Research Topics
Genomes and GenesSpecies | M J WebsterSummaryAffiliation: Stanley Medical Research Institute Country: USA Publications
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Detail Information
Publications
Synaptophysin and GAP-43 mRNA levels in the hippocampus of subjects with schizophreniaM J Webster
Stanley Foundation Research Program, Department of Psychiatry, Uniformed Services University for the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
Schizophr Res 49:89-98. 2001..GAP-43 mRNA levels were not significantly reduced in either group. The implications of these findings are discussed in relation to neuroleptic treatment and the pathophysiology of mental illness...- Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disordersM J Webster
Stanley Foundation Laboratory of Brain Research, Department of Psychiatry, Uniformed Services University of Health Sciences, Bethesda, MD 20814 4799, USA
Mol Psychiatry 7:985-94, 924. 2002..The severity and heterogeneity of this reduction may underlie some of the clinical heterogeneity seen in these disorders... - Infectious pathogen detection arrays: viral detection in cell lines and postmortem brain tissueConcepcion Conejero-Goldberg
Stanley Brain Research Laboratory, Clinical Center, National Institutes of Health, Bethesda, MD, USA
Biotechniques 39:741-51. 2005..This method may be used to provide evidence of viral infection in postmortem tissue from psychiatric patients as well as a wide range of other diagnostic categories... - BDNF and trkB mRNA expression in the hippocampus and temporal cortex during the human lifespanM J Webster
Stanley Laboratory of Brain Research, USUHS, Bethesda, MD 20814, USA
Gene Expr Patterns 6:941-51. 2006.... 
Developmental changes in human dopamine neurotransmission: cortical receptors and terminatorsDebora A Rothmond
Schizophrenia Research Institute, 405 Liverpool St, Darlinghurst NSW 2010 AU
BMC Neurosci 13:18. 2012....- Effects of typical and atypical antipsychotic drugs on gene expression profiles in the liver of schizophrenia subjectsKwang H Choi
Stanley Laboratory of Brain Research, Rockville, MD 20850, USA
BMC Psychiatry 9:57. 2009..Although much progress has been made on antipsychotic drug development, precise mechanisms behind the action of typical and atypical antipsychotics are poorly understood... - Putative psychosis genes in the prefrontal cortex: combined analysis of gene expression microarraysKwang Ho Choi
Stanley Laboratory of Brain Research, 9800 Medical Center Dr Bldg 2C, Rockville, MD 20850, USA
BMC Psychiatry 8:87. 2008..Bipolar disorder with psychotic features may be closely related to schizophrenia and therefore, psychosis may be an alternative phenotype compared to the traditional diagnosis categories... - Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophreniaLaura W Harris
Institute of Biotechnology, University of Cambridge, Cambridge, UK
BMC Med Genomics 2:28. 2009..CONCLUSION: The observed changes imply that molecular mechanisms critical for adolescent brain development are disturbed in schizophrenia patients... - Tissue preparation and bankingMaree J Webster
Stanley Laboratory of Brain Research, Department of Psychiatry, USUHS, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
Prog Brain Res 158:3-14. 2006..Moreover, the lower pH of these groups is not entirely due to agonal factors and/or smoking, indicating that these subjects may have additional metabolic abnormalities that contribute to the lower pH values... - BDNF mRNA expression during postnatal development, maturation and aging of the human prefrontal cortexMaree J Webster
Stanley Laboratory of Brain Research, Department of Psychiatry, Uniformed Services University for the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 4799, USA
Brain Res Dev Brain Res 139:139-50. 2002..The increase in BDNF at this critical time in human development may have important implications for the etiology and treatment of the severe mental disorders that tend to present during this time... 
Molecular evidence that cortical synaptic growth predominates during the first decade of life in humansMaree J Webster
Stanley Medical Research Institute, 9800 Medical Center Drive, Rockville, MD 20850, USA
Int J Dev Neurosci 29:225-36. 2011....- Reduced GAP-43 mRNA in dorsolateral prefrontal cortex of patients with schizophreniaC S Weickert
Clinical Brain Disorders Branch, IRP NIMH NIH, Bldg 10, Rm 4N 308, Bethesda, MD 20892 1385, USA
Cereb Cortex 11:136-47. 2001.... - Postnatal alterations in dopaminergic markers in the human prefrontal cortexC S Weickert
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Boulevard, Building 10, CRC6 5340, Bethesda, MD 20892, USA
Neuroscience 144:1109-19. 2007..The peak in DAR1 mRNA levels around adolescence/early adulthood may be of particular relevance to neuropsychiatric disorders such as schizophrenia in which symptoms manifest during the same developmental period... - Multivariate analysis of prefrontal cortical data from the Stanley Foundation Neuropathology ConsortiumM B Knable
Stanley Foundation Research Programs, Bethesda, MD 20814, USA
Brain Res Bull 55:651-9. 2001..It is argued that the abnormal findings are not simply due to stochastic processes but represent viable markers for independent replication and further study as candidate genes or targets for new treatments... - Localization of epidermal growth factor receptors and putative neuroblasts in human subependymal zoneC S Weickert
Clinical Brain Disorders Branch, IRP NIMH NIH, NIMH, Bethesda, Maryland 20892 1385, USA
J Comp Neurol 423:359-72. 2000..Our results show that neuroblast-like cells exist in the human SEZ and support the theory that SEZ of postnatal human brain has neurogenic potential... - Glial fibrillary acidic protein mRNA levels in the cingulate cortex of individuals with depression, bipolar disorder and schizophreniaM J Webster
Stanley Lab of Brain Research, Department of Psychiatry, Uniformed Services University for the Health Sciences, Bethesda, MD 20814 4799, USA
Neuroscience 133:453-61. 2005..Thus, astrocytes positive for GFAP may contribute to the decrease in glial density previously described in subjects with major mental illness, however the relative contribution of astrocytes may vary with diagnosis... - Expression of estrogen receptor alpha exon-deleted mRNA variants in the human and non-human primate frontal cortexW R Perlman
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD 20892 1385, USA
Neuroscience 134:81-95. 2005.... - Alterations in trkB mRNA in the human prefrontal cortex throughout the lifespanT B Romanczyk
Clinical Brain Disorders Branch, IRP, NIMH, NIH, Building 10 4 N312, MSC 1385, Bethesda, MD 20892 1385, USA
Eur J Neurosci 15:269-80. 2002..The results suggest that neurons in the human dorsolateral prefrontal cortex are responsive to neurotrophins throughout postnatal life and that this responsiveness may be modulated during the human lifespan... - Immunohistochemical localization of phosphorylated glial fibrillary acidic protein in the prefrontal cortex and hippocampus from patients with schizophrenia, bipolar disorder, and depressionM J Webster
Stanley Laboratory of Brain Research, USUHS, 4301 Jones Bridge Road, Bethesda, Maryland 20814, USA
Brain Behav Immun 15:388-400. 2001..The mechanism by which this deficit occurs is not known, but it may adversely effect the regulation of neuronal metabolism, communication, and response to injury... - Correlation analysis between genome-wide expression profiles and cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disordersS Kim
Stanley Brain Research Laboratory, Stanley Medical Research Institute, Rockville, MD 20850, USA
Mol Psychiatry 15:326-36. 2010.... - Association between SNPs and gene expression in multiple regions of the human brainS Kim
Stanley Brain Research Laboratory, Stanley Medical Research Institute, Rockville, MD 20850, USA
Transl Psychiatry 2:e113. 2012..stanleyresearch.org)... - Immunohistochemical localization of the cell adhesion molecules Thy-1 and L1 in the human prefrontal cortex patients with schizophrenia, bipolar disorder, and depressionM J Webster
Stanley Foundation Research Program, Neuroscience Center at St Elizabeths, Washington, DC 20032, USA
Mol Psychiatry 4:46-52. 1999..Quantifying the intensity of immunostaining in the prefrontal cortex of patients with schizophrenia, bipolar disorder and depression failed to reveal any significant differences when compared to that of normal controls... - Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disordersS Kim
Stanley Brain Research Laboratory, Stanley Medical Research Institute, Rockville, MD 20850, USA
Mol Psychiatry 16:452-61. 2011..Our findings may provide novel insights into the genetic causalities associated with cytoarchitectural abnormalities in the PFC of subjects with major psychiatric disorders as well as into the etiology of such disorders... - Molecular abnormalities in the major psychiatric illnesses: Classification and Regression Tree (CRT) analysis of post-mortem prefrontal markersM B Knable
Stanley Foundation Research Programs, Bethesda, MD 20814, USA
Mol Psychiatry 7:392-404. 2002..Three of the nine markers observed with CRT overlapped with the ANOVA results. Six of the nine markers observed with the CRT technique pertained to aspects of glutamatergic, GABA-ergic, and dopaminergic neurotransmission... - Elevated neuregulin-1 and ErbB4 protein in the prefrontal cortex of schizophrenic patientsVictor Z Chong
MiNDS Unit, CBDB, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg 10, Bethesda, MD 20892, USA
Schizophr Res 100:270-80. 2008..We hypothesize that ErbB4 proteolytic processing may also be altered in schizophrenia, yielding altered ratios of functionally distinct forms of ErbB4... - Decreased expression of mineralocorticoid receptor mRNA in the prefrontal cortex in schizophrenia and bipolar disorderGuo Qiang Xing
Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Int J Neuropsychopharmacol 7:143-53. 2004..Whether these findings may be linked to the abnormal prefrontal function, HPA axis activation, or the deficits in SWS found in these major psychiatric illnesses remains to be further explored... - Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology ConsortiumMichael B Knable
The Stanley Medical Research Institute, Bethesda, MD 20814, USA
Mol Psychiatry 9:609-20, 544. 2004.... - Changes in NMDA receptor subunit mRNAs and cyclophilin mRNA during development of the human hippocampusAmanda J Law
Department of Psychiatry, University of Oxford, OX3 7JX, United Kingdom
Ann N Y Acad Sci 1003:426-30. 2003 - Oligodendrocyte dysfunction in schizophrenia and bipolar disorderDmitri Tkachev
Department of Neurobiology, Babraham Institute, Cambridge, UK
Lancet 362:798-805. 2003..Our study also showed similar expression changes to the schizophrenia group in bipolar brains, which thus lends support to the notion that the disorders share common causative and pathophysiological pathways... - Expression of NMDA receptor NR1, NR2A and NR2B subunit mRNAs during development of the human hippocampal formationAmanda J Law
Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
Eur J Neurosci 18:1197-205. 2003..Changes in subunit composition may thus contribute to maturational differences in human hippocampal N-methyl-d-aspartate receptor function, and to their role in the pathophysiology of schizophrenia and other neurodevelopmental disorders... - Meta-analysis of 12 genomic studies in bipolar disorderMichael Elashoff
Elashoff Consulting, Germantown, MD 20876, USA
J Mol Neurosci 31:221-43. 2007..In addition to these general conclusions, we also summarize the primary biological findings of the meta-analysis, focusing on areas that confirm previous research and also on novel findings... - Discordant changes in cortical TrkC mRNA and protein during the human lifespanSenda Beltaifa
Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
Eur J Neurosci 21:2433-44. 2005..Our results suggest that truncated trkC is prevalent in the human PFC and that neurons and glia may be responsive to NT-3 in the PFC throughout life... - Deficient hippocampal neuron expression of proteasome, ubiquitin, and mitochondrial genes in multiple schizophrenia cohortsC Anthony Altar
Psychiatric Genomics, Inc, Gaithersburg, Maryland 20878, USA
Biol Psychiatry 58:85-96. 2005..Hippocampal dentate granule neurons are altered in schizophrenia, but it is unknown if their gene expressions change in schizophrenia or other psychiatric diseases... - Alteration in estrogen receptor alpha mRNA levels in frontal cortex and hippocampus of patients with major mental illnessWilliam R Perlman
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U.S. Department of Health and Human Services, MD 20892-1385, USA
Biol Psychiatry 58:812-24. 2005..CONCLUSIONS: Our results suggest that alterations in ERalpha mRNA levels exist in distinct telencephalic regions in male and female MDD patients, and in both genders in schizophrenia... - Age-related differences in glucocorticoid receptor mRNA levels in the human brainWilliam R Perlman
MiNDS Unit, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 1385, USA
Neurobiol Aging 28:447-58. 2007..Increased GR mRNA in prefrontal cortex during adolescence and adulthood suggests that human GR-mediated forebrain regulation of cognition and the neuroendocrine stress response may be more salient during late maturation and at maturity... - Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brainsE Fuller Torrey
Stanley Medical Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
Biol Psychiatry 57:252-60. 2005..Previous studies of postmortem neurochemical markers in severe psychiatric disorders have been carried out on different brain collections, making it difficult to compare results... - Synaptophysin protein and mRNA expression in the human hippocampal formation from birth to old ageSharon L Eastwood
Department of Psychiatry of the University of Oxford, Neurosciences Building, Warneford Hospital, Oxford, United Kingdom
Hippocampus 16:645-54. 2006.... - Reduced glucocorticoid and estrogen receptor alpha messenger ribonucleic acid levels in the amygdala of patients with major mental illnessWilliam R Perlman
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland, USA
Biol Psychiatry 56:844-52. 2004..We also hypothesized that estrogen receptor alpha (ERalpha) mRNA expression might be altered in the amygdala, on the basis of observed gender differences in mental illness... - Application and optimization of microarray technologies for human postmortem brain studiesMargaret M Ryan
Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, United Kingdom
Biol Psychiatry 55:329-36. 2004.... - Widespread expression of ErbB2, ErbB3 and ErbB4 in non-human primate brainMia Thompson
MiNDS Unit Clinical Brain Disorders Branch, IRP NIMH NIH, NIH, Mail Stop 1385, Building 10 Room 4D18, Bethesda, MD 20892, USA
Brain Res 1139:95-109. 2007..The ubiquitous expression of ErbB receptors indicates that many cell populations throughout the brain of juvenile and adult primates have the potential to respond to NRG-1 in a variety of ways...