinal lipid absorption...
  15. ncbi request reprint Transport of vitamin E by differentiated Caco-2 cells
    Kamran Anwar
    Department of Anatomy, State University of New York Downstate Medical Center, Brooklyn, NY, USA
    J Lipid Res 47:1261-73. 2006
    ..Transport via I-HDL might contribute to vitamin E absorption in patients with abetalipoproteinemia receiving large oral doses of the vitamin...
  16. pmc NR2F1 and IRE1beta suppress microsomal triglyceride transfer protein expression and lipoprotein assembly in undifferentiated intestinal epithelial cells
    Kezhi Dai
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11230, USA, USA
    Arterioscler Thromb Vasc Biol 30:568-74. 2010
    ..Our aim was to elucidate mechanisms involved in the acquisition of lipid transport properties during enterocyte differentiation...
  17. pmc Microsomal triglyceride transfer protein enhances cellular cholesteryl esterification by relieving product inhibition
    Jahangir Iqbal
    Department of Anatomy and Cell Biology and Pediatrics, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    J Biol Chem 283:19967-80. 2008
    ..We speculate that non-lipoprotein-producing cells may use different mechanisms to alleviate product inhibition and modulate cholesteryl ester biosynthesis...
  18. pmc Diurnal regulation of MTP and plasma triglyceride by CLOCK is mediated by SHP
    Xiaoyue Pan
    Department of Cell Biology and Pediatrics, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Cell Metab 12:174-86. 2010
    ..Together, these studies describe a role of Clock/Shp in the diurnal regulation of MTP and plasma triglyceride and indicate that disruptions in circadian regulation might cause hyperlipidemia...
  19. doi request reprint Serine palmitoyltransferase (SPT) deficient mice absorb less cholesterol
    Zhiqiang Li
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, USA
    Biochim Biophys Acta 1791:297-306. 2009
    ..This may be also true for ABCA1 which locates on basal membrane of enterocytes. Manipulation of SPT activity could thus provide a novel alternative treatment for dyslipidemia...
  20. ncbi request reprint Differential, tissue-specific, transcriptional regulation of apolipoprotein B secretion by transforming growth factor beta
    Karnail Singh
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    J Biol Chem 277:39515-24. 2002
    ..In this regulation, the presence of cytokine-responsive motif in the tissue-specific enhancer element confers cell-specific response...
  21. ncbi request reprint Multiple, independently regulated pathways of cholesterol transport across the intestinal epithelial cells
    Jahangir Iqbal
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
    J Biol Chem 278:31610-20. 2003
    ....
  22. ncbi request reprint Mechanisms involved in vitamin E transport by primary enterocytes and in vivo absorption
    Kamran Anwar
    Molecular and Cellular Biology Program, School of Graduate Studies, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    J Lipid Res 48:2028-38. 2007
    ..Absorption with chylomicrons is the major pathway of vitamin E absorption. The HDL pathway may be important when chylomicron assembly is defective and can be exploited to deliver vitamin E without increasing fat consumption...
  23. ncbi request reprint Inhibiting proteasomal degradation of microsomal triglyceride transfer protein prevents CCl4-induced steatosis
    Xiaoyue Pan
    Department of Anatomy, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    J Biol Chem 282:17078-89. 2007
    ..These studies identify MTP as a major target of CCl(4) and its degradation as a novel mechanism involved in the onset of steatosis, suggesting that inhibition of proteolysis may prevent some forms of steatosis...
  24. ncbi request reprint Liver microsomal triglyceride transfer protein is involved in hepatitis C liver steatosis
    Silvia Mirandola
    VIMM Venetian Institute of Molecular Medicine, Padova, Italy
    Gastroenterology 130:1661-9. 2006
    ..We therefore investigated liver MTP gene expression and its lipid transfer activity in untreated cases infected with the major HCV genotypes showing variable degrees of hepatic steatosis...
  25. ncbi request reprint Evidence for multiple complementary pathways for efficient cholesterol absorption in mice
    Jahangir Iqbal
    Department of Anatomy and Cell Biology, and Pediatrics, SUNY Downstate Medical Center, Brooklyn, NY, USA
    J Lipid Res 46:1491-501. 2005
    ..Nonetheless, long-term studies involving multiple feedings showed significant reduction in cholesterol absorption after 4 days. We propose that multiple compensatory mechanisms ensure efficient cholesterol absorption in mice...
  26. doi request reprint Fibrillar collagen type I stimulation of apolipoprotein B secretion in Caco-2 cells is mediated by beta1 integrin
    Don R Ratcliffe
    Department of Anatomy, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    Biochim Biophys Acta 1791:1144-54. 2009
    ..This new observation that extracellular matrix proteins can enhance apoB secretion in Caco-2 cells could be useful to explore the modulation of lipid transport by these proteins...
  27. ncbi request reprint Phospholipid transfer protein-deficient mice absorb less cholesterol
    Ruijie Liu
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave, Box 5, Brooklyn, NY 11203, USA
    Arterioscler Thromb Vasc Biol 27:2014-21. 2007
    ..Because small intestine is one of the major tissue expressing PLTP, we hypothesize that PLTP deficient small intestine absorbs less cholesterol, thus contributing to the diminishing of cholesterol levels in the plasma...
  28. ncbi request reprint Transfer of cholesteryl esters and phospholipids as well as net deposition by microsomal triglyceride transfer protein
    Paul Rava
    Department of Anatomy and Cell Biology and Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    J Lipid Res 46:1779-85. 2005
    ..These methods may help identify specific inhibitors for individual lipid transfer activities, in characterizing different domains involved in transfer, and in the isolation of mutants that bind but cannot transfer lipids...
  29. ncbi request reprint Pluronic L81 enhances triacylglycerol accumulation in the cytosol and inhibits chylomicron secretion
    Sumbul Fatma
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    J Lipid Res 47:2422-32. 2006
    ..They inhibit fat absorption by decreasing TG transport to the endoplasmic reticulum and increase drug efficacy against cancer cells by competing for their excretion...
  30. ncbi request reprint Expression of a recombinant protein of the platelet F11 receptor (F11R) (JAM-1/JAM-A) in insect cells: F11R is naturally phosphorylated in the extracellular domain
    Mamdouh H Kedees
    Department of Anatomy and Cell Biology, State University of New York, Downstate Medical Center at Brooklyn, Brooklyn, NY 11203, USA
    Platelets 16:99-109. 2005
    ..The findings reported here provide new information on specific domains of F11R that can lead to the generation of therapeutic agents expected to be useful in the treatment of cardiovascular diseases...
  31. ncbi request reprint A simple, rapid, and sensitive fluorescence assay for microsomal triglyceride transfer protein
    Humra Athar
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    J Lipid Res 45:764-72. 2004
    ..Furthermore, the assay was useful in studying the inhibition of the cellular as well as purified MTP by its antagonists. This new method is amenable to automation and can be easily adopted for large-scale, high-throughput screening...
  32. ncbi request reprint F11-receptor (F11R/JAM) mediates platelet adhesion to endothelial cells: role in inflammatory thrombosis
    Anna Babinska
    Department of Anatomy Cell Biology, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Thromb Haemost 88:843-50. 2002
    ..Agents that block the F11R-mediated adhesion of platelets to EC may be of therapeutic value in controlling thrombosis and preventing heart attacks and stroke...
  33. pmc Acquisition of triacylglycerol transfer activity by microsomal triglyceride transfer protein during evolution
    Paul Rava
    Molecular and Cellular Biology Program, School of Graduate Studies, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    Biochemistry 46:12263-74. 2007
    ....