Robert Zeiser

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Acute graft-versus-host disease-challenge for a broader application of allogeneic hematopoietic cell transplantation
    Robert Zeiser
    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Curr Stem Cell Res Ther 1:203-12. 2006
  2. pmc Tissue-specific homing and expansion of donor NK cells in allogeneic bone marrow transplantation
    Janelle A Olson
    Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA 94305, USA
    J Immunol 183:3219-28. 2009
  3. pmc Low doses of natural killer T cells provide protection from acute graft-versus-host disease via an IL-4-dependent mechanism
    Dennis B Leveson-Gower
    Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA, USA
    Blood 117:3220-9. 2011
  4. pmc In vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activity
    Ryosei Nishimura
    Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University, CA 94305, USA
    Blood 112:2563-74. 2008
  5. pmc Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells
    Robert Zeiser
    Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Blood 111:453-62. 2008
  6. ncbi request reprint In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation
    Vu H Nguyen
    Department of Medicine, Division of Bone Marrow Transplantation, Stanford University, Stanford, CA 94305, USA
    Blood 109:2649-56. 2007
  7. ncbi request reprint Role of naturally arising regulatory T cells in hematopoietic cell transplantation
    Vu H Nguyen
    Center for Clinical Science Research, Department of Medicine, Division of Bone Marrow Transplantation, Stanford University, Stanford, CA 94305, USA
    Biol Blood Marrow Transplant 12:995-1009. 2006
  8. pmc Host-derived interleukin-18 differentially impacts regulatory and conventional T cell expansion during acute graft-versus-host disease
    Robert Zeiser
    Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Biol Blood Marrow Transplant 13:1427-38. 2007
  9. pmc Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease
    Robert Zeiser
    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, CA 94305, USA
    Blood 109:2225-33. 2007
  10. pmc Follicular lymphoma B cells induce the conversion of conventional CD4+ T cells to T-regulatory cells
    Weiyun Z Ai
    Department of Medicine, Divisions of Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int J Cancer 124:239-44. 2009

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Acute graft-versus-host disease-challenge for a broader application of allogeneic hematopoietic cell transplantation
    Robert Zeiser
    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Curr Stem Cell Res Ther 1:203-12. 2006
    ..A better understanding of the mechanisms involved in aGVHD pathogenesis might allow for a broader application of novel stem cell therapies...
  2. pmc Tissue-specific homing and expansion of donor NK cells in allogeneic bone marrow transplantation
    Janelle A Olson
    Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA 94305, USA
    J Immunol 183:3219-28. 2009
    ..IL-2 enhanced expansion and antitumor activity of NK cells. These results provide significant insight into the behavior and potential therapeutic impact of NK cells in BMT...
  3. pmc Low doses of natural killer T cells provide protection from acute graft-versus-host disease via an IL-4-dependent mechanism
    Dennis B Leveson-Gower
    Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA, USA
    Blood 117:3220-9. 2011
    ..These studies elucidate the biologic function of donor-type CD4(+)NKT cells in suppressing GVHD in an allogeneic transplantation setting, demonstrating clinical potential in reducing GVHD in HCT...
  4. pmc In vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activity
    Ryosei Nishimura
    Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University, CA 94305, USA
    Blood 112:2563-74. 2008
    ..Due to these properties, allogeneic CIK cells had reduced expansion and caused less tissue damage. We conclude that CIK cells have the potential to separate graft-versus-tumor effects from GVHD...
  5. pmc Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells
    Robert Zeiser
    Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Blood 111:453-62. 2008
    ....
  6. ncbi request reprint In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation
    Vu H Nguyen
    Department of Medicine, Division of Bone Marrow Transplantation, Stanford University, Stanford, CA 94305, USA
    Blood 109:2649-56. 2007
    ....
  7. ncbi request reprint Role of naturally arising regulatory T cells in hematopoietic cell transplantation
    Vu H Nguyen
    Center for Clinical Science Research, Department of Medicine, Division of Bone Marrow Transplantation, Stanford University, Stanford, CA 94305, USA
    Biol Blood Marrow Transplant 12:995-1009. 2006
    ..In this review, we discuss the current knowledge of Treg biology and the potential therapeutic strategies and barriers of Treg immunotherapy in human hematopoietic cell transplantation...
  8. pmc Host-derived interleukin-18 differentially impacts regulatory and conventional T cell expansion during acute graft-versus-host disease
    Robert Zeiser
    Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Biol Blood Marrow Transplant 13:1427-38. 2007
    ..We conclude that host-derived IL-18 is a major factor for IFN-gamma production that may have a protective effect on CD4(+)-mediated aGVHD, but is nonessential for Treg expansion in an allogeneic environment...
  9. pmc Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease
    Robert Zeiser
    Division of Bone Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, CA 94305, USA
    Blood 109:2225-33. 2007
    ..These data demonstrate that early CD30 signaling is critical for Treg-mediated aGvHD protection after major MHC-mismatch bone marrow transplantation...
  10. pmc Follicular lymphoma B cells induce the conversion of conventional CD4+ T cells to T-regulatory cells
    Weiyun Z Ai
    Department of Medicine, Divisions of Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int J Cancer 124:239-44. 2009
    ..Our study provides evidence for a tumor-specific mechanism by which FL tumor cells promote immune escape through the induction of Treg...
  11. pmc CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation
    Kavya Rakhra
    Division of Oncology, Departments of Medicine, Pathology and Molecular Imaging, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cancer Cell 18:485-98. 2010
    ..Hence, CD4(+) T cells are required for the remodeling of the tumor microenvironment through the expression of chemokines, such as thrombospondins, in order to elicit oncogene addiction...
  12. pmc Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity
    Robert Zeiser
    Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Blood 110:4588-98. 2007
    ....
  13. pmc Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production
    Robert Zeiser
    Center for Clinical Science Research, Division of Bone Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Blood 108:390-9. 2006
    ..Our data indicate that RAPA and MMF rather than CSA preserve function of Treg cells in pathologic immune responses such as GVHD without weakening the GVT effect...
  14. ncbi request reprint Allogeneic haematopoietic cell transplantation for multiple myeloma: reducing transplant-related mortality while harnessing the graft-versus-myeloma effect
    Robert Zeiser
    Department of Medicine, Division of Bone Marrow Transplantation, Stanford University School of Medicine, 300 Pasteur Drive, CA 94305, USA
    Eur J Cancer 42:1601-11. 2006
    ..Strategies including donor lymphocyte infusions as part of the allogeneic protocol and antigenic targets for GVM effect are reviewed...
  15. ncbi request reprint CD101 surface expression discriminates potency among murine FoxP3+ regulatory T cells
    Irina Fernandez
    Departamento de Biologia Celular, Universidad Simon Bolivar, Caracas, Venezuela corrected
    J Immunol 179:2808-14. 2007
    ..Among the CD101(high) Treg all of the in vivo suppressor activity was contained within the CD62L(high) subpopulation. We conclude that CD101 expression distinguishes murine Treg with potent suppressor activity...
  16. ncbi request reprint Stem cell plasticity: the debate begins to clarify
    Alexandros Spyridonidis
    Freiburg University Medical Center, Department of Hematology Oncology, Hugstetter Strasse 55, Freiburg, Germany
    Stem Cell Rev 1:37-43. 2005
    ..This review discusses the current status of the "plasticity" debate and presents existing data on detection methodology, underlying mechanisms, physiological implications, and clinical significance...
  17. ncbi request reprint The death receptor pathway is not involved in alloreactive T-cell induced mitochondrial membrane permeability
    Carsten Grüllich
    Division of Haematology Oncology, Daprtment of Medicine, Freiburg University Hospital, University of Freiburg, Germany
    Leuk Lymphoma 46:1207-16. 2005
    ..Furthermore, the granule exocytosis pathway does not require caspases to induce MMP...
  18. pmc XXIII International Association for Comparative Research on Leukemia and Related Diseases Symposium: from molecular pathogenesis to targeted therapy in leukemia and solid tumors
    Björn Hackanson
    Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA
    Cancer Res 68:5512-8. 2008
  19. ncbi request reprint Fatal varicella zoster virus encephalitis in two patients following allogeneic hematopoietic stem cell transplantation
    Björn Hackanson
    Department of Hematology Oncology, Freiburg University Medical Center, Freiburg, Germany
    Clin Transplant 19:566-70. 2005
    ..Varicella zoster virus (VZV) reactivation in this setting most commonly manifests as dermatomal herpes zoster but in some cases life-threatening VZV encephalitis occurs...
  20. ncbi request reprint Capillary electrophoresis for chimerism monitoring by PCR amplification of microsatellite markers after allogeneic hematopoietic cell transplantation
    Alexandros Spyridonidis
    Department of Hematology and Oncology, Albert Ludwigs University Medical Center, Freiburg, Germany
    Clin Transplant 19:350-6. 2005
    ..In the light of increasing numbers of non-myeloablative aHCT as a treatment modality sensitive, rapid, and accurate chimerism monitoring techniques acquire novel relevance...
  21. ncbi request reprint Immunopathogenesis of acute graft-versus-host disease: implications for novel preventive and therapeutic strategies
    Robert Zeiser
    Department of Hematology and Oncology, Albert Ludwigs University Medical Center Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    Ann Hematol 83:551-65. 2004
    ....
  22. ncbi request reprint Intestinal cryptosporidiosis mimicking acute graft-versus-host disease following matched unrelated hematopoietic stem cell transplantation
    Claudia I Muller
    Transplantation 77:1478-9. 2004