M J Webster

Summary

Affiliation: Stanley Medical Research Institute
Country: USA

Publications

  1. ncbi request reprint Synaptophysin and GAP-43 mRNA levels in the hippocampus of subjects with schizophrenia
    M J Webster
    Stanley Foundation Research Program, Department of Psychiatry, Uniformed Services University for the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
    Schizophr Res 49:89-98. 2001
  2. ncbi request reprint Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders
    M J Webster
    Stanley Foundation Laboratory of Brain Research, Department of Psychiatry, Uniformed Services University of Health Sciences, Bethesda, MD 20814 4799, USA
    Mol Psychiatry 7:985-94, 924. 2002
  3. ncbi request reprint Infectious pathogen detection arrays: viral detection in cell lines and postmortem brain tissue
    Concepcion Conejero-Goldberg
    Stanley Brain Research Laboratory, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Biotechniques 39:741-51. 2005
  4. ncbi request reprint BDNF and trkB mRNA expression in the hippocampus and temporal cortex during the human lifespan
    M J Webster
    Stanley Laboratory of Brain Research, USUHS, Bethesda, MD 20814, USA
    Gene Expr Patterns 6:941-51. 2006
  5. pmc Association between SNPs and gene expression in multiple regions of the human brain
    S Kim
    Stanley Brain Research Laboratory, Stanley Medical Research Institute, Rockville, MD 20850, USA
    Transl Psychiatry 2:e113. 2012
  6. pmc Glucocorticoid receptor mRNA and protein isoform alterations in the orbitofrontal cortex in schizophrenia and bipolar disorder
    Duncan Sinclair
    Schizophrenia Research Institute, Liverpool St, Darlinghurst, NSW, 2011, Australia
    BMC Psychiatry 12:84. 2012
  7. pmc Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex
    Leonora E Long
    Schizophrenia Research Institute, Darlinghurst, NSW 2010, Australia
    BMC Neurosci 13:87. 2012
  8. pmc Developmental changes in human dopamine neurotransmission: cortical receptors and terminators
    Debora A Rothmond
    Schizophrenia Research Institute, 405 Liverpool St, Darlinghurst NSW 2010 AU
    BMC Neurosci 13:18. 2012
  9. pmc Effects of typical and atypical antipsychotic drugs on gene expression profiles in the liver of schizophrenia subjects
    Kwang H Choi
    Stanley Laboratory of Brain Research, Rockville, MD 20850, USA
    BMC Psychiatry 9:57. 2009
  10. pmc Putative psychosis genes in the prefrontal cortex: combined analysis of gene expression microarrays
    Kwang Ho Choi
    Stanley Laboratory of Brain Research, 9800 Medical Center Dr Bldg 2C, Rockville, MD 20850, USA
    BMC Psychiatry 8:87. 2008

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Synaptophysin and GAP-43 mRNA levels in the hippocampus of subjects with schizophrenia
    M J Webster
    Stanley Foundation Research Program, Department of Psychiatry, Uniformed Services University for the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
    Schizophr Res 49:89-98. 2001
    ..GAP-43 mRNA levels were not significantly reduced in either group. The implications of these findings are discussed in relation to neuroleptic treatment and the pathophysiology of mental illness...
  2. ncbi request reprint Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders
    M J Webster
    Stanley Foundation Laboratory of Brain Research, Department of Psychiatry, Uniformed Services University of Health Sciences, Bethesda, MD 20814 4799, USA
    Mol Psychiatry 7:985-94, 924. 2002
    ..The severity and heterogeneity of this reduction may underlie some of the clinical heterogeneity seen in these disorders...
  3. ncbi request reprint Infectious pathogen detection arrays: viral detection in cell lines and postmortem brain tissue
    Concepcion Conejero-Goldberg
    Stanley Brain Research Laboratory, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Biotechniques 39:741-51. 2005
    ..This method may be used to provide evidence of viral infection in postmortem tissue from psychiatric patients as well as a wide range of other diagnostic categories...
  4. ncbi request reprint BDNF and trkB mRNA expression in the hippocampus and temporal cortex during the human lifespan
    M J Webster
    Stanley Laboratory of Brain Research, USUHS, Bethesda, MD 20814, USA
    Gene Expr Patterns 6:941-51. 2006
    ....
  5. pmc Association between SNPs and gene expression in multiple regions of the human brain
    S Kim
    Stanley Brain Research Laboratory, Stanley Medical Research Institute, Rockville, MD 20850, USA
    Transl Psychiatry 2:e113. 2012
    ..stanleyresearch.org)...
  6. pmc Glucocorticoid receptor mRNA and protein isoform alterations in the orbitofrontal cortex in schizophrenia and bipolar disorder
    Duncan Sinclair
    Schizophrenia Research Institute, Liverpool St, Darlinghurst, NSW, 2011, Australia
    BMC Psychiatry 12:84. 2012
    ..A critical component of the HPA axis which mediates cellular stress responses in the OFC, and has been implicated in psychiatric illness, is the glucocorticoid receptor (GR)...
  7. pmc Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex
    Leonora E Long
    Schizophrenia Research Institute, Darlinghurst, NSW 2010, Australia
    BMC Neurosci 13:87. 2012
    ....
  8. pmc Developmental changes in human dopamine neurotransmission: cortical receptors and terminators
    Debora A Rothmond
    Schizophrenia Research Institute, 405 Liverpool St, Darlinghurst NSW 2010 AU
    BMC Neurosci 13:18. 2012
    ....
  9. pmc Effects of typical and atypical antipsychotic drugs on gene expression profiles in the liver of schizophrenia subjects
    Kwang H Choi
    Stanley Laboratory of Brain Research, Rockville, MD 20850, USA
    BMC Psychiatry 9:57. 2009
    ..Although much progress has been made on antipsychotic drug development, precise mechanisms behind the action of typical and atypical antipsychotics are poorly understood...
  10. pmc Putative psychosis genes in the prefrontal cortex: combined analysis of gene expression microarrays
    Kwang Ho Choi
    Stanley Laboratory of Brain Research, 9800 Medical Center Dr Bldg 2C, Rockville, MD 20850, USA
    BMC Psychiatry 8:87. 2008
    ..Bipolar disorder with psychotic features may be closely related to schizophrenia and therefore, psychosis may be an alternative phenotype compared to the traditional diagnosis categories...
  11. pmc Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia
    Laura W Harris
    Institute of Biotechnology, University of Cambridge, Cambridge, UK
    BMC Med Genomics 2:28. 2009
    ..CONCLUSION: The observed changes imply that molecular mechanisms critical for adolescent brain development are disturbed in schizophrenia patients...
  12. ncbi request reprint Tissue preparation and banking
    Maree J Webster
    Stanley Laboratory of Brain Research, Department of Psychiatry, USUHS, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Prog Brain Res 158:3-14. 2006
    ..Moreover, the lower pH of these groups is not entirely due to agonal factors and/or smoking, indicating that these subjects may have additional metabolic abnormalities that contribute to the lower pH values...
  13. doi request reprint Molecular evidence that cortical synaptic growth predominates during the first decade of life in humans
    Maree J Webster
    Stanley Medical Research Institute, 9800 Medical Center Drive, Rockville, MD 20850, USA
    Int J Dev Neurosci 29:225-36. 2011
    ....
  14. ncbi request reprint BDNF mRNA expression during postnatal development, maturation and aging of the human prefrontal cortex
    Maree J Webster
    Stanley Laboratory of Brain Research, Department of Psychiatry, Uniformed Services University for the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 4799, USA
    Brain Res Dev Brain Res 139:139-50. 2002
    ..The increase in BDNF at this critical time in human development may have important implications for the etiology and treatment of the severe mental disorders that tend to present during this time...
  15. ncbi request reprint Reduced GAP-43 mRNA in dorsolateral prefrontal cortex of patients with schizophrenia
    C S Weickert
    Clinical Brain Disorders Branch, IRP NIMH NIH, Bldg 10, Rm 4N 308, Bethesda, MD 20892 1385, USA
    Cereb Cortex 11:136-47. 2001
    ....
  16. ncbi request reprint Postnatal alterations in dopaminergic markers in the human prefrontal cortex
    C S Weickert
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Boulevard, Building 10, CRC6 5340, Bethesda, MD 20892, USA
    Neuroscience 144:1109-19. 2007
    ..The peak in DAR1 mRNA levels around adolescence/early adulthood may be of particular relevance to neuropsychiatric disorders such as schizophrenia in which symptoms manifest during the same developmental period...
  17. doi request reprint Correlation analysis between genome-wide expression profiles and cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders
    S Kim
    Stanley Brain Research Laboratory, Stanley Medical Research Institute, Rockville, MD 20850, USA
    Mol Psychiatry 15:326-36. 2010
    ....
  18. ncbi request reprint Multivariate analysis of prefrontal cortical data from the Stanley Foundation Neuropathology Consortium
    M B Knable
    Stanley Foundation Research Programs, Bethesda, MD 20814, USA
    Brain Res Bull 55:651-9. 2001
    ..It is argued that the abnormal findings are not simply due to stochastic processes but represent viable markers for independent replication and further study as candidate genes or targets for new treatments...
  19. ncbi request reprint Localization of epidermal growth factor receptors and putative neuroblasts in human subependymal zone
    C S Weickert
    Clinical Brain Disorders Branch, IRP NIMH NIH, NIMH, Bethesda, Maryland 20892 1385, USA
    J Comp Neurol 423:359-72. 2000
    ..Our results show that neuroblast-like cells exist in the human SEZ and support the theory that SEZ of postnatal human brain has neurogenic potential...
  20. ncbi request reprint Expression of estrogen receptor alpha exon-deleted mRNA variants in the human and non-human primate frontal cortex
    W R Perlman
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD 20892 1385, USA
    Neuroscience 134:81-95. 2005
    ....
  21. ncbi request reprint Glial fibrillary acidic protein mRNA levels in the cingulate cortex of individuals with depression, bipolar disorder and schizophrenia
    M J Webster
    Stanley Lab of Brain Research, Department of Psychiatry, Uniformed Services University for the Health Sciences, Bethesda, MD 20814 4799, USA
    Neuroscience 133:453-61. 2005
    ..Thus, astrocytes positive for GFAP may contribute to the decrease in glial density previously described in subjects with major mental illness, however the relative contribution of astrocytes may vary with diagnosis...
  22. ncbi request reprint Alterations in trkB mRNA in the human prefrontal cortex throughout the lifespan
    T B Romanczyk
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Building 10 4 N312, MSC 1385, Bethesda, MD 20892 1385, USA
    Eur J Neurosci 15:269-80. 2002
    ..The results suggest that neurons in the human dorsolateral prefrontal cortex are responsive to neurotrophins throughout postnatal life and that this responsiveness may be modulated during the human lifespan...
  23. ncbi request reprint Immunohistochemical localization of phosphorylated glial fibrillary acidic protein in the prefrontal cortex and hippocampus from patients with schizophrenia, bipolar disorder, and depression
    M J Webster
    Stanley Laboratory of Brain Research, USUHS, 4301 Jones Bridge Road, Bethesda, Maryland 20814, USA
    Brain Behav Immun 15:388-400. 2001
    ..The mechanism by which this deficit occurs is not known, but it may adversely effect the regulation of neuronal metabolism, communication, and response to injury...
  24. doi request reprint Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders
    S Kim
    Stanley Brain Research Laboratory, Stanley Medical Research Institute, Rockville, MD 20850, USA
    Mol Psychiatry 16:452-61. 2011
    ..Our findings may provide novel insights into the genetic causalities associated with cytoarchitectural abnormalities in the PFC of subjects with major psychiatric disorders as well as into the etiology of such disorders...
  25. ncbi request reprint Immunohistochemical localization of the cell adhesion molecules Thy-1 and L1 in the human prefrontal cortex patients with schizophrenia, bipolar disorder, and depression
    M J Webster
    Stanley Foundation Research Program, Neuroscience Center at St Elizabeths, Washington, DC 20032, USA
    Mol Psychiatry 4:46-52. 1999
    ..Quantifying the intensity of immunostaining in the prefrontal cortex of patients with schizophrenia, bipolar disorder and depression failed to reveal any significant differences when compared to that of normal controls...
  26. ncbi request reprint Molecular abnormalities in the major psychiatric illnesses: Classification and Regression Tree (CRT) analysis of post-mortem prefrontal markers
    M B Knable
    Stanley Foundation Research Programs, Bethesda, MD 20814, USA
    Mol Psychiatry 7:392-404. 2002
    ..Three of the nine markers observed with CRT overlapped with the ANOVA results. Six of the nine markers observed with the CRT technique pertained to aspects of glutamatergic, GABA-ergic, and dopaminergic neurotransmission...
  27. pmc Decreased BDNF and TrkB mRNA expression in multiple cortical areas of patients with schizophrenia and mood disorders
    M T Ray
    1 Stanley Medical Research Institute, Laboratory of Brain Research, Rockville, MD, USA 2 Trinity Washington University, NE Washington, DC, USA
    Transl Psychiatry 4:e389. 2014
    ....
  28. doi request reprint p11 is up-regulated in the forebrain of stressed rats by glucocorticoid acting via two specific glucocorticoid response elements in the p11 promoter
    L Zhang
    Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Neuroscience 153:1126-34. 2008
    ....
  29. ncbi request reprint Decreased expression of mineralocorticoid receptor mRNA in the prefrontal cortex in schizophrenia and bipolar disorder
    Guo Qiang Xing
    Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Int J Neuropsychopharmacol 7:143-53. 2004
    ..Whether these findings may be linked to the abnormal prefrontal function, HPA axis activation, or the deficits in SWS found in these major psychiatric illnesses remains to be further explored...
  30. ncbi request reprint Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium
    Michael B Knable
    The Stanley Medical Research Institute, Bethesda, MD 20814, USA
    Mol Psychiatry 9:609-20, 544. 2004
    ....
  31. ncbi request reprint Alteration in estrogen receptor alpha mRNA levels in frontal cortex and hippocampus of patients with major mental illness
    William R Perlman
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, MD 20892 1385, USA
    Biol Psychiatry 58:812-24. 2005
    ..We hypothesized that gender-specific alterations in DLPFC and hippocampus estrogen receptor alpha (ERalpha) mRNA levels may exist in MMI patients...
  32. ncbi request reprint Changes in NMDA receptor subunit mRNAs and cyclophilin mRNA during development of the human hippocampus
    Amanda J Law
    Department of Psychiatry, University of Oxford, OX3 7JX, United Kingdom
    Ann N Y Acad Sci 1003:426-30. 2003
  33. ncbi request reprint Oligodendrocyte dysfunction in schizophrenia and bipolar disorder
    Dmitri Tkachev
    Department of Neurobiology, Babraham Institute, Cambridge, UK
    Lancet 362:798-805. 2003
    ..Here, we investigated oligodendrocyte-specific and myelination-associated gene expression in schizophrenia and bipolar affective disorder...
  34. ncbi request reprint Expression of NMDA receptor NR1, NR2A and NR2B subunit mRNAs during development of the human hippocampal formation
    Amanda J Law
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Eur J Neurosci 18:1197-205. 2003
    ..Changes in subunit composition may thus contribute to maturational differences in human hippocampal N-methyl-d-aspartate receptor function, and to their role in the pathophysiology of schizophrenia and other neurodevelopmental disorders...
  35. ncbi request reprint Application and optimization of microarray technologies for human postmortem brain studies
    Margaret M Ryan
    Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Biol Psychiatry 55:329-36. 2004
    ....
  36. ncbi request reprint Reduced glucocorticoid and estrogen receptor alpha messenger ribonucleic acid levels in the amygdala of patients with major mental illness
    William R Perlman
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 56:844-52. 2004
    ..We also hypothesized that estrogen receptor alpha (ERalpha) mRNA expression might be altered in the amygdala, on the basis of observed gender differences in mental illness...
  37. ncbi request reprint Discordant changes in cortical TrkC mRNA and protein during the human lifespan
    Senda Beltaifa
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Eur J Neurosci 21:2433-44. 2005
    ..Our results suggest that truncated trkC is prevalent in the human PFC and that neurons and glia may be responsive to NT-3 in the PFC throughout life...
  38. pmc Elevated neuregulin-1 and ErbB4 protein in the prefrontal cortex of schizophrenic patients
    Victor Z Chong
    MiNDS Unit, CBDB, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg 10, Bethesda, MD 20892, USA
    Schizophr Res 100:270-80. 2008
    ..We hypothesize that ErbB4 proteolytic processing may also be altered in schizophrenia, yielding altered ratios of functionally distinct forms of ErbB4...
  39. ncbi request reprint Meta-analysis of 12 genomic studies in bipolar disorder
    Michael Elashoff
    Elashoff Consulting, Germantown, MD 20876, USA
    J Mol Neurosci 31:221-43. 2007
    ..In addition to these general conclusions, we also summarize the primary biological findings of the meta-analysis, focusing on areas that confirm previous research and also on novel findings...
  40. ncbi request reprint Deficient hippocampal neuron expression of proteasome, ubiquitin, and mitochondrial genes in multiple schizophrenia cohorts
    C Anthony Altar
    Psychiatric Genomics, Inc, Gaithersburg, Maryland 20878, USA
    Biol Psychiatry 58:85-96. 2005
    ..Hippocampal dentate granule neurons are altered in schizophrenia, but it is unknown if their gene expressions change in schizophrenia or other psychiatric diseases...
  41. ncbi request reprint Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains
    E Fuller Torrey
    Stanley Medical Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Biol Psychiatry 57:252-60. 2005
    ..Previous studies of postmortem neurochemical markers in severe psychiatric disorders have been carried out on different brain collections, making it difficult to compare results...
  42. ncbi request reprint Synaptophysin protein and mRNA expression in the human hippocampal formation from birth to old age
    Sharon L Eastwood
    Department of Psychiatry of the University of Oxford, Neurosciences Building, Warneford Hospital, Oxford, United Kingdom
    Hippocampus 16:645-54. 2006
    ....
  43. ncbi request reprint Age-related differences in glucocorticoid receptor mRNA levels in the human brain
    William R Perlman
    MiNDS Unit, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 1385, USA
    Neurobiol Aging 28:447-58. 2007
    ..Increased GR mRNA in prefrontal cortex during adolescence and adulthood suggests that human GR-mediated forebrain regulation of cognition and the neuroendocrine stress response may be more salient during late maturation and at maturity...
  44. ncbi request reprint Widespread expression of ErbB2, ErbB3 and ErbB4 in non-human primate brain
    Mia Thompson
    MiNDS Unit Clinical Brain Disorders Branch, IRP NIMH NIH, NIH, Mail Stop 1385, Building 10 Room 4D18, Bethesda, MD 20892, USA
    Brain Res 1139:95-109. 2007
    ..The ubiquitous expression of ErbB receptors indicates that many cell populations throughout the brain of juvenile and adult primates have the potential to respond to NRG-1 in a variety of ways...