Stacy W Blain

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. ncbi request reprint Breast cancer banishes p27 from nucleus
    Stacy W Blain
    Nat Med 8:1076-8. 2002
  2. ncbi request reprint Switching cyclin D-Cdk4 kinase activity on and off
    Stacy W Blain
    Departments of Pediatrics and Anatomy and Cell Biology and Program in Molecular and Cellular Biology of the School of Graduate Studies, SUNY Downstate Medical Center, Brooklyn, New York, USA
    Cell Cycle 7:892-8. 2008
  3. ncbi request reprint p27 as a target for cancer therapeutics
    Stacy W Blain
    Department of Cell Biology and Genetics, Memorial Sloan Kettering Cancer Institute, 1275 York Avenue, New York, NY 10021, USA
    Cancer Cell 3:111-5. 2003
  4. pmc Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity
    Melissa K James
    Department of Pediatrics, SUNY Downstate Medical Center, 450 Clarkson Ave, Box 49, Brooklyn, NY 11203, USA
    Mol Cell Biol 28:498-510. 2008
  5. doi request reprint Chk1 has an essential role in the survival of differentiated cortical neurons in the absence of DNA damage
    Weizhen Ye
    Department of Pediatrics, State University of New York, Downstate Medical Center, Brooklyn, 12003, USA
    Apoptosis 16:449-59. 2011
  6. pmc p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes
    Arpita Ray
    Program in Molecular and Cellular Biology, School of Graduate Studies, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    Mol Cell Biol 29:986-99. 2009
  7. pmc Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma
    Ellen Hukkelhoven
    Gerstner School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 287:38523-30. 2012
  8. pmc S phase entry causes homocysteine-induced death while ataxia telangiectasia and Rad3 related protein functions anti-apoptotically to protect neurons
    Weizhen Ye
    Department of Paediatrics, State University of New York, Downstate Medical Centre, Brooklyn, NY 11203, USA
    Brain 133:2295-312. 2010

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Breast cancer banishes p27 from nucleus
    Stacy W Blain
    Nat Med 8:1076-8. 2002
  2. ncbi request reprint Switching cyclin D-Cdk4 kinase activity on and off
    Stacy W Blain
    Departments of Pediatrics and Anatomy and Cell Biology and Program in Molecular and Cellular Biology of the School of Graduate Studies, SUNY Downstate Medical Center, Brooklyn, New York, USA
    Cell Cycle 7:892-8. 2008
    ..This perspective highlights the significance of this finding in terms of normal cell cycle progression and tumor development...
  3. ncbi request reprint p27 as a target for cancer therapeutics
    Stacy W Blain
    Department of Cell Biology and Genetics, Memorial Sloan Kettering Cancer Institute, 1275 York Avenue, New York, NY 10021, USA
    Cancer Cell 3:111-5. 2003
  4. pmc Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity
    Melissa K James
    Department of Pediatrics, SUNY Downstate Medical Center, 450 Clarkson Ave, Box 49, Brooklyn, NY 11203, USA
    Mol Cell Biol 28:498-510. 2008
    ..These data show that the growth-state-dependent tyrosine phosphorylation of p27 modulates its inhibitory activity in vivo...
  5. doi request reprint Chk1 has an essential role in the survival of differentiated cortical neurons in the absence of DNA damage
    Weizhen Ye
    Department of Pediatrics, State University of New York, Downstate Medical Center, Brooklyn, 12003, USA
    Apoptosis 16:449-59. 2011
    ..Our results indicate that Chk1 is essential for neuronal survival, and perturbation of this pathway increases a cell's sensitivity to naturally accumulating DNA damage...
  6. pmc p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes
    Arpita Ray
    Program in Molecular and Cellular Biology, School of Graduate Studies, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    Mol Cell Biol 29:986-99. 2009
    ....
  7. pmc Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma
    Ellen Hukkelhoven
    Gerstner School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 287:38523-30. 2012
    ..Consequently, we conclude that tyrosine phosphorylation contributes to the conversion of CDK inhibitors from tumor-suppressive roles to oncogenic roles...
  8. pmc S phase entry causes homocysteine-induced death while ataxia telangiectasia and Rad3 related protein functions anti-apoptotically to protect neurons
    Weizhen Ye
    Department of Paediatrics, State University of New York, Downstate Medical Centre, Brooklyn, NY 11203, USA
    Brain 133:2295-312. 2010
    ..As cell cycle events appear to be maintained in vivo in affected neurons for weeks to years before apoptosis is observed, activation of the DNA damage response might be able to hold cell cycle-induced death in check...