Research Topics
| Nicholas DelihasSummaryAffiliation: State University of New York Country: USA Publications
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Publications
Stem loop sequences specific to transposable element IS605 are found linked to lipoprotein genes in Borrelia plasmidsNicholas Delihas
Department of Molecular Genetics and Microbiology, School of Medicine, State University of New York, Stony Brook, New York, United States of America
PLoS ONE 4:e7941. 2009..In Helicobacter pylori, flanking regions of the IS605 transposase gene contain sequences that fold into identical small stem loops. These function in transposition at the single-stranded DNA level...
Targeting the expression of anti-apoptotic proteins by antisense oligonucleotidesN Delihas
Department of Molecular Genetics and Microbiology, School of Medicine, SUNY, Stony Brook, NY 11794 5222, USA
Curr Drug Targets 2:167-80. 2001..The primary focus of this review is an analysis of recent uses of ASO biotechnology to inhibit anti-apoptotic gene expression in tumor cells...
MicF: an antisense RNA gene involved in response of Escherichia coli to global stress factorsN Delihas
Department of Molecular Genetics and Microbiology School of Medicine, SUNY, Stony Brook, NY 11794 5222, USA
J Mol Biol 313:1-12. 2001..The crystal structure of one these transcriptional activators, Rob, complexed with the micF promoter has been reported. Here, we review new developments in the micF regulatory network...
Intergenic regions of Borrelia plasmids contain phylogenetically conserved RNA secondary structure motifsNicholas Delihas
Department of Molecular Genetics and Microbiology, School of Medicine, SUNY, Stony Brook, NY 11794 5222, USA
BMC Genomics 10:101. 2009..These regions have many fragmented genes, repeated sequences and appear to be in a state of flux, but they may serve as reservoirs for evolutionary change and/or maintain stable motifs such as small RNA genes...
Annotation and evolutionary relationships of a small regulatory RNA gene micF and its target ompF in Yersinia speciesNicholas Delihas
Department of Molecular Genetics and Microbiology, School of Medicine, SUNY Stony Brook, NY 11794 5222, USA
BMC Microbiol 3:13. 2003..We report by using sequences that represent "gene signatures" as probes, e.g., mRNA 5'UTR sequences, closely related genes can be accurately located in genomic sequences...
Regulation of gene expression by trans-encoded antisense RNAsN Delihas
Department of Molecular Genetics and Microbiology, School of Medicine, State University of New York, Stony Brook 11794 5222, USA
Mol Microbiol 15:411-4. 1995..It is possible that currently known unlinked antisense RNA genes are part of a larger class of heretofore undiscovered regulatory RNA genes. Possible ways of detecting other unlinked antisense RNA genes are discussed...
micF RNA in ompB mutants of Escherichia coli: different pathways regulate micF RNA levels in response to osmolarity and temperature changeJ Coyer
Department of Microbiology, School of Medicine, State University of New York, Stony Brook 11794
J Bacteriol 172:4143-50. 1990..This showed that osmolal regulation but not temperature regulation of micF depends on these upstream sequences and suggested that while osmolal regulation of the micF gene depends on OmpR, thermal regulation does not...
Regulating the regulator: MicF RNA controls expression of the global regulator LrpNicholas Delihas
Department of Molecular Genetics and Microbiology, School of Medicine, State University of New York, Stony Brook, NY 11794 5222, USA
Mol Microbiol 84:401-4. 2012..2012; Corcoran et al., 2012). Thus MicF RNA is a central factor in a regulatory network that regulates bacterial cell physiology...
Impact of small repeat sequences on bacterial genome evolutionNicholas Delihas
Department of Molecular Genetics and Microbiology, School of Medicine, State University of New York, Stony Brook, NY, USA
Genome Biol Evol 3:959-73. 2011..The diverse structure, eclectic functions, and evolutionary aspects of repeat elements are described...
micF RNA is a substrate for RNase EM Schmidt
Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook 11794 5222, USA
FEMS Microbiol Lett 133:209-13. 1995..Two cleavage sites were mapped, and both are found in the sequence context UA/UUU and are located within 10 nucleotides upstream of stem-loop structures. These results help define a generalized RNase E cleavage/recognition pattern...
