N Dean

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. ncbi The VRG4 gene is required for GDP-mannose transport into the lumen of the Golgi in the yeast, Saccharomyces cerevisiae
    N Dean
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York, Stony Brook, New York 11794 5215, USA
    J Biol Chem 272:31908-14. 1997
  2. ncbi The OST4 gene of Saccharomyces cerevisiae encodes an unusually small protein required for normal levels of oligosaccharyltransferase activity
    J H Chi
    Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, New York 11794 5215, USA
    J Biol Chem 271:3132-40. 1996
  3. ncbi Identification of a conserved motif in the yeast golgi GDP-mannose transporter required for binding to nucleotide sugar
    X D Gao
    Department of Biochemistry, Institute for Cell and Developmental Biology, State University of New York, Stony Brook, New York 11794-5215, USA
    J Biol Chem 276:4424-32. 2001
  4. ncbi Distinct protein domains of the yeast Golgi GDP-mannose transporter mediate oligomer assembly and export from the endoplasmic reticulum
    X D Gao
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York, Stony Brook, New York 11794 5215, USA
    J Biol Chem 275:17718-27. 2000
  5. pmc Saccharomyces cerevisiae HOC1, a suppressor of pkc1, encodes a putative glycosyltransferase
    A M Neiman
    Department of Biochemistry and Cell Biology, State University of New York, Stony Brook 11794 5215, USA
    Genetics 145:637-45. 1997
  6. ncbi Asparagine-linked glycosylation in the yeast Golgi
    N Dean
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York, Stony Brook, NY 11794 5215, USA
    Biochim Biophys Acta 1426:309-22. 1999
  7. pmc ERD1, a yeast gene required for the retention of luminal endoplasmic reticulum proteins, affects glycoprotein processing in the Golgi apparatus
    K G Hardwick
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 9:623-30. 1990
  8. ncbi ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway
    J C Semenza
    MRC Laboratory of Molecular Biology, Cambridge, England
    Cell 61:1349-57. 1990
  9. ncbi The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum
    J F Cipollo
    Department of Biomedical Sciences, State University of New York at Albany, Albany, New York 12201, USA
    J Biol Chem 276:21828-40. 2001
  10. ncbi Bid antisense attenuates bile acid-induced apoptosis and cholestatic liver injury
    H Higuchi
    Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic, and Foundation, Rochester, Minnesota 55905, USA
    J Pharmacol Exp Ther 299:866-73. 2001

Collaborators

Detail Information

Publications10

  1. ncbi The VRG4 gene is required for GDP-mannose transport into the lumen of the Golgi in the yeast, Saccharomyces cerevisiae
    N Dean
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York, Stony Brook, New York 11794 5215, USA
    J Biol Chem 272:31908-14. 1997
    ..Alternatively, the essential function of Vrg4p in yeast involves its effect on sphingolipids, which would imply a critical role for mannosylinositol phosphorylceramides or mannosyl diphosphoinositol ceramides on growth and viability...
  2. ncbi The OST4 gene of Saccharomyces cerevisiae encodes an unusually small protein required for normal levels of oligosaccharyltransferase activity
    J H Chi
    Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, New York 11794 5215, USA
    J Biol Chem 271:3132-40. 1996
    ..Deletion of the OST4 gene greatly diminishes OTase activity but does not abolish it. These results suggest that the OST4 gene encodes a subunit or accessory component of OTase that is essential at high temperature...
  3. ncbi Identification of a conserved motif in the yeast golgi GDP-mannose transporter required for binding to nucleotide sugar
    X D Gao
    Department of Biochemistry, Institute for Cell and Developmental Biology, State University of New York, Stony Brook, New York 11794-5215, USA
    J Biol Chem 276:4424-32. 2001
    ..Taken together, these data are consistent with the model that amino acids in this region of the yeast GDP-mannose transporter mediate the recognition of or binding to nucleotide sugar prior to its transport into the Golgi...
  4. ncbi Distinct protein domains of the yeast Golgi GDP-mannose transporter mediate oligomer assembly and export from the endoplasmic reticulum
    X D Gao
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York, Stony Brook, New York 11794 5215, USA
    J Biol Chem 275:17718-27. 2000
    ..These studies are consistent with a model in which Vrg4p oligomerizes in the ER and is subsequently transported to the Golgi via a mechanism that involves positive sorting rather than passive default...
  5. pmc Saccharomyces cerevisiae HOC1, a suppressor of pkc1, encodes a putative glycosyltransferase
    A M Neiman
    Department of Biochemistry and Cell Biology, State University of New York, Stony Brook 11794 5215, USA
    Genetics 145:637-45. 1997
    ..The function of HOC1 appears to be distinct from that of OCH1. Taken together, these results suggest that HOC1 encodes a Golgi-localized putative mannosyltransferase required for the proper construction of the cell wall...
  6. ncbi Asparagine-linked glycosylation in the yeast Golgi
    N Dean
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York, Stony Brook, NY 11794 5215, USA
    Biochim Biophys Acta 1426:309-22. 1999
    ..Current views on how these enzymes may be regulated and how glycosylation relates on other cellular processes are also discussed...
  7. pmc ERD1, a yeast gene required for the retention of luminal endoplasmic reticulum proteins, affects glycoprotein processing in the Golgi apparatus
    K G Hardwick
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 9:623-30. 1990
    ..The sequence of ERD1 predicts a membrane protein with several transmembrane domains, a conclusion supported by analysis of ERD1-SUC2 fusion proteins...
  8. ncbi ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway
    J C Semenza
    MRC Laboratory of Molecular Biology, Cambridge, England
    Cell 61:1349-57. 1990
    ..The gene is also required, perhaps indirectly, for normal protein transport through the Golgi, and hence for growth. We discuss possible roles for ERD2 in the secretory pathway...
  9. ncbi The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum
    J F Cipollo
    Department of Biomedical Sciences, State University of New York at Albany, Albany, New York 12201, USA
    J Biol Chem 276:21828-40. 2001
    ..All of these Alg11-related proteins share a 23-amino acid sequence that is found in over 60 proteins from bacteria to man whose function is in sugar metabolism, implicating this sequence as a potential sugar nucleotide binding motif...
  10. ncbi Bid antisense attenuates bile acid-induced apoptosis and cholestatic liver injury
    H Higuchi
    Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic, and Foundation, Rochester, Minnesota 55905, USA
    J Pharmacol Exp Ther 299:866-73. 2001
    ..These results suggest that bile acid cytotoxicity is Bid-dependent despite the absence of Fas. Bid antisense therapy is a promising approach for the treatment of cholestatic liver injury...