Patricia K Coyle
Affiliation: State University of New York
- Use of interferon beta in multiple sclerosis: rationale for early treatment and evidence for dose- and frequency-dependent effects on clinical responseP K Coyle
Department of Neurology, SUNY at Stony Brook, New York 11794, USA
Mult Scler 8:2-9. 2002....
- Lyme diseasePatricia K Coyle
Department of Neurology, School of Medicine, State University of New York at Stony Brook, HSC, T 12 Room 020, Stony Brook, NY 11794 8121, USA
Curr Neurol Neurosci Rep 2:479-87. 2002..This infection provides an important model system to understand how interactions between an organism, vector, and host lead to disease. It also provides a model to study how infectious agents lead to neurologic disease...
- High-dose cyclophosphamide for moderate to severe refractory multiple sclerosisDouglas E Gladstone
Department of Medicine, State University of New York at Stony Brook, USA
Arch Neurol 63:1388-93. 2006..High-dose cyclophosphamide is active in immune-mediated illnesses...
- Evidence-based medicine and clinical trialsPatricia K Coyle
Loyola University Medical Center, Maywood, Illinois, USA
Neurology 68:S3-7. 2007....
- Switching algorithms: from one immunomodulatory agent to anotherPatricia K Coyle
Multiple Sclerosis Comprehensive Care Center, Stony Brook University Medical Center, Stony Brook, New York, USA
J Neurol 255:44-50. 2008..A treatment algorithm is proposed for decision-making when switching therapies appears warranted...
- Gender issuesPatricia K Coyle
Multiple Sclerosis Comprehensive Care Center, School of Medicine, SUNY at Stony Brook, Stony Brook, NY 11794, USA
Neurol Clin 23:39-60, v-vi. 2005
- Relapses matter: the costs & consequences of multiple sclerosis relapsesPatricia K Coyle
Stony Brook University Medical Center, Stony Brook, New York, USA
J Neurol Sci 256:S1-4. 2007
- Neurologic aspects of Lyme diseaseP K Coyle
Department of Neurology, School of Medicine, State University of New York, Stony Brook, Stony Brook, New York, USA
Med Clin North Am 86:261-84. 2002..Although there is a preventive vaccine based on the lipoprotein OspA, newer vaccines in development may prove more desirable. Lyme disease provides a valuable model to study how infectious pathogens cause neurologic disease...
- Early treatment of multiple sclerosis to prevent neurologic damagePatricia K Coyle
MS Comprehensive Care Center, Stony Brook University Medical Center, Stony Brook, NY 11794, USA
Neurology 71:S3-7. 2008..This article reviews data on early treatment. Such an approach requires the ability to recognize clinically isolated syndrome features that indicate a diagnosis of MS...
- The role of natalizumab in the treatment of multiple sclerosisPatricia K Coyle
Department of Neurology, Stony Brook University Medical Center and Stony Brook MS Comprehensive Care Center, Stony Brook, USA
Am J Manag Care 16:S164-70. 2010....
- Multiple sclerosis gender issues: clinical practices of women neurologistsP K Coyle
MS Comprehensive Care Center, SUNY at Stony Brook, New York, NY, USA
Mult Scler 10:582-8. 2004..The survey results described here provide insight into how neurologists manage reproductive health issues among women with MS...
- Reactive Lyme serology in optic neuritisPatrick Sibony
Department of Ophthalmology and Neurology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
J Neuroophthalmol 25:71-82. 2005..Even so, there is a general impression that optic neuritis is a common manifestation of LD...
- Cerebrospinal fluid findings in children with Lyme disease-associated facial nerve palsyA L Belman
Department of Neurology, School of Medicine, State University of New York at Stony Brook, USA
Arch Pediatr Adolesc Med 151:1224-8. 1997..To determine the relative frequency of abnormal cerebrospinal fluid (CSF) findings in children with Lyme disease-associated facial nerve palsy...
- Combined cardiomyopathy and skeletal myopathy: a variant with atrial fibrillation and ventricular tachycardiaS C Vlay
Stony Brook Arrhythmia Study and Sudden Death Prevention Center, Division of Cardiology, Department of Medicine, Department of Neurology, SUNY Health Sciences Center, Stony Brook, New York, USA
Pacing Clin Electrophysiol 24:1389-97. 2001..Atrophy and wasting of the facial and temporalis muscles were common. Skeletal muscle biopsy revealed myofiber atrophy consistent with myopathy...
- Glucocorticoids in central nervous system bacterial infectionP K Coyle
Department of Neurology, State University of New York at Stony Brook, 11794, USA
Arch Neurol 56:796-801. 1999..To evaluate evidence-based data on adjunctive glucocorticoid therapy in central nervous system bacterial infections...
- Study and treatment of post Lyme disease (STOP-LD): a randomized double masked clinical trialL B Krupp
Department of Neurology, Stony Brook University Medical Center, Stony Brook, NY 11794 8121, USA
Neurology 60:1923-30. 2003..To determine whether post Lyme syndrome (PLS) is antibiotic responsive...
- Overview of acute and chronic meningitisP K Coyle
Professor, Department of Neurology, School of Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794 8121, USA
Neurol Clin 17:691-710. 1999..Most cases of meningitis are caused by infection. The causal agent is generally predictable based on the type of meningitis, host factors, and clues from the history and examination. CSF examination remains the critical diagnostic test...
- Cognitive dysfunction lateralizes with NAA in multiple sclerosisJ W Pan
Medical Department, Brookhaven National Laboratory, Upton, New York, USA
Appl Neuropsychol 8:155-60. 2001..63, p < .005) for the left periventricular (PV) NAA concentrations with performance on the verbal Selective Reminding Test. Right PVNAA was significantly (p < .02) correlated with the Tower of Hanoi performance, with r = .58...
- Trend for decreasing Multiple Sclerosis Severity Scores (MSSS) with increasing calendar year of enrollment into the New York State Multiple Sclerosis ConsortiumIlya Kister
Multiple Sclerosis Care Center, Department of Neurology, New York University School of Medicine, NYU Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003 3804, USA
Mult Scler 17:725-33. 2011..Although the natural history of multiple sclerosis has been charted extensively, it is still not known whether the trajectory of disability accumulation has changed in the era of disease-modifying therapies (DMTs)...
- Glatiramer acetate in primary progressive multiple sclerosis: results of a multinational, multicenter, double-blind, placebo-controlled trialJerry S Wolinsky
Department of Neurology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Ann Neurol 61:14-24. 2007..To determine whether glatiramer acetate (GA) slows accumulation of disability in primary progressive multiple sclerosis...
- Longitudinal correlates of fatigue in multiple sclerosisE Patrick
Department of Neurology, State University of New York at Stony Brook, New York 11794 8121, USA
Mult Scler 15:258-61. 2009..To determine the predictors of longitudinal changes in fatigue based on pain, mood, and neurological impairment across multiple sclerosis (MS) subtypes...
- Human T lymphocyte response to Borrelia burgdorferi infection: no correlation between human leukocyte function antigen type 1 peptide response and clinical statusRichard S Kalish
Department of Dermatology, State University of New York at Stony Brook, 11794 8165, USA
J Infect Dis 187:102-8. 2003..Reactivity to OspA and LFA-1 was significantly correlated (P<.001) and was observed in 18 (78%) of 23 of OspA-responsive subjects. However, there was no correlation between T cell response to human LFA-1 peptide and clinical status...
- Survey of training programs' means for promoting neurology and attracting traineesJ C Adair
Department of Neurology, University of New Mexico Health Sciences Center and New Mexico Veterans Healthcare System, Albuquerque, NM, USA
Neurology 67:936-9. 2006..To determine neurology training opportunities available to medical students and to define factors that influence program choice...
- Issues and practices in multiple sclerosisJack S Burks
Washoe Institute of Neurosciences, University of Nevada School of Medicine, Reno 89509, USA
Neurorehabil Neural Repair 16:307-20. 2002..This review summarizes the main points of this discussion and is intended to serve as a reference for neurologists involved in the care of patients with MS...
- Increased serum neopterin levels in adults with Down syndromePankaj D Mehta
Department of Immunology, Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
J Neuroimmunol 164:129-33. 2005..This lack of correlation between neopterin and Abeta levels suggests that the higher neopterin concentrations in DS group reflect inflammatory cell activation rather than AD neuropathology...
- Recent advances in the neuroimaging of multiple sclerosisWilliam D Rooney
Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Curr Neurol Neurosci Rep 5:217-24. 2005..Specific disease measures such as endothelial activation, microglial activation, and cell trafficking are accessible to neuroimaging and offer significant promise for improved characterization of central nervous system involvement in MS...
- Preferential presence of decorin-binding protein B (BBA25) and BBA50 antibodies in cerebrospinal fluid of patients with neurologic Lyme diseaseErol Fikrig
Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Clin Microbiol 42:1243-6. 2004..Decorin-binding protein B (BBA25) and BBA50 (hypothetical protein) elicited immunoglobulin G (IgG) or IgM detectable in CSF-but not sera-of patients, demonstrating preferential antibody production during neuroborreliosis...