M A Yenari

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Gene therapy for treatment of cerebral ischemia using defective herpes simplex viral vectors
    M A Yenari
    Department of Neurology, Stanford Stroke Center, Stanford, CA, USA
    Neurol Res 23:543-52. 2001
  2. ncbi request reprint Diffusion- and perfusion-weighted magnetic resonance imaging of focal cerebral ischemia and cortical spreading depression under conditions of mild hypothermia
    M A Yenari
    Department of Neurosurgery, Stanford University Medical Center, 120 Welch Road, HSLS Bldg P304, Stanford, CA 94305 5487, USA
    Brain Res 885:208-19. 2000
  3. ncbi request reprint Ischemic vulnerability of primary murine microglial cultures
    M A Yenari
    Department of Neurosurgery, Stanford University Medical Center, CA 94305, USA
    Neurosci Lett 298:5-8. 2001
  4. ncbi request reprint L-selectin inhibition does not reduce injury in a rabbit model of transient focal cerebral ischemia
    M A Yenari
    Department of Neurosurgery, Stanford University Medical Center, Palo Alto, CA, USA
    Neurol Res 23:72-8. 2001
  5. ncbi request reprint Calbindin d28k overexpression protects striatal neurons from transient focal cerebral ischemia
    M A Yenari
    Department of Neurosurgery, Stanford University, California, USA
    Stroke 32:1028-35. 2001
  6. ncbi request reprint Gene therapy for treatment of cerebral ischemia using defective herpes simplex viral vectors
    M A Yenari
    Department of Neurosurgery, Stanford Stroke Center, Stanford University Medical Center, Stanford, California, USA
    Ann N Y Acad Sci 939:340-57. 2001
  7. ncbi request reprint Gene therapy effectiveness differs for neuronal survival and behavioral performance
    R G Phillips
    Department of Biological Sciences, Stanford University, Stanford, CA 94305-5020 USA
    Gene Ther 8:579-85. 2001
  8. ncbi request reprint Overexpression of HSP72 after induction of experimental stroke protects neurons from ischemic damage
    B Hoehn
    Department of Neurosurgery, Stanford University, Stanford, California 94305-5487, USA
    J Cereb Blood Flow Metab 21:1303-9. 2001
  9. ncbi request reprint Glutathione peroxidase overexpression inhibits cytochrome C release and proapoptotic mediators to protect neurons from experimental stroke
    B Hoehn
    Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, Calif 94305 5327, USA
    Stroke 34:2489-94. 2003
  10. ncbi request reprint Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions
    J E Lee
    Department of Anesthesia, Stanford University, Stanford, CA 94305, USA
    Exp Neurol 170:129-39. 2001

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Gene therapy for treatment of cerebral ischemia using defective herpes simplex viral vectors
    M A Yenari
    Department of Neurology, Stanford Stroke Center, Stanford, CA, USA
    Neurol Res 23:543-52. 2001
    ..Although gene therapy is limited to the few hundred cells the vector is capable of transfecting, we consider the possibility of such gene therapy becoming relevant to clinical neurology in the future...
  2. ncbi request reprint Diffusion- and perfusion-weighted magnetic resonance imaging of focal cerebral ischemia and cortical spreading depression under conditions of mild hypothermia
    M A Yenari
    Department of Neurosurgery, Stanford University Medical Center, 120 Welch Road, HSLS Bldg P304, Stanford, CA 94305 5487, USA
    Brain Res 885:208-19. 2000
    ..The ADC decrease during SD was greater during mild hypothermia, and suggests that the source of the ADC is more complex than previously believed...
  3. ncbi request reprint Ischemic vulnerability of primary murine microglial cultures
    M A Yenari
    Department of Neurosurgery, Stanford University Medical Center, CA 94305, USA
    Neurosci Lett 298:5-8. 2001
    ..We conclude that microglia display susceptibility to ischemia-like insults that most resembles astrocytes, and that activation in some settings renders them capable of generating factors that enhance their own survival...
  4. ncbi request reprint L-selectin inhibition does not reduce injury in a rabbit model of transient focal cerebral ischemia
    M A Yenari
    Department of Neurosurgery, Stanford University Medical Center, Palo Alto, CA, USA
    Neurol Res 23:72-8. 2001
    ..We conclude that antagonism of neutrophil adhesion at the level of L-selectin does not alter ischemic injury in experimental stroke...
  5. ncbi request reprint Calbindin d28k overexpression protects striatal neurons from transient focal cerebral ischemia
    M A Yenari
    Department of Neurosurgery, Stanford University, California, USA
    Stroke 32:1028-35. 2001
    ..Calbindin D28K (CaBP) is one such intracellular calcium buffer. We investigated whether CaBP overexpression is neuroprotective against transient focal cerebral ischemia...
  6. ncbi request reprint Gene therapy for treatment of cerebral ischemia using defective herpes simplex viral vectors
    M A Yenari
    Department of Neurosurgery, Stanford Stroke Center, Stanford University Medical Center, Stanford, California, USA
    Ann N Y Acad Sci 939:340-57. 2001
    ..Although gene therapy is limited to the few hundred cells the vector is capable of transfecting, we consider the possibility of such gene therapy becoming relevant to clinical neurology in the future...
  7. ncbi request reprint Gene therapy effectiveness differs for neuronal survival and behavioral performance
    R G Phillips
    Department of Biological Sciences, Stanford University, Stanford, CA 94305-5020 USA
    Gene Ther 8:579-85. 2001
    ..Despite equivalent magnitude and pattern of sparing of neurons with the immediate and 1 h delay approaches, the delay animals took a significantly longer time after insult to return to normal performance...
  8. ncbi request reprint Overexpression of HSP72 after induction of experimental stroke protects neurons from ischemic damage
    B Hoehn
    Department of Neurosurgery, Stanford University, Stanford, California 94305-5487, USA
    J Cereb Blood Flow Metab 21:1303-9. 2001
    ..Future strategies aimed at enhancing HSP72 expression after clinical stroke may be worth pursuing. The authors suggest that in the future HSP72 may be an effective treatment for stroke...
  9. ncbi request reprint Glutathione peroxidase overexpression inhibits cytochrome C release and proapoptotic mediators to protect neurons from experimental stroke
    B Hoehn
    Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, Calif 94305 5327, USA
    Stroke 34:2489-94. 2003
    ..Here we test whether overexpression with the use of gene therapy of the antioxidant glutathione peroxidase (Gpx), delivered before or after experimental stroke, is protective against ischemic injury...
  10. ncbi request reprint Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions
    J E Lee
    Department of Anesthesia, Stanford University, Stanford, CA 94305, USA
    Exp Neurol 170:129-39. 2001
    ..The protective effects may be related to the nature and severity of the insults, as well as subpopulations of brain cells and dose-dependent effects of HSP70 overexpression...
  11. ncbi request reprint Reversal of early diffusion-weighted magnetic resonance imaging abnormalities does not necessarily reflect tissue salvage in experimental cerebral ischemia
    T M Ringer
    Department of Neurosurgery, Stanford University, CA, USA
    Stroke 32:2362-9. 2001
    ..These observations suggest that caution is warranted when relying solely on DWI for assessment of ischemic damage...
  12. ncbi request reprint MRI of subacute hemorrhagic transformation in the rat suture occlusion model
    T Neumann-Haefelin
    Lucas MRI Center, Department of Radiology, Stanford Stroke Center, Stanford University, USA
    Neuroreport 12:309-11. 2001
    ..This indicates that subacute HT at 2-7 days occurs independently of the severity of acute tissue and BBB damage...
  13. ncbi request reprint Delayed induction and long-term effects of mild hypothermia in a focal model of transient cerebral ischemia: neurological outcome and infarct size
    C M Maier
    Department of Neurosurgery, Stanford Stroke Center, Stanford University Medical Center, California 94305, USA
    J Neurosurg 94:90-6. 2001
    ..These studies lend further support to the use of mild hypothermia in the treatment of stroke...
  14. ncbi request reprint Serial MRI after transient focal cerebral ischemia in rats: dynamics of tissue injury, blood-brain barrier damage, and edema formation
    T Neumann-Haefelin
    Department of Radiology, Lucas MRS MRI Center, Stanford Stroke Center, Stanford University, CA, USA
    Stroke 31:1965-72; discussion 1972-3. 2000
    ....
  15. pmc Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex
    S Kelly
    Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 101:11839-44. 2004
    ..Thus, transplanted human CNS (hCNS)-derived neurospheres survived robustly in naive and ischemic brains, and the microenvironment influenced their migration and fate...
  16. ncbi request reprint Mild hypothermia reduces ICAM-1 expression, neutrophil infiltration and microglia/monocyte accumulation following experimental stroke
    G J Wang
    Department of Neurosurgery, Stanford University, CA 94305, USA
    Neuroscience 114:1081-90. 2002
    ....
  17. ncbi request reprint Mild hypothermia increases Bcl-2 protein expression following global cerebral ischemia
    Z Zhang
    Department of Neurosurgery, Stanford University School of Medicine, 1201 Welch Rd. MSLS Building, P304, Stanford, CA 94305-5487, USA
    Brain Res Mol Brain Res 95:75-85. 2001
    ..These data suggest that mild hypothermia attenuates apoptotic death, and that this protection may be related to increases in Bcl-2...
  18. pmc Apocynin improves outcome in experimental stroke with a narrow dose range
    X N Tang
    Department of Neurology, University of California, San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Neuroscience 154:556-62. 2008
    ..Apocynin at protective doses markedly prevented ischemia-induced increases in O.*. Our data suggested that apocynin can protect against experimental stroke, but with a narrow therapeutic window...
  19. ncbi request reprint Stroke: molecular mechanisms and potential targets for treatment
    Z Zheng
    Department of Neurosurgery, Stanford University, 1201 Welch Rd, MSLS Bldg P304, Stanford, CA 94305 5487, USA
    Curr Mol Med 3:361-72. 2003
    ..Knowledge of such molecular events has fueled interest in developing specific molecular targets with the hope of someday affecting outcome in clinical stroke...
  20. pmc Influence of therapeutic hypothermia on regeneration after cerebral ischemia
    M A Yenari
    Department of Neurology, University of California, and San Francisco Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
    Front Neurol Neurosci 32:122-8. 2013
    ..In this chapter, we will provide up-to-date data from experimental studies and clinical reports on the effect of therapeutic hypothermia on neuroregeneration, with perspectives on future research. ..
  21. ncbi request reprint Many mechanisms for hsp70 protection from cerebral ischemia
    Rona G Giffard
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosurg Anesthesiol 16:53-61. 2004
    ..Despite these new insights into the ways in which Hsp70 functions as an anti-death protein, further surprises are likely as we continue to gain insight into the functioning of this multifaceted protein...
  22. ncbi request reprint Microglia potentiate damage to blood-brain barrier constituents: improvement by minocycline in vivo and in vitro
    Midori A Yenari
    Department of Neurology, University of California, San Francisco Veterans Affairs Medical Center, California 94121, USA
    Stroke 37:1087-93. 2006
    ..We determined the effect of microglia on the BBB and its primary constituents, endothelial cells (ECs) and astrocytes, after ischemia using in vivo and in vitro models...
  23. ncbi request reprint Mild hypothermia decreases GSK3beta expression following global cerebral ischemia
    Stephen Kelly
    Department of Neurosurgery, Stanford University, Stanford, CA 94121, USA
    Neurocrit Care 2:212-7. 2005
    ..This article reports that GSK3beta expression following global cerebral ischemia (GCI) is altered by the neuroprotectant, mild hypothermia (33 degrees C)...
  24. ncbi request reprint Mild postischemic hypothermia prolongs the time window for gene therapy by inhibiting cytochrome C release
    Heng Zhao
    Department of Neurosurgery, Stanford University, Stanford, CA 94305 5327, USA
    Stroke 35:572-7. 2004
    ..5 hours after stroke but not when delivered 5 hours after stroke onset. Here we determine whether hypothermia prolongs the therapeutic window for gene therapy...
  25. ncbi request reprint Glycogen synthase kinase 3beta inhibitor Chir025 reduces neuronal death resulting from oxygen-glucose deprivation, glutamate excitotoxicity, and cerebral ischemia
    Stephen Kelly
    Department of Neurosurgery, Stanford University, CA 94305 5487, USA
    Exp Neurol 188:378-86. 2004
    ..These data show that Chir025-mediated inhibition of GSK3beta is neuroprotective and that the mechanism is probably not anti-apoptotic...
  26. ncbi request reprint Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury
    Rona G Giffard
    Department of Anesthesia, Stanford University, Stanford, CA 94305, USA
    J Exp Biol 207:3213-20. 2004
    ..Protection from ischemia and ischemia-like injury by chaperones thus involves at least anti-apoptotic, anti-necrotic and anti-protein aggregation mechanisms...
  27. ncbi request reprint Protein kinase C delta mediates cerebral reperfusion injury in vivo
    Rachel Bright
    Department of Molecular Pharmacology, Stanford Stroke Center, Stanford University School of Medicine, Stanford, California 94305 5174, USA
    J Neurosci 24:6880-8. 2004
    ..These data support a deleterious role for deltaPKC during reperfusion and suggest that deltaV1-1 delivery, even hours after commencement of reperfusion, may provide a therapeutic advantage after cerebral ischemia...
  28. pmc FasL shedding is reduced by hypothermia in experimental stroke
    Liping Liu
    Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, California, USA
    J Neurochem 106:541-50. 2008
    ..Hypothermia prevented total FasL decreases, and most of it remained membrane-bound. These findings reveal new observations regarding the effect of mild hypothermia on the Fas/FasL and MMP systems...
  29. ncbi request reprint Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: influence of Bcl-2
    Stephen Kelly
    Department of Neurosurgery, Stanford University, Stanford, CA 94305 5327, USA
    Ann Neurol 52:160-7. 2002
    ..We show that HSP72 overexpression protects cornu ammonis 1 region of the hippocampus neurons from global cerebral ischemia, and that this protection may be mediated in part by increased Bcl-2 expression...
  30. ncbi request reprint Bcl-2 overexpression protects against neuron loss within the ischemic margin following experimental stroke and inhibits cytochrome c translocation and caspase-3 activity
    Heng Zhao
    Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Drive R200, Stanford, CA 94305 5327, USA
    J Neurochem 85:1026-36. 2003
    ..This suggests a potential therapeutic strategy for stroke...
  31. ncbi request reprint Heat shock proteins and neuroprotection
    Midori A Yenari
    Department of Neurosurgery, Stanford University, 1201 Welch Road, MSLS Building P304, Stanford, CA 94305 3487, USA
    Adv Exp Med Biol 513:281-99. 2002
    ..This review will cover these studies, along with potential mechanisms by which Hsp70 might mediate cellular protection...
  32. ncbi request reprint Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke
    Zhen Zheng
    Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Cereb Blood Flow Metab 28:53-63. 2008
    ..The findings of the present work establish an anti-inflammatory role for Hsp70 in the context of brain ischemia as a novel mechanism of protection...
  33. ncbi request reprint Therapeutic hypothermia: neuroprotective mechanisms
    Liping Liu
    Dept of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, Neurology 127, 4150 Clement St, San Francisco, CA 94121, USA
    Front Biosci 12:816-25. 2007
    ..Therapeutic hypothermia is likely to undergo phase III clinical trials in various clinical settings. Novel technologies are being developed to optimize the safety and efficacy of this promising approach...
  34. ncbi request reprint Post-ischemic inflammation: molecular mechanisms and therapeutic implications
    Zhen Zheng
    Department of Neurosurgery Stanford University School of Medicine, Stanford, USA
    Neurol Res 26:884-92. 2004
    ..This review focuses on some recent advances regarding the regulation of inflammatory signaling pathways, the detrimental effects of post-ischemic inflammation and the potential molecular targets for ischemic stroke therapy...
  35. ncbi request reprint Monitoring the protective effects of minocycline treatment with radiolabeled annexin V in an experimental model of focal cerebral ischemia
    Xian Nan Tang
    Department of Neurology, University of California San Francisco, San Francisco, CA 94121, USA
    J Nucl Med 48:1822-8. 2007
    ..We now explore the feasibility of using (99m)Tc-annexin V, an in vivo marker of apoptosis, with SPECT to monitor the antiapoptotic effects of minocycline therapy...
  36. ncbi request reprint The application of HSP70 as a target for gene therapy
    Zhen Zheng
    Dept of Neurology, University of California, The San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Front Biosci 11:699-707. 2006
    ..Gaining insight into these recent advances may have profound implications in the development of HSP70-based clinical studies...
  37. ncbi request reprint Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection
    Midori A Yenari
    Department of Neurology, University of California, San Francisco, Caifornia 94121, USA
    Ann N Y Acad Sci 1053:74-83. 2005
    ..We suggest that HSPs are capable of protecting brain cells from lethal insults through a variety of mechanisms and should be explored as a potential therapy against stroke and other neurodegenerative diseases...
  38. ncbi request reprint Conditions of protection by hypothermia and effects on apoptotic pathways in a rat model of permanent middle cerebral artery occlusion
    Heng Zhao
    Department of Neurosurgery, Stanford University, Stanford, California 94305 5327, USA
    J Neurosurg 107:636-41. 2007
    ..This models a scenario in which the MCA remains occluded but partial reperfusion occurs through collateral vessels. The authors also determined whether hypothermia mediates ischemic damage by blocking apoptotic pathways...
  39. pmc epsilonPKC confers acute tolerance to cerebral ischemic reperfusion injury
    Rachel Bright
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Neurosci Lett 441:120-4. 2008
    ..Here we demonstrate the role of acute and transient epsilonPKC in early cerebral tolerance in vivo and suggest that extra-parenchymal mechanisms, such as vasoconstriction, may contribute to the conferred protection...
  40. ncbi request reprint Influence of hypothermia on post-ischemic inflammation: role of nuclear factor kappa B (NFkappaB)
    Midori A Yenari
    Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121, United States
    Neurochem Int 49:164-9. 2006
    ..These data suggest that the protective effect of hypothermia on cerebral injury is, in part, related to NFkappaB inhibition due to decreased activity of IKK...
  41. ncbi request reprint Biphasic cytochrome c release after transient global ischemia and its inhibition by hypothermia
    Heng Zhao
    Department of Neurosurgery, Stanford University, Stanford, California 94305 5327, USA
    J Cereb Blood Flow Metab 25:1119-29. 2005
    ..Thus, biphasic cytochrome c release occurs after transient global ischemia and mild hypothermia protects against ischemic damage by blocking the second phase of cytochrome c release, possibly by blocking caspase activity...
  42. ncbi request reprint Gene therapy in neurological disease
    Midori A Yenari
    Department of Neurosurgery and Neurology, Stanford University School of Medicine, CA, USA
    Methods Mol Med 104:75-88. 2005
    ..Although application to clinical stroke is probably remote, viral vector-mediated gene therapy provides a unique and powerful tool in the study of molecular mechanisms involved in brain injury...
  43. ncbi request reprint Mild hypothermia attenuates cytochrome c release but does not alter Bcl-2 expression or caspase activation after experimental stroke
    Midori A Yenari
    Department of Neurosurgery, Stanford University Medical Center, California, USA
    J Cereb Blood Flow Metab 22:29-38. 2002
    ..Furthermore, the authors show it is unlikely that mild hypothermia alters the intrinsic apoptotic pathway...
  44. ncbi request reprint Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation
    Hyung Soo Han
    Department of Neurology, Stanford University Medical Center, Stanford, California 94305, USA
    J Neurosci 22:3921-8. 2002
    ..We conclude that mild hypothermia significantly inhibits the inflammatory response by affecting microglial iNOS-NO generation. Therapies directed against microglia or their activation may be useful in treating stroke...
  45. ncbi request reprint Use of diffusion weighted MRI to predict the occurrence and severity of hemorrhagic transformation in a rabbit model of embolic stroke
    Alessandro Adami
    Department of Neurology and Neurological Sciences, Stanford University, CA 94305 5487, USA
    Brain Res 944:32-9. 2002
    ..25% vs. no HT: 12%, 5.00-16.00% (median, 25th-75th %, P<0.001). Petechial HT when percentages were in the intermediate range. Quantitative analysis of initial ADC value might identify individual stroke patients at risk of severe HT...
  46. ncbi request reprint Neuroprotection: heat shock proteins
    Stephen Kelly
    Department of Neurosurgery, Stanford University Medical Center, California 94305 5487, USA
    Curr Med Res Opin 18:s55-60. 2002
    ....
  47. ncbi request reprint Attenuation of nitric oxide synthase isoform expression by mild hypothermia after focal cerebral ischemia: variations depending on timing of cooling
    Murat Karabiyikoglu
    Department of Neurosurgery, Stanford Stroke Center, Stanford University Medical Center, Stanford, California, USA
    J Neurosurg 98:1271-6. 2003
    ..In this study the authors examined the influence of mild hypothermia on early expression of nitric oxide synthase (NOS) isoforms and peroxynitrite generation after experimental stroke...
  48. ncbi request reprint Gene therapy and hypothermia for stroke treatment
    Midori A Yenari
    Department of Neurosurgery, Stanford University, California 94305, USA
    Ann N Y Acad Sci 993:54-68; discussion 79-81. 2003
    ....
  49. ncbi request reprint Mild hypothermia inhibits inflammation after experimental stroke and brain inflammation
    Holly Deng
    Departments of Neurosurgery, Stanford University, Stanford, Calif, USA
    Stroke 34:2495-501. 2003
    ..Protection may be due in part to inhibiting inflammation. To clarify, we examined leukocyte infiltration, microglial activation, and adhesion molecule expression in models of stroke and pure brain inflammation...
  50. ncbi request reprint Cellular and molecular events underlying ischemia-induced neuronal apoptosis
    Zhen Zheng
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA
    Drug News Perspect 16:497-503. 2003
    ..In this review, we examine some of these findings and their potential therapeutic implications for ischemic stroke...
  51. ncbi request reprint Pathophysiology of acute ischemic stroke
    Midori A Yenari
    Department of Neurosurgery, Stanford University, Stanford, Calif 94305 5487, USA
    Cleve Clin J Med 71:S25-7. 2004
  52. ncbi request reprint Therapeutic hypothermia for acute ischemic stroke: what do laboratory studies teach us?
    Derk W Krieger
    Department of Neurology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Stroke 35:1482-9. 2004
    ..With that in mind, a critical review of the pertinent literature is presented, taking into consideration potential limitations in translating such laboratory work to the clinical level...
  53. ncbi request reprint Catalase over-expression protects striatal neurons from transient focal cerebral ischemia
    Wenping Gu
    Departments of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Drive R200, Stanford, CA 94305 5327, USA
    Neuroreport 15:413-6. 2004
    ..Thus, the timing of catalase over-expression relative to ischemia is a critical variable determining its potential therapeutic value...
  54. ncbi request reprint The 70 kDa heat shock protein suppresses matrix metalloproteinases in astrocytes
    Jong Eun Lee
    Department of Anatomy, College of Medicine, Room 136 A, Yonsei University, 134 Shinchon dong, Seodaemun Ku, Seoul 120 752, Korea
    Neuroreport 15:499-502. 2004
    ..Zymograms and Western blots showed that Hsp70 over-expression suppressed MMP-2 and MMP-9. These findings suggest that Hsp70 may protect by regulating MMPs...
  55. ncbi request reprint Bcl-2 transfection via herpes simplex virus blocks apoptosis-inducing factor translocation after focal ischemia in the rat
    Heng Zhao
    Department of Neurosurgery, Stanford University, Stanford, CA, USA
    J Cereb Blood Flow Metab 24:681-92. 2004
    ..Our data also suggest that AIF translocated into nuclei after cytochrome c was released into the cytosol. Bcl-2 transfection in the peri-infarct region blocked nuclear AIF translocation and improved cortical neuron survival...
  56. ncbi request reprint Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade
    Lijun Xu
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    J Cereb Blood Flow Metab 22:21-8. 2002
    ....