Research Topics
| Margaret R HammerschlagSummaryAffiliation: State University of New York Country: USA Publications
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Publications
Chlamydial and gonococcal infections in infants and childrenMargaret R Hammerschlag
Division of Infectious Diseases, Department of Pediatrics, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203 2098, USA
Clin Infect Dis 53:S99-102. 2011..Prenatal screening and treatment of pregnant women, which has been demonstrated to be very effective for the prevention of neonatal gonococcal ophthalmia, is the most effective strategy for preventing neonatal chlamydial infection...- Guidelines for the use of molecular biological methods to detect sexually transmitted pathogens in cases of suspected sexual abuse in childrenMargaret R Hammerschlag
Division of Pediatric Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, NY, USA
Methods Mol Biol 903:307-17. 2012..In addition, if these assays ever become legally admissible in court, there will be recommendations that more than one NAAT assay be used in order to assure confirmation of the diagnostic result... - Treatment of chlamydial infectionsMargaret R Hammerschlag
SUNY Downstate Medical Center, Division of Infectious Diseases, Department of Pediatrics, 450 Clarkson Avenue, Brooklyn, NY 11203 2098, USA
Expert Opin Pharmacother 13:545-52. 2012..The majority of published studies have relied on serology for diagnosis, making it difficult to assess microbiologic efficacy... 
Use of cethromycin, a new ketolide, for treatment of community-acquired respiratory infectionsMargaret R Hammerschlag
State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203 2098, USA
Expert Opin Investig Drugs 17:387-400. 2008..In 2007 the indications for treatment of AECB and sinusitis were removed from the labeling. Cethromycin (ABT-773) is the only other ketolide currently under clinical development...
Medical and legal implications of testing for sexually transmitted infections in childrenMargaret R Hammerschlag
Division of Pediatric Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203 2098, USA
Clin Microbiol Rev 23:493-506. 2010....- Molecular characterization of Chlamydophila pneumoniae isolates from Western barred bandicootsAndrei Kutlin
Department of Pediatrics, SUNY Downstate Medical Center, Brooklyn, New York, USA
J Med Microbiol 56:407-17. 2007..The data from this study support the previous observations that C. pneumoniae is not restricted to humans and may be widespread in an animal reservoir with a potential risk of transmission to humans... - In vitro activities of rifamycin derivatives ABI-1648 (Rifalazil, KRM-1648), ABI-1657, and ABI-1131 against Chlamydia trachomatis and recent clinical isolates of Chlamydia pneumoniaePatricia M Roblin
Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn 11203-2098, USA
Antimicrob Agents Chemother 47:1135-6. 2003..0025 micro g/ml for C. trachomatis and 0.00125 to 0.0025 micro g/ml for C. pneumoniae. ABI-1648, ABI-1657, and ABI-1131 were 10- to 1,000-fold more active than azithromycin and levofloxacin... - In vitro activity of garenoxacin against recent clinical isolates of Chlamydia pneumoniaePatricia M Roblin
Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Box 49, 450 Clarkson Avenue, Brooklyn, NY 11203-2098, USA
Int J Antimicrob Agents 21:578-80. 2003..pneumoniae was 0.03 mg/l (range 0.015-0.03 mg/l)... - In vitro activity of CEM-101, a new fluoroketolide antibiotic, against Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniaePatricia M Roblin
Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, New York 11203 2098, USA
Antimicrob Agents Chemother 54:1358-9. 2010..pneumoniae were inhibited and the minimal bactericidal concentration at which 90% of the isolates were killed by CEM-101 were 0.25 microg/ml (ranges, 0.125 to 0.5 microg/ml for C. trachomatis and 0.25 to 1.0 microg/ml for C. pneumoniae)... - Genetic and culture-based approaches for detecting macrolide resistance in Chlamydia pneumoniaePaul F Riska
Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, NY, USA
Antimicrob Agents Chemother 48:3586-90. 2004..Attempts to induce antibiotic resistance in vitro were made. No genetic mechanism was identified for the phenotypic change in these C. pneumoniae isolates. No macrolide resistance was obtained in vitro... - Effect of gemifloxacin on viability of Chlamydia pneumoniae (Chlamydophila pneumoniae) in an in vitro continuous infection modelAndrei Kutlin
Department of Pediatrics, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Box 49, Brooklyn, NY 11203-2098, USA
J Antimicrob Chemother 49:763-7. 2002..Both antibiotics decreased levels of interleukin-6 and interleukin-8 in this model, but this effect appeared to be secondary to the antichlamydial activity, as the cytokine levels correlated with the concentrations of microorganisms... - Infection with Simkania negevensis in Brooklyn, New YorkSwati Kumar
Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, NY, USA
Pediatr Infect Dis J 24:989-92. 2005..Simkania negevensis is a Chlamydia-like intracellular organism that is prevalent in populations from a wide range of geographic areas. The role of the organism in respiratory disease in the United States is unknown... - In vitro models of acute and long-term continuous infection of human respiratory epithelial cells with Chlamydophila pneumoniae have opposing effects on host cell apoptosisStephan A Kohlhoff
Department of Pediatrics, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
Microb Pathog 44:34-42. 2008..pneumoniae. Induction of apoptosis may help to propagate the infection, while inhibition of apoptosis could help protect the organism in chronic infection... - Isolation and antimicrobial susceptibilities of Chlamydial isolates from Western barred bandicootsSwati Kumar
Department of Pediatrics, Division of Infectious Diseases, State University of New York, Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
J Clin Microbiol 45:392-4. 2007..25 to 2 microg/ml, and 0.25 to 0.5 microg/ml, respectively. The MICs at which 90% of isolates were inhibited and the minimal bactericidal concentrations were within the ranges reported previously for human isolates of C. pneumoniae... - Appropriate use of nonculture tests for the detection of sexually transmitted diseases in children and adolescentsMargaret R Hammerschlag
Division of Infectious Diseases, Department of Pediatrics, SUNY Downstate Medical Center, Brooklyn, NY 11203-2093, USA
Semin Pediatr Infect Dis 14:54-9. 2003.... - Is Chlamydia pneumoniae infection associated with stroke in children with sickle cell disease?Meenakshi Goyal
Division of Hematology Oncology, Department of Pediatrics, State University of New York, Downstate Medical Center, Brooklyn, New York 11203 2098, USA
Pediatrics 113:e318-21. 2004..This hyperplasia is hypothesized to result from an inflammatory response similar to that in atherosclerosis and has been attributed to infection by Chlamydia pneumoniae... - Microbiological efficacy of ABT-773 (cethromycin) for the treatment of community-acquired pneumonia due to Chlamydia pneumoniaeMargaret R Hammerschlag
Department of Pediatrics, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York, NY 11203 2098, USA
J Antimicrob Chemother 51:1025-8. 2003..MICs and MBCs for 13 isolates of C. pneumoniae from 12 patients obtained before and after therapy were performed against ABT-773. The MIC90 and MBC90 of ABT-773 were 0.015 mg/L... - Absence of Chlamydia pneumoniae and signs of atherosclerotic cardiovascular disease in adolescents with systemic lupus erythematosusCorinna S Bowser
Division of Allergy and Immunology, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, NY, USA
Pediatr Cardiol 29:545-51. 2008..Serum triglycerides were higher in the lupus group (p = 0.03). Children and adolescents with SLE might have accelerated atherosclerosis; however, we did not observe an association with C. pneumoniae infection in this population... - Acute respiratory infection due to Chlamydia pneumoniae: current status of diagnostic methodsSwati Kumar
Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
Clin Infect Dis 44:568-76. 2007..Adoption of a more unified approach, both for choices of diagnostic methods and for validation of new molecular assays, is long overdue and will be critically important for development of a standardized test for clinical laboratories... - Emergence of resistance to rifampin and rifalazil in Chlamydophila pneumoniae and Chlamydia trachomatisAndrei Kutlin
Department of Pediatrics, SUNY Downstate Medical Center, 450 Clarkson Avenue, Box 49, Brooklyn, NY 11203, USA
Antimicrob Agents Chemother 49:903-7. 2005..This is the first description of antibiotic resistance-associated mutations in C. pneumoniae and of rifampin resistance in C. trachomatis not associated with mutations in the rpoB gene... - Chlamydia trachomatis and Chlamydia pneumoniae infections in children and adolescentsMargaret R Hammerschlag
Department of Pediatrics, Division of Infectious Diseases, State University of New York Downstate Medical Center, Brooklyn, New York, USA
Pediatr Rev 25:43-51. 2004 - Sophorolipids as antibacterial agentsJoseph N Sleiman
Department of 1Pediatrics and 3Surgery, SUNY Downstate Medical Center, Brooklyn, New York, USA
Ann Clin Lab Sci 39:60-3. 2009..The SLs may be used as anti-inflammatory agents or immunomodulators without affecting the host's bacterial flora... - The role of Chlamydia pneumoniae infection in children with chronic sinusitisAnthony Cultrara
Department of Otolaryngology Division of Infectious Diseases, State University of New York Downstate Medical Center, Brooklyn 11203, USA
Arch Otolaryngol Head Neck Surg 129:1094-7. 2003..Chlamydia pneumoniae infection is a frequent cause of lower respiratory disease in both adults and children. However, its role in upper respiratory disease, including sinusitis, is less clear... - In vitro activities of BMS-284756 against Chlamydia trachomatis and recent clinical isolates of Chlamydia pneumoniaeSheila Malay
Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, New York 11203-2098, USA
Antimicrob Agents Chemother 46:517-8. 2002..pneumoniae and C. trachomatis was 0.015 microg/ml (range, 0.015 to 0.03 microg/ml). BMS-284756 was the most active quinolone tested... - Pneumonia due to Chlamydia pneumoniae in children: epidemiology, diagnosis, and treatmentMargaret R Hammerschlag
Department of Pediatrics, Division of Infectious Diseases, State University of New York Downstate Medical Center, Brooklyn, New York 11203 2098, USA
Pediatr Pulmonol 36:384-90. 2003.... - Methicillin-resistant Staphylococcus aureus colonization in otitis-prone childrenHaidy A Marzouk
Division of Pediatric Otolaryngology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
Arch Otolaryngol Head Neck Surg 137:1217-22. 2011.... - In vitro activity of a new antibiotic, NVP-PDF386 (VRC4887), against Chlamydia pneumoniaePatricia M Roblin
Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, New York 11203-2098, USA
Antimicrob Agents Chemother 47:1447-8. 2003..pneumoniae were 0.008 micro g/ml (range, 0.008 to 0.015 micro g/ml) compared to 0.25 and 0.06 micro g/ml for levofloxacin and clarithromycin, respectively... - The intracellular life of chlamydiaeMargaret R Hammerschlag
Departments of Pediatrics and Medicine, Division of Pediatric Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, NY 11203 2098, USA
Semin Pediatr Infect Dis 13:239-48. 2002.... - Chlamydia pneumoniae and the heart: impact of diagnostic methodsMargaret R Hammerschlag
Division of Pediatric Infectious Diseases, State University of New York Downstate Medical Center, University Hospital of Brooklyn, Brooklyn, New York, USA
Curr Clin Top Infect Dis 22:24-41. 2002 - Epidemiology of sexually transmitted infections in suspected child victims of sexual assaultRebecca G Girardet
Department of Pediatrics, University of Texas Houston Medical School, Houston, Texas 77030, USA
Pediatrics 124:79-86. 2009.... - Advances in the management of Chlamydia pneumoniae infectionsMargaret R Hammerschlag
Division of Pediatric Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, NY 11203 2098, USA
Expert Rev Anti Infect Ther 1:493-503. 2003..pneumoniae infection, it cannot be determined who is infected and who is not, which means that it cannot be assumed that any effect seen is due to successful treatment or eradication of C. pneumoniae... - Minocycline treatment results in reduced oral steroid requirements in adult asthmaAmmar Daoud
Center for Allergy and Asthma Research, State University of New York Downstate Medical Center, Brooklyn, New York, USA
Allergy Asthma Proc 29:286-94. 2008..01). This preliminary study of minocycline therapy showed oral steroid-sparing properties for those with moderate persistent and severe persistent asthma... - Chlamydia and Chlamydiales: beyond Chlamydia trachomatisMargaret R Hammerschlag
Division of Pediatric Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, NY, USA
Pediatr Infect Dis J 26:639-40. 2007 - Sexual assault and abuse of childrenMargaret R Hammerschlag
Division of Pediatric Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, NY 11203 2098, USA
Clin Infect Dis 53:S103-9. 2011.... - Recurrent intravascular-catheter-related bacteremia caused by Delftia acidovorans in a hemodialysis patientKobkul Chotikanatis
Division of Pediatric Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
J Clin Microbiol 49:3418-21. 2011..The isolate appeared to become resistant to cephalosporins after antibiotic treatment, but resistance could not be confirmed with additional testing. In vitro susceptibility testing for cephalosporins is not reliable for this organism... - Spontaneous Escherichia coli cellulitis in a child with nephrotic syndromeJoseph N Sleiman
Department of Pediatrics, Division of Infectious Diseases, Box 49, State University of New York Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
Pediatr Infect Dis J 26:266-7. 2007..Gram-positive bacteria, including streptococci and staphylococci, are the most common causes of bacterial cellulitis. We report a case of spontaneous Escherichia coli cellulitis in a patient with steroid-dependent nephrotic syndrome... - Effect of prolonged treatment with azithromycin, clarithromycin, or levofloxacin on Chlamydia pneumoniae in a continuous-infection ModelAndrei Kutlin
Department of Pediatrics, State University of New York Health Science Center at Brooklyn, Brooklyn, New York 11203-2098, USA
Antimicrob Agents Chemother 46:409-12. 2002..These data suggest that the dosage and duration of antibiotic therapy currently being used may not be sufficient to eradicate a putative chronic C. pneumoniae infection...