Richard Zare

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Hadamard transform time-of-flight mass spectrometry: more signal, more of the time
    Richard N Zare
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Angew Chem Int Ed Engl 42:30-5. 2003
  2. ncbi request reprint Time-dependent depolarization of aligned D(2) caused by hyperfine coupling
    Nate C M Bartlett
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Phys Chem Chem Phys 12:15689-94. 2010
  3. doi request reprint The hydrogen games and other adventures in chemistry
    Richard N Zare
    Department of Chemistry, Stanford University, Stanford, California 94305 5080 email
    Annu Rev Phys Chem 64:1-19. 2013
  4. ncbi request reprint Reaction dynamics: concluding remarks
    Richard N Zare
    Department of Chemistry, Stanford University, 333 Campus Drive, Stanford, California 94305 5080, USA
    Faraday Discuss 157:501-4. 2012
  5. doi request reprint Separation of bacteria with imprinted polymeric films
    Romana Schirhagl
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Analyst 137:1495-9. 2012
  6. doi request reprint Microfluidic capture and release of bacteria in a conical nanopore array
    Peng Guo
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Lab Chip 12:558-61. 2012
  7. doi request reprint Microfluidic platforms for single-cell analysis
    Richard N Zare
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Annu Rev Biomed Eng 12:187-201. 2010
  8. ncbi request reprint Chemistry. Resonances in reaction dynamics
    Richard N Zare
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    Science 311:1383-5. 2006
  9. ncbi request reprint Duty cycle and modulation efficiency of two-channel Hadamard transform time-of-flight mass spectrometry
    Oh Kyu Yoon
    Department of Chemistry, Stanford University, S G Mudd Building, Stanford, CA 94305 5080, USA
    J Am Soc Mass Spectrom 16:1888-901. 2005
  10. doi request reprint Single-molecule spectroscopy using microfluidic platforms
    Samuel Kim
    Department of Chemistry, Stanford University, Stanford, California, USA
    Methods Enzymol 472:119-32. 2010

Collaborators

  • O Trapp
  • Charles R Martin
  • Ann Wainright
  • Masaru Kato
  • Bo Huang
  • Hongkai Wu
  • Romana Schirhagl
  • Nate C M Bartlett
  • Samuel Kim
  • Eric W Hall
  • Rebecca J Whelan
  • Maria T Dulay
  • Fang Yu
  • Aaron R Wheeler
  • Brian K Kobilka
  • Peng Guo
  • Ingo Fuereder
  • Gabriele Trapp
  • Yiqi Luo
  • Marion R Martin
  • Oh Kyu Yoon
  • Joel R Kimmel
  • Thomas D Perroud
  • Facundo M Fernandez
  • L Marcus Wilhelmsson
  • Hitomi Mukaibo
  • Tapas Goswami
  • Stuart C Althorpe
  • Foudhil Bouakline
  • Justin Jankunas
  • Bruno C Medeiros
  • John A Harrison
  • Justinas Jankunas
  • Serguei Koulikov
  • Alexander A Kachanov
  • Davida J Ankeny Brown
  • Albert S Chiou
  • Sebastien Granier
  • Han Nim Choi
  • Devaki Bhaya
  • Arthur Grossman
  • Ignacio A Zuleta
  • Matthew D Robbins
  • Tina Chou
  • John P Cooke
  • Karsten Sydow
  • Aaron Wheeler
  • Kevin Farrell
  • William R Throndset
  • Ian D Manger
  • Yish Hann Liao
  • Mark I Wallace
  • Antoine Daridon
  • Andrew M Leach
  • Thorsten Wohland
  • Karin Markides
  • Bengt Norden
  • Lars Neumann
  • Magnus Wetterhall
  • Kaushik Mukherjee
  • Nestor Rodriguez
  • José M Vadillo

Detail Information

Publications33

  1. ncbi request reprint Hadamard transform time-of-flight mass spectrometry: more signal, more of the time
    Richard N Zare
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Angew Chem Int Ed Engl 42:30-5. 2003
    ..These features translate to a mass spectral storage rate that is the fastest among similar instruments, which enables its use as a detector for high-speed separations...
  2. ncbi request reprint Time-dependent depolarization of aligned D(2) caused by hyperfine coupling
    Nate C M Bartlett
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Phys Chem Chem Phys 12:15689-94. 2010
    ....
  3. doi request reprint The hydrogen games and other adventures in chemistry
    Richard N Zare
    Department of Chemistry, Stanford University, Stanford, California 94305 5080 email
    Annu Rev Phys Chem 64:1-19. 2013
    ..Although my group and others have been studying this seemingly simple reaction for well over 30 years, it continues to provoke questions about the properties of matter...
  4. ncbi request reprint Reaction dynamics: concluding remarks
    Richard N Zare
    Department of Chemistry, Stanford University, 333 Campus Drive, Stanford, California 94305 5080, USA
    Faraday Discuss 157:501-4. 2012
    ..This Discussion also marked a maturation of the field of reaction dynamics in that so much emphasis was placed on what the combination of theory and experiment could tell us about the detailed course of chemical transformations...
  5. doi request reprint Separation of bacteria with imprinted polymeric films
    Romana Schirhagl
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Analyst 137:1495-9. 2012
    ..Capture specificity and separation can be further enhanced by orienting the imprints parallel to the flow vector and tuning the pH to a lower range...
  6. doi request reprint Microfluidic capture and release of bacteria in a conical nanopore array
    Peng Guo
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Lab Chip 12:558-61. 2012
    ..The device can also specifically capture cyanobacteria from a mixed suspension of cyanobacteria and chlamydomonas with a selectivity as high as 90%...
  7. doi request reprint Microfluidic platforms for single-cell analysis
    Richard N Zare
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Annu Rev Biomed Eng 12:187-201. 2010
    ..The microfluidic approach offers a rapid, accurate, and cost-effective tool for single-cell biology. We present an overview of the recent developments in microfluidic technology for chemical-content analysis of individual cells...
  8. ncbi request reprint Chemistry. Resonances in reaction dynamics
    Richard N Zare
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    Science 311:1383-5. 2006
  9. ncbi request reprint Duty cycle and modulation efficiency of two-channel Hadamard transform time-of-flight mass spectrometry
    Oh Kyu Yoon
    Department of Chemistry, Stanford University, S G Mudd Building, Stanford, CA 94305 5080, USA
    J Am Soc Mass Spectrom 16:1888-901. 2005
    ..When both channels are optimized, the two-channel advantage can be exploited to achieve a further improvement over a single-channel experiment...
  10. doi request reprint Single-molecule spectroscopy using microfluidic platforms
    Samuel Kim
    Department of Chemistry, Stanford University, Stanford, California, USA
    Methods Enzymol 472:119-32. 2010
    ....
  11. ncbi request reprint Microfluidic device for single-cell analysis
    Aaron R Wheeler
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Anal Chem 75:3581-6. 2003
    ..These assays, and others, are achieved with significant improvements in reagent consumption, analysis time, and temporal resolution over macroscale alternatives...
  12. doi request reprint Microfluidic purification and analysis of hematopoietic stem cells from bone marrow
    Romana Schirhagl
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Lab Chip 11:3130-5. 2011
    ..The results were evaluated by comparing them against the results obtained from flow cytometry, confocal microscopy, and Coulter counting...
  13. ncbi request reprint Differential cross sections for H + D2 → HD(v' = 2, j' = 0,3,6,9) + D at center-of-mass collision energies of 1.25, 1.61, and 1.97 eV
    Nate C M Bartlett
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Phys Chem Chem Phys 13:8175-9. 2011
    ..The experimental results are compared to quantum mechanical calculations and show good, but not fully quantitative agreement...
  14. ncbi request reprint Hadamard transform time-of-flight mass spectrometry: a high-speed detector for capillary-format separations
    Facundo M Fernandez
    Department of Chemistry, Stanford University, California 94305 5080, USA
    Anal Chem 74:1611-7. 2002
    ..Pulsed-pressurized injection of reserpine was used to experimentally simulate narrower peaks than those obtained in the pCE. HT-TOFMS was able to sample peaks having widths in the millisecond range...
  15. doi request reprint Microfluidic device for immunoassays based on surface plasmon resonance imaging
    Yiqi Luo
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Lab Chip 8:694-700. 2008
    ..When gold nanoparticles are selectively coupled to the immunocomplex to cause signal amplification, the sensitivity reaches the ten to one hundred picomolar level but the time required increases to about 60 min...
  16. doi request reprint Ultraviolet thermal lensing detection of amino acids
    Fang Yu
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    J Chromatogr A 1216:3423-30. 2009
    ..We suggest that as UV laser sources become available, UV TL may become a method of choice for measuring the concentrations of many analytes in different separation formats in which the volume is highly limited...
  17. ncbi request reprint Photon counting histogram for one-photon excitation
    Thomas D Perroud
    Department of Chemistry, Stanford University, Stanford, California 94305 9262, USA
    Chemphyschem 4:1121-3. 2003
  18. ncbi request reprint Visible light-induced photopolymerization of an in situ macroporous sol-gel monolith
    Maria T Dulay
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    J Sep Sci 30:2979-85. 2007
    ..Operational parameters, such as mobile phase composition, field strength, and column temperature were varied to assess how they affect the separation performance of the monolith...
  19. ncbi request reprint Use of a mixture of n-dodecyl-beta-D-maltoside and sodium dodecyl sulfate in poly(dimethylsiloxane) microchips to suppress adhesion and promote separation of proteins
    Bo Huang
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Anal Chem 79:9145-9. 2007
    ..1% (w/v) DDM and 0.03% (w/v) SDS. We have also analyzed the composition of light-harvesting protein-chromophore complexes in cyanobacteria...
  20. ncbi request reprint Reaction of Cl with CD4 excited to the second C-D stretching overtone
    Marion R Martin
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Chem Phys 126:044315. 2007
    ....
  21. ncbi request reprint Electroosmotic flow in a poly(dimethylsiloxane) channel does not depend on percent curing agent
    Aaron R Wheeler
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Electrophoresis 25:1120-4. 2004
    ..EOF was found to be constant for PDMS formed with each ratio, which implies that the negative surface charges do not arise from chemical species present only in the base or the curing agent...
  22. pmc Chemical cytometry on a picoliter-scale integrated microfluidic chip
    Hongkai Wu
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Proc Natl Acad Sci U S A 101:12809-13. 2004
    ..As a demonstration of the use of this integrated microfluidic device, electropherograms of amino acids from individual Jurkat T cells are recorded and compared with those collected from a multiple-cell homogenate...
  23. ncbi request reprint Capillary electrophoretic and micellar electrokinetic separations of asymmetric dimethyl-L-arginine and structurally related amino acids: quantitation in human plasma
    Gabriele Trapp
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Sep Sci 27:1483-90. 2004
    ..125 microM LOQ)...
  24. ncbi request reprint A soft on-column metal coating procedure for robust sheathless electrospray emitters used in capillary electrophoresis-mass spectrometry
    Oliver Trapp
    Stanford University, Department of Chemistry, Stanford, CA 94395 5080, USA
    Electrophoresis 26:1358-65. 2005
    ..The performance was judged to be excellent...
  25. ncbi request reprint Construction of microfluidic chips using polydimethylsiloxane for adhesive bonding
    Hongkai Wu
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Lab Chip 5:1393-8. 2005
    ..The major advantages of this bonding method are its generality and its ease of use...
  26. ncbi request reprint Phospholipid biotinylation of polydimethylsiloxane (PDMS) for protein immobilization
    Bo Huang
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Lab Chip 6:369-73. 2006
    ..We demonstrate the immobilization of biotinylated antibodies and lectins through biotin-avidin interactions...
  27. ncbi request reprint Single-cell immunosensors for protein detection
    Rebecca J Whelan
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Biosens Bioelectron 19:331-6. 2003
    ..Ovalbumin can be detected in micromolar concentrations. Possible fundamental constraints on the size of a detectable analyte are discussed...
  28. ncbi request reprint Counting low-copy number proteins in a single cell
    Bo Huang
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Science 315:81-4. 2007
    ..PCC 7942) and observed marked differences in the levels of specific complexes in cell populations that were grown under nitrogen-depleted conditions...
  29. ncbi request reprint Analysis of biomolecular interactions using a miniaturized surface plasmon resonance sensor
    Rebecca J Whelan
    Department of Chemistry, Stanford University, 94305 5080, USA
    Anal Chem 74:4570-6. 2002
    ..Thus, this sensor shows promise as an inexpensive, portable, and accurate tool for bioanalytical applications in laboratory and clinical settings...
  30. ncbi request reprint Effect of preparatory conditions on the performance of photopolymerized sol-gel monoliths for capillary electrochromatography
    Masaru Kato
    Department of Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    J Chromatogr A 961:45-51. 2002
    ..Mixtures of polycyclic aromatic hydrocarbons and alkylbenzenes were separated with theoretical plate numbers greater than 100 000 plates/m...
  31. ncbi request reprint Determination of glutamine and serine in rat cerebrospinal fluid using capillary electrochromatography with a modified photopolymerized sol-gel monolithic column
    Masaru Kato
    Department of Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada Shizuoka, Shizuoka, 422 8526, Japan
    J Chromatogr A 1004:209-15. 2003
    ..This separation method with the end-capped monolithic column was applied to rat cerebrospinal fluid. The dominant amino acid found was Gln at a concentration of 420 microM along with small quantities of Ser (54 microM)...
  32. ncbi request reprint Integration of on-line protein digestion, peptide separation, and protein identification using pepsin-coated photopolymerized sol-gel columns and capillary electrophoresis/mass spectrometry
    Masaru Kato
    Department of Analytical Chemistry, School of Pharmaceutical Sciences and COE Program in the 21st Century, University of Shizuoka, 52 1 Yada Shizuoka, Shizuoka 422 8526, Japan
    Anal Chem 76:1896-902. 2004
    ..The on-line digestion of insulin chain beta and lysozyme provides identification of the proteolytic peptides. Recovery was achieved for 100% of the insulin chain beta amino acid sequence and 73% of the lysozyme amino acid sequence...
  33. pmc Genetic screening using the colour change of a PNA-DNA hybrid-binding cyanine dye
    L Marcus Wilhelmsson
    Department of Physical Chemistry, Chalmers University of Technology, S 412 96 Gothenburg, Sweden
    Nucleic Acids Res 30:E3. 2002
    ..Our results demonstrate that this diagnostic method may be sufficiently sensitive to discriminate between even a fully complementary and a single mutation DNA sequence...

Research Grants9

  1. Nanoparticle Formation and Biodistribution for Optimizing Therapy
    Richard Zare; Fiscal Year: 2007
    ..One benefit may be a new form of chemotherapy with much lower dosages of drugs and lower side effects in the patient. ..
  2. DRUG ASSAYS USING ELECTROPHORESIS WITH CELL BIOSENSORS
    Richard Zare; Fiscal Year: 1999
    ..The long-term objective of this research program is to implement capillary electrophoresis coupled to single-cell biosensors to probe the chemical connectivity between individual neurons and to identify novel neurotransmitters. ..
  3. SYNAPTIC TRANSMISSION AND SINGLE VESICLE ANALYSIS
    Richard Zare; Fiscal Year: 2001
    ..abstract_text> ..