Affiliation: State University of New York
- Partial truncation of the NH2-terminus affects physical characteristics and membrane binding, aggregation, and fusion properties of annexin A7Devendra G Naidu
Department of Pediatrics, Division of Neonatology, Stony Brook University School of Medicine, Health Sciences Center, T 11, Room 051, Stony Brook, NY 11794 8111, USA
Biochim Biophys Acta 1734:152-68. 2005..We speculate that interactions between the NH2- and COOH-termini are required for membrane binding, and aggregation and fusion properties of annexin A7...
- Synexin and GTP increase surfactant secretion in permeabilized alveolar type II cellsA Chander
Division of Neonatology, Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Am J Physiol Lung Cell Mol Physiol 280:L991-8. 2001..Thus our results support a direct role for synexin in surfactant secretion. Our study also suggests that membrane fusion during surfactant secretion may be mediated by two independent mechanisms...
- Calcium ionophore and phorbol ester increase membrane binding of annexin a7 in alveolar type II cellsAvinash Chander
Department of Pediatrics, Division of Neonatology, State University of New York, Stony Brook, NY 11794 8111, USA
Cell Calcium 33:11-7. 2003..Collectively, our findings suggest that these two agents modify membrane proteins to regulate anx a7 binding, which may facilitate increased membrane fusion activity during stimulation of surfactant secretion...
- Diminished lung compliance and elevated surfactant lipids and proteins in nutritionally obese young ratsL S Inselman
Department of Pediatrics, Division of Pulmonology, Alfred I duPont Hospital for Children, 1600 Rockland Road, Wilmington, Delaware 19899, USA
Lung 182:101-17. 2004..We speculate that intrapulmonary lipid deposition and possible surfactant deficiency relative to alveolar surface area may contribute to the reduction in lung compliance in obese rats...
- Coordinate packaging of newly synthesized phosphatidylcholine and phosphatidylglycerol in lamellar bodies in alveolar type II cellsA Chander
Department of Pediatrics, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Lipids 35:35-43. 2000..We speculate that the newly synthesized surfactant phospholipids, PC, DSPC, and PG, are coordinately transported into lamellar bodies by a mechanism requiring the acidic pH, presumably, of lamellar bodies...
- Mitochondrial localization of catalase provides optimal protection from H2O2-induced cell death in lung epithelial cellsYuko Arita
Department of Pediatrics, CardioPulmonary Research Institute, Winthrop University Hospital, SUNY Stony Brook School of Medicine, Suite 505, 222 Station Plaza North, Mineola, NY 11501, USA
Am J Physiol Lung Cell Mol Physiol 290:L978-86. 2006..This has important implications in antioxidant supplementation trials to prevent ROS-induced lung injury in critically ill patients...
- Exudative lung injury is associated with decreased levels of surfactant proteins in a rat model of meconium aspirationG M Cleary
Division of Neonatal Perinatal Medicine, Department of Pediatrics, Thomas Jefferson University and Hospital, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
Pediatrics 100:998-1003. 1997..This study investigated the delayed effects of meconium on alveolar surfactant phospholipids and protein levels in spontaneously breathing animals...
- Hyperoxia and nitric oxide reduce surfactant components (DSPC and surfactant proteins) and increase apoptosis in adult and fetal rat type II pneumocytesV Bhandari
Department of Pediatrics, Albert Einstein Medical Center, 5501 Old York Road, Philadelphia, PA 19141, USA
Lung 180:301-17. 2002..The effect of hyperoxia and NO could be abrogated with catalase and superoxide dismutase. These findings may have significant clinical implications in the use of NO in premature infants...
- A ten-residue domain (Y11-A20) in the NH2-terminus modulates membrane association of annexin A7Avinash Chander
Department of Pediatrics, Stony Brook University School of Medicine, Stony Brook, NY 11794 8111, USA
Biochim Biophys Acta 1761:775-84. 2006..For binding and fusion of biological membranes, the 10-29-residue domain may be required although the annexin A7 properties are primarily modulated through the Y(11)-A(20) domain...
- A role for diacylglycerol in annexin A7-mediated fusion of lung lamellar bodiesAvinash Chander
Division of Neonatology and the Brady Laboratory, Department of Pediatrics, Stony Brook University Medical Center, Stony Brook, NY 11794, USA
Biochim Biophys Acta 1771:1308-18. 2007..Thus, increased diacylglycerol in lamellar bodies following cell stimulation with secretagogues may enhance membrane fusion activity of annexin A7...
- Leptin enhances lung maturity in the fetal ratSusan M Kirwin
Department of Biomedical Research and Pediatrics, Alfred I. duPont Hospital for Children/Nemours Children's Clinic, Delaware 19803, USA
Pediatr Res 60:200-4. 2006..Collectively, these results suggest that leptin is a cytokine regulator of rat fetal lung maturity...