David Yeomans

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. doi A rodent model of trigeminal neuralgia
    David C Yeomans
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
    Methods Mol Biol 851:121-31. 2012
  2. pmc Selective nociceptor activation in volunteers by infrared diode laser
    Alexander Z Tzabazis
    Department of Anesthesia, Friedrich Alexander University, Erlangen, Germany
    Mol Pain 7:18. 2011
  3. pmc Morphine reduces local cytokine expression and neutrophil infiltration after incision
    J David Clark
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
    Mol Pain 3:28. 2007
  4. pmc Chronic morphine administration enhances nociceptive sensitivity and local cytokine production after incision
    DeYong Liang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
    Mol Pain 4:7. 2008
  5. pmc Enkephalin-encoding herpes simplex virus-1 decreases inflammation and hotplate sensitivity in a chronic pancreatitis model
    Hong Yang
    Dept of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX, USA
    Mol Pain 4:8. 2008
  6. pmc Thermal nociceptive properties of trigeminal afferent neurons in rats
    Jason M Cuellar
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    Mol Pain 6:39. 2010
  7. doi Herpes virus-based recombinant herpes vectors: gene therapy for pain and molecular tool for pain science
    D C Yeomans
    Department of Anesthesia, Stanford University, Stanford, CA 94305 511, USA
    Gene Ther 16:502-8. 2009
  8. ncbi Recombinant herpes vector-mediated analgesia in a primate model of hyperalgesia
    David C Yeomans
    Department of Anesthesia and Stanford Pain and Analgesia Research Center, Stanford University School of Medicine, Stanford, CA 94305 5117, USA
    Mol Ther 13:589-97. 2006
  9. ncbi Decrease in inflammatory hyperalgesia by herpes vector-mediated knockdown of Nav1.7 sodium channels in primary afferents
    D C Yeomans
    Department of Anesthesia and Stanford Pain and Analgesia Research Center, Stanford University, Stanford, CA 94305 5117, USA
    Hum Gene Ther 16:271-7. 2005
  10. ncbi Reversal of ongoing thermal hyperalgesia in mice by a recombinant herpesvirus that encodes human preproenkephalin
    David C Yeomans
    Department of Anesthesia, Stanford University, Stanford, CA 94305, USA
    Mol Ther 9:24-9. 2004

Research Grants

  1. NOCICEPTOR SELECTIVE ANALGESIA
    David Yeomans; Fiscal Year: 2001
  2. In Vivo Genetic Manipulation of Neuronal Excitability
    David Yeomans; Fiscal Year: 2004
  3. Recombinant Herpes Injection into Trigeminal Ganglia
    David Yeomans; Fiscal Year: 2004
  4. Activation of Thermonociceptors by Infrared Diode Laser
    David Yeomans; Fiscal Year: 2005
  5. Chronic Compression of the Trigeminal Ganglia
    David Yeomans; Fiscal Year: 2007
  6. Chronic Compression of the Trigeminal Ganglia
    David Yeomans; Fiscal Year: 2009

Collaborators

Detail Information

Publications29

  1. doi A rodent model of trigeminal neuralgia
    David C Yeomans
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
    Methods Mol Biol 851:121-31. 2012
    ..The chapter then describes means of behaviorally assessing the robust mechanical hypersensitivity consequent to the compression that can be used to determine the efficacy of potential therapies for this devastating condition...
  2. pmc Selective nociceptor activation in volunteers by infrared diode laser
    Alexander Z Tzabazis
    Department of Anesthesia, Friedrich Alexander University, Erlangen, Germany
    Mol Pain 7:18. 2011
    ....
  3. pmc Morphine reduces local cytokine expression and neutrophil infiltration after incision
    J David Clark
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
    Mol Pain 3:28. 2007
    ..Our studies were directed towards determining if opioids alter cytokine production near incisions and to identify cell populations responsible for producing these cytokines...
  4. pmc Chronic morphine administration enhances nociceptive sensitivity and local cytokine production after incision
    DeYong Liang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
    Mol Pain 4:7. 2008
    ..Most of these proposed mechanisms involve plastic events in the central or peripheral nervous systems. Alterations in the abundance of peripheral mediators of nociception have not previously been explored...
  5. pmc Enkephalin-encoding herpes simplex virus-1 decreases inflammation and hotplate sensitivity in a chronic pancreatitis model
    Hong Yang
    Dept of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX, USA
    Mol Pain 4:8. 2008
    ..The model was used to assess time course and efficacy of a replication defective herpes simplex virus type 1 vector construct delivering human cDNA encoding preproenkephalin (HSV-ENK)...
  6. pmc Thermal nociceptive properties of trigeminal afferent neurons in rats
    Jason M Cuellar
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    Mol Pain 6:39. 2010
    ..This study uses a highly controlled and reproducible diode laser stimulator to investigate the activation of trigeminal afferents to noxious skin heating...
  7. doi Herpes virus-based recombinant herpes vectors: gene therapy for pain and molecular tool for pain science
    D C Yeomans
    Department of Anesthesia, Stanford University, Stanford, CA 94305 511, USA
    Gene Ther 16:502-8. 2009
    ..These experiments uniquely allowed for spatially and temporally selective investigations into the function of these proteins in pain, highly valuable information in target validation for therapy development...
  8. ncbi Recombinant herpes vector-mediated analgesia in a primate model of hyperalgesia
    David C Yeomans
    Department of Anesthesia and Stanford Pain and Analgesia Research Center, Stanford University School of Medicine, Stanford, CA 94305 5117, USA
    Mol Ther 13:589-97. 2006
    ..This approach may be a viable means of treating localized cutaneous burning pain and hyperalgesia...
  9. ncbi Decrease in inflammatory hyperalgesia by herpes vector-mediated knockdown of Nav1.7 sodium channels in primary afferents
    D C Yeomans
    Department of Anesthesia and Stanford Pain and Analgesia Research Center, Stanford University, Stanford, CA 94305 5117, USA
    Hum Gene Ther 16:271-7. 2005
    ..These results provide clear evidence of the involvement of an increased expression of the Nav1.7 channel in nociceptive neurons in the development of inflammatory hyperalgesia...
  10. ncbi Reversal of ongoing thermal hyperalgesia in mice by a recombinant herpesvirus that encodes human preproenkephalin
    David C Yeomans
    Department of Anesthesia, Stanford University, Stanford, CA 94305, USA
    Mol Ther 9:24-9. 2004
    ..These results suggest that herpesvirus vectors encoding analgesic peptides may be useful in attenuating centrally mediated, ongoing neuropathic pain and/or hyperalgesia...
  11. doi Cytokine profile in human skin in response to experimental inflammation, noxious stimulation, and administration of a COX-inhibitor: a microdialysis study
    M S Angst
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5117, USA
    Pain 139:15-27. 2008
    ..Explored human bioassay is a promising tool for studying the pathology and pharmacology of inflammatory and chronic pain conditions...
  12. ncbi Ameroid rings for gradual chronic constriction of the sciatic nerve in rats: contribution of different nerves to neuropathic pain
    A Tzabazis
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, S 276 Stanford, CA 94305, USA
    Brain Res Bull 64:127-32. 2004
    ..The uninjured saphenous afferents, in particular C fibers, mediate thermal hyperalgesia after chronic constriction of the sciatic nerve using an ameroid ring...
  13. ncbi Peripheral and central p38 MAPK mediates capsaicin-induced hyperalgesia
    S M Sweitzer
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Pain 111:278-85. 2004
    ..These results suggest that p38 MAPK plays a role in the development of hyperalgesic states, exerting effects both centrally in the spinal cord and peripherally in sensory C fibers...
  14. ncbi Virally mediated delivery of enkephalin and other neuropeptide transgenes in experimental pain models
    Steven P Wilson
    Department of Pharmacology and Physiology, University of South Carolina School of Medicine, Columbia, South Carolina 29208, USA
    Ann N Y Acad Sci 971:515-21. 2002
    ..These results raise the possibility that herpes-mediated, gene-based approaches to treat chronic pain states may be useful in therapy of chronic pain in humans...
  15. doi Joint capsule treatment with enkephalin-encoding HSV-1 recombinant vector reduces inflammatory damage and behavioural sequelae in rat CFA monoarthritis
    Ying Lu
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX, USA
    Eur J Neurosci 27:1153-65. 2008
    ..Targeted delivery of enkephalin-encoding HSV-1 vector generated safe, sustained opioid-induced analgesia with protective anti-inflammatory blunting in rat inflammatory arthritis...
  16. ncbi Porcine chromaffin cells, culture, and transplant for antinociceptive effects in rodents and primates
    Ying Lu
    Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neurol Res 26:707-12. 2004
    ..Compared with the same number of bovine chromaffin cells, porcine chromaffin cells showed a more robust and longer antinociceptive effect, and could be a better source of cells for human transplantation...
  17. ncbi Differential opioid inhibition of C- and A delta- fiber mediated thermonociception after stimulation of the nucleus raphe magnus
    Ying Lu
    Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois, USA
    Anesth Analg 98:414-9, table of contents. 2004
    ..These findings suggest that nociception evoked by the activation of A delta or C fiber nociceptors is under pharmacologically distinguishable descending control from the nucleus raphe magnus...
  18. ncbi Afferent fiber-selective shift in opiate potency following targeted opioid receptor knockdown
    Toni L Jones
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5117, USA
    Pain 106:365-71. 2003
    ....
  19. ncbi Antihyperalgesic effect of a recombinant herpes virus encoding antisense for calcitonin gene-related peptide
    Alexander Z Tzabazis
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California, USA
    Anesthesiology 106:1196-203. 2007
    ..Therefore, attenuating evoked release of CGRP from central terminals of nociceptors should have an antihyperalgesic effect...
  20. pmc Treatment of inflamed pancreas with enkephalin encoding HSV-1 recombinant vector reduces inflammatory damage and behavioral sequelae
    Ying Lu
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA
    Mol Ther 15:1812-9. 2007
    ..Targeted transgene delivery and met-ENK expression successfully produced decreased inflammation in experimental pancreatitis...
  21. ncbi Differential activation of trigeminal C or Adelta nociceptors by infrared diode laser in rats: behavioral evidence
    Alexander Tzabazis
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Brain Res 1037:148-56. 2005
    ..We conclude that different settings of the stimulator used in this study were capable of selectively activating trigeminal Adelta or C thermonociceptors...
  22. pmc ASIC3 in muscle mediates mechanical, but not heat, hyperalgesia associated with muscle inflammation
    Kathleen A Sluka
    Graduate Program in Physical Therapy and Rehabilitation Science, 1 252 Medical Education Bldg, The University of Iowa, Iowa City, IA 52242, USA
    Pain 129:102-12. 2007
    ..Thus, ASIC3 in primary afferent fibers innervating muscle is critical to development of hyperalgesia that results from muscle insult...
  23. ncbi Blockade of the complement C5a receptor reduces incisional allodynia, edema, and cytokine expression
    J David Clark
    Department of Anesthesia, Stanford University School of Medicine, California 94304, USA
    Anesthesiology 104:1274-82. 2006
    ..Complement-mediated enhancement of the inflammation surrounding surgical incisions may increase pain...
  24. ncbi Antinociceptive action of a p38alpha MAPK inhibitor, SD-282, in a diabetic neuropathy model
    Sarah M Sweitzer
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5117, USA
    Pain 109:409-19. 2004
    ..These results indicate a potential therapeutic value of p38alpha MAPK inhibitors in the treatment of aberrant pain sensitivity produced by diabetes...
  25. ncbi Conformation-dependent effects of VIP on nociception in rats
    David C Yeomans
    Department of Pharmacology, College of Medicine, University of Illinois at Chicago, 60612, USA
    Peptides 24:617-22. 2003
    ....
  26. pmc Effect of anti-NGF antibodies in a rat tibia fracture model of complex regional pain syndrome type I
    Ilya Sabsovich
    Physical Medicine and Rehabilitation Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Pain 138:47-60. 2008
    ..Conversely, anti-NGF did not decrease hindpaw edema, warmth or cytokine production. Collectively, anti-NGF reduced some but not all signs characteristic of CRPS illustrating the complexity of CRPS pathogenesis and NGF signaling...
  27. ncbi Protein kinase C epsilon and gamma: involvement in formalin-induced nociception in neonatal rats
    Sarah M Sweitzer
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California, USA
    J Pharmacol Exp Ther 309:616-25. 2004
    ..Identifying the molecular mechanisms responsible for age-specific patterns of nociception is necessary for the rational development of novel therapeutic strategies for treating pediatric pain...
  28. ncbi GABAB receptors on central terminals of C-afferents mediate intersegmental Adelta-afferent evoked hypoalgesia
    Toni L Jones
    Anesthesia Department, Stanford University School of Medicine, CA 94305, USA
    Eur J Pain 9:233-42. 2005
    ..These findings indicate an intersegmental, sciatic Adelta-afferent-evoked hypoalgesic effect on saphenous C-afferent responses that is mediated by pre-synaptic GABA(B) receptors on the terminals of those C-afferents...
  29. ncbi Conditional analgesia from spinally transplanted adrenal chromaffin cells
    David C Yeomans
    Pain 95:191-4. 2002

Research Grants8

  1. NOCICEPTOR SELECTIVE ANALGESIA
    David Yeomans; Fiscal Year: 2001
    ....
  2. In Vivo Genetic Manipulation of Neuronal Excitability
    David Yeomans; Fiscal Year: 2004
    ..7 channels in chronic pain patients, providing a long-term genetic therapy for their pain. ..
  3. Recombinant Herpes Injection into Trigeminal Ganglia
    David Yeomans; Fiscal Year: 2004
    ..In so doing, we hope to provide initial support for what may be a new long-lasting treatment for trigeminal nerve-related pain. ..
  4. Activation of Thermonociceptors by Infrared Diode Laser
    David Yeomans; Fiscal Year: 2005
    ....
  5. Chronic Compression of the Trigeminal Ganglia
    David Yeomans; Fiscal Year: 2007
    ..These mechanistic studies, in turn, can lead to the determination of new targets for pharmacdceutical development, as well as for gene therapy approaches. ..
  6. Chronic Compression of the Trigeminal Ganglia
    David Yeomans; Fiscal Year: 2009
    ..These mechanistic studies, in turn, can lead to the determination of new targets for pharmacdceutical development, as well as for gene therapy approaches. ..