J A Yesavage

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. doi request reprint Sleep-disordered breathing in Vietnam veterans with posttraumatic stress disorder
    Jerome A Yesavage
    Department of Veterans Affairs Health Care System, Palo Alto, CA 94304, USA
    Am J Geriatr Psychiatry 20:199-204. 2012
  2. ncbi request reprint Donepezil and flight simulator performance: effects on retention of complex skills
    J A Yesavage
    Palo Alto Veterans Affairs Health Care System, Stanford University School of Medicine, Stanford, CA 94305 5550, USA
    Neurology 59:123-5. 2002
  3. ncbi request reprint Modeling the prevalence and incidence of Alzheimer's disease and mild cognitive impairment
    Jerome A Yesavage
    Palo Alto Veterans Affairs Health Care System, 3801 Miranda Avenue, MC 151Y, Palo Alto, CA 94304, USA
    J Psychiatr Res 36:281-6. 2002
  4. ncbi request reprint Age and disease severity predict choice of atypical neuroleptic: a signal detection approach to physicians' prescribing decisions
    Jerome A Yesavage
    Palo Alto Veterans Affairs Health Care System, MC 151Y, Palo Alto, CA, USA
    J Psychiatr Res 37:535-8. 2003
  5. ncbi request reprint Sleep/wake cycle disturbance in Alzheimer's disease: how much is due to an inherent trait?
    Jerome A Yesavage
    Department of Veterans Affairs Health Care System, Palo Alto, California 94304, USA
    Int Psychogeriatr 14:73-81. 2002
  6. ncbi request reprint Sleep/wake disruption in Alzheimer's disease: APOE status and longitudinal course
    Jerome A Yesavage
    National Institute of Aging Alzheimer s Disease Core Center, Palo Alto VA Health Care System 151Y, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    J Geriatr Psychiatry Neurol 17:20-4. 2004
  7. ncbi request reprint Use of a VA pharmacy database to screen for areas at high risk for disease: Parkinson's disease and exposure to pesticides
    J A Yesavage
    Sierra Pacific Mental Illness Research, Education, and Clinical Center, Palo Alto VA Health Care System, Palo Alto, CA 94304, USA
    J Geriatr Psychiatry Neurol 17:36-8. 2004
  8. ncbi request reprint Spatial test for agricultural pesticide "blow-in" effect on prevalence of Parkinson's disease
    J A Yesavage
    Sierra Pacific Mental Illness Research, Education, and Clinical Center, Palo Alto Veterans Affairs Health Care System, Palo Alto, CA 94304, USA
    J Geriatr Psychiatry Neurol 19:32-5. 2006
  9. ncbi request reprint Development of diagnostic criteria for defining sleep disturbance in Alzheimer's disease
    Jerome A Yesavage
    Sierra Pacific Mental Illness Research, Education, and Clinical Center, Palo Alto VA Health Care System, Palo Alto, CA 94304, USA
    J Geriatr Psychiatry Neurol 16:131-9. 2003
  10. ncbi request reprint Should one use medications in combination with cognitive training? If so, which ones?
    Jerome Yesavage
    Palo Alto Veterans Affairs Health Care System, Palo Alto, CA 94304, USA
    J Gerontol B Psychol Sci Soc Sci 62:11-8. 2007

Research Grants

  1. TREATMENTS FOR INSOMNIA
    Jerome Yesavage; Fiscal Year: 2003
  2. STANFORD ALZHEIMER'S DISEASE CORE CENTER
    Jerome Yesavage; Fiscal Year: 2004
  3. Age-Related Longitudinal Changes in Aviator Performance
    Jerome Yesavage; Fiscal Year: 2007

Detail Information

Publications66

  1. doi request reprint Sleep-disordered breathing in Vietnam veterans with posttraumatic stress disorder
    Jerome A Yesavage
    Department of Veterans Affairs Health Care System, Palo Alto, CA 94304, USA
    Am J Geriatr Psychiatry 20:199-204. 2012
    ..To study the prevalence of sleep-disordered breathing (SDB) in Vietnam- era veterans...
  2. ncbi request reprint Donepezil and flight simulator performance: effects on retention of complex skills
    J A Yesavage
    Palo Alto Veterans Affairs Health Care System, Stanford University School of Medicine, Stanford, CA 94305 5550, USA
    Neurology 59:123-5. 2002
    ..05. Donepezil appears to have beneficial effects on retention of training on complex aviation tasks in nondemented older adults...
  3. ncbi request reprint Modeling the prevalence and incidence of Alzheimer's disease and mild cognitive impairment
    Jerome A Yesavage
    Palo Alto Veterans Affairs Health Care System, 3801 Miranda Avenue, MC 151Y, Palo Alto, CA 94304, USA
    J Psychiatr Res 36:281-6. 2002
    ..Due to its substantial prevalence, MCI may be an important target for screening and possible intervention...
  4. ncbi request reprint Age and disease severity predict choice of atypical neuroleptic: a signal detection approach to physicians' prescribing decisions
    Jerome A Yesavage
    Palo Alto Veterans Affairs Health Care System, MC 151Y, Palo Alto, CA, USA
    J Psychiatr Res 37:535-8. 2003
    ....
  5. ncbi request reprint Sleep/wake cycle disturbance in Alzheimer's disease: how much is due to an inherent trait?
    Jerome A Yesavage
    Department of Veterans Affairs Health Care System, Palo Alto, California 94304, USA
    Int Psychogeriatr 14:73-81. 2002
    ..We discuss how "state-trait" analyses can be helpful in identifying areas of assessment most likely to be fruitful objectives of physiologic and genetic research on sleep/wake disturbance in AD...
  6. ncbi request reprint Sleep/wake disruption in Alzheimer's disease: APOE status and longitudinal course
    Jerome A Yesavage
    National Institute of Aging Alzheimer s Disease Core Center, Palo Alto VA Health Care System 151Y, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    J Geriatr Psychiatry Neurol 17:20-4. 2004
    ..In these data, APOE status was associated with the progression of sleep/wake disturbances in AD. Overall, there was greater deterioration on sleep parameters in patients negative for the epsilon4 allele...
  7. ncbi request reprint Use of a VA pharmacy database to screen for areas at high risk for disease: Parkinson's disease and exposure to pesticides
    J A Yesavage
    Sierra Pacific Mental Illness Research, Education, and Clinical Center, Palo Alto VA Health Care System, Palo Alto, CA 94304, USA
    J Geriatr Psychiatry Neurol 17:36-8. 2004
    ..However, a thorough exploration of alternative explanations is needed to reach definitive conclusions regarding the findings suggested by this method...
  8. ncbi request reprint Spatial test for agricultural pesticide "blow-in" effect on prevalence of Parkinson's disease
    J A Yesavage
    Sierra Pacific Mental Illness Research, Education, and Clinical Center, Palo Alto Veterans Affairs Health Care System, Palo Alto, CA 94304, USA
    J Geriatr Psychiatry Neurol 19:32-5. 2006
    ..The results did not support the hypothesis of increasing prevalence of Parkinsonism attributable to wind drift...
  9. ncbi request reprint Development of diagnostic criteria for defining sleep disturbance in Alzheimer's disease
    Jerome A Yesavage
    Sierra Pacific Mental Illness Research, Education, and Clinical Center, Palo Alto VA Health Care System, Palo Alto, CA 94304, USA
    J Geriatr Psychiatry Neurol 16:131-9. 2003
    ..This article attempts to develop better-defined provisional criteria with the goal of promoting epidemiological, physiological, and, especially, pharmacological research on sleep/wake disturbances...
  10. ncbi request reprint Should one use medications in combination with cognitive training? If so, which ones?
    Jerome Yesavage
    Palo Alto Veterans Affairs Health Care System, Palo Alto, CA 94304, USA
    J Gerontol B Psychol Sci Soc Sci 62:11-8. 2007
    ..As the number of cognitively impaired older adults grows, it is likely that there will be pressure to treat more broadly with both medications and cognitive training...
  11. pmc Circadian clock gene polymorphisms and sleep-wake disturbance in Alzheimer disease
    Jerome A Yesavage
    Department of Veterans Affairs Health Care System, Stanford University School of Medicine, Palo Alto, California
    Am J Geriatr Psychiatry 19:635-43. 2011
    ..The goal of this study is to report indices of sleep-wake function collected from individuals with AD in relation to relevant polymorphisms in circadian clock-related genes...
  12. ncbi request reprint Acetylcholinesterase inhibitor in combination with cognitive training in older adults
    Jerome A Yesavage
    Palo Alto Veterans Affairs Health Care System, Palo Alto, CA, USA
    J Gerontol B Psychol Sci Soc Sci 63:P288-94. 2008
    ....
  13. pmc Initial cognitive performance predicts longitudinal aviator performance
    Jerome A Yesavage
    Stanford VA Aging Clinical Research Center, VA Palo Alto Health Care System, Palo Alto, CA 94304 1207, USA
    J Gerontol B Psychol Sci Soc Sci 66:444-53. 2011
    ..The goal of the study was to improve prediction of longitudinal flight simulator performance by studying cognitive factors that may moderate the influence of chronological age...
  14. ncbi request reprint Relationship of age and simulated flight performance
    J A Yesavage
    Department of Veterans Affairs Health Care System, Palo Alto, California, USA
    J Am Geriatr Soc 47:819-23. 1999
    ..To determine the relationship between age and aviator performance on a flight simulator...
  15. ncbi request reprint Nocturnal sleep apnea/hypopnea is associated with lower memory performance in APOE epsilon4 carriers
    R O'HARA
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5550, USA
    Neurology 65:642-4. 2005
    ..This is the first study to provide preliminary evidence for a negative interaction of APOE epsilon4 and OSAH on memory in older adults, which may have important implications for treating cognitive decline and delaying dementia onset...
  16. ncbi request reprint Influence of the menstrual cycle on flight simulator performance after alcohol ingestion
    M S Mumenthaler
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California, 94305 5550, USA
    J Stud Alcohol 62:422-33. 2001
    ..The present study tested the hypothesis that flight simulator performance during acute alcohol intoxication and 8 hours after drinking differs between the menstrual and the luteal phase of the menstrual cycle...
  17. pmc The roles of COMT val158met status and aviation expertise in flight simulator performance and cognitive ability
    Q Kennedy
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5550, USA
    Behav Genet 41:700-8. 2011
    ..These preliminary results indicate that COMT val158met polymorphic variation can affect a real-world task...
  18. ncbi request reprint Acetyl L-carnitine slows decline in younger patients with Alzheimer's disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach
    J O Brooks
    Stanford University School of Medicine, California, USA
    Int Psychogeriatr 10:193-203. 1998
    ..To assess the longitudinal effects of acety-L-carnitine (ALC) on patients diagnosed with Alzheimer's disease...
  19. doi request reprint Which older adults maintain benefit from cognitive training? Use of signal detection methods to identify long-term treatment gains
    J K Fairchild
    Department of Veterans Affairs and Sierra Pacific MIRECC, Palo Alto, California 94304, USA
    Int Psychogeriatr 25:607-16. 2013
    ..The goal of the current study is to identify baseline characteristics of long-term treatment responders and of those able to maintain their initial benefit from cognitive training...
  20. pmc Donepezil delays progression to AD in MCI subjects with depressive symptoms
    P H Lu
    Departments of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Neurology 72:2115-21. 2009
    ..To determine whether the presence of depression predicts higher rate of progression to Alzheimer disease (AD) in patients with amnestic mild cognitive impairment (aMCI) and whether donepezil treatment beneficially affect this relationship...
  21. ncbi request reprint Non-pharmacologic management of sleep disturbance in Alzheimer's disease
    R David
    Department of Veterans Affairs Health Care System, Palo Alto, California 94304, USA
    J Nutr Health Aging 14:203-6. 2010
    ....
  22. ncbi request reprint Relationship of CogScreen-AE to flight simulator performance and pilot age
    J L Taylor
    Department of Veterans Affairs Health Care System, Palo Alto, CA 94304 1207, USA
    Aviat Space Environ Med 71:373-80. 2000
    ..We report on the relationship between CogScreen-Aeromedical Edition (AE) factor scores and flight simulator performance in aircraft pilots aged 50-69...
  23. pmc BDNF polymorphism predicts the rate of decline in skilled task performance and hippocampal volume in healthy individuals
    M Millan Sanchez
    VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Transl Psychiatry 1:e51. 2011
    ..Translational Psychiatry (2011) 1, e51; doi:10.1038/tp.2011.47; published online 25 October 2011...
  24. pmc MR spectroscopy for assessment of memantine treatment in mild to moderate Alzheimer dementia
    J W Ashford
    War Related Illness and Injury Study Center, VA Palo Alto Health Care System, Palo Alto, CA, USA
    J Alzheimers Dis 26:331-6. 2011
    ..The objective of this study was to test whether memantine would slow or prevent the loss of neurons in mild to moderate AD patients...
  25. ncbi request reprint Ethanol pharmacokinetics in white women: nonlinear model fitting versus zero-order elimination analyses
    M S Mumenthaler
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5550, USA
    Alcohol Clin Exp Res 24:1353-62. 2000
    ....
  26. ncbi request reprint Rate of cognitive decline in AD is accelerated by the interleukin-1 alpha -889 *1 allele
    G M Murphy
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305, USA
    Neurology 56:1595-7. 2001
    ..There was no difference in rate of decline between patients with and without the APOE epsilon 4 allele. These results support the hypothesis that inflammation is important in the clinical course of AD...
  27. ncbi request reprint Mnemonic training in older adults: effects of age, length of training, and type of cognitive pretraining
    J O Brooks
    Stanford University School of Medicine, California, USA
    Int Psychogeriatr 11:75-84. 1999
    ..To improve performance with mnemonic techniques for remembering words and proper names...
  28. ncbi request reprint On disentangling states versus traits: demonstration of a new technique using the Alzheimer's disease assessment scale
    Joy L Taylor
    Department of Veterans Affairs, Sierra Pacific Mental Illness Research, Education, and Clinical Center, Palo Alto, California 94304, USA
    Alzheimer Dis Assoc Disord 16:254-60. 2002
    ..We discuss how state-trait analyses can be helpful in focusing attention on those areas of assessment most likely to accomplish specific objectives...
  29. ncbi request reprint Relationship between variations in estradiol and progesterone levels across the menstrual cycle and human performance
    M S Mumenthaler
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5550, USA
    Psychopharmacology (Berl) 155:198-203. 2001
    ..Studies about whether or not the cognitive performance of women is influenced by changes in levels of sex steroid hormones across the menstrual cycle have produced ambiguous results...
  30. ncbi request reprint Dissociation between two forms of conceptual priming in Alzheimer's disease
    C J Vaidya
    Department of Psychology, Stanford University, California 94305, USA
    Neuropsychology 13:516-24. 1999
    ..This dissociation in AD suggests that conceptual priming is not a unitary form of memory but rather is mediated by separable memory systems...
  31. ncbi request reprint Effects of menstrual cycle and female sex steroids on ethanol pharmacokinetics
    M S Mumenthaler
    Department of Psychiatry and Behavioral Sciences, Stanford University, School of Medicine, California 94305 5550, USA
    Alcohol Clin Exp Res 23:250-5. 1999
    ..Because previous studies about the topic have used few subjects and revealed controversial results, we consider our negative findings based on 24 subjects meaningful...
  32. ncbi request reprint Convergent behavioral and neuropsychological evidence for a distinction between identification and production forms of repetition priming
    J D Gabrieli
    Department of Psychology, Stanford University, California 94305, USA
    J Exp Psychol Gen 128:479-98. 1999
    ..There may be separable cognitive and neural bases for implicit modulation of identification and production forms of knowledge...
  33. pmc Pilot age and expertise predict flight simulator performance: a 3-year longitudinal study
    Joy L Taylor
    Department of Veterans Affairs and Sierra Pacific MIRECC, Palo Alto, CA, USA
    Neurology 68:648-54. 2007
    ..We investigated the influence of age and aviation expertise (indexed by Federal Aviation Administration pilot ratings) on longitudinal flight simulator performance...
  34. ncbi request reprint Donepezil treatment and Alzheimer disease: can the results of randomized clinical trials be applied to Alzheimer disease patients in clinical practice?
    Jared R Tinklenberg
    Sierra Pacific Mental Illness, Research, Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA
    Am J Geriatr Psychiatry 15:953-60. 2007
    ....
  35. doi request reprint Increasing the ranks of academic researchers in mental health: a multisite approach to postdoctoral fellowship training
    Ruth O'Hara
    Sierra Pacific MIRECC, VA Palo Alto Health Care System, Palo Alto, California 94304, USA
    Acad Med 85:41-7. 2010
    ..The VA's multisite fellowship program plays a valuable role in preparing substantial numbers of psychiatry and psychology trainees for a range of academic clinical research and leadership positions in the field of mental health...
  36. pmc Age and expertise effects in aviation decision making and flight control in a flight simulator
    Quinn Kennedy
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
    Aviat Space Environ Med 81:489-97. 2010
    ..We examined the roles of age, expertise, and their relationship on aviation decision making and flight control performance during a flight simulator task...
  37. ncbi request reprint Factors in choosing atypical antipsychotics: toward understanding the bases of physicians' prescribing decisions
    Jennifer Hoblyn
    Palo Alto Veterans Affairs Health Care System, Sierra Pacific Mental Illness Research, Education, and Clinical Center, Palo Alto, CA 94304, USA
    J Psychiatr Res 40:160-6. 2006
    ..Off-label prescribing of medications, polypharmacy, and other questionable prescribing practices have led investigators to examine a large VA pharmacy database to determine if physician prescribing decisions appear reasonable...
  38. ncbi request reprint Nicotine deprivation and pilot performance during simulated flight
    Martin S Mumenthaler
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Aviat Space Environ Med 81:660-4. 2010
    ..We tested the hypotheses that nicotine withdrawal affects aircraft pilot performance within 12 h of smoking cessation and that chewing nicotine gum leads to significant relief of these withdrawal effects...
  39. ncbi request reprint Strategies to reduce site differences in multisite studies: a case study of Alzheimer disease progression
    Art Noda
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA
    Am J Geriatr Psychiatry 14:931-8. 2006
    ....
  40. ncbi request reprint Cognitive ability, expertise, and age differences in following air-traffic control instructions
    Joy L Taylor
    Psychiatry Service, Sierra Pacific Mental Illness Research, Education and Clinical Center, Department of Veterans Affairs, Palo Alto, CA 94304 1207, USA
    Psychol Aging 20:117-33. 2005
    ..Results are discussed within frameworks of deliberate practice and cognitive mediation of age differences...
  41. ncbi request reprint VA practice patterns and practice guidelines for treating posttraumatic stress disorder
    Craig S Rosen
    National Center for PTSD, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA
    J Trauma Stress 17:213-22. 2004
    ..Exposure therapy was rarely used. Additional research is needed on training, clinical resources, and organizational factors that may influence VA implementation of guideline recommendations...
  42. ncbi request reprint How well are clinicians following dementia practice guidelines?
    Craig S Rosen
    VA Sierra Pacific Mental Illness Research, Education and Clinical Center, Center for Health Care Evaluation, VA Palo Alto Health Care System, Menlo Park, CA 94025, USA
    Alzheimer Dis Assoc Disord 16:15-23. 2002
    ..These results suggest possible priorities for quality improvement efforts. Further research is needed to clarify reasons for particular gaps between guidelines and practice and to identify specific targets for intervention...
  43. ncbi request reprint Differential associations between entorhinal and hippocampal volumes and memory performance in older adults
    Allyson C Rosen
    Department of Psychology, Stanford University, Stanford, California 94305, USA
    Behav Neurosci 117:1150-60. 2003
    ..57) with delayed paragraph recall. These results suggest that entorhinal and hippocampal volumes are related to individual differences in dissociable kinds of memory performance among healthy older adults...
  44. ncbi request reprint Ethical, and practical issues in applying functional imaging to the clinical management of Alzheimer's disease
    Allyson C Rosen
    Department of Psychology, Jordan Hall, Bldg 420, Stanford University, Stanford, CA 94305, USA
    Brain Cogn 50:498-519. 2002
    ..Various potential clinical applications of functional imaging are briefly reviewed and discussed with respect to associated ethical conflicts...
  45. ncbi request reprint Hormone replacement therapy and longitudinal cognitive performance in postmenopausal women
    Ruth O'Hara
    Dept of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5550, USA
    Am J Geriatr Psychiatry 13:1107-10. 2005
    ..The authors examined the impact of hormone replacement therapy (HRT) on longitudinal cognitive performance (controlling for mood state) in 69 community-dwelling, postmenopausal women...
  46. ncbi request reprint Use of an external mnemonic to augment the efficacy of an internal mnemonic in older adults
    John O Brooks
    Palo Alto Veterans Affairs Health Care System, Palo Alto, California 94304, USA
    Int Psychogeriatr 15:59-67. 2003
    ..Participants wrote two types of lists during the study phase: (a) a list of study words and/or (b) a loci list. At recall, participants were not allowed to refer to either of the lists they had written during the study...
  47. ncbi request reprint Validation of a 26-point telephone version of the Mini-Mental State Examination
    Lori A Newkirk
    Stanford VA Alzheimer s Center, Veterans Affairs Palo Alto Health Care System 116F PAD, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    J Geriatr Psychiatry Neurol 17:81-7. 2004
    ..Use of this practical measure can enhance reassessment if returning to the clinic is difficult or if a change in the patient's medical condition merits a check of mental status by telephone...
  48. ncbi request reprint Factors associated with psychiatric hospitalization of individuals diagnosed with dementia and comorbid bipolar disorder
    John O Brooks
    Palo Alto Veterans Affairs Health Care System, Palo Alto, California 94304, USA
    J Geriatr Psychiatry Neurol 19:72-7. 2006
    ..These findings suggest that disorders with increased frequency in BD affect the course of dementia...
  49. ncbi request reprint Caution regarding the use of pilot studies to guide power calculations for study proposals
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif 94305, USA
    Arch Gen Psychiatry 63:484-9. 2006
    ..The argument herein is not meant to discourage clinical researchers from performing pilot studies (or review committees from requiring them) but simply to caution against their use for the objective of guiding power calculations...
  50. ncbi request reprint Psychoactive drugs and pilot performance: a comparison of nicotine, donepezil, and alcohol effects
    Martin S Mumenthaler
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuropsychopharmacology 28:1366-73. 2003
    ....
  51. ncbi request reprint The development and initial validation of the Terminally Ill Grief or Depression Scale (TIGDS)
    Vyjeyanthi S Periyakoil
    Palo Alto Veterans Affairs Health Care System, Palo Alto 94304, USA
    Int J Methods Psychiatr Res 14:202-12. 2005
    ..The TIGDS depression subscale showed strong convergent validity and the TIGDS grief subscale showed strong discriminant validity with the HADS total score...
  52. ncbi request reprint A retrospective chart review of gabapentin for the treatment of aggressive and agitated behavior in patients with dementias
    J W Hawkins
    VA Palo Alto Health Care System, Mental Illness Research, Educational and Clinical Center, Menlo Park, CA 94205, USA
    Am J Geriatr Psychiatry 8:221-5. 2000
    ..Two of the 24 patients discontinued use of the medication because of excessive sedation. No other significant side effects were noted in treatment lasting up to 2 years...
  53. ncbi request reprint Which Alzheimer patients are at risk for rapid cognitive decline?
    Ruth O'Hara
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, Stanford, California 94305 5550, USA
    J Geriatr Psychiatry Neurol 15:233-8. 2002
    ..This information could help clinicians target these patients for pharmacologic interventions, facilitate long-term care planning, and potentially create savings by delaying or stabilizing the course of the disease...
  54. pmc Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease
    M Britschgi
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 106:12145-50. 2009
    ....
  55. doi request reprint Subclinical anxiety symptoms, sleep, and daytime dysfunction in older adults with primary insomnia
    Adam P Spira
    University of California, San Francisco, Department of Medicine, Division of Geriatrics, San Francisco, CA, USA
    J Geriatr Psychiatry Neurol 21:56-60. 2008
    ..Thus, subclinical anxiety symptoms may be an important target for clinical intervention to improve sleep and functioning in older adults with primary insomnia."..
  56. ncbi request reprint Neuropsychiatric diagnosis and management of chronic sequelae of war-related mild to moderate traumatic brain injury
    Joshua D Halbauer
    Department of Veterans Affairs VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
    J Rehabil Res Dev 46:757-96. 2009
    ..With a multidimensional approach (such as the biopsychosocial model) applied to each symptom cluster, psychological, occupational, and social dysfunction can be delineated and managed...
  57. ncbi request reprint How to drastically reduce priming in word stem completion--and still present the words
    J O Brooks
    Stanford University School of Medicine, California, USA
    Mem Cognit 27:208-19. 1999
    ..These results are not readily accounted for by extant theoretical approaches and point to important methodological issues regarding stem completion...
  58. ncbi request reprint Remote memory for public figures in Alzheimer's disease: relationships to regional cortical and limbic brain volumes
    R Fama
    Neuropsychiatry Program, SRI International, Menlo Park, California, USA
    J Int Neuropsychol Soc 7:384-90. 2001
    ....
  59. ncbi request reprint In Alzheimer disease, increased wake fragmentation found in those with lower hypocretin-1
    L F Friedman
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
    Neurology 68:793-4. 2007
  60. pmc Scheduled bright light for treatment of insomnia in older adults
    Leah Friedman
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, California 94304, USA
    J Am Geriatr Soc 57:441-52. 2009
    ..To determine whether bright light can improve sleep in older individuals with insomnia...
  61. ncbi request reprint Variable effects of aging on frontal lobe contributions to memory
    Allyson C Rosen
    Departments of Psychology, Jordan Hall, Bldg 420, Stanford University, Stanford, CA 94305, USA
    Neuroreport 13:2425-8. 2002
    ..Thus, successful aging was characterized by preserved left prefrontal and enhanced right prefrontal activation that may have provided compensatory encoding resources...
  62. ncbi request reprint No improvement of posttraumatic stress disorder symptoms with guanfacine treatment
    Thomas C Neylan
    Department of Psychiatry, University of California, San Francisco, USA
    Am J Psychiatry 163:2186-8. 2006
    ..The authors report an 8-week, double-blind, randomized controlled trial of guanfacine versus placebo for posttraumatic stress disorder (PTSD)...
  63. ncbi request reprint Telephonic Remote Evaluation of Neuropsychological Deficits (TREND): longitudinal monitoring of elderly community-dwelling volunteers using touch-tone telephones
    James C Mundt
    Healthcare Technology Systems, Inc, Madison, WI 53717, USA
    Alzheimer Dis Assoc Disord 21:218-24. 2007
    ..Such assessments might benefit routine clinical care and large-scale, longitudinal research in the future, but will require additional research over longer periods...
  64. ncbi request reprint Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins
    Sandip Ray
    Satoris, Inc, 2686 Middlefield Road, Suite E, Redwood City, California 94063, USA
    Nat Med 13:1359-62. 2007
    ..Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease...
  65. pmc High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial
    Paul S Aisen
    Department of Neurosciences, University of California, San Diego, 9500 Gilman Dr, M C 0949, La Jolla, CA 92093, USA
    JAMA 300:1774-83. 2008
    ..Prior studies of B vitamins to reduce homocysteine in AD have not had sufficient size or duration to assess their effect on cognitive decline...
  66. ncbi request reprint The Cost-Time Index: a new method for measuring the efficiencies of recruitment-resources in clinical trials
    Ken S Ota
    Western University, College of Osteopathic Medicine of the Pacific, Pomona, CA 91766, USA
    Contemp Clin Trials 27:494-7. 2006
    ..The authors demonstrate the utility of the Cost-Time Index and recommend its use as an additional variable in future studies regarding recruitment strategies in clinical trials...

Research Grants23

  1. TREATMENTS FOR INSOMNIA
    Jerome Yesavage; Fiscal Year: 2003
    ..This five-year application will ultimately include 90 treatment subjects aged >60 years (three groups of 30 each). ..
  2. STANFORD ALZHEIMER'S DISEASE CORE CENTER
    Jerome Yesavage; Fiscal Year: 2004
    ..We feel that this multi-factorial and interdisciplinary approach may best address complex questions current to AD research. ..
  3. Age-Related Longitudinal Changes in Aviator Performance
    Jerome Yesavage; Fiscal Year: 2007
    ..We plan to test the hypothesis that longitudinal simulator performance can be predicted by measures of cognitive processing speed. ..