Research Topics
Species | Jamie M ZeitzerSummaryAffiliation: Stanford University Country: USA Publications
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Publications
Nocturia compounds nocturnal wakefulness in older individuals with insomniaJamie M Zeitzer
Department of Psychiatry, Stanford University, Palo Alto CA 94304, USA
J Clin Sleep Med 9:259-62. 2013..To determine the impact of nocturia on objective measures of sleep in older individuals with insomnia...- Phenotyping apathy in individuals with Alzheimer disease using functional principal component analysisJamie M Zeitzer
Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA Psychiatry Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA Electronic address
Am J Geriatr Psychiatry 21:391-7. 2013..To determine if there is a specific pattern of gross motor activity associated with apathy in individuals with Alzheimer disease (AD)... - Time-course of cerebrospinal fluid histamine in the wake-consolidated squirrel monkeyJamie M Zeitzer
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
J Sleep Res 21:189-94. 2012.... - Plasma melatonin rhythms in young and older humans during sleep, sleep deprivation, and wakeJamie M Zeitzer
Department of Psychiatry, Stanford University, Palo Alto, CA 94304, USA
Sleep 30:1437-43. 2007..To determine the effects of sleep and sleep deprivation on plasma melatonin concentrations in humans and whether these effects are age-dependent... - Faster REM sleep EEG and worse restedness in older insomniacs with HLA DQB1*0602Jamie Marc Zeitzer
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford CA, United States
Psychiatry Res 187:397-400. 2011..Thus, DQB1*0602 positivity is associated with both a shift in EEG power spectrum to faster frequencies during REM sleep and a diminution of restedness given the same sleep quantity... 
Increasing length of wakefulness and modulation of hypocretin-1 in the wake-consolidated squirrel monkeyJamie M Zeitzer
Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA
Am J Physiol Regul Integr Comp Physiol 293:R1736-42. 2007..Concomitants of wakefulness that affect hypocretin-1 in polyphasic species, such as locomotion, food intake, and food deprivation, likely have a more minor role in monophasic species, such as humans...- The neurobiology of hypocretins (orexins), narcolepsy and related therapeutic interventionsJamie M Zeitzer
Department of Psychiatry, Stanford University, 701 B Welch Road, Palo Alto, CA 94304, USA
Trends Pharmacol Sci 27:368-74. 2006..Hypocretin receptor agonists are likely to be ideal therapeutic options for hypocretin-deficient narcolepsy but such compounds are still not available in humans... - Response of the human circadian system to millisecond flashes of lightJamie M Zeitzer
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, United States of America
PLoS ONE 6:e22078. 2011..These data are consistent with the hypothesis that the circadian system can temporally integrate extraordinarily brief light exposures... - Effectiveness of evening phototherapy for insomnia is reduced by bright daytime light exposureJamie M Zeitzer
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, United States
Sleep Med 12:805-7. 2011..To examine the effect of ambulatory daytime light exposure on phase delays and on the advances produced by timed exposure to bright evening or morning light... - Modafinil and γ-hydroxybutyrate have sleep state-specific pharmacological actions on hypocretin-1 physiology in a primate model of human sleepJamie M Zeitzer
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, USA
Behav Pharmacol 20:643-52. 2009..Furthermore, hypocretin neurons do not seem to respond to an 'effort' to remain awake, but rather keep track of time spent awake as a wake-promoting counterbalance to extended wakefulness... - Circadian and homeostatic regulation of hypocretin in a primate model: implications for the consolidation of wakefulnessJamie M Zeitzer
Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California 94304, USA
J Neurosci 23:3555-60. 2003..In the squirrel monkey, hypocretin-1 works in opposition to the accumulating sleep drive during the day to maintain a constant level of wake... - Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsyShengwen Zhang
Psychiatry and Behavioural Sciences, Stanford University, Palo Alto, CA 94304 5742, USA
J Physiol 581:649-63. 2007..This investigation illustrates the need for coordinated study of multiple phenotypes in mouse models with altered sleep/wake patterns... 
Modeling the effects of obstructive sleep apnea and hypertension in Vietnam veterans with PTSDLisa M Kinoshita
Department of Veterans Affairs, VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
Sleep Breath 16:1201-9. 2012..We hypothesized that in addition to indices of OSA severity, hypertension is associated with worse cognitive performance in such adults...- Lesions of the suprachiasmatic nucleus eliminate the daily rhythm of hypocretin-1 releaseShengwen Zhang
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA
Sleep 27:619-27. 2004..No correlation was found between CSF hypocretin-1 and corticosterone. CONCLUSIONS: Hypocretin-1 release is under SCN control. Locomotor activity influences the activity of the hypocretin neurons... - Locomotor-dependent and -independent components to hypocretin-1 (orexin A) regulation in sleep-wake consolidating monkeysJamie M Zeitzer
Department of Psychiatry and Behavioural Sciences, Stanford University, Palo Alto, CA 94304, USA
J Physiol 557:1045-53. 2004..In this wake-consolidating animal, locomotion is not necessary for CSF hypocretin-1 to increase throughout the daytime, but high levels of locomotion are likely to provide a small positive feedback onto the hypocretin system... - Circadian clock gene polymorphisms and sleep-wake disturbance in Alzheimer diseaseJerome A Yesavage
Department of Veterans Affairs Health Care System, Stanford University School of Medicine, Palo Alto, California
Am J Geriatr Psychiatry 19:635-43. 2011..The goal of this study is to report indices of sleep-wake function collected from individuals with AD in relation to relevant polymorphisms in circadian clock-related genes... - Preliminary evidence that hippocampal volumes in monkeys predict stress levels of adrenocorticotropic hormoneDavid M Lyons
Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, California 94305 5485, USA
Biol Psychiatry 62:1171-4. 2007..Hippocampal volumes previously determined in monkeys by magnetic resonance imaging are used to test the hypothesis that small hippocampi predict increased stress levels of adrenocorticotropic hormone (ACTH)... - Brief morning light treatment for sleep/wake disturbances in older memory-impaired individuals and their caregiversLeah Friedman
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA
Sleep Med 13:546-9. 2012..As such, we examined the effectiveness of a "user-friendly" phototherapy protocol that would be readily usable in the home environment... - Scheduled bright light for treatment of insomnia in older adultsLeah Friedman
Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, California 94304, USA
J Am Geriatr Soc 57:441-52. 2009..To determine whether bright light can improve sleep in older individuals with insomnia... - Diurnal variation of cerebrospinal fluid hypocretin-1 (Orexin-A) levels in control and depressed subjectsRonald M Salomon
Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA
Biol Psychiatry 54:96-104. 2003..Shortened rapid eye movement latency is observed in both narcolepsy and depression. Cerebrospinal fluid hypocretin-1 levels have not been reported in mood disorders... - Initial cognitive performance predicts longitudinal aviator performanceJerome A Yesavage
Stanford VA Aging Clinical Research Center, VA Palo Alto Health Care System, Palo Alto, CA 94304 1207, USA
J Gerontol B Psychol Sci Soc Sci 66:444-53. 2011..The goal of the study was to improve prediction of longitudinal flight simulator performance by studying cognitive factors that may moderate the influence of chronological age... - Modeling caffeine concentrations with the Stanford Caffeine Questionnaire: preliminary evidence for an interaction of chronotype with the effects of caffeine on sleepPhilip Nova
School of Humanities and Sciences, Stanford University, Stanford, CA 94304, USA
Sleep Med 13:362-7. 2012..To examine the validity of a novel caffeine intake questionnaire and to examine the effects of caffeine on sleep in college students... - Insomnia in the context of traumatic brain injuryJamie M Zeitzer
VA Palo Alto Health Care System, 3801 Miranda Avenue 151Y, Palo Alto, CA 94304, USA
J Rehabil Res Dev 46:827-36. 2009.... - Lack of Association Between COMT Polymorphisms and Apathy in Alzheimer's DiseaseRenaud David
Centre Mémoire de Ressources de Recherche EA CoBTeK, CHU University of Nice Sophia Antipolis, Nice, France
J Alzheimers Dis 27:155-61. 2011..None of the candidate gene SNPs were significantly associated with the presence of apathy in either cohort. We did not find any SNPs in COMT that were consistently associated with apathy in individuals with AD... - The role of hypocretins (orexins) in sleep regulation and narcolepsyShahrad Taheri
Stanford University Center for Narcolepsy, 701 Welch Road B, Basement, Palo Alto, California 94304 5742, USA
Annu Rev Neurosci 25:283-313. 2002..The aim of this review is to describe and discuss the current knowledge regarding the hypocretin neurotransmitter system in narcolepsy and normal sleep... - CSF hypocretin-1 assessment in sleep and neurological disordersPatrice Bourgin
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
Lancet Neurol 7:649-62. 2008..Although hypocretin-1 deficiency in narcolepsy might have therapeutic relevance, additional research is needed in this area... - Sleep apnea, apolipoprotein epsilon 4 allele, and TBI: mechanism for cognitive dysfunction and development of dementiaRuth O'Hara
Sierra Pacific Mental Illness Research, Education, and Clinical Center MIRECC, 151 Y, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
J Rehabil Res Dev 46:837-50. 2009..Increased understanding of the relationships among sleep apnea, the APOE epsilon 4 allele, and cognition could improve our ability to ameliorate one significant source of cognitive impairment and risk for dementia associated with TBI... - Decreased daytime motor activity associated with apathy in Alzheimer disease: an actigraphic studyRenaud David
Centre Mémoire de Ressources de Recherche, Nice University Hospital, Nice, France
Am J Geriatr Psychiatry 20:806-14. 2012..The aim of our study was to assess the relationship between apathy and daytime motor activity in AD, using ambulatory actigraphy... - Preliminary evidence that plasma oxytocin levels are elevated in major depressionKaren J Parker
Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA 94305, USA
Psychiatry Res 178:359-62. 2010..Additional research is required to elucidate the role of OT in the pathophysiology of this psychiatric disorder... - Neuropsychiatric diagnosis and management of chronic sequelae of war-related mild to moderate traumatic brain injuryJoshua D Halbauer
Department of Veterans Affairs VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
J Rehabil Res Dev 46:757-96. 2009..With a multidimensional approach (such as the biopsychosocial model) applied to each symptom cluster, psychological, occupational, and social dysfunction can be delineated and managed... - Peak of circadian melatonin rhythm occurs later within the sleep of older subjectsJeanne F Duffy
Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Physiol Endocrinol Metab 282:E297-303. 2002..In healthy older subjects, the relative timing of the melatonin rhythm with respect to sleep may not play a causal role in sleep disruption... - Extracellular adenosine in the human brain during sleep and sleep deprivation: an in vivo microdialysis studyJamie M Zeitzer
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Sleep 29:455-61. 2006..Thus, if energy homeostasis is a function of sleep, an increased rate of adenosine release into the extracellular milieu of the amygdala, cortex, or hippocampus is unlikely to be a marker of such a process... - Temporal dynamics of late-night photic stimulation of the human circadian timing systemJamie M Zeitzer
Brigham and Women's Hosp, Boston, MA
Am J Physiol Regul Integr Comp Physiol 289:R839-44. 2005.... - Bilateral oculosympathetic paresis associated with loss of nocturnal melatonin secretion in patients with spinal cord injuryJamie M Zeitzer
Division of Sleep Medicine, Harvard Medical School Boston, Massachusetts, USA
J Spinal Cord Med 28:55-9. 2005..CONCLUSION: The presence of bilateral oculosympathetic paresis can be predictive of the complete loss of the nocturnal production of melatonin... - Decreased sensitivity to phase-delaying effects of moderate intensity light in older subjectsJeanne F Duffy
Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Neurobiol Aging 28:799-807. 2007..These findings suggest an age-related reduction in the phase-delaying response to moderate light levels. However, our findings alone do not explain the altered phase relationship between sleep and circadian rhythms associated with aging... - A physiologically based mathematical model of melatonin including ocular light suppression and interactions with the circadian pacemakerMelissa A St Hilaire
Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Pineal Res 43:294-304. 2007..This updated model has been incorporated into an existing mathematical model of the human circadian pacemaker and can be used to simulate experimental protocols under a number of conditions... - Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndromeOludare B Taiwo
University of Minnesota, Department of Veterinary and Biomedical Sciences, Rm 295, Animal Science Veterinary Medicine Building, 1988 Fitch Avenue, St Paul, MN 55113, USA
Sleep Med 8:260-5. 2007..Cerebrospinal fluid (CSF) hypocretin-1 (Hcrt-1) concentrations are low in patients with narcolepsy-cataplexy, a sleep disorder characterized by hypersomnolence and rapid eye movement (REM) sleep abnormalities...