Research Topics
| Richard ZareSummaryAffiliation: Stanford University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
The hydrogen games and other adventures in chemistryRichard N Zare
Department of Chemistry, Stanford University, Stanford, California 94305 5080 email
Annu Rev Phys Chem 64:1-19. 2013..Although my group and others have been studying this seemingly simple reaction for well over 30 years, it continues to provoke questions about the properties of matter...
Reaction dynamics: concluding remarksRichard N Zare
Department of Chemistry, Stanford University, 333 Campus Drive, Stanford, California 94305 5080, USA
Faraday Discuss 157:501-4. 2012..This Discussion also marked a maturation of the field of reaction dynamics in that so much emphasis was placed on what the combination of theory and experiment could tell us about the detailed course of chemical transformations...- Separation of bacteria with imprinted polymeric filmsRomana Schirhagl
Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
Analyst 137:1495-9. 2012..Capture specificity and separation can be further enhanced by orienting the imprints parallel to the flow vector and tuning the pH to a lower range... - Microfluidic capture and release of bacteria in a conical nanopore arrayPeng Guo
Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
Lab Chip 12:558-61. 2012..The device can also specifically capture cyanobacteria from a mixed suspension of cyanobacteria and chlamydomonas with a selectivity as high as 90%... - Time-dependent depolarization of aligned D(2) caused by hyperfine couplingNate C M Bartlett
Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
Phys Chem Chem Phys 12:15689-94. 2010.... - Microfluidic platforms for single-cell analysisRichard N Zare
Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
Annu Rev Biomed Eng 12:187-201. 2010..The microfluidic approach offers a rapid, accurate, and cost-effective tool for single-cell biology. We present an overview of the recent developments in microfluidic technology for chemical-content analysis of individual cells... - Hadamard transform time-of-flight mass spectrometry: more signal, more of the timeRichard N Zare
Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
Angew Chem Int Ed Engl 42:30-5. 2003..These features translate to a mass spectral storage rate that is the fastest among similar instruments, which enables its use as a detector for high-speed separations... - Chemistry. Resonances in reaction dynamicsRichard N Zare
Department of Chemistry, Stanford University, Stanford, CA 94305, USA
Science 311:1383-5. 2006 - Duty cycle and modulation efficiency of two-channel Hadamard transform time-of-flight mass spectrometryOh Kyu Yoon
Department of Chemistry, Stanford University, S.G. Mudd Building, Stanford, CA 94305-5080, USA
J Am Soc Mass Spectrom 16:1888-901. 2005..When both channels are optimized, the two-channel advantage can be exploited to achieve a further improvement over a single-channel experiment... - Single-molecule spectroscopy using microfluidic platformsSamuel Kim
Department of Chemistry, Stanford University, Stanford, California, USA
Methods Enzymol 472:119-32. 2010.... - Microfluidic device for single-cell analysisAaron R Wheeler
Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA
Anal Chem 75:3581-6. 2003..These assays, and others, are achieved with significant improvements in reagent consumption, analysis time, and temporal resolution over macroscale alternatives... - Microfluidic purification and analysis of hematopoietic stem cells from bone marrowRomana Schirhagl
Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
Lab Chip 11:3130-5. 2011..The results were evaluated by comparing them against the results obtained from flow cytometry, confocal microscopy, and Coulter counting... - Differential cross sections for H + D2 → HD(v' = 2, j' = 0,3,6,9) + D at center-of-mass collision energies of 1.25, 1.61, and 1.97 eVNate C M Bartlett
Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
Phys Chem Chem Phys 13:8175-9. 2011..The experimental results are compared to quantum mechanical calculations and show good, but not fully quantitative agreement... - Hadamard transform time-of-flight mass spectrometry: a high-speed detector for capillary-format separationsFacundo M Fernandez
Department of Chemistry, Stanford University, California 94305 5080, USA
Anal Chem 74:1611-7. 2002..Pulsed-pressurized injection of reserpine was used to experimentally simulate narrower peaks than those obtained in the pCE. HT-TOFMS was able to sample peaks having widths in the millisecond range... - Microfluidic device for immunoassays based on surface plasmon resonance imagingYiqi Luo
Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
Lab Chip 8:694-700. 2008..When gold nanoparticles are selectively coupled to the immunocomplex to cause signal amplification, the sensitivity reaches the ten to one hundred picomolar level but the time required increases to about 60 min... - Ultraviolet thermal lensing detection of amino acidsFang Yu
Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
J Chromatogr A 1216:3423-30. 2009..We suggest that as UV laser sources become available, UV TL may become a method of choice for measuring the concentrations of many analytes in different separation formats in which the volume is highly limited... - Photon counting histogram for one-photon excitationThomas D Perroud
Department of Chemistry, Stanford University, Stanford, California 94305-9262, USA
Chemphyschem 4:1121-3. 2003 - Visible light-induced photopolymerization of an in situ macroporous sol-gel monolithMaria T Dulay
Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
J Sep Sci 30:2979-85. 2007..Operational parameters, such as mobile phase composition, field strength, and column temperature were varied to assess how they affect the separation performance of the monolith... - Use of a mixture of n-dodecyl-beta-D-maltoside and sodium dodecyl sulfate in poly(dimethylsiloxane) microchips to suppress adhesion and promote separation of proteinsBo Huang
Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
Anal Chem 79:9145-9. 2007..1% (w/v) DDM and 0.03% (w/v) SDS. We have also analyzed the composition of light-harvesting protein-chromophore complexes in cyanobacteria... - Reaction of Cl with CD4 excited to the second C-D stretching overtoneMarion R Martin
Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
J Chem Phys 126:044315. 2007.... - Electroosmotic flow in a poly(dimethylsiloxane) channel does not depend on percent curing agentAaron R Wheeler
Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA
Electrophoresis 25:1120-4. 2004..EOF was found to be constant for PDMS formed with each ratio, which implies that the negative surface charges do not arise from chemical species present only in the base or the curing agent... 
Chemical cytometry on a picoliter-scale integrated microfluidic chipHongkai Wu
Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA
Proc Natl Acad Sci U S A 101:12809-13. 2004..As a demonstration of the use of this integrated microfluidic device, electropherograms of amino acids from individual Jurkat T cells are recorded and compared with those collected from a multiple-cell homogenate...- Capillary electrophoretic and micellar electrokinetic separations of asymmetric dimethyl-L-arginine and structurally related amino acids: quantitation in human plasmaGabriele Trapp
Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA
J Sep Sci 27:1483-90. 2004..125 microM LOQ)... - A soft on-column metal coating procedure for robust sheathless electrospray emitters used in capillary electrophoresis-mass spectrometryOliver Trapp
Stanford University, Department of Chemistry, Stanford, CA 94395-5080, USA
Electrophoresis 26:1358-65. 2005..The performance was judged to be excellent... - Construction of microfluidic chips using polydimethylsiloxane for adhesive bondingHongkai Wu
Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA
Lab Chip 5:1393-8. 2005..The major advantages of this bonding method are its generality and its ease of use... - Phospholipid biotinylation of polydimethylsiloxane (PDMS) for protein immobilizationBo Huang
Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA
Lab Chip 6:369-73. 2006..We demonstrate the immobilization of biotinylated antibodies and lectins through biotin-avidin interactions... - Single-cell immunosensors for protein detectionRebecca J Whelan
Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA
Biosens Bioelectron 19:331-6. 2003..Ovalbumin can be detected in micromolar concentrations. Possible fundamental constraints on the size of a detectable analyte are discussed... - Counting low-copy number proteins in a single cellBo Huang
Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
Science 315:81-4. 2007..PCC 7942) and observed marked differences in the levels of specific complexes in cell populations that were grown under nitrogen-depleted conditions... - Analysis of biomolecular interactions using a miniaturized surface plasmon resonance sensorRebecca J Whelan
Department of Chemistry, Stanford University, 94305-5080, USA
Anal Chem 74:4570-6. 2002..Thus, this sensor shows promise as an inexpensive, portable, and accurate tool for bioanalytical applications in laboratory and clinical settings... - Effect of preparatory conditions on the performance of photopolymerized sol-gel monoliths for capillary electrochromatographyMasaru Kato
Department of Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan
J Chromatogr A 961:45-51. 2002..Mixtures of polycyclic aromatic hydrocarbons and alkylbenzenes were separated with theoretical plate numbers greater than 100 000 plates/m... - Determination of glutamine and serine in rat cerebrospinal fluid using capillary electrochromatography with a modified photopolymerized sol-gel monolithic columnMasaru Kato
Department of Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada Shizuoka, Shizuoka, 422 8526, Japan
J Chromatogr A 1004:209-15. 2003..This separation method with the end-capped monolithic column was applied to rat cerebrospinal fluid. The dominant amino acid found was Gln at a concentration of 420 microM along with small quantities of Ser (54 microM)... - Integration of on-line protein digestion, peptide separation, and protein identification using pepsin-coated photopolymerized sol-gel columns and capillary electrophoresis/mass spectrometryMasaru Kato
Department of Analytical Chemistry, School of Pharmaceutical Sciences and COE Program in the 21st Century, University of Shizuoka, 52 1 Yada Shizuoka, Shizuoka 422 8526, Japan
Anal Chem 76:1896-902. 2004..The on-line digestion of insulin chain beta and lysozyme provides identification of the proteolytic peptides. Recovery was achieved for 100% of the insulin chain beta amino acid sequence and 73% of the lysozyme amino acid sequence... - Genetic screening using the colour change of a PNA-DNA hybrid-binding cyanine dyeL Marcus Wilhelmsson
Department of Physical Chemistry, Chalmers University of Technology, S 412 96 Gothenburg, Sweden
Nucleic Acids Res 30:E3. 2002..Our results demonstrate that this diagnostic method may be sufficiently sensitive to discriminate between even a fully complementary and a single mutation DNA sequence...
Research Grants
- Nanoparticle Formation and Biodistribution for Optimizing TherapyRichard Zare; Fiscal Year: 2007..One benefit may be a new form of chemotherapy with much lower dosages of drugs and lower side effects in the patient. ..
- DRUG ASSAYS USING ELECTROPHORESIS WITH CELL BIOSENSORSRichard Zare; Fiscal Year: 1999..The long-term objective of this research program is to implement capillary electrophoresis coupled to single-cell biosensors to probe the chemical connectivity between individual neurons and to identify novel neurotransmitters. ..
- SYNAPTIC TRANSMISSION AND SINGLE VESICLE ANALYSISRichard Zare; Fiscal Year: 2001..abstract_text> ..