Research Topics
| Anthony J YunSummaryAffiliation: Stanford University Country: USA Publications
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Detail Information
Publications
Are we eating more than we think? Illegitimate signaling and xenohormesis as participants in the pathogenesis of obesityAnthony J Yun
Stanford University, Department of Radiology, 470 University Avenue, Palo Alto, CA 94301 United States
Med Hypotheses 67:36-40. 2006..New strategies for manufacturing biologics by manipulating stress conditions or controlling fatty acid attachments to proteins are envisioned...- Many diseases may reflect dysfunctions of autonomic balance attributable to evolutionary displacementA Joon Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 62:847-51. 2004..We postulate that many diseases are manifestations of this general phenomenon. Implications for existing and future therapeutic strategies are discussed... - Clinical benefits of hydration and volume expansion in a wide range of illnesses may be attributable to reduction of sympatho-vagal ratioA Joon Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 64:646-50. 2005..The empiric benefits of hydration and volume expansion portend novel methods to treat a wide range of clinical conditions through pharmacologic or electrical modulation of cardiovascular or gastrointestinal baroreceptors... - Can thromboembolism be the result, rather than the inciting cause, of acute vascular events such as stroke, pulmonary embolism, mesenteric ischemia, and venous thrombosis?: a maladaptation of the prehistoric trauma responseAnthony J Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 64:706-16. 2005..Unexplained hypercoagulability of cancer may also operate through tumor-induced adrenergia and inflammation... - Paradoxical strategy for treating chronic diseases where the therapeutic effect is derived from compensatory response rather than drug effectAnthony J Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 64:1050-9. 2005..Perhaps alternating agonists and antagonist may exercise the entire dynamic range of pathways and improve health... - The smoking gun: many conditions associated with tobacco exposure may be attributable to paradoxical compensatory autonomic responses to nicotineAnthony J Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 64:1073-9. 2005..Other conditions associated with tobacco exposure may also operate through similar autonomic and immune dysfunctions. Therapeutic implications are discussed... - The dynamic range of biologic functions and variation of many environmental cues may be declining in the modern age: implications for diseases and therapeuticsAnthony J Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 65:173-8. 2005..Generalizing from these observations, we anticipate benefits of therapeutic and lifestyle approaches that expand, rather than reduce, the dynamic range of many biologic experiences... - A paradigm for viewing biologic systems as scale-free networks based on energy efficiency: implications for present therapies and the future of evolutionAnthony J Yun
Stanford University, Department of Radiology, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 67:651-7. 2006..Post-Darwinian evolution may favor indefinite persistence to optimize energy efficiency. We describe strategies to reprogram or decommission legacy hubs that participate in human disease and death... - Integrating systems biology and medical imaging: understanding disease distribution in the lung modelAnthony J Yun
Department of Radiology, Stanford University, 470 University Ave, Palo Alto, CA 94301, USA
AJR Am J Roentgenol 186:925-30. 2006..This hypothetic framework can apply to diseases outside the realm of pulmonary biology and illustrates the potential benefit of integrating advances in systems biology and medical imaging... - The link between T helper balance and lymphoproliferative diseaseAnthony J Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 65:587-90. 2005..Various clinical conditions or treatments that shift Th1/Th2 balance, including HIV infection, transplant-related immune suppression, and autoimmune disorders, can also influence the status of lymphoproliferative diseases... - Opening the floodgates: benign prostatic hyperplasia may represent another disease in the compendium of ailments caused by the global sympathetic bias that emerges with agingAnthony J Yun
Stanford University, Radiology, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 67:392-4. 2006..We envision novel pharmacologic and device-based neuromodulation therapies for BPH and related urologic dysfunctions based on these principles... - Adventitial dysfunction: an evolutionary model for understanding atherosclerosisAnthony J Yun
Department of Radiology, Stanford University, Palo Alto, CA 94301, USA
Med Hypotheses 65:962-5. 2005..We envision novel mechanical and biopharmaceutical solutions that target the adventitia to prevent or treat atherosclerosis including novel drug delivery strategies, exo-stents that wrap vessels, and neuromodulation of vessels... - A general theory of evolution based on energy efficiency: its implications for diseasesAnthony J Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 66:664-70. 2006..The key to this transition may involve novel methods to address the promotion of health and cognitive plasticity. We describe the implications of this theory for human diseases... - Sympathetic and T helper (Th)2 bias may ameliorate uterine fibroids, independent of sex steroidsAnthony J Yun
Stanford University, Department of Radiology, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 65:1172-5. 2005..Fibroids have been observed among animals in captivity that are presumably reproductively isolated... - Efficient inefficiency: biochemical "junk" may represent molecular bridesmaids awaiting emergent function as a buffer against environmental fluctuationAnthony J Yun
Stanford University, Radiology, 470 University Avenue, Palo Alto, CA 94301, United States
Med Hypotheses 67:914-21. 2006..The immune and cognitive systems that selectively sample and prune environmental content may serve as additional portals for innovation... - Contrast nephropathy may be partly mediated by autonomic dysfunction: renal failure considered as a modern maladaptation of the prehistoric trauma responseAnthony J Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 66:776-83. 2006.... - Autonomic dysregulation as a basis of cardiovascular, endocrine, and inflammatory disturbances associated with obstructive sleep apnea and other conditions of chronic hypoxia, hypercapnia, and acidosisA Joon Yun
Stanford University, 300 Pasteur Drive, Palo Alto, CA 94310, USA
Med Hypotheses 62:852-6. 2004..Our proposal may extend to any chronic respiratory or metabolic conditions that manifest hypoxia, hypercapnia, and acidosis and elicit a maladaptive autonomic and inflammatory response... - Sudden death among infants and adults: companion disorders of maladaptive sympathetic biasAnthony J Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 62:857-60. 2004..Our hypothesis may not only help explain the survival benefits of drugs such as beta-blockers and devices such as synchronization therapy, but also portend new application of similar therapies for many conditions of sympathetic bias... - Brewing controversies: Darwinian perspective on the adaptive and maladaptive effects of caffeine and ethanol as dietary autonomic modulatorsAnthony J Yun
Stanford University, Radiology, 470 University Avenue, Palo Alto, CA 94301, United States
Med Hypotheses 68:31-6. 2007..In an environment where the Darwinian value of knowledge has increasingly supplanted that of physical traits, the consumption of caffeine and alcohol may represent both a cause and an effect of modern human evolution... - Stress dysfunctions as a unifying paradigm for illness: repairing relationships instead of individuals as a new gateway for medicineAnthony J Yun
Palo Alto Institute, 470 University Avenue, Palo Alto, CA 94301, United States
Med Hypotheses 68:697-704. 2007.... - Temporal variation of autonomic balance and diseases during circadian, seasonal, reproductive, and lifespan cyclesA Joon Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 63:155-62. 2004..Termination of organisms during senescence, achieved by emergence of autonomic imbalance and other systemic dysfunctions, is explored from a Darwinian perspective... - Pineal attrition, loss of cognitive plasticity, and onset of puberty during the teen years: is it a modern maladaptation exposed by evolutionary displacement?A Joon Yun
Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 63:939-50. 2004..Pineal involution may represent a potential target for therapeutic extension or restoration of plasticity after puberty. Extending plasticity may have far-reaching consequences for human evolution... - Autonomic dysfunction may be an under-recognized cause of female fertility disordersA Joon Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 63:172-7. 2004..Our hypothesis portends new potential methods to treat fertility disorders by modulating autonomic balance... - Modulation of autonomic balance by tumors and virusesA Joon Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 63:344-51. 2004..A more general for understanding spatial distribution of diseases based on gradients of autonomic balance in the body are explored. Darwinian perspectives are discussed... - Tumors may modulate host immunity partly through hypoxia-induced sympathetic biasA Joon Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 63:352-6. 2004..Validation of our hypothesis may shed more light on the biology of cancer and reveal novel diagnostic and therapeutic strategies... - Modulation of host immunity by HIV may be partly achieved through usurping host autonomic functionsA Joon Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 63:362-6. 2004..Autonomic remodeling by HIV may exemplify this phenomenon. Our hypothesis has implications for treatment of HIV and its associated syndromes... - Maldaptation of the link between inflammation and bone turnover may be a key determinant of osteoporosisA Joon Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 63:532-7. 2004..Osteoporosis may result from disequilibrium between structural demand for key minerals and their biologic demand during maladaptive states of inflammation... - Environmental discontinuity hypothesis: Buffer dysfunctions as a source of human diseaseAnthony J Yun
Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 68:434-8. 2007..Acute discontinuous changes in pressure and oxygen levels related to air travel may contribute to autonomic dysfunction, venous thromboembolism, and viral infections. Therapeutic implications are discussed... - Enhanced fertility after diagnostic hysterosalpingography using oil-based contrast agents may be attributable to immunomodulationAnthony J Yun
Department of Radiology, Stanford University, 470 University Ave, Palo Alto, CA 94301, USA
AJR Am J Roentgenol 183:1725-7. 2004 - Integrating the theories of Darwin and Bernoulli: maladaptive baroreceptor network dysfunction may explain the pathogenesis of aortic aneurysmsBuford R Conley
Palo Alto Institute, Palo Alto, CA, USA
Med Hypotheses 65:266-72. 2005..Lessons learned from bifurcation sensors and their potential maladaptations may generalize to other types of branching systems including botany, civil engineering, and Pitot tube aeronautics... - Obesity and ADHD may represent different manifestations of a common environmental oversampling syndrome: a model for revealing mechanistic overlap among cognitive, metabolic, and inflammatory disordersKimberly A Bazar
San Mateo Medical Center, Department of Dermatology, 987 Addison Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 66:263-9. 2006.... - Peripheral arterial disease: a manifestation of evolutionary dislocation and feed-forward dysfunctionJohn D Simpson
Palo Alto Institute, 470 University Avenue, Palo Alto, CA 94301, United States
Med Hypotheses 67:947-50. 2006.... - The incorporation of iodine in thyroid hormone may stem from its role as a prehistoric signal of ecologic opportunity: an evolutionary perspective and implications for modern diseasesAnthony J Yun
Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 65:804-10. 2005..Iodine acquired through sodium iodide supplementation may independently contribute to some biologic dysfunctions currently attributed to sodium... - The link between carotid artery disease and ischemic stroke may be partially attributable to autonomic dysfunction and failure of cerebrovascular autoregulation triggered by Darwinian maladaptation of the carotid baroreceptors and chemoreceptorsJohn D Doux
Department of Dermatology, Stanford University Medical Center, Palo Alto, CA 94301, USA
Med Hypotheses 66:176-81. 2006..Modulation of carotid sensors may yield pervasive health benefits beyond those found by treating cerebrovascular disease... - Can chronic use of anti-inflammatory agents paradoxically promote chronic inflammation through compensatory host response?John D Doux
Stanford University, 470 University Ave, Palo Alto, CA 94301, USA
Med Hypotheses 65:389-91. 2005..Inflammation is a promoter of adrenergia and thrombosis, and the constellation of these effects may predispose to excess risk of acute cardiovascular events... - A new wrinkle: skin manifestations of aging may relate to autonomic dysfunctionKimberly A Bazar
Stanford University, Palo Alto, CA 94301, USA
Med Hypotheses 67:1274-6. 2006..For all of these dermatologic conditions, local and systemic administration of drugs and medical devices that pharmacologically or electrically modulate autonomic nervous system activity may yield benefits as well... - Menstrual variation of autonomic balance may be a factor in exacerbations of certain diseases during the menstrual cyclePatrick Y Lee
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 63:163-7. 2004..Our hypothesis portends new therapeutic paradigms based on cyclical modulation of autonomic balance to address catamenial variations of medical conditions... - Is atherosclerosis a neurogenic phenomenon?Rakesh S Marwah
Palo Alto Institute, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 69:884-7. 2007..Once we regard atherosclerosis as a neurogenic phenomenon manifested in adventitial autonomic dysfunction, novel diagnostic and therapeutic paradigms become evident... - A new mechanism for diverticular diseases: aging-related vagal withdrawalAnthony J Yun
Stanford University, USA
Med Hypotheses 64:252-5. 2005..Novel approaches to preventing and treating diverticular diseases by promoting vagal activity are proposed including the electrical or pharmacologic modulation of the autonomic system... - Unhappy meal: how our need to detect stress may have shaped our preferences for tasteAnthony J Yun
Palo Alto Institute, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 69:746-51. 2007..We anticipate that low-stress and stress-free food may have therapeutic potential in the treatment of diseases and the promotion of health... - Conditions of aging as manifestations of sympathetic bias unmasked by loss of parasympathetic functionPatrick Y Lee
Department of Medicine, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 62:868-70. 2004..Maintenance and restoration of parasympathetic function may enable upstream control over the deleterious aspects of inherent end-organ adrenergic bias... - When normal is not: the dilemma of interpreting laboratory averages of bioactive molecules subject to heterogeneous regulatory feedback and epigenetic mosaicismJohn D Doux
Palo Alto Institute, Palo Alto, CA 94301, USA
Med Hypotheses 66:1216-21. 2006..The proposed idea has broad implications for disease pathogenesis, diagnosis, and therapies. A model where individual tissues employ illegitimate signaling to subvert the concerns of the organism as a whole is also proposed... - Negative pressure ventilation via diaphragmatic pacing: a potential gateway for treating systemic dysfunctionsAnthony J Yun
Palo Alto Institute, 470 University Avenue, Palo Alto, CA 94301, USA
Expert Rev Med Devices 4:315-9. 2007..Diaphragmatic pacing could also reduce sympathetic bias, which may contribute to a wide range of diseases associated with autonomic dysfunction... - Acute coronary syndromes and heart failure may reflect maladaptations of trauma physiology that was shaped during pre-modern evolutionPatrick Y Lee
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 62:861-7. 2004.... - Enhanced fertility after diagnostic hysterosalpingography: the debate continuesAnthony J Yun
AJR Am J Roentgenol 184:347; author reply 347-8. 2005 - Salmeterol and paroxetine: more evidence for paradoxical medicineAnthony J Yun
Med Hypotheses 66:1037-8. 2006 - The intellectual lineage of paradoxical pharmacology strategyAnthony J Yun
Med Hypotheses 65:815. 2005 - The hegemony of empiricism: the opportunity for theoretical science in medicineAnthony J Yun
Med Hypotheses 70:478-81. 2008....