Christopher R Bishop

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. ncbi Contribution of the striatum to the effects of 5-HT1A receptor stimulation in L-DOPA-treated hemiparkinsonian rats
    Christopher Bishop
    Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, Binghamton, NY 13902, USA
    J Neurosci Res 87:1645-58. 2009
  2. ncbi MDMA and fenfluramine reduce L-DOPA-induced dyskinesia via indirect 5-HT1A receptor stimulation
    Christopher Bishop
    Behavioural Neuroscience Program, Department of Psychology, State University of New York at Binghamton, 4400 Vestal Parkway East, Binghamton, NY 13902 6000, USA
    Eur J Neurosci 23:2669-76. 2006
  3. ncbi Striatal 5-HT1A receptor stimulation reduces D1 receptor-induced dyskinesia and improves movement in the hemiparkinsonian rat
    Kristin B Dupre
    Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, 4400 Vestal Parkway East, Binghamton, NY 13902 6000, USA
    Neuropharmacology 55:1321-8. 2008
  4. ncbi Serotonin 1B receptor stimulation reduces D1 receptor agonist-induced dyskinesia
    Karen L Eskow Jaunarajs
    Department of Psychology, Binghamton University, State University of New York, Binghamton, New York 13902, USA
    Neuroreport 20:1265-9. 2009
  5. ncbi The partial 5-HT(1A) agonist buspirone reduces the expression and development of l-DOPA-induced dyskinesia in rats and improves l-DOPA efficacy
    Karen L Eskow
    Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, 4400 Vestal Parkway East, Binghamton, NY 13902 6000, USA
    Pharmacol Biochem Behav 87:306-14. 2007
  6. ncbi The differential effects of 5-HT(1A) receptor stimulation on dopamine receptor-mediated abnormal involuntary movements and rotations in the primed hemiparkinsonian rat
    Kristin B Dupre
    Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, 4400 Vestal Parkway East, Binghamton, NY 13902 6000, USA
    Brain Res 1158:135-43. 2007
  7. ncbi Effects of coincident 5-HT1A receptor stimulation and NMDA receptor antagonism on L-DOPA-induced dyskinesia and rotational behaviors in the hemi-parkinsonian rat
    Kristin B Dupre
    Department of Psychology, Behavioral Neuroscience Program, State University of New York at Binghamton, Binghamton, NY 13902 6000, USA
    Psychopharmacology (Berl) 199:99-108. 2008
  8. ncbi Behavioral and neurochemical effects of chronic L-DOPA treatment on nonmotor sequelae in the hemiparkinsonian rat
    Karen L Eskow Jaunarajs
    Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, Binghamton, New York, USA
    Behav Pharmacol 21:627-37. 2010
  9. ncbi The role of the dorsal raphe nucleus in the development, expression, and treatment of L-dopa-induced dyskinesia in hemiparkinsonian rats
    Karen L Eskow
    Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, Binghamton, New York 13902 6000, USA
    Synapse 63:610-20. 2009
  10. ncbi Behavioral and cellular modulation of L-DOPA-induced dyskinesia by beta-adrenoceptor blockade in the 6-hydroxydopamine-lesioned rat
    David Lindenbach
    Behavioral Neuroscience Program, Department of Psychology, Binghamton University, P O Box 6000, Binghamton, NY 13902 6000, USA
    J Pharmacol Exp Ther 337:755-65. 2011

Research Grants

  1. Regulation of L-DOPA-induced dyskinesia by 5-HT1A receptor mechanisms
    Christopher R Bishop; Fiscal Year: 2010

Collaborators

  • Terrence Deak
  • DONALD KUHN
  • G C Parker
  • Kristin B Dupre
  • Karen L Eskow
  • Karen L Eskow Jaunarajs
  • Jennifer L Taylor
  • Christopher J Barnum
  • John Y Park
  • David Lindenbach
  • Corinne Y Ostock
  • Aimee Steiniger
  • Anna Klioueva
  • Paul D Walker
  • Nirmal Bhide
  • Thomas Button
  • Alexander Moore
  • Sando O Dickinson
  • Catherine Kelly
  • Giselle E Negron
  • Lydia Lormand
  • Giselle Negron
  • Salmahn Alam
  • Vikas Gupta
  • Kenner C Rice
  • Thomas Ullrich

Detail Information

Publications16

  1. ncbi Contribution of the striatum to the effects of 5-HT1A receptor stimulation in L-DOPA-treated hemiparkinsonian rats
    Christopher Bishop
    Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, Binghamton, NY 13902, USA
    J Neurosci Res 87:1645-58. 2009
    ..Collectively, these results support the hypothesis that the cellular and behavioral properties of 5-HT1AR agonists are conveyed in part via a population of functional 5-HT1AR within the striatum...
  2. ncbi MDMA and fenfluramine reduce L-DOPA-induced dyskinesia via indirect 5-HT1A receptor stimulation
    Christopher Bishop
    Behavioural Neuroscience Program, Department of Psychology, State University of New York at Binghamton, 4400 Vestal Parkway East, Binghamton, NY 13902 6000, USA
    Eur J Neurosci 23:2669-76. 2006
    ..These results suggest that 5-HT-augmenting compounds such as MDMA and FEN probably convey antidyskinetic properties in part via stimulation of 5-HT1A receptors...
  3. ncbi Striatal 5-HT1A receptor stimulation reduces D1 receptor-induced dyskinesia and improves movement in the hemiparkinsonian rat
    Kristin B Dupre
    Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, 4400 Vestal Parkway East, Binghamton, NY 13902 6000, USA
    Neuropharmacology 55:1321-8. 2008
    ..Collectively, these results support an important functional interaction between 5-HT1AR and D1R in the striatum with implications for the improved treatment of Parkinson's disease...
  4. ncbi Serotonin 1B receptor stimulation reduces D1 receptor agonist-induced dyskinesia
    Karen L Eskow Jaunarajs
    Department of Psychology, Binghamton University, State University of New York, Binghamton, New York 13902, USA
    Neuroreport 20:1265-9. 2009
    ..These findings suggest that 5-HT1B receptor stimulation directly diminishes D1 receptor-mediated dyskinesia, implicating an important target for the treatment of L-DOPA-induced dyskinesia...
  5. ncbi The partial 5-HT(1A) agonist buspirone reduces the expression and development of l-DOPA-induced dyskinesia in rats and improves l-DOPA efficacy
    Karen L Eskow
    Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, 4400 Vestal Parkway East, Binghamton, NY 13902 6000, USA
    Pharmacol Biochem Behav 87:306-14. 2007
    ..In l-DOPA-naïve rats, buspirone delayed LID development while improving l-DOPA's anti-parkinsonian efficacy indicating the potential long-term benefits of 5-HT(1A) agonists for reduction of l-DOPA-related side effects...
  6. ncbi The differential effects of 5-HT(1A) receptor stimulation on dopamine receptor-mediated abnormal involuntary movements and rotations in the primed hemiparkinsonian rat
    Kristin B Dupre
    Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, 4400 Vestal Parkway East, Binghamton, NY 13902 6000, USA
    Brain Res 1158:135-43. 2007
    ....
  7. ncbi Effects of coincident 5-HT1A receptor stimulation and NMDA receptor antagonism on L-DOPA-induced dyskinesia and rotational behaviors in the hemi-parkinsonian rat
    Kristin B Dupre
    Department of Psychology, Behavioral Neuroscience Program, State University of New York at Binghamton, Binghamton, NY 13902 6000, USA
    Psychopharmacology (Berl) 199:99-108. 2008
    ..While the mechanism(s) by which these effects occur are unclear, recent research suggests that modulation of glutamate neurotransmission contributes...
  8. ncbi Behavioral and neurochemical effects of chronic L-DOPA treatment on nonmotor sequelae in the hemiparkinsonian rat
    Karen L Eskow Jaunarajs
    Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, Binghamton, New York, USA
    Behav Pharmacol 21:627-37. 2010
    ....
  9. ncbi The role of the dorsal raphe nucleus in the development, expression, and treatment of L-dopa-induced dyskinesia in hemiparkinsonian rats
    Karen L Eskow
    Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, Binghamton, New York 13902 6000, USA
    Synapse 63:610-20. 2009
    ..These current findings reveal the integral contribution of the RRN in the development and expression of LID and implicate a prominent role for dorsal raphe 5-HT1AR in the efficacious properties of 5-HT1AR agonists...
  10. ncbi Behavioral and cellular modulation of L-DOPA-induced dyskinesia by beta-adrenoceptor blockade in the 6-hydroxydopamine-lesioned rat
    David Lindenbach
    Behavioral Neuroscience Program, Department of Psychology, Binghamton University, P O Box 6000, Binghamton, NY 13902 6000, USA
    J Pharmacol Exp Ther 337:755-65. 2011
    ..This research confirms previous work suggesting that (±)propranolol reduces LID through βAR antagonism and presents novel evidence indicating a potential striatal locus of pharmacological action...
  11. ncbi Estrous cycle and food availability affect feeding induced by amygdala 5-HT receptor blockade
    Graham C Parker
    Department of Psychology, Wayne State University, 71 West Warren Avenue, Detroit, MI 48202, USA
    Pharmacol Biochem Behav 71:701-7. 2002
    ..05) showed rats ate more during the first hour in estrus than in diestrus to lab chow but not Froot Loops. These data suggest pBLA MET differentially affects feeding over the estrous cycle depending on the palatability of food available...
  12. ncbi Serotonin 2A receptor antagonist treatment reduces dopamine D1 receptor-mediated rotational behavior but not L-DOPA-induced abnormal involuntary movements in the unilateral dopamine-depleted rat
    Jennifer L Taylor
    Cellular and Clinical Neurobiology Program, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neuropharmacology 50:761-8. 2006
    ..The finding that M100907 suppresses rotations induced by D1, but not D2, agonists may provide a partial explanation for the lack of effect of a selective 5-HT2A antagonist on l-DOPA-induced AIMs behaviors...
  13. ncbi Dopamine D1 and D2 receptor contributions to L-DOPA-induced dyskinesia in the dopamine-depleted rat
    Jennifer L Taylor
    Cellular and Clinical Neurobiology Program, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Pharmacol Biochem Behav 81:887-93. 2005
    ..01, 0.1 and 1.0 mg/kg), limb (0.1 and 1.0 mg/kg), and orolingual (0.1 and 1.0 mg/kg) AIMs. These results indicate the importance of D1 and D2 receptors to LID and further validate the rat AIMs model...
  14. ncbi Serotonin 5-HT2A but not 5-HT2C receptor antagonism reduces hyperlocomotor activity induced in dopamine-depleted rats by striatal administration of the D1 agonist SKF 82958
    Christopher Bishop
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, 540 East Canfield, Detroit, MI 48201, USA
    Neuropharmacology 49:350-8. 2005
    ..These results indicate that DA depletion strengthens striatal 5-HT2A/D1 receptor interactions and suggest that 5-HT2A receptor antagonists may prove useful in reducing D1-related movements...
  15. ncbi Serotonin 5-HT2A receptors underlie increased motor behaviors induced in dopamine-depleted rats by intrastriatal 5-HT2A/2C agonism
    Christopher Bishop
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, 540 E. Canfield, Detroit, MI 48201, USA
    J Pharmacol Exp Ther 310:687-94. 2004
    ..0 microg]. Such results support the hypothesis that 5-HT(2A) receptor-mediated signaling events are strengthened within the striatum under conditions of DA depletion to provide a more potent regulation of motor activity...
  16. ncbi Intrastriatal serotonin 5-HT2 receptors mediate dopamine D1-induced hyperlocomotion in 6-hydroxydopamine-lesioned rats
    Christopher Bishop
    Department of Anatomy and Cell Biology, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Synapse 50:164-70. 2003
    ....

Research Grants3

  1. Regulation of L-DOPA-induced dyskinesia by 5-HT1A receptor mechanisms
    Christopher R Bishop; Fiscal Year: 2010
    ..Studies of this application will investigate a novel pharmacologic target that shows promise in reducing dyskinesia, prolonging L-DOPA's benefit and improving the quality of life for the PD patient. ..