A Chander

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. ncbi Partial truncation of the NH2-terminus affects physical characteristics and membrane binding, aggregation, and fusion properties of annexin A7
    Devendra G Naidu
    Department of Pediatrics, Division of Neonatology, Stony Brook University School of Medicine, Health Sciences Center, T 11, Room 051, Stony Brook, NY 11794 8111, USA
    Biochim Biophys Acta 1734:152-68. 2005
  2. ncbi Synexin and GTP increase surfactant secretion in permeabilized alveolar type II cells
    A Chander
    Division of Neonatology, Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Physiol Lung Cell Mol Physiol 280:L991-8. 2001
  3. ncbi Calcium ionophore and phorbol ester increase membrane binding of annexin a7 in alveolar type II cells
    Avinash Chander
    Department of Pediatrics, Division of Neonatology, State University of New York, Stony Brook, NY 11794 8111, USA
    Cell Calcium 33:11-7. 2003
  4. ncbi Diminished lung compliance and elevated surfactant lipids and proteins in nutritionally obese young rats
    L S Inselman
    Department of Pediatrics, Division of Pulmonology, Alfred I duPont Hospital for Children, 1600 Rockland Road, Wilmington, Delaware 19899, USA
    Lung 182:101-17. 2004
  5. ncbi Coordinate packaging of newly synthesized phosphatidylcholine and phosphatidylglycerol in lamellar bodies in alveolar type II cells
    A Chander
    Department of Pediatrics, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Lipids 35:35-43. 2000
  6. ncbi Mitochondrial localization of catalase provides optimal protection from H2O2-induced cell death in lung epithelial cells
    Yuko Arita
    Department of Pediatrics, CardioPulmonary Research Institute, Winthrop University Hospital, SUNY Stony Brook School of Medicine, Suite 505, 222 Station Plaza North, Mineola, NY 11501, USA
    Am J Physiol Lung Cell Mol Physiol 290:L978-86. 2006
  7. ncbi Exudative lung injury is associated with decreased levels of surfactant proteins in a rat model of meconium aspiration
    G M Cleary
    Division of Neonatal Perinatal Medicine, Department of Pediatrics, Thomas Jefferson University and Hospital, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Pediatrics 100:998-1003. 1997
  8. ncbi Hyperoxia and nitric oxide reduce surfactant components (DSPC and surfactant proteins) and increase apoptosis in adult and fetal rat type II pneumocytes
    V Bhandari
    Department of Pediatrics, Albert Einstein Medical Center, 5501 Old York Road, Philadelphia, PA 19141, USA
    Lung 180:301-17. 2002
  9. ncbi A ten-residue domain (Y11-A20) in the NH2-terminus modulates membrane association of annexin A7
    Avinash Chander
    Department of Pediatrics, Stony Brook University School of Medicine, Stony Brook, NY 11794 8111, USA
    Biochim Biophys Acta 1761:775-84. 2006
  10. pmc A role for diacylglycerol in annexin A7-mediated fusion of lung lamellar bodies
    Avinash Chander
    Division of Neonatology and the Brady Laboratory, Department of Pediatrics, Stony Brook University Medical Center, Stony Brook, NY 11794, USA
    Biochim Biophys Acta 1771:1308-18. 2007

Collaborators

  • Yuchi Li
  • Jonathan M Davis
  • L S Inselman
  • V Bhandari
  • Alan R Spitzer
  • Susan M Kirwin
  • Yuko Arita
  • Devendra G Naidu
  • Jeffrey A Kazzaz
  • J Andres Melendez
  • S Hella Harkness
  • Darlise Dimatteo
  • Sandra G Hassink
  • Hshi Chi Koo
  • Linda Johnson
  • Saptarashi Paul
  • Ansamma Joseph
  • Vicky L Funanage
  • Carol Barone
  • Xiao Liang Chen
  • Abhijit Raha
  • G M Cleary
  • D A Ciesielka
  • S T Higgins
  • M J Antunes

Detail Information

Publications11

  1. ncbi Partial truncation of the NH2-terminus affects physical characteristics and membrane binding, aggregation, and fusion properties of annexin A7
    Devendra G Naidu
    Department of Pediatrics, Division of Neonatology, Stony Brook University School of Medicine, Health Sciences Center, T 11, Room 051, Stony Brook, NY 11794 8111, USA
    Biochim Biophys Acta 1734:152-68. 2005
    ..We speculate that interactions between the NH2- and COOH-termini are required for membrane binding, and aggregation and fusion properties of annexin A7...
  2. ncbi Synexin and GTP increase surfactant secretion in permeabilized alveolar type II cells
    A Chander
    Division of Neonatology, Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Physiol Lung Cell Mol Physiol 280:L991-8. 2001
    ..Thus our results support a direct role for synexin in surfactant secretion. Our study also suggests that membrane fusion during surfactant secretion may be mediated by two independent mechanisms...
  3. ncbi Calcium ionophore and phorbol ester increase membrane binding of annexin a7 in alveolar type II cells
    Avinash Chander
    Department of Pediatrics, Division of Neonatology, State University of New York, Stony Brook, NY 11794 8111, USA
    Cell Calcium 33:11-7. 2003
    ..Collectively, our findings suggest that these two agents modify membrane proteins to regulate anx a7 binding, which may facilitate increased membrane fusion activity during stimulation of surfactant secretion...
  4. ncbi Diminished lung compliance and elevated surfactant lipids and proteins in nutritionally obese young rats
    L S Inselman
    Department of Pediatrics, Division of Pulmonology, Alfred I duPont Hospital for Children, 1600 Rockland Road, Wilmington, Delaware 19899, USA
    Lung 182:101-17. 2004
    ..We speculate that intrapulmonary lipid deposition and possible surfactant deficiency relative to alveolar surface area may contribute to the reduction in lung compliance in obese rats...
  5. ncbi Coordinate packaging of newly synthesized phosphatidylcholine and phosphatidylglycerol in lamellar bodies in alveolar type II cells
    A Chander
    Department of Pediatrics, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Lipids 35:35-43. 2000
    ..We speculate that the newly synthesized surfactant phospholipids, PC, DSPC, and PG, are coordinately transported into lamellar bodies by a mechanism requiring the acidic pH, presumably, of lamellar bodies...
  6. ncbi Mitochondrial localization of catalase provides optimal protection from H2O2-induced cell death in lung epithelial cells
    Yuko Arita
    Department of Pediatrics, CardioPulmonary Research Institute, Winthrop University Hospital, SUNY Stony Brook School of Medicine, Suite 505, 222 Station Plaza North, Mineola, NY 11501, USA
    Am J Physiol Lung Cell Mol Physiol 290:L978-86. 2006
    ..This has important implications in antioxidant supplementation trials to prevent ROS-induced lung injury in critically ill patients...
  7. ncbi Exudative lung injury is associated with decreased levels of surfactant proteins in a rat model of meconium aspiration
    G M Cleary
    Division of Neonatal Perinatal Medicine, Department of Pediatrics, Thomas Jefferson University and Hospital, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Pediatrics 100:998-1003. 1997
    ..This study investigated the delayed effects of meconium on alveolar surfactant phospholipids and protein levels in spontaneously breathing animals...
  8. ncbi Hyperoxia and nitric oxide reduce surfactant components (DSPC and surfactant proteins) and increase apoptosis in adult and fetal rat type II pneumocytes
    V Bhandari
    Department of Pediatrics, Albert Einstein Medical Center, 5501 Old York Road, Philadelphia, PA 19141, USA
    Lung 180:301-17. 2002
    ..The effect of hyperoxia and NO could be abrogated with catalase and superoxide dismutase. These findings may have significant clinical implications in the use of NO in premature infants...
  9. ncbi A ten-residue domain (Y11-A20) in the NH2-terminus modulates membrane association of annexin A7
    Avinash Chander
    Department of Pediatrics, Stony Brook University School of Medicine, Stony Brook, NY 11794 8111, USA
    Biochim Biophys Acta 1761:775-84. 2006
    ..For binding and fusion of biological membranes, the 10-29-residue domain may be required although the annexin A7 properties are primarily modulated through the Y(11)-A(20) domain...
  10. pmc A role for diacylglycerol in annexin A7-mediated fusion of lung lamellar bodies
    Avinash Chander
    Division of Neonatology and the Brady Laboratory, Department of Pediatrics, Stony Brook University Medical Center, Stony Brook, NY 11794, USA
    Biochim Biophys Acta 1771:1308-18. 2007
    ..Thus, increased diacylglycerol in lamellar bodies following cell stimulation with secretagogues may enhance membrane fusion activity of annexin A7...
  11. ncbi Leptin enhances lung maturity in the fetal rat
    Susan M Kirwin
    Department of Biomedical Research and Pediatrics, Alfred I duPont Hospital for Children Nemours Children s Clinic, Delaware 19803, USA
    Pediatr Res 60:200-4. 2006
    ..Collectively, these results suggest that leptin is a cytokine regulator of rat fetal lung maturity...