Margaret R Hammerschlag

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. doi request reprint Chlamydial and gonococcal infections in infants and children
    Margaret R Hammerschlag
    Division of Infectious Diseases, Department of Pediatrics, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203 2098, USA
    Clin Infect Dis 53:S99-102. 2011
  2. doi request reprint Guidelines for the use of molecular biological methods to detect sexually transmitted pathogens in cases of suspected sexual abuse in children
    Margaret R Hammerschlag
    Division of Pediatric Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, NY, USA
    Methods Mol Biol 903:307-17. 2012
  3. doi request reprint Treatment of chlamydial infections
    Margaret R Hammerschlag
    SUNY Downstate Medical Center, Division of Infectious Diseases, Department of Pediatrics, 450 Clarkson Avenue, Brooklyn, NY 11203 2098, USA
    Expert Opin Pharmacother 13:545-52. 2012
  4. pmc Medical and legal implications of testing for sexually transmitted infections in children
    Margaret R Hammerschlag
    Division of Pediatric Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203 2098, USA
    Clin Microbiol Rev 23:493-506. 2010
  5. ncbi request reprint Use of cethromycin, a new ketolide, for treatment of community-acquired respiratory infections
    Margaret R Hammerschlag
    State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203 2098, USA
    Expert Opin Investig Drugs 17:387-400. 2008
  6. ncbi request reprint Molecular characterization of Chlamydophila pneumoniae isolates from Western barred bandicoots
    Andrei Kutlin
    Department of Pediatrics, SUNY Downstate Medical Center, Brooklyn, New York, USA
    J Med Microbiol 56:407-17. 2007
  7. ncbi request reprint In vitro activity of garenoxacin against recent clinical isolates of Chlamydia pneumoniae
    Patricia M Roblin
    Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Box 49, 450 Clarkson Avenue, Brooklyn, NY 11203 2098, USA
    Int J Antimicrob Agents 21:578-80. 2003
  8. pmc In vitro activities of rifamycin derivatives ABI-1648 (Rifalazil, KRM-1648), ABI-1657, and ABI-1131 against Chlamydia trachomatis and recent clinical isolates of Chlamydia pneumoniae
    Patricia M Roblin
    Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn 11203 2098, USA
    Antimicrob Agents Chemother 47:1135-6. 2003
  9. pmc In vitro activity of CEM-101, a new fluoroketolide antibiotic, against Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae
    Patricia M Roblin
    Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, New York 11203 2098, USA
    Antimicrob Agents Chemother 54:1358-9. 2010
  10. pmc Genetic and culture-based approaches for detecting macrolide resistance in Chlamydia pneumoniae
    Paul F Riska
    Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, NY, USA
    Antimicrob Agents Chemother 48:3586-90. 2004

Collaborators

Detail Information

Publications40

  1. doi request reprint Chlamydial and gonococcal infections in infants and children
    Margaret R Hammerschlag
    Division of Infectious Diseases, Department of Pediatrics, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203 2098, USA
    Clin Infect Dis 53:S99-102. 2011
    ..Prenatal screening and treatment of pregnant women, which has been demonstrated to be very effective for the prevention of neonatal gonococcal ophthalmia, is the most effective strategy for preventing neonatal chlamydial infection...
  2. doi request reprint Guidelines for the use of molecular biological methods to detect sexually transmitted pathogens in cases of suspected sexual abuse in children
    Margaret R Hammerschlag
    Division of Pediatric Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, NY, USA
    Methods Mol Biol 903:307-17. 2012
    ..In addition, if these assays ever become legally admissible in court, there will be recommendations that more than one NAAT assay be used in order to assure confirmation of the diagnostic result...
  3. doi request reprint Treatment of chlamydial infections
    Margaret R Hammerschlag
    SUNY Downstate Medical Center, Division of Infectious Diseases, Department of Pediatrics, 450 Clarkson Avenue, Brooklyn, NY 11203 2098, USA
    Expert Opin Pharmacother 13:545-52. 2012
    ..The life cycle of Chlamydia spp. and the ability to cause persistent, often subclinical infection, has major ramifications for diagnosis and treatment of C. trachomatis and C. pneumoniae infections in humans...
  4. pmc Medical and legal implications of testing for sexually transmitted infections in children
    Margaret R Hammerschlag
    Division of Pediatric Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203 2098, USA
    Clin Microbiol Rev 23:493-506. 2010
    ....
  5. ncbi request reprint Use of cethromycin, a new ketolide, for treatment of community-acquired respiratory infections
    Margaret R Hammerschlag
    State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203 2098, USA
    Expert Opin Investig Drugs 17:387-400. 2008
    ..In 2007 the indications for treatment of AECB and sinusitis were removed from the labeling. Cethromycin (ABT-773) is the only other ketolide currently under clinical development...
  6. ncbi request reprint Molecular characterization of Chlamydophila pneumoniae isolates from Western barred bandicoots
    Andrei Kutlin
    Department of Pediatrics, SUNY Downstate Medical Center, Brooklyn, New York, USA
    J Med Microbiol 56:407-17. 2007
    ..The data from this study support the previous observations that C. pneumoniae is not restricted to humans and may be widespread in an animal reservoir with a potential risk of transmission to humans...
  7. ncbi request reprint In vitro activity of garenoxacin against recent clinical isolates of Chlamydia pneumoniae
    Patricia M Roblin
    Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Box 49, 450 Clarkson Avenue, Brooklyn, NY 11203 2098, USA
    Int J Antimicrob Agents 21:578-80. 2003
    ..pneumoniae was 0.03 mg/l (range 0.015-0.03 mg/l)...
  8. pmc In vitro activities of rifamycin derivatives ABI-1648 (Rifalazil, KRM-1648), ABI-1657, and ABI-1131 against Chlamydia trachomatis and recent clinical isolates of Chlamydia pneumoniae
    Patricia M Roblin
    Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn 11203 2098, USA
    Antimicrob Agents Chemother 47:1135-6. 2003
    ..0025 micro g/ml for C. trachomatis and 0.00125 to 0.0025 micro g/ml for C. pneumoniae. ABI-1648, ABI-1657, and ABI-1131 were 10- to 1,000-fold more active than azithromycin and levofloxacin...
  9. pmc In vitro activity of CEM-101, a new fluoroketolide antibiotic, against Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae
    Patricia M Roblin
    Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, New York 11203 2098, USA
    Antimicrob Agents Chemother 54:1358-9. 2010
    ..pneumoniae were inhibited and the minimal bactericidal concentration at which 90% of the isolates were killed by CEM-101 were 0.25 microg/ml (ranges, 0.125 to 0.5 microg/ml for C. trachomatis and 0.25 to 1.0 microg/ml for C. pneumoniae)...
  10. pmc Genetic and culture-based approaches for detecting macrolide resistance in Chlamydia pneumoniae
    Paul F Riska
    Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, NY, USA
    Antimicrob Agents Chemother 48:3586-90. 2004
    ..Attempts to induce antibiotic resistance in vitro were made. No genetic mechanism was identified for the phenotypic change in these C. pneumoniae isolates. No macrolide resistance was obtained in vitro...
  11. ncbi request reprint Effect of gemifloxacin on viability of Chlamydia pneumoniae (Chlamydophila pneumoniae) in an in vitro continuous infection model
    Andrei Kutlin
    Department of Pediatrics, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Box 49, Brooklyn, NY 11203 2098, USA
    J Antimicrob Chemother 49:763-7. 2002
    ..Both antibiotics decreased levels of interleukin-6 and interleukin-8 in this model, but this effect appeared to be secondary to the antichlamydial activity, as the cytokine levels correlated with the concentrations of microorganisms...
  12. doi request reprint Doxycycline suppresses Chlamydia pneumoniae-mediated increases in ongoing immunoglobulin E and interleukin-4 responses by peripheral blood mononuclear cells of patients with allergic asthma
    M S Dzhindzhikhashvili
    Center for Allergy and Asthma Research at SUNY Downstate, State University of New York SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    J Antimicrob Chemother 68:2363-8. 2013
    ..Whereas tetracyclines have anti-chlamydial activity, their effect on human IgE responses to C. pneumoniae has not been studied...
  13. ncbi request reprint Infection with Simkania negevensis in Brooklyn, New York
    Swati Kumar
    Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, NY, USA
    Pediatr Infect Dis J 24:989-92. 2005
    ..Simkania negevensis is a Chlamydia-like intracellular organism that is prevalent in populations from a wide range of geographic areas. The role of the organism in respiratory disease in the United States is unknown...
  14. pmc Isolation and antimicrobial susceptibilities of Chlamydial isolates from Western barred bandicoots
    Swati Kumar
    Department of Pediatrics, Division of Infectious Diseases, State University of New York, Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    J Clin Microbiol 45:392-4. 2007
    ..25 to 2 microg/ml, and 0.25 to 0.5 microg/ml, respectively. The MICs at which 90% of isolates were inhibited and the minimal bactericidal concentrations were within the ranges reported previously for human isolates of C. pneumoniae...
  15. ncbi request reprint In vitro models of acute and long-term continuous infection of human respiratory epithelial cells with Chlamydophila pneumoniae have opposing effects on host cell apoptosis
    Stephan A Kohlhoff
    Department of Pediatrics, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Microb Pathog 44:34-42. 2008
    ..pneumoniae. Induction of apoptosis may help to propagate the infection, while inhibition of apoptosis could help protect the organism in chronic infection...
  16. ncbi request reprint Appropriate use of nonculture tests for the detection of sexually transmitted diseases in children and adolescents
    Margaret R Hammerschlag
    Division of Infectious Diseases, Department of Pediatrics, SUNY Downstate Medical Center, Brooklyn, NY 11203 2093, USA
    Semin Pediatr Infect Dis 14:54-9. 2003
    ....
  17. ncbi request reprint Is Chlamydia pneumoniae infection associated with stroke in children with sickle cell disease?
    Meenakshi Goyal
    Division of Hematology Oncology, Department of Pediatrics, State University of New York, Downstate Medical Center, Brooklyn, New York 11203 2098, USA
    Pediatrics 113:e318-21. 2004
    ..This hyperplasia is hypothesized to result from an inflammatory response similar to that in atherosclerosis and has been attributed to infection by Chlamydia pneumoniae...
  18. ncbi request reprint Absence of Chlamydia pneumoniae and signs of atherosclerotic cardiovascular disease in adolescents with systemic lupus erythematosus
    Corinna S Bowser
    Division of Allergy and Immunology, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, NY, USA
    Pediatr Cardiol 29:545-51. 2008
    ..Serum triglycerides were higher in the lupus group (p = 0.03). Children and adolescents with SLE might have accelerated atherosclerosis; however, we did not observe an association with C. pneumoniae infection in this population...
  19. pmc Emergence of resistance to rifampin and rifalazil in Chlamydophila pneumoniae and Chlamydia trachomatis
    Andrei Kutlin
    Department of Pediatrics, SUNY Downstate Medical Center, 450 Clarkson Avenue, Box 49, Brooklyn, NY 11203, USA
    Antimicrob Agents Chemother 49:903-7. 2005
    ..This is the first description of antibiotic resistance-associated mutations in C. pneumoniae and of rifampin resistance in C. trachomatis not associated with mutations in the rpoB gene...
  20. ncbi request reprint Acute respiratory infection due to Chlamydia pneumoniae: current status of diagnostic methods
    Swati Kumar
    Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    Clin Infect Dis 44:568-76. 2007
    ..Adoption of a more unified approach, both for choices of diagnostic methods and for validation of new molecular assays, is long overdue and will be critically important for development of a standardized test for clinical laboratories...
  21. ncbi request reprint Chlamydia trachomatis and Chlamydia pneumoniae infections in children and adolescents
    Margaret R Hammerschlag
    Department of Pediatrics, Division of Infectious Diseases, State University of New York Downstate Medical Center, Brooklyn, New York, USA
    Pediatr Rev 25:43-51. 2004
  22. ncbi request reprint Microbiological efficacy of ABT-773 (cethromycin) for the treatment of community-acquired pneumonia due to Chlamydia pneumoniae
    Margaret R Hammerschlag
    Department of Pediatrics, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York, NY 11203 2098, USA
    J Antimicrob Chemother 51:1025-8. 2003
    ..MICs and MBCs for 13 isolates of C. pneumoniae from 12 patients obtained before and after therapy were performed against ABT-773. The MIC90 and MBC90 of ABT-773 were 0.015 mg/L...
  23. ncbi request reprint Pneumonia due to Chlamydia pneumoniae in children: epidemiology, diagnosis, and treatment
    Margaret R Hammerschlag
    Department of Pediatrics, Division of Infectious Diseases, State University of New York Downstate Medical Center, Brooklyn, New York 11203 2098, USA
    Pediatr Pulmonol 36:384-90. 2003
    ....
  24. ncbi request reprint The role of Chlamydia pneumoniae infection in children with chronic sinusitis
    Anthony Cultrara
    Department of Otolaryngology Division of Infectious Diseases, State University of New York Downstate Medical Center, Brooklyn 11203, USA
    Arch Otolaryngol Head Neck Surg 129:1094-7. 2003
    ..Chlamydia pneumoniae infection is a frequent cause of lower respiratory disease in both adults and children. However, its role in upper respiratory disease, including sinusitis, is less clear...
  25. pmc In vitro activities of BMS-284756 against Chlamydia trachomatis and recent clinical isolates of Chlamydia pneumoniae
    Sheila Malay
    Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, New York 11203 2098, USA
    Antimicrob Agents Chemother 46:517-8. 2002
    ..pneumoniae and C. trachomatis was 0.015 microg/ml (range, 0.015 to 0.03 microg/ml). BMS-284756 was the most active quinolone tested...
  26. ncbi request reprint Sophorolipids as antibacterial agents
    Joseph N Sleiman
    Department of 1Pediatrics and 3Surgery, SUNY Downstate Medical Center, Brooklyn, New York, USA
    Ann Clin Lab Sci 39:60-3. 2009
    ..The SLs may be used as anti-inflammatory agents or immunomodulators without affecting the host's bacterial flora...
  27. doi request reprint Asthmatic children have increased specific anti-Mycoplasma pneumoniae IgM but not IgG or IgE-values independent of history of respiratory tract infection
    Tamar A Smith-Norowitz
    Department of Pediatrics, Center for Allergy and Asthma Research, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Pediatr Infect Dis J 32:599-603. 2013
    ..Specific IgM and IgG isotypes are involved in the immune response to M. pneumoniae, but little is known about the role of specific IgE antibodies against M. pneumoniae in asthma...
  28. doi request reprint Methicillin-resistant Staphylococcus aureus colonization in otitis-prone children
    Haidy A Marzouk
    Division of Pediatric Otolaryngology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Arch Otolaryngol Head Neck Surg 137:1217-22. 2011
    ....
  29. pmc In vitro activity of a new antibiotic, NVP-PDF386 (VRC4887), against Chlamydia pneumoniae
    Patricia M Roblin
    Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, New York 11203 2098, USA
    Antimicrob Agents Chemother 47:1447-8. 2003
    ..pneumoniae were 0.008 micro g/ml (range, 0.008 to 0.015 micro g/ml) compared to 0.25 and 0.06 micro g/ml for levofloxacin and clarithromycin, respectively...
  30. ncbi request reprint Epidemiology of sexually transmitted infections in suspected child victims of sexual assault
    Rebecca G Girardet
    Department of Pediatrics, University of Texas Houston Medical School, Houston, Texas 77030, USA
    Pediatrics 124:79-86. 2009
    ....
  31. ncbi request reprint The intracellular life of chlamydiae
    Margaret R Hammerschlag
    Departments of Pediatrics and Medicine, Division of Pediatric Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, NY 11203 2098, USA
    Semin Pediatr Infect Dis 13:239-48. 2002
    ....
  32. ncbi request reprint Chlamydia pneumoniae and the heart: impact of diagnostic methods
    Margaret R Hammerschlag
    Division of Pediatric Infectious Diseases, State University of New York Downstate Medical Center, University Hospital of Brooklyn, Brooklyn, New York, USA
    Curr Clin Top Infect Dis 22:24-41. 2002
  33. ncbi request reprint Advances in the management of Chlamydia pneumoniae infections
    Margaret R Hammerschlag
    Division of Pediatric Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, NY 11203 2098, USA
    Expert Rev Anti Infect Ther 1:493-503. 2003
    ..pneumoniae infection, it cannot be determined who is infected and who is not, which means that it cannot be assumed that any effect seen is due to successful treatment or eradication of C. pneumoniae...
  34. pmc In vitro activity of nemonoxacin, a novel nonfluorinated quinolone antibiotic, against Chlamydia trachomatis and Chlamydia pneumoniae
    Kobkul Chotikanatis
    Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, New York, USA
    Antimicrob Agents Chemother 58:1800-1. 2014
    ..The minimal bactericidal concentrations at which 90% of the isolates were killed by nemonoxacin (MBC90s) were 0.06 μg/ml for C. trachomatis (range, 0.03 to 0.125 μg/ml) and 0.25 for C. pneumoniae (range, 0.015 to 0.5 μg/ml). ..
  35. doi request reprint Minocycline treatment results in reduced oral steroid requirements in adult asthma
    Ammar Daoud
    Center for Allergy and Asthma Research, State University of New York Downstate Medical Center, Brooklyn, New York, USA
    Allergy Asthma Proc 29:286-94. 2008
    ..01). This preliminary study of minocycline therapy showed oral steroid-sparing properties for those with moderate persistent and severe persistent asthma...
  36. ncbi request reprint Chlamydia and Chlamydiales: beyond Chlamydia trachomatis
    Margaret R Hammerschlag
    Division of Pediatric Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, NY, USA
    Pediatr Infect Dis J 26:639-40. 2007
  37. doi request reprint Sexual assault and abuse of children
    Margaret R Hammerschlag
    Division of Pediatric Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, NY 11203 2098, USA
    Clin Infect Dis 53:S103-9. 2011
    ....
  38. pmc Recurrent intravascular-catheter-related bacteremia caused by Delftia acidovorans in a hemodialysis patient
    Kobkul Chotikanatis
    Division of Pediatric Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    J Clin Microbiol 49:3418-21. 2011
    ..The isolate appeared to become resistant to cephalosporins after antibiotic treatment, but resistance could not be confirmed with additional testing. In vitro susceptibility testing for cephalosporins is not reliable for this organism...
  39. ncbi request reprint Spontaneous Escherichia coli cellulitis in a child with nephrotic syndrome
    Joseph N Sleiman
    Department of Pediatrics, Division of Infectious Diseases, Box 49, State University of New York Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Pediatr Infect Dis J 26:266-7. 2007
    ..Gram-positive bacteria, including streptococci and staphylococci, are the most common causes of bacterial cellulitis. We report a case of spontaneous Escherichia coli cellulitis in a patient with steroid-dependent nephrotic syndrome...
  40. pmc Effect of prolonged treatment with azithromycin, clarithromycin, or levofloxacin on Chlamydia pneumoniae in a continuous-infection Model
    Andrei Kutlin
    Department of Pediatrics, State University of New York Health Science Center at Brooklyn, Brooklyn, New York 11203 2098, USA
    Antimicrob Agents Chemother 46:409-12. 2002
    ..These data suggest that the dosage and duration of antibiotic therapy currently being used may not be sufficient to eradicate a putative chronic C. pneumoniae infection...