P Dandona

Summary

Affiliation: State University of New York at Buffalo
Country: USA

Publications

  1. ncbi A mixed anti-inflammatory and pro-inflammatory response associated with a high dose of corticosteroids
    P Dandona
    Division of Endocrinology, State University of New York at Buffalo, 115 Flint Rd, Williamsville, NY 14221, USA
    Curr Mol Med 14:793-801. 2014
  2. pmc Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3
    Rupali Deopurkar
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York, USA
    Diabetes Care 33:991-7. 2010
  3. pmc Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance
    Husam Ghanim
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, NY, USA
    Diabetes Care 32:2281-7. 2009
  4. pmc Testosterone concentrations in diabetic and nondiabetic obese men
    Sandeep Dhindsa
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, New York, USA
    Diabetes Care 33:1186-92. 2010
  5. pmc Low estradiol concentrations in men with subnormal testosterone concentrations and type 2 diabetes
    Sandeep Dhindsa
    State University of New York at Buffalo, Buffalo, NY, USA
    Diabetes Care 34:1854-9. 2011
  6. doi Insulin infusion suppresses while glucose infusion induces Toll-like receptors and high-mobility group-B1 protein expression in mononuclear cells of type 1 diabetes patients
    Paresh Dandona
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, NY 14209, USA
    Am J Physiol Endocrinol Metab 304:E810-8. 2013
  7. ncbi Cardiovascular benefits of exogenous insulin
    Ajay Chaudhuri
    Diabetes Endocrinology Center of Western New York, Division of Endocrinology, Kaleida Health Millard Fillmore Hospital, Buffalo, New York, USA
    J Clin Endocrinol Metab 97:3079-91. 2012
  8. pmc Sitagliptin exerts an antinflammatory action
    Antoine Makdissi
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 97:3333-41. 2012
  9. pmc Reduction in inflammation and the expression of amyloid precursor protein and other proteins related to Alzheimer's disease following gastric bypass surgery
    Husam Ghanim
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 97:E1197-201. 2012
  10. ncbi Anti-inflammatory effects of insulin
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, Buffalo, New York 14209, USA
    Curr Opin Clin Nutr Metab Care 10:511-7. 2007

Collaborators

Detail Information

Publications113 found, 100 shown here

  1. ncbi A mixed anti-inflammatory and pro-inflammatory response associated with a high dose of corticosteroids
    P Dandona
    Division of Endocrinology, State University of New York at Buffalo, 115 Flint Rd, Williamsville, NY 14221, USA
    Curr Mol Med 14:793-801. 2014
    ..We have now investigated the effect of a high dose of hydrocortisone (300mg=60 mg prednisolone) on NFκB binding and the expression of TLRs, the mediators of TLR signal transduction, MyD88 and TRIF and HMG-B1...
  2. pmc Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3
    Rupali Deopurkar
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York, USA
    Diabetes Care 33:991-7. 2010
    ..Saturated fat and carbohydrates, components of the HFHC meal, known to induce oxidative stress and inflammation, also induce an increase in LPS, TLR-4, and SOCS3...
  3. pmc Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance
    Husam Ghanim
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, NY, USA
    Diabetes Care 32:2281-7. 2009
    ....
  4. pmc Testosterone concentrations in diabetic and nondiabetic obese men
    Sandeep Dhindsa
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, New York, USA
    Diabetes Care 33:1186-92. 2010
    ..To determine the prevalence of subnormal testosterone concentrations in patients with obesity and with type 2 diabetes in a primary care clinic population...
  5. pmc Low estradiol concentrations in men with subnormal testosterone concentrations and type 2 diabetes
    Sandeep Dhindsa
    State University of New York at Buffalo, Buffalo, NY, USA
    Diabetes Care 34:1854-9. 2011
    ....
  6. doi Insulin infusion suppresses while glucose infusion induces Toll-like receptors and high-mobility group-B1 protein expression in mononuclear cells of type 1 diabetes patients
    Paresh Dandona
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, NY 14209, USA
    Am J Physiol Endocrinol Metab 304:E810-8. 2013
    ..The induction of significant oxidative and inflammatory stress by small amounts of glucose in patients with type 1 diabetes may have important pathophysiological and therapeutic implications...
  7. ncbi Cardiovascular benefits of exogenous insulin
    Ajay Chaudhuri
    Diabetes Endocrinology Center of Western New York, Division of Endocrinology, Kaleida Health Millard Fillmore Hospital, Buffalo, New York, USA
    J Clin Endocrinol Metab 97:3079-91. 2012
    ..This review aims to summarize current knowledge regarding the cardiovascular, antiinflammatory, and antiatherogenic effects of insulin, and the effect of intensive glycemic control in acute cardiovascular disease...
  8. pmc Sitagliptin exerts an antinflammatory action
    Antoine Makdissi
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 97:3333-41. 2012
    ..Because DPP-IV is expressed as CD26 on cell membranes and because CD26 mediates proinflammatory signals, we hypothesized that sitagliptin may exert an antiinflammatory effect...
  9. pmc Reduction in inflammation and the expression of amyloid precursor protein and other proteins related to Alzheimer's disease following gastric bypass surgery
    Husam Ghanim
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 97:E1197-201. 2012
    ....
  10. ncbi Anti-inflammatory effects of insulin
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, Buffalo, New York 14209, USA
    Curr Opin Clin Nutr Metab Care 10:511-7. 2007
    ..Apart from being novel, they are central to our understanding of why hyperglycemia is a prognosticator of bad clinical outcomes including patients with acute coronary syndromes, stroke and in patients in the intensive care unit...
  11. pmc Insulin infusion in acute illness
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, and Kaleida Health, Buffalo, New York, New York, USA
    J Clin Invest 115:2069-72. 2005
    ....
  12. ncbi Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade
    P Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, NY 14209, USA
    J Hum Hypertens 21:20-7. 2007
    ....
  13. ncbi Antioxidant activity of carvedilol in cardiovascular disease
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, New York 14209, USA
    J Hypertens 25:731-41. 2007
    ..Furthermore, anti-inflammatory effects of carvedilol have now been described. Although further clinical investigations are required, these properties may contribute to the improvement in clinical outcomes observed with carvedilol...
  14. ncbi Proinflammatory effects of glucose and anti-inflammatory effect of insulin: relevance to cardiovascular disease
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, New York, USA
    Am J Cardiol 99:15B-26B. 2007
    ..This may neutralize the beneficial effects of insulin. Such regimens should therefore be avoided in the future and replaced by regimens that infuse insulin to restore and maintain euglycemia...
  15. ncbi Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation
    Paresh Dandona
    Division of Endocrinology, Diabetes, and Metabolism, Diabetes Endocrinology Center of Western New York, State University of New York at Buffalo, and Kaleida Health, Buffalo, NY 14209, USA
    Circulation 111:1448-54. 2005
  16. ncbi Increased plasma concentration of macrophage migration inhibitory factor (MIF) and MIF mRNA in mononuclear cells in the obese and the suppressive action of metformin
    Paresh Dandona
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 89:5043-7. 2004
    ....
  17. doi Hypogonadotrophic hypogonadism in type 2 diabetes
    P Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York, USA
    Aging Male 11:107-17. 2008
    ..In addition, low testosterone levels are associated with an increase in cardiovascular events. Testosterone therapy may therefore, reduce cardiovascular risk. This important aspect requires further investigation...
  18. ncbi Endothelial dysfunction and hypertension in diabetes mellitus
    Paresh Dandona
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, 3 Gates Circle, Buffalo, NY 14209, USA
    Med Clin North Am 88:911-31, x-xi. 2004
    ....
  19. ncbi Endothelial dysfunction, inflammation and diabetes
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, 3 Gates Circle, Buffalo, NY 14209, USA
    Rev Endocr Metab Disord 5:189-97. 2004
  20. ncbi Endothelial dysfunction in patients with type 2 diabetes and the effects of thiazolidinedione antidiabetic agents
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, NY 14209, USA
    J Diabetes Complications 18:91-102. 2004
    ..These effects may be of considerable clinical significance if sustained during long-term therapy, given the morbidity and mortality associated with atherosclerosis in T2DM patients...
  21. ncbi Anti-inflammatory effects of insulin and the pro-inflammatory effects of glucose
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, Kaleida Health, Buffalo, NY, USA
    Semin Thorac Cardiovasc Surg 18:293-301. 2006
    ..This may neutralize the benefits of insulin. Such regimes should, therefore, be avoided in future and replaced by regimes that infuse insulin to restore and maintain euglycemia...
  22. ncbi Effect of hyperglycemia and insulin in acute coronary syndromes
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, Buffalo, New York, USA
    Am J Cardiol 99:12H-18H. 2007
    ..We also provide a mechanistic justification for the benefits of maintaining euglycemia with insulin infusion in hospitalized patients...
  23. doi Thiazolidinediones-improving endothelial function and potential long-term benefits on cardiovascular disease in subjects with type 2 diabetes
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, 3 Gates Circle, Buffalo, NY 14209, USA
    J Diabetes Complications 22:62-75. 2008
    ..Recent studies have demonstrated that thiazolidinediones improve endothelial function in subjects with and without type 2 diabetes...
  24. pmc Exenatide exerts a potent antiinflammatory effect
    Ajay Chaudhuri
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 97:198-207. 2012
    ..Our objective was to determine whether exenatide exerts an antiinflammatory effect...
  25. pmc Update: Hypogonadotropic hypogonadism in type 2 diabetes and obesity
    Paresh Dandona
    Division of Endocrinology, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 96:2643-51. 2011
    ..Trials of a longer duration are clearly required to definitively establish the benefits and risks of testosterone replacement in patients with type 2 diabetes and low testosterone...
  26. pmc Insulin suppresses the expression of amyloid precursor protein, presenilins, and glycogen synthase kinase-3beta in peripheral blood mononuclear cells
    Paresh Dandona
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 96:1783-8. 2011
    ..Our objective was to determine whether peripheral blood mononuclear cells express amyloid precursor protein (APP) and other mediators involved in the pathogenesis of Alzheimer's disease and whether their expression is suppressed by insulin...
  27. pmc Macronutrient intake induces oxidative and inflammatory stress: potential relevance to atherosclerosis and insulin resistance
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health 3 Gates Circle Buffalo, NY 14209, USA
    Exp Mol Med 42:245-53. 2010
    ..Hopefully, a comprehensive understanding of these actions of macronutrients and their long term effects will allow us to formulate food combinations which will lead to healthy eating habits and improvement in our overall health status...
  28. pmc Suppressive effect of insulin infusion on chemokines and chemokine receptors
    Husam Ghanim
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, New York, USA
    Diabetes Care 33:1103-8. 2010
    ..We also investigated the effect of insulin on other chemokines...
  29. doi Hypogonadotropic hypogonadism in men with type 2 diabetes
    Paresh Dandona
    Diabetes Endocrinology Center of Western New York, State University of New York at Buffalo, 3 Gates Circle, Buffalo, NY 14209, USA
    Postgrad Med 121:45-51. 2009
    ..Clinical trials are required to determine whether testosterone replacement therapy alleviates insulin resistance, inflammation, and symptoms related to sexual dysfunction care...
  30. doi Insulin as an anti-inflammatory and antiatherogenic modulator
    Paresh Dandona
    Kaleida Health, Buffalo, New York, USA
    J Am Coll Cardiol 53:S14-20. 2009
    ..Trials to test this hypothesis are in progress...
  31. ncbi Hypogonadotrophic hypogonadism in type 2 diabetes, obesity and the metabolic syndrome
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, 3 Gates Circle, Buffalo, NY 14209, USA
    Curr Mol Med 8:816-28. 2008
    ..Clinical trials are required to determine whether testosterone replacement alleviates symptoms related to sexual dysfunction, and features of the metabolic syndrome, insulin resistance and inflammation...
  32. doi Use of insulin to improve glycemic control in diabetes mellitus
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, Buffalo, NY 14209, USA
    Cardiovasc Drugs Ther 22:241-51. 2008
    ....
  33. ncbi Effects of antidiabetic and antihyperlipidemic agents on C-reactive protein
    Paresh Dandona
    Diabetes Endocrinology Center of Western New York, State University of New York at Buffalo Kaleida Health, 3 Gates Circle, Buffalo, NY 14209, USA
    Mayo Clin Proc 83:333-42. 2008
    ..This article reviews available data on antidiabetic and antihyperlipidemic agents that reduce CRP concentrations in addition to their primary effect of lowering glucose or lipid levels...
  34. ncbi Insulin as an anti-inflammatory and antiatherosclerotic hormone
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York, Kaleida Health Buffalo, New York, USA
    Clin Cornerstone . 2003
    ..The authors conclude that insulin is both anti-inflammatory and antiatherogenic and may be of use in the treatment of cardiovascular inflammatory conditions, including AMI...
  35. pmc Insulin suppresses endotoxin-induced oxidative, nitrosative, and inflammatory stress in humans
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York, USA
    Diabetes Care 33:2416-23. 2010
    ..To investigate whether insulin reduces the magnitude of oxidative, nitrosative, and inflammatory stress and tissue damage responses induced by endotoxin (lipopolysaccharide [LPS])...
  36. ncbi Angiotensin II receptor blocker valsartan suppresses reactive oxygen species generation in leukocytes, nuclear factor-kappa B, in mononuclear cells of normal subjects: evidence of an antiinflammatory action
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 88:4496-501. 2003
    ..In contrast, quinapril and simvastatin produced no similar effect over the period of 1 wk. Our observations may also have implications to clinical situations in which a rapid antiinflammatory effect is required...
  37. ncbi Insulin suppresses plasma concentration of vascular endothelial growth factor and matrix metalloproteinase-9
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, Buffalo, New York, USA
    Diabetes Care 26:3310-4. 2003
    ..VEGF and MMP-9 play a central regulatory role in angiogenesis, contribute to the pathogenesis of proliferative retinopathy, and have also been found to accelerate atherosclerosis...
  38. ncbi Carvedilol inhibits reactive oxygen species generation by leukocytes and oxidative damage to amino acids
    P Dandona
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, NY 14209, USA
    Circulation 101:122-4. 2000
    ..The purpose of this study was to test whether carvedilol has an antioxidant effect in humans in vivo...
  39. ncbi The potential therapeutic role of insulin in acute myocardial infarction in patients admitted to intensive care and in those with unspecified hyperglycemia
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, USA
    Diabetes Care 26:516-9. 2003
  40. ncbi The potential influence of inflammation and insulin resistance on the pathogenesis and treatment of atherosclerosis-related complications in type 2 diabetes
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 88:2422-9. 2003
  41. ncbi A rational approach to pathogenesis and treatment of type 2 diabetes mellitus, insulin resistance, inflammation, and atherosclerosis
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, Buffalo, New York, USA
    Am J Cardiol 90:27G-33G. 2002
    ..The use of TZDs as potent anti-inflammatory agents in patients with type 2 diabetes is an approach that would normalize glucose levels, as well as potentially alleviate the long-term risk of atherosclerosis...
  42. ncbi Endothelium, inflammation, and diabetes
    Paresh Dandona
    SUNY Buffalo, Kaleida, Health, 3 Gates Circle, Buffalo, NY 14209, USA
    Curr Diab Rep 2:311-5. 2002
    ....
  43. ncbi The anti-inflammatory and potential anti-atherogenic effect of insulin: a new paradigm
    P Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, and Kaleida Health, Buffalo, New York 14209, USA
    Diabetologia 45:924-30. 2002
  44. ncbi Insulin resistance and endothelial dysfunction in atherosclerosis: implications and interventions
    Paresh Dandona
    Diabetes Endocrinology Center of Western New York, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209, USA
    Diabetes Technol Ther 4:809-15. 2002
    ..These beneficial effects of TZDs may help to decrease the risk of vascular damage and atherosclerosis in patients with insulin resistance or diabetes...
  45. ncbi Nuclear factor-kappaB suppressive and inhibitor-kappaB stimulatory effects of troglitazone in obese patients with type 2 diabetes: evidence of an antiinflammatory action?
    A Aljada
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York, and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 86:3250-6. 2001
    ....
  46. ncbi Suppression of nuclear factor-kappaB and stimulation of inhibitor kappaB by troglitazone: evidence for an anti-inflammatory effect and a potential antiatherosclerotic effect in the obese
    H Ghanim
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 86:1306-12. 2001
    ..Plasma IL-10 concentration increased significantly, whereas plasma CRP concentrations decreased. We conclude that troglitazone has an antiinflammatory action that may contribute to its putative antiatherosclerotic effects...
  47. ncbi Inhibitory effect of a two day fast on reactive oxygen species (ROS) generation by leucocytes and plasma ortho-tyrosine and meta-tyrosine concentrations
    P Dandona
    Division of Endocrinology, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 86:2899-902. 2001
    ..055 mmol/mol at 48h and m-tyrosine/phenylalanine ratio fell from 0.363 +/- 0.063 mmol/mol to 0.340 +/- 0.064 mmol/mol (p < 0.05). Thus, a 48h fast may reduce ROS generation, total oxidative load and oxidative damage to amino acids...
  48. ncbi The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation
    P Dandona
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York, and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 86:355-62. 2001
    ....
  49. ncbi Troglitazone reduces the expression of PPARgamma while stimulating that of PPARalpha in mononuclear cells in obese subjects
    A Aljada
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, 14209, USA
    J Clin Endocrinol Metab 86:3130-3. 2001
    ..These effects may be relevant to its insulin sensitizing and anti-inflammatory effects...
  50. ncbi Acute suppressive effect of hydrocortisone on p47 subunit of nicotinamide adenine dinucleotide phosphate oxidase
    P Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, USA
    Metabolism 50:548-52. 2001
    ..Therefore, it would appear that the decrease in intranuclear NFkappaB and an increase in IL-10 may cause the inhibitory modulation on p47(phox) subunit and ROS generation by MNC following hydrocortisone and other glucocorticoids...
  51. ncbi Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?
    P Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 86:3257-65. 2001
    ..This acute anti-inflammatory effect, if demonstrated in the long term, may have implications for atherosclerosis and its complications...
  52. ncbi Effect of dexamethasone on reactive oxygen species generation by leukocytes and plasma interleukin-10 concentrations: a pharmacodynamic study
    P Dandona
    Division of Endocrinology and Metabolism, State University of New York at Buffalo, and the Kaleida Health System, 14209, USA
    Clin Pharmacol Ther 66:58-65. 1999
    ..26; P < .004). Dexamethasone (and possibly other glucocorticoids) therefore exerts its immunosuppressive and anti-inflammatory effects by inhibiting ROS generation by leukocytes and by increasing the plasma concentrations of IL-10...
  53. ncbi Evidence for a potent antiinflammatory effect of rosiglitazone
    Priya Mohanty
    Division of Endocrinology, Diabetes and Metabolism, State University of New York, and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 89:2728-35. 2004
    ..These observations may have implications for atherogenesis in the long term in subjects treated with rosiglitazone and possibly other thiazolidinediones...
  54. ncbi Anti-inflammatory effects of insulin and pro-inflammatory effects of glucose: relevance to the management of acute myocardial infarction and other acute coronary syndromes
    Paresh Dandona
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, New York, USA
    Rev Cardiovasc Med 7:S25-34. 2006
    ..Hyperglycemia induced by infusions of a fixed dose of insulin with high rates of glucose may neutralize the benefit of insulin, and such regimens should be replaced by infusion of insulin to restore and maintain euglycemia...
  55. ncbi Circulating mononuclear cells in the obese are in a proinflammatory state
    Husam Ghanim
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, NY, USA
    Circulation 110:1564-71. 2004
    ....
  56. pmc An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol
    Husam Ghanim
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 95:E1-8. 2010
    ..Resveratrol have been shown to exert an antiinflammatory and antiaging effects in vitro and in animal models...
  57. ncbi Role of inflammatory mediators in the suppression of insulin receptor phosphorylation in circulating mononuclear cells of obese subjects
    H Ghanim
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, Buffalo, NY, USA
    Diabetologia 50:278-85. 2007
    ....
  58. ncbi Insulin-mediated venodilation is impaired in patients with high cholesterol
    B H Sung
    Department of Medicine, State University of New York, and Millard Fillmore Hospital, Buffalo 14209, USA
    Hypertension 31:1266-71. 1998
    ..Absence of normal insulin-mediated but not sodium nitroprusside-induced venodilation in hypercholesterolemia suggests that insulin-mediated vasodilation is endothelium dependent...
  59. doi Effects of insulin and other antihyperglycaemic agents on lipid profiles of patients with diabetes
    A Chaudhuri
    SUNY at Buffalo Kaleidahealth, Buffalo, NY 14209, USA
    Diabetes Obes Metab 13:869-79. 2011
    ..Further studies are needed to understand the precise effect and the mechanisms of these effects of insulin on lipids...
  60. ncbi Vasodilatory effects of troglitazone improve blood pressure at rest and during mental stress in type 2 diabetes mellitus
    B H Sung
    Department of Medicine, State University of New York and CGF Millard Fillmore Hospital, Buffalo, NY, USA
    Hypertension 34:83-8. 1999
    ..A reduction in vascular resistance may be a primary hemodynamic mechanism of the manner in which troglitazone lowers BP. Insulin sensitizers may offer potential therapeutic advantage in subjects with DM with elevated BP...
  61. ncbi Moderately obese, insulin-resistant women exhibit abnormal vascular reactivity to stress
    B H Sung
    Department of Medicine, State University of New York, and Millard Fillmore Health System, Buffalo 14209, USA
    Hypertension 30:848-53. 1997
    ..This hyperreactivity may be a marker for future hypertension in obese, normotensive, hyperinsulinemic individuals...
  62. ncbi Low-dose rosiglitazone exerts an antiinflammatory effect with an increase in adiponectin independently of free fatty acid fall and insulin sensitization in obese type 2 diabetics
    Husam Ghanim
    Diabetes Endocrinology Center of Western New York, 3 Gates Circle, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 91:3553-8. 2006
    ..We have previously demonstrated an early and potent antiinflammatory effect of troglitazone and rosiglitazone...
  63. ncbi Prolonged reactive oxygen species generation and nuclear factor-kappaB activation after a high-fat, high-carbohydrate meal in the obese
    Chinmay Patel
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 92:4476-9. 2007
    ....
  64. ncbi Heparin inhibits reactive oxygen species generation by polymorphonuclear and mononuclear leucocytes
    P Dandona
    Department of Medicine, State University of New York at Buffalo and Kaleida Health, 14209, USA
    Thromb Res 96:437-43. 1999
    ..This effect of heparin may be of particular relevance to its use in unstable angina and following thrombolysis in acute myocardial infarction in preventing reperfusion injury...
  65. pmc A practical guide to male hypogonadism in the primary care setting
    P Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, NY, USA
    Int J Clin Pract 64:682-96. 2010
    ..These risks, however, are often exaggerated and should not outweigh the benefits of testosterone treatment...
  66. ncbi Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects
    Devjit Tripathy
    Division of Endocrinology, Diabetes and Metabolism, State University of New York and Kaleida Health, Buffalo, New York 14209, USA
    Diabetes 52:2882-7. 2003
    ..1% (P < 0.01) at 2, 4, and 6 h, respectively. We conclude that an increase in FFA concentration induces oxidative stress and has a proinflammatory effect; it also impairs postischemic flow-mediated vasodilation of the brachial artery...
  67. ncbi Differential effects of glucose and alcohol on reactive oxygen species generation and intranuclear nuclear factor-kappaB in mononuclear cells
    Sandeep Dhindsa
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, Buffalo, NY 14209, USA
    Metabolism 53:330-4. 2004
    ..2) While 75 g glucose (300 calories) induces an increase in ROS generation and intranuclear NF-kappaB, equicaloric amounts of alcohol did not produce these effects...
  68. ncbi Anti-inflammatory and profibrinolytic effect of insulin in acute ST-segment-elevation myocardial infarction
    Ajay Chaudhuri
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, and Kaleida Health, Buffalo, NY 14209, USA
    Circulation 109:849-54. 2004
    ..We assessed this potential effect of insulin in STEMI patients treated with fibrinolytics...
  69. ncbi Insulin resistance as a proinflammatory state: mechanisms, mediators, and therapeutic interventions
    Rajesh Garg
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, 3 Gates Circle, Buffalo, NY 14209, USA
    Curr Drug Targets 4:487-92. 2003
    ..These effects may be of considerable clinical significance if sustained during long-term therapy, given the morbidity and mortality associated with atherosclerosis, the major complication of insulin resistance...
  70. ncbi Exenatide therapy in obese patients with type 2 diabetes mellitus treated with insulin
    Prabhakar Viswanathan
    The Division of Endocrinology, Diabetes, and Metabolism, State University of New York, Buffalo, and Kaleida Health, Buffalo, New York, USA
    Endocr Pract 13:444-50. 2007
    ..To evaluate the effect of exenatide on clinical parameters in obese patients with type 2 diabetes mellitus whose hyperglycemia is not adequately controlled despite treatment with oral hypoglycemic agents and insulin...
  71. ncbi Orange juice or fructose intake does not induce oxidative and inflammatory response
    Husam Ghanim
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209, USA
    Diabetes Care 30:1406-11. 2007
    ..We hypothesized that the intake of 300 calories as orange juice or fructose, the other major carbohydrate in orange juice, would induce a significantly smaller response than that of glucose...
  72. ncbi Hyperglycemia, insulin, and acute ischemic stroke: a mechanistic justification for a trial of insulin infusion therapy
    Rajesh Garg
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, New York 14209, USA
    Stroke 37:267-73. 2006
    ..Hyperglycemia is associated with increased mortality and morbidity in acute ischemic stroke...
  73. ncbi Insulin inhibits NFkappaB and MCP-1 expression in human aortic endothelial cells
    A Aljada
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 86:450-3. 2001
    ....
  74. ncbi Increase in intranuclear nuclear factor kappaB and decrease in inhibitor kappaB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect
    Ahmad Aljada
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, NY, USA
    Am J Clin Nutr 79:682-90. 2004
    ..In view of the stimulatory effect of glucose on reactive oxygen species (ROS) generation, we investigated the possibility that a mixed meal stimulates ROS generation and possibly induces concomitant proinflammatory changes...
  75. ncbi Glucose intake induces an increase in activator protein 1 and early growth response 1 binding activities, in the expression of tissue factor and matrix metalloproteinase in mononuclear cells, and in plasma tissue factor and matrix metalloproteinase concen
    Ahmad Aljada
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, and Kaleida Health, 14209, USA
    Am J Clin Nutr 80:51-7. 2004
    ....
  76. ncbi Contrasting testosterone concentrations in type 1 and type 2 diabetes
    Rashmi Tomar
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, Buffalo, New York, USA
    Diabetes Care 29:1120-2. 2006
  77. ncbi Glucose ingestion induces an increase in intranuclear nuclear factor kappaB, a fall in cellular inhibitor kappaB, and an increase in tumor necrosis factor alpha messenger RNA by mononuclear cells in healthy human subjects
    Ahmad Aljada
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, NY 14209, USA
    Metabolism 55:1177-85. 2006
    ..These data are consistent with profound acute pro-inflammatory changes in MNCs after glucose intake...
  78. ncbi Targeting glucose in acute myocardial infarction: has glucose, insulin, and potassium infusion missed the target?
    Ajay Chaudhuri
    Department of Endocrinology, State University at New York at Buffalo and Kaleida Health, Buffalo, New York, USA
    Diabetes Care 30:3026-8. 2007
  79. pmc Testosterone concentration in young patients with diabetes
    Anil Chandel
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, Buffalo, New York, USA
    Diabetes Care 31:2013-7. 2008
    ..We have now investigated the total and free testosterone concentrations in young (aged 18-35 years) type 1 and type 2 diabetic patients...
  80. ncbi Effect of modified glucose-insulin-potassium on free fatty acids, matrix metalloproteinase, and myoglobin in ST-elevation myocardial infarction
    Ajay Chaudhuri
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, and Kaleida Health, Buffalo, New York, USA
    Am J Cardiol 100:1614-8. 2007
    ..This provided additional rationale for conducting a trial to assess the clinical benefits of this modified GIK regimen in patients with acute MI...
  81. ncbi Reactive oxygen species contribute to oxygen-related lung injury after acid aspiration
    N Nader-Djalal
    Department of Anesthesiology, State University of New York, Buffalo School of Medicine and Biomedical Sciences, USA
    Anesth Analg 87:127-33. 1998
    ..The decrease in antioxidant capacity after low pH aspiration with exposure to hyperoxia may contribute to this increase...
  82. ncbi Hydrocortisone suppresses intranuclear activator-protein-1 (AP-1) binding activity in mononuclear cells and plasma matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9)
    A Aljada
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, 14209, USA
    J Clin Endocrinol Metab 86:5988-91. 2001
    ..Thus, HC may reduce the extracellular spread of inflammation through the inhibition of matrix metalloproteinases...
  83. ncbi Inflammation: the link between insulin resistance, obesity and diabetes
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, 3 Gates Circle, Buffalo, NY 14209, USA
    Trends Immunol 25:4-7. 2004
    ..This might interfere with the anti-inflammatory effect of insulin, which in turn might promote inflammation...
  84. ncbi Low testosterone and high C-reactive protein concentrations predict low hematocrit in type 2 diabetes
    Vishal Bhatia
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, Buffalo, New York, USA
    Diabetes Care 29:2289-94. 2006
    ..We have now hypothesized that type 2 diabetic subjects with hypogonadotrophic hypogonadism may have a lower hematocrit because testosterone stimulates, whereas chronic inflammation suppresses, erythropoiesis...
  85. ncbi Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations
    Ahmad Aljada
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 87:1419-22. 2002
    ..These effects suggest a potential beneficial effect of insulin in thrombin formation and fibrinolysis in atherothrombosis...
  86. ncbi Free fatty acid-induced insulin resistance in the obese is not prevented by rosiglitazone treatment
    Sandeep Dhindsa
    Diabetes Endocrinology Center of Western New York, Distinguished Chief of Endocrinology, State University of New York at Buffalo, 3 Gates Circle, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 90:5058-63. 2005
    ..Elevation of free fatty acids (FFAs) by the infusion of triglyceride-heparin emulsion infusion (TG-Hep) causes insulin resistance (IR). We examined the effect of insulin sensitizer (rosiglitazone) on FFA-induced IR...
  87. ncbi Both lipid and protein intakes stimulate increased generation of reactive oxygen species by polymorphonuclear leukocytes and mononuclear cells
    Priya Mohanty
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, USA
    Am J Clin Nutr 75:767-72. 2002
    ..It was recently shown that glucose challenge leads to increased generation of reactive oxygen species (ROS) by polymorphonuclear leukocytes (PMNs) and mononuclear cells (MNCs)...
  88. ncbi Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes
    Sandeep Dhindsa
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 89:5462-8. 2004
    ..001). FT correlated strongly with cFT (r = 0.919; P < 0.001) but not with SHBG. LH levels correlated positively with FT (r = 0.287; P < 0.05). We conclude that hypogonadotropic hypogonadism occurs commonly in type 2 diabetes...
  89. ncbi High levels of oestrogen receptor-alpha in tumorigenesis: inhibition of cell growth and angiogenic factors
    S H Ali
    Diabetes Endocrinology Center of Western New York, Kaleida Health System, Buffalo, NY, USA
    Cell Prolif 34:223-31. 2001
    ..The results shown here demonstrate that a higher level of oestrogen receptor-alpha in the cell, through its effect on certain angiogenic factors, may play a role in the control of angiogenesis...
  90. pmc Acute modulation of toll-like receptors by insulin
    Husam Ghanim
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York, USA
    Diabetes Care 31:1827-31. 2008
    ..Toll-like receptors (TLRs) are major determinants of the inflammatory response to viral and bacterial pathogens. We have now hypothesized that low-dose insulin infusion in obese type 2 diabetic patients suppresses TLR expression...
  91. pmc Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression
    Husam Ghanim
    Division of Endocrinology, State University of New York at Buffalo, Buffalo, NY, USA
    Am J Clin Nutr 91:940-9. 2010
    ..The intake of glucose or a high-fat, high-carbohydrate (HFHC) meal, but not orange juice, induces an increase in inflammation and oxidative stress in circulating mononuclear cells (MNCs) of normal-weight subjects...
  92. ncbi Tumor necrosis factor-alpha inhibits insulin-induced increase in endothelial nitric oxide synthase and reduces insulin receptor content and phosphorylation in human aortic endothelial cells
    Ahmad Aljada
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, Buffalo, USA
    Metabolism 51:487-91. 2002
    ..Although the inhibition of IR autophosphorylation by TNF-alpha is known to occur at the adipocyte level, the data on the inhibitory effect of TNF-alpha on insulin-induced e-NOS expression and IRP contents are novel...
  93. ncbi Relationship of prostate-specific antigen to age and testosterone in men with type 2 diabetes mellitus
    Sandeep Dhindsa
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, Buffalo, New York Kaleida Health, Buffalo, NY, USA
    Endocr Pract 14:1000-5. 2008
    ....
  94. ncbi Vascular reactivity and thiazolidinediones
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, Buffalo, New York, USA
    Am J Med 115:81S-86S. 2003
    ..In addition, these effects of TZDs may have implications for reducing the incidence and severity of atherosclerosis in the long term...
  95. pmc A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal
    Husam Ghanim
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 96:1409-14. 2011
    ..High-fat, high-carbohydrate (HFHC) meals are known to induce oxidative and inflammatory stress, an increase in plasma endotoxin concentrations, and an increase in the expression of suppressor of cytokine signaling-3 (SOCS-3)...
  96. ncbi Oral modified insulin (HIM2) in patients with type 1 diabetes mellitus: results from a phase I/II clinical trial
    Stephen Clement
    Division of Endocrinology and Metabolism, Georgetown University Medical Center, Washington, DC 20007, USA
    Metabolism 53:54-8. 2004
    ..Further clinical investigation is necessary...
  97. ncbi Control of postprandial plasma glucose by an oral insulin product (HIM2) in patients with type 2 diabetes
    Mark Kipnes
    Diabetes and Glandular Disease Research Associates, San Antonio, Texas 78229, USA
    Diabetes Care 26:421-6. 2003
    ..Subcutaneous insulin and oral placebo were also administered for comparison...

Research Grants7

  1. Inflammation in obesity: Modulation by Weight Loss
    Paresh Dandona; Fiscal Year: 2009
    ..abstract_text> ..
  2. Inflammation in obesity: Modulation by Weight Loss
    Paresh Dandona; Fiscal Year: 2005
    ..abstract_text> ..
  3. Inflammation in obesity: Modulation by Weight Loss
    Paresh Dandona; Fiscal Year: 2006
    ..abstract_text> ..
  4. Inflammation in obesity: Modulation by Weight Loss
    Paresh Dandona; Fiscal Year: 2007
    ..abstract_text> ..
  5. HYPOGONADOTROPIC HYPOGONADISM, INSULIN SENSITIVITY AND INFLAMMATION IN TYPE 2 DIA
    Paresh Dandona; Fiscal Year: 2009
    ..The decrease in inflammation with testosterone treatment may have relevance for atherosclerosis and cardiovascular risk. ..
  6. HYPOGONADOTROPIC HYPOGONADISM, INSULIN SENSITIVITY AND INFLAMMATION IN TYPE 2 DIA
    Paresh Dandona; Fiscal Year: 2010
    ..The decrease in inflammation with testosterone treatment may have relevance for atherosclerosis and cardiovascular risk. ..