Affiliation: State University of New York
- Effects of space flight conditions on the function of the immune system and catecholamine production simulated in a rodent model of hindlimb unloadingHernan Aviles
Department of Biology, Binghamton University, Binghamton, NY 13902 6000, USA
Neuroimmunomodulation 12:173-81. 2005..Previous studies have indicated that mice exposed to hindlimb-unloading conditions have decreased resistance to infections compared to restrained and normally housed control mice...
- Active hexose correlated compound activates immune function to decrease bacterial load in a murine model of intramuscular infectionHernan Aviles
Department of Biological Sciences, Binghamton University, State University of New York, 85 Murray Hill Rd, Binghamton, NY 13902 6000, USA
Am J Surg 195:537-45. 2008..The objective of this study was to clarify the mechanisms by which active hexose correlated compound (AHCC) increases survival in a murine model of intramuscular infection...
- Active hexose correlated compound (AHCC) enhances resistance to infection in a mouse model of surgical wound infectionHernan Aviles
Department of Biological Sciences, State University of New York at Binghamton, Binghamton, New York 13902 6000, USA
Surg Infect (Larchmt) 7:527-35. 2006..The objective of this study was to test the prophylactic effects of oral administration of active hexose correlated compound (AHCC), a natural immunoenhancer, on survival in a mouse model of surgical soft tissue infection...
- Kinetics of systemic cytokine and brain chemokine gene expression in murine toxoplasma infectionHernan Aviles
Department of Biological Sciences, Northern Arizona University, Arizona, USA
J Parasitol 94:1282-8. 2008..The early production of IFN-gamma and the delayed expression of CXCR4 and CXCR5 indicate that T. gondii induces an early robust cellular immune response, followed by a strong and sustained antibody-mediated immunity...
- Enhancement of in vitro growth of pathogenic bacteria by norepinephrine: importance of inoculum density and role of transferrinPhyllis M O'Donnell
Department of Biological Sciences, Binghamton University, State University of New York, Binghamton, NY 13902 6000, USA
Appl Environ Microbiol 72:5097-9. 2006..The results indicated that a reduced inoculum density is essential for observing norepinephrine-induced effects. Additional studies using serum-free media suggested that transferrin plays a role in norepinephrine-induced growth...
- Active hexose correlated compound enhances the immune function of mice in the hindlimb-unloading model of spaceflight conditionsHernan Aviles
Morehouse U, Atlanta, GA
J Appl Physiol 97:1437-44. 2004..These findings suggest that AHCC can be used as a potent immunoenhancer, especially in cases in which the immune system is suppressed by any condition, including diseases such as human immunodeficiency virus infection and cancer...
- Active hexose correlated compound enhances resistance to Klebsiella pneumoniae infection in mice in the hindlimb-unloading model of spaceflight conditionsHernan Aviles
Department of Microbiology, Morehouse School of Medicine, Atlanta, GA 30310-1495, USA
J Appl Physiol 95:491-6. 2003..decreased mortality, 2). increased time to death, and 3). increased ability to clear bacteria. The results suggest that AHCC can decrease the deleterious effects of the hindlimb-unloading model on immunity and resistance to infection...
- Increased susceptibility to Pseudomonas aeruginosa infection under hindlimb-unloading conditionsHernan Aviles
Morehouse U Sch Med, Atlanta, GA
J Appl Physiol 95:73-80. 2003..These results suggest that hindlimb unloading may induce the production of corticosterone, which may play a critical role in the modulation of the immune system leading to increased susceptibility to P. aeruginosa infection...
- Effects of the hindlimb-unloading model of spaceflight conditions on resistance of mice to infection with Klebsiella pneumoniaeTesfaye Belay
Morehouse Sch Med, Atlanta, GA
J Allergy Clin Immunol 110:262-8. 2002..The complex physiologic changes observed during hindlimb unloading, including stress, have a key role in the pathophysiology of this infection...
- Catecholamines and in vitro growth of pathogenic bacteria: enhancement of growth varies greatly among bacterial speciesTesfaye Belay
Morehouse Sch Med, Atlanta, GA
Life Sci 73:1527-35. 2003..The results of the present study extend previous observations that showed differential capability of catecholamines to enhance bacterial growth in vitro...