H Begleiter

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. pmc Description of the data from the Collaborative Study on the Genetics of Alcoholism (COGA) and single-nucleotide polymorphism genotyping for Genetic Analysis Workshop 14
    Howard J Edenberg
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN, USA
    BMC Genet 6:S2. 2005
  2. ncbi request reprint What is inherited in the predisposition toward alcoholism? A proposed model
    H Begleiter
    Department of Psychiatry, State University of New York, Downstate Medical Center, Brooklyn 11203, USA
    Alcohol Clin Exp Res 23:1125-35. 1999
  3. ncbi request reprint Genetics of human brain oscillations
    Henri Begleiter
    Neurodynamics Laboratory, Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Int J Psychophysiol 60:162-71. 2006
  4. ncbi request reprint Quantitative trait loci analysis of human event-related brain potentials: P3 voltage
    H Begleiter
    Department of Psychiatry, SUNY Health Science Center at Brooklyn, NY 11203, USA
    Electroencephalogr Clin Neurophysiol 108:244-50. 1998
  5. ncbi request reprint Familial transmission of substance dependence: alcohol, marijuana, cocaine, and habitual smoking: a report from the Collaborative Study on the Genetics of Alcoholism
    L J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Gen Psychiatry 55:982-8. 1998
  6. ncbi request reprint Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking
    L J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet 90:299-302. 2000
  7. ncbi request reprint The P300 brain potential is reduced in smokers
    A P Anokhin
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA
    Psychopharmacology (Berl) 149:409-13. 2000
  8. ncbi request reprint Auditory P3a deficits in male subjects at high risk for alcoholism
    M Hada
    Department of Psychiatry, SUNY Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    Biol Psychiatry 49:726-38. 2001
  9. ncbi request reprint P300 event-related potential amplitude as an endophenotype of alcoholism--evidence from the collaborative study on the genetics of alcoholism
    V Hesselbrock
    Department of Psychiatry, MC 2103, University of Connecticut School of Medicine, 263 Farmington Ave, Farmington, CT 06030 2103, USA
    J Biomed Sci 8:77-82. 2001
  10. ncbi request reprint A genome screen of maximum number of drinks as an alcoholism phenotype
    N L Saccone
    Department of Psychiatry, Washington University, St Louis, Missouri 63110, USA
    Am J Med Genet 96:632-7. 2000

Research Grants

  1. BRAIN DYSFUNCTION AND ALCHOLISM
    Henri Begleiter; Fiscal Year: 2002
  2. IRPG1 R01 NOVEL PHENOTYPES FOR THE GENETIC ANALYSIS
    Henri Begleiter; Fiscal Year: 2002
  3. BRAIN DYSFUNCTION AND ALCOHOLISM
    Henri Begleiter; Fiscal Year: 2003
  4. BRAIN DYSFUNCTION AND ALCOHOLISM
    Henri Begleiter; Fiscal Year: 1980
  5. COLLABORATIVE STUDY ON THE GENETICS OF ALCOHOLISM/COGA
    Henri Begleiter; Fiscal Year: 2004

Collaborators

Detail Information

Publications62

  1. pmc Description of the data from the Collaborative Study on the Genetics of Alcoholism (COGA) and single-nucleotide polymorphism genotyping for Genetic Analysis Workshop 14
    Howard J Edenberg
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN, USA
    BMC Genet 6:S2. 2005
    ..CIDR, Affymetrix, and Illumina provided single-nucleotide polymorphism genotyping of a large subset of the COGA subjects. This article briefly describes the dataset that was provided...
  2. ncbi request reprint What is inherited in the predisposition toward alcoholism? A proposed model
    H Begleiter
    Department of Psychiatry, State University of New York, Downstate Medical Center, Brooklyn 11203, USA
    Alcohol Clin Exp Res 23:1125-35. 1999
    ..Moreover, these electrophysiological abnormalities are heritable and predictive of future alcohol abuse or dependence...
  3. ncbi request reprint Genetics of human brain oscillations
    Henri Begleiter
    Neurodynamics Laboratory, Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Int J Psychophysiol 60:162-71. 2006
    ..It is concluded that the advent of genomics and proteomics and a fuller understanding of gene regulation will open new horizons on the critical electrical events so essential for human brain function...
  4. ncbi request reprint Quantitative trait loci analysis of human event-related brain potentials: P3 voltage
    H Begleiter
    Department of Psychiatry, SUNY Health Science Center at Brooklyn, NY 11203, USA
    Electroencephalogr Clin Neurophysiol 108:244-50. 1998
    ....
  5. ncbi request reprint Familial transmission of substance dependence: alcohol, marijuana, cocaine, and habitual smoking: a report from the Collaborative Study on the Genetics of Alcoholism
    L J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Gen Psychiatry 55:982-8. 1998
    ..Alcoholism and substance dependence frequently co-occur. Accordingly, we evaluated the familial transmission of alcohol, marijuana, and cocaine dependence and habitual smoking in the Collaborative Study on the Genetics of Alcoholism...
  6. ncbi request reprint Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking
    L J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet 90:299-302. 2000
    ..There also was no evidence for unequal transmission of DRD2 alleles for the phenotypes "ever smoker" or comorbid alcohol dependence and habitual smoking. This study does not support linkage of the DRD2 with smoking...
  7. ncbi request reprint The P300 brain potential is reduced in smokers
    A P Anokhin
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA
    Psychopharmacology (Berl) 149:409-13. 2000
    ..Identification of differences between smokers and non-smokers on basic characteristics of neurocognitive functioning may help to elucidate the mechanisms of tobacco dependence...
  8. ncbi request reprint Auditory P3a deficits in male subjects at high risk for alcoholism
    M Hada
    Department of Psychiatry, SUNY Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    Biol Psychiatry 49:726-38. 2001
    ..The lower P3a amplitude coupled with more disorganized current source density maps suggest inefficient brain functioning in high-risk subjects...
  9. ncbi request reprint P300 event-related potential amplitude as an endophenotype of alcoholism--evidence from the collaborative study on the genetics of alcoholism
    V Hesselbrock
    Department of Psychiatry, MC 2103, University of Connecticut School of Medicine, 263 Farmington Ave, Farmington, CT 06030 2103, USA
    J Biomed Sci 8:77-82. 2001
    ..These data provide significant support for P300 as an endophenotype for alcohol dependence...
  10. ncbi request reprint A genome screen of maximum number of drinks as an alcoholism phenotype
    N L Saccone
    Department of Psychiatry, Washington University, St Louis, Missouri 63110, USA
    Am J Med Genet 96:632-7. 2000
    ..The present analysis on log(M) allows more individuals to be included and thus is potentially more powerful...
  11. ncbi request reprint The genetics of oscillations in the human brain
    B Porjesz
    Department of Psychiatry, Box 1203, SUNY, Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Suppl Clin Neurophysiol 57:441-9. 2004
  12. ncbi request reprint Warp-averaging event-related potentials
    K Wang
    Department of Psychiatry, Box 1203, Neurodynamics Laboratory, SUNY Health Science Center at Brooklyn, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Clin Neurophysiol 112:1917-24. 2001
    ..To align the repeated single trials of the event-related potential (ERP) in order to get an improved estimate of the ERP...
  13. ncbi request reprint Mismatch negativity in subjects at high risk for alcoholism
    X L Zhang
    State University of New York, Health Science Center at Brooklyn, 11203, USA
    Alcohol Clin Exp Res 25:330-7. 2001
    ..The presence of these preexisting central nervous system states may lead to ethanol use for self-medication, which then may facilitate the development of both tolerance to and dependence on ethanol...
  14. ncbi request reprint Visual p3 in female alcoholics
    V R Prabhu
    Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, Brooklyn, New York 11203, USA
    Alcohol Clin Exp Res 25:531-9. 2001
    ..The findings are discussed in terms of functional and physiologic significance of the P3 amplitude in alcoholic women and its relationship to drinking behaviors...
  15. ncbi request reprint Suppression of early evoked gamma band response in male alcoholics during a visual oddball task
    Ajayan Padmanabhapillai
    Department of Psychiatry, Neurodynamics Laboratory, SUNY Health Science Center, Brooklyn, NY, USA
    Int J Psychophysiol 60:15-26. 2006
    ..This perhaps can be characterized by a deficient top-down processing mechanism...
  16. ncbi request reprint Marital status, alcohol dependence, and GABRA2: evidence for gene-environment correlation and interaction
    Danielle M Dick
    Department of Psychiatry, Washington University in St Louis, Box 8134, 660 South Euclid Ave, St Louis, MO 63130, USA
    J Stud Alcohol 67:185-94. 2006
    ..This article explores how this genetic risk factor interacts with marital status, another factor previously shown to be associated with the risk for alcohol dependence...
  17. pmc Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence
    Anthony L Hinrichs
    Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Hum Genet 78:103-11. 2006
    ..6%), whereas 45% of African Americans carry the allele (MAF 26%), which makes it a much more significant risk factor in the African American population...
  18. ncbi request reprint Amplitude modulation of gamma band oscillations at alpha frequency produced by photic driving
    David B Chorlian
    Neurodynamics Laboratory, Department of Psychiatry, SUNY HSCB, 450 Clarkson Ave, Brooklyn, NY, USA
    Int J Psychophysiol 61:262-78. 2006
    ....
  19. ncbi request reprint Endophenotypes successfully lead to gene identification: results from the collaborative study on the genetics of alcoholism
    Danielle M Dick
    Washington University School of Medicine, St Louis, MO, USA
    Behav Genet 36:112-26. 2006
    ..Our results provide an illustration of the successful use of endophenotypes to identify genes involved in the predisposition to a complex psychiatric phenotype, a strategy originally proposed by Gottesman and Shields in 1972...
  20. pmc Event-related oscillations in offspring of alcoholics: neurocognitive disinhibition as a risk for alcoholism
    Chella Kamarajan
    Neurodynamics Laboratory, Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    Biol Psychiatry 59:625-34. 2006
    ....
  21. ncbi request reprint Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample
    Arpana Agrawal
    Department of Psychiatry, Washington University in St Louis, St Louis, MO, USA
    Behav Genet 36:640-50. 2006
    ..There was no association with other genes in the GABAA cluster on chromosome 4 with illicit drug dependence...
  22. ncbi request reprint A cholinergic receptor gene (CHRM2) affects event-related oscillations
    Kevin A Jones
    Department of Psychiatry, SUNY Health Science Center, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USA
    Behav Genet 36:627-39. 2006
    ..These findings underscore the utility of electrophysiology and neurogenetics in the understanding of cognitive function and the study of brain-related disorders...
  23. ncbi request reprint Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task
    Ajayan Padmanabhapillai
    Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, SUNY, HSCB, Brooklyn, NY 11203, USA
    Int J Psychophysiol 62:262-71. 2006
    ..The results indicate that the deficient early evoked gamma band response may precede the development of alcoholism and could be a potential endophenotypic marker of alcoholism risk...
  24. pmc A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs
    Saurabh Ghosh
    Human Genetics Unit, Indian Statistical Institute, Kolkata, India
    Am J Med Genet B Neuropsychiatr Genet 147:1301-5. 2008
    ..We also obtain evidence for epistatic interaction between a region on Chromosome 1 and one on Chromosome 15. Although alcoholism as a covariate does not have any effect on the linkage scan, it has an effect on the epistatic interaction...
  25. ncbi request reprint Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1
    Danielle M Dick
    Washington University in St Louis, St Louis, Missouri, USA
    Alcohol Clin Exp Res 31:1645-53. 2007
    ..Recently the genetic polymorphism most widely analyzed in DRD2, Taq1A, has been discovered to reside in a neighboring gene, ankyrin repeat and kinase domain containing 1 (ANKK1), located 10 kb downstream from DRD2...
  26. ncbi request reprint Genetic influences on bipolar EEG power spectra
    Yongqiang Tang
    Neurodynamics Laboratory, Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USA
    Int J Psychophysiol 65:2-9. 2007
    ..Other heritability patterns were also identified within each frequency band. Our results suggest that substantial proportions of the variability in the bipolar EEG measures are explained by genetic factors...
  27. ncbi request reprint Reduced frontal lobe activity in subjects with high impulsivity and alcoholism
    Andrew C H Chen
    Henri Begleiter Neurodynamics Laboratory, Department of Psychiatry, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Alcohol Clin Exp Res 31:156-65. 2007
    ..This study assessed whether there is a relationship between impulsivity and alcohol dependence, and their correlations with P3 (P300) amplitude, a proposed endophenotype of alcoholism...
  28. ncbi request reprint Heritability of bipolar EEG spectra in a large sib-pair population
    Yongqiang Tang
    Neurodynamics Laboratory, SUNY Downstate Medical Center, Brooklyn, NY, USA
    Behav Genet 37:302-13. 2007
    ..The results from the bipolar derivations are in greater accord with genetic findings in brain anatomy and show the possibility of multiple genetic sources for the phenotypic variability of EEG activity...
  29. ncbi request reprint Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence
    Danielle M Dick
    Department of Psychiatry, Washington University in St Louis, 660 South Euclid Ave, Box 8134, St Louis, MO 63130, USA
    Behav Genet 37:265-72. 2007
    ..These results remain significant after taking into account alcohol dependence and depression diagnoses in the sample...
  30. pmc Delta and theta oscillations as risk markers in adolescent offspring of alcoholics
    Madhavi Rangaswamy
    Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, NY 11203, USA
    Int J Psychophysiol 63:3-15. 2007
    ....
  31. ncbi request reprint Patterns of regional brain activity in alcohol-dependent subjects
    Elizabeth P Hayden
    University of Western Ontario, London, Ontario, Canada
    Alcohol Clin Exp Res 30:1986-91. 2006
    ..It is also unclear whether psychiatric comorbidity in AD subjects accounts for additional variance in frontal asymmetry, beyond a diagnosis of AD alone...
  32. ncbi request reprint S-transform time-frequency analysis of P300 reveals deficits in individuals diagnosed with alcoholism
    Kevin A Jones
    Neurodynamics Laboratory, Department of Psychiatry, SUNY Health Science Center, Brooklyn, New York, NY 11203, USA
    Clin Neurophysiol 117:2128-43. 2006
    ..In this work, we aim to further understand the nature of the event-related oscillation (ERO) components which form the P300 wave and how these components may be used to differentiate alcoholic individuals from controls...
  33. pmc Alcoholism is a disinhibitory disorder: neurophysiological evidence from a Go/No-Go task
    Chella Kamarajan
    Neurodynamics Laboratory, Department of Psychiatry, SUNY Downstate Medical Center, Box 1203, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Biol Psychol 69:353-73. 2005
    ..It is proposed that the No-Go P3, the electrophysiological signature of response inhibition, can be considered as an endophenotypic marker in alcoholism...
  34. pmc Spatial-anatomical mapping of NoGo-P3 in the offspring of alcoholics: evidence of cognitive and neural disinhibition as a risk for alcoholism
    Chella Kamarajan
    Department of Psychiatry, Neurodynamics Laboratory, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Clin Neurophysiol 116:1049-61. 2005
    ..The magnitude and functional mapping of event-related potential P3(00) components were analyzed, in order to examine the possible response inhibition deficits in the offspring of alcoholics...
  35. ncbi request reprint The utility of neurophysiological markers in the study of alcoholism
    Bernice Porjesz
    Neurodynamics Laboratory, Department of Psychiatry, SUNY, Downstate Medical Center, Brooklyn, NY 11203, USA
    Clin Neurophysiol 116:993-1018. 2005
    ..The utility of these neuroelectric measures as endophenotypes for psychiatric genetics is evaluated...
  36. pmc Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus
    Bernice Porjesz
    Department of Psychiatry, State University of New York, Health Science Center, Brooklyn, NY 11203, USA
    Proc Natl Acad Sci U S A 99:3729-33. 2002
    ..Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing...
  37. ncbi request reprint Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprinting
    Jiuzhou Song
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, Indiana 46202 5122, USA
    Am J Med Genet B Neuropsychiatr Genet 117:39-45. 2003
    ..Maternal transmissions provided no evidence for association. These data are consistent with an association between the expressed alleles in the GABA(A)-gene cluster on chromosome 15 and alcoholism that is modulated by genetic imprinting...
  38. ncbi request reprint Functional magnetic resonance imaging of brain activity in the visual oddball task
    Babak A Ardekani
    Center for Advanced Brain Imaging, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Brain Res Cogn Brain Res 14:347-56. 2002
    ..Activation of thalamus, insula, and the occipitotemporal cortex has been reported less consistently. The present study lends further support to the involvement of these structures in visual target detection...
  39. ncbi request reprint Suggestive linkage on chromosome 1 for a quantitative alcohol-related phenotype
    Danielle M Dick
    Indiana University School of Medicine, Indianapolis, Indiana 46202 525, USA
    Alcohol Clin Exp Res 26:1453-60. 2002
    ..Here, we develop quantitative phenotypes that characterize drinking patterns among both alcoholic and nonalcoholic subjects, and use these phenotypes in subsequent linkage analyses...
  40. ncbi request reprint Linkage and linkage disequilibrium mapping of ERP and EEG phenotypes
    Bernice Porjesz
    Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, Box 1203, HSCB, 450 Clarkson Avenue, Brooklyn, NY 11203 2098, USA
    Biol Psychol 61:229-48. 2002
    ..The advent of genomics and proteomics and a fuller understanding of gene regulation, will open new horizons on the critical electrical events so essential for human brain function...
  41. ncbi request reprint Beta power in the EEG of alcoholics
    Madhavi Rangaswamy
    Department of Psychiatry, State University of New York, SUNY Health Sciences Center at Brooklyn, 450 Clarkson Avenue, Brooklyn, NY, USA
    Biol Psychiatry 52:831-42. 2002
    ..In this study, the magnitude and spatial distribution of beta power in the resting electroencephalogram (EEG) were examined to address the possibility of an excitation-inhibition imbalance in the central nervous system of alcoholics...
  42. ncbi request reprint Complexity measures of event related potential surface Laplacian data calculated using the wavelet packet transform
    Kevin Jones
    Department of Psychiatry, SUNY Health Science Center at Brooklyn, 11203, USA
    Brain Topogr 14:333-44. 2002
    ..Parametric and non-parametric analyses show differences in the complexity data which are significant between the control group and the alcoholic and high-risk groups...
  43. ncbi request reprint Alcohol-related ERP changes recorded from different modalities: a topographic analysis
    Howard L Cohen
    Department of Psychiatry, State University of New York, Health Science Center at Brooklyn SUNY HSCB, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Alcohol Clin Exp Res 26:303-17. 2002
    ..The second purpose was to employ current source density (CSD) analyses to investigate topographic differences between alcoholics and controls within each modality...
  44. ncbi request reprint Defining alcohol-related phenotypes in humans. The Collaborative Study on the Genetics of Alcoholism
    Laura Jean Bierut
    Washington University School of Medicine, St Louis, Missouri, USA
    Alcohol Res Health 26:208-13. 2002
    ..Genetic analyses have identified regions on several chromosomes that are associated with these phenotypes and need to be studied further...
  45. ncbi request reprint A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence
    Laura Jean Bierut
    School of Medicine, Washington University School of Medicine, 4940 Children s Place, St Louis, MO 63110, USA
    Am J Med Genet A 124:19-27. 2004
    ..Finally, there is also evidence of an area on chromosome 2 that may reflect a common genetic vulnerability locus to both habitual smoking and alcohol dependence...
  46. ncbi request reprint A functional MRI study of visual oddball: evidence for frontoparietal dysfunction in subjects at risk for alcoholism
    Madhavi Rangaswamy
    Department of Psychiatry, SUNY Health Sciences Center at Brooklyn, State University of New York, Brooklyn, NY 11203, USA
    Neuroimage 21:329-39. 2004
    ..This finding indicates that a dysfunctional frontoparietal circuit may underlie the low P300 responses seen in HR subjects. This perhaps implies a deficiency in the rehearsal component of the working memory system...
  47. ncbi request reprint Alcoholism and human electrophysiology
    Bernice Porjesz
    Department of Psychiatry and Neuroscience, State University of New York, Downstate Medical Center, Brooklyn, New York, USA
    Alcohol Res Health 27:153-60. 2003
    ..These differences are consistent with an imbalance between excitation and inhibition processes in the brains of alcoholics...
  48. pmc The role of brain oscillations as functional correlates of cognitive systems: a study of frontal inhibitory control in alcoholism
    Chella Kamarajan
    Neurodynamics Laboratory, Department of Psychiatry, SUNY Health Science Center, Brooklyn, NY, USA
    Int J Psychophysiol 51:155-80. 2004
    ..A neuro-cognitive model has been provided to explain the findings. It is suggested that the oscillatory correlates during cognitive processing can be an endophenotypic marker in alcoholism...
  49. ncbi request reprint Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: implications for human brain dynamics and cognition
    Kevin A Jones
    Department of Psychiatry, Neurodynamics Laboratory, SUNY Health Science Center, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USA
    Int J Psychophysiol 53:75-90. 2004
    ..001). These findings were not observed for the equivalent non-target case data, suggesting a role for the CHRM2 gene in higher cognitive processing in humans...
  50. pmc Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations
    Howard J Edenberg
    Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Hum Genet 74:705-14. 2004
    ....
  51. ncbi request reprint Resting EEG in offspring of male alcoholics: beta frequencies
    Madhavi Rangaswamy
    Department of Psychiatry, State University of New York, Health Science Center at Brooklyn SUNY HSCB, Box 1203, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Int J Psychophysiol 51:239-51. 2004
    ..The results indicate that increased EEG beta power can be considered as a likely marker of risk for developing alcoholism and may be used as a predictive endophenotype...
  52. ncbi request reprint Association of GABRG3 with alcohol dependence
    Danielle M Dick
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Alcohol Clin Exp Res 28:4-9. 2004
    ..Both linkage and association to the region on chromosome 15q that contains a cluster of GABAA receptor genes have previously been reported, but the role of these genes in alcoholism remains inconclusive...
  53. ncbi request reprint Impulsivity and addiction: a tribute to Henri Begleiter
    Bernice Porjesz
    Henri Begleiter Neurodynamics Laboratory, SUNY Downstate Medical Center, Brooklyn, New York, USA
    ScientificWorldJournal 7:121-3. 2007
  54. ncbi request reprint Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome
    Jen C Wang
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 13:1903-11. 2004
    ..These findings provide strong evidence that variants within or close to the CHRM2 locus influence risk for two common psychiatric disorders...
  55. ncbi request reprint Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis
    Howard J Edenberg
    Indiana University School of Medicine, Indianapolis, USA
    Hum Mol Genet 15:1539-49. 2006
    ..01) There was weaker evidence that variations in ADH1A and ADH1B might also play a role in modifying risk. Among African-Americans, there was evidence that the ADH1B*3 allele was protective...
  56. ncbi request reprint From rats to monkeys to man-the neurophysiology of alcoholism: a tribute to Henri Begleiter
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, California, USA
    Alcohol Clin Exp Res 30:1641-2. 2006
  57. ncbi request reprint High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Boulevard, Rockville, MD 20857, USA
    Arch Gen Psychiatry 63:999-1008. 2006
    ..Alcoholic subjects have low levels of dopamine D(2) receptors in striatum, and increasing D(2) receptor levels in laboratory animals reduces alcohol consumption...
  58. ncbi request reprint Linkage mapping of beta 2 EEG waves via non-parametric regression
    Saurabh Ghosh
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Campus Box 8134, St Louis, MO 63110 1093, USA
    Am J Med Genet B Neuropsychiatr Genet 118:66-71. 2003
    ..While regressing out the effect of alcoholism does not affect the linkage findings, the epistatic interactions become statistically insignificant...
  59. ncbi request reprint Theta power in the EEG of alcoholics
    Madhavi Rangaswamy
    Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, USA
    Alcohol Clin Exp Res 27:607-15. 2003
    ..Some state- and trait-related issues of theta power increases in the EEG of alcoholics were also examined...
  60. ncbi request reprint The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages
    Danielle M Dick
    Department of Psychiatry and Psychology, Washington University School of Medicine, St Louis, MO 63110, USA
    Behav Genet 36:577-90. 2006
    ..GABRA2 is also associated with other drug dependence in our sample, both in adolescence and adulthood...
  61. ncbi request reprint Auditory P3 in female alcoholics
    Sudha Suresh
    Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
    Alcohol Clin Exp Res 27:1064-74. 2003
    ..The characteristics of P3 reduction were further examined by studying the reduction in family history-positive and -negative individuals...
  62. ncbi request reprint Henri Begleiter, 1935-2006
    Ting Kai Li
    1National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
    Neuropsychopharmacology 31:1840. 2006

Research Grants21

  1. BRAIN DYSFUNCTION AND ALCHOLISM
    Henri Begleiter; Fiscal Year: 2002
    ..The electrophysiological results obtained from this application may find that aspects of brain dysfunction (i.e. lack of differential inhibition) may be involved in a predisposition for alcoholism. ..
  2. IRPG1 R01 NOVEL PHENOTYPES FOR THE GENETIC ANALYSIS
    Henri Begleiter; Fiscal Year: 2002
    ..Finally, the eighth IRPG site (Rutgers University) will be responsible for DNA extraction and cell lines, as well as a major repository. ..
  3. BRAIN DYSFUNCTION AND ALCOHOLISM
    Henri Begleiter; Fiscal Year: 2003
    ..We propose to identify brain oscillations that are predictive of relapse and explore the role of neurophysiological features of CNS disinhibition in predicting relapse in alcoholic patients ..
  4. BRAIN DYSFUNCTION AND ALCOHOLISM
    Henri Begleiter; Fiscal Year: 1980
    ..We also plan to retest these patients one year after the initial studies. We propose to conduct parallel studies with neurological patients who have unilateral lesions in either frontal cortex or parietal cortex...
  5. COLLABORATIVE STUDY ON THE GENETICS OF ALCOHOLISM/COGA
    Henri Begleiter; Fiscal Year: 2004
    ..abstract_text> ..