George P Yang

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint From scarless fetal wounds to keloids: molecular studies in wound healing
    George P Yang
    Department of Surgery, Stanford University, Stanford, California 94305, USA
    Wound Repair Regen 11:411-8. 2003
  2. ncbi request reprint Differential transcriptional responses of keloid and normal keratinocytes to serum stimulation
    Wei Xia
    Department of Surgery, Stanford University Medical School, Stanford, California, USA
    J Surg Res 135:156-63. 2006
  3. ncbi request reprint Increased CCN2 transcription in keloid fibroblasts requires cooperativity between AP-1 and SMAD binding sites
    Wei Xia
    Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Ann Surg 246:886-95. 2007
  4. pmc Unfolded protein response regulation in keloid cells
    Paris D Butler
    Department of Surgery, Stanford University School of Medicine, Stanford, California 94305 5148, USA
    J Surg Res 167:151-7. 2011
  5. ncbi request reprint The angiogenic factor Del1 prevents apoptosis of endothelial cells through integrin binding
    Zhen Wang
    Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Surgery 151:296-305. 2012
  6. pmc Use of organotypic coculture to study keloid biology
    Paris D Butler
    Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Am J Surg 195:144-8. 2008
  7. ncbi request reprint Increased transcriptional response to mechanical strain in keloid fibroblasts due to increased focal adhesion complex formation
    Zhen Wang
    Department of Surgery, Stanford University Medical School, Stanford 94305, and Palo Alto VA Health Care System, California, USA
    J Cell Physiol 206:510-7. 2006
  8. ncbi request reprint Increased rate of hair regrowth in mice with constitutive overexpression of Del1
    Gloria P Hsu
    Department of Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    J Surg Res 146:73-80. 2008
  9. pmc Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271
    Alexander D Boiko
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94304 5542, USA
    Nature 466:133-7. 2010
  10. ncbi request reprint P38 MAP kinase mediates transforming growth factor-beta2 transcription in human keloid fibroblasts
    Wei Xia
    Department of Surgery, Stanford University Medical School, California, USA
    Am J Physiol Regul Integr Comp Physiol 290:R501-8. 2006

Research Grants

  1. Differential Gene Expression in Keloids
    George Yang; Fiscal Year: 2007

Collaborators

Detail Information

Publications23

  1. ncbi request reprint From scarless fetal wounds to keloids: molecular studies in wound healing
    George P Yang
    Department of Surgery, Stanford University, Stanford, California 94305, USA
    Wound Repair Regen 11:411-8. 2003
    ..In this article, we discuss new findings in scarless fetal repair, angiogenesis in wound healing, and keloid pathogenesis. This serves to highlight the advances that have been made and also how much remains to be understood...
  2. ncbi request reprint Differential transcriptional responses of keloid and normal keratinocytes to serum stimulation
    Wei Xia
    Department of Surgery, Stanford University Medical School, Stanford, California, USA
    J Surg Res 135:156-63. 2006
    ..We used the transcriptional response to serum stimulation to examine how TGF-beta expression is stimulated in KKs...
  3. ncbi request reprint Increased CCN2 transcription in keloid fibroblasts requires cooperativity between AP-1 and SMAD binding sites
    Wei Xia
    Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Ann Surg 246:886-95. 2007
    ..We examined the transcriptional response to serum stimulation as an in vitro model of wound healing in keloid fibroblasts to identify molecular mechanisms leading to their aberrant growth...
  4. pmc Unfolded protein response regulation in keloid cells
    Paris D Butler
    Department of Surgery, Stanford University School of Medicine, Stanford, California 94305 5148, USA
    J Surg Res 167:151-7. 2011
    ..Since keloids have hypersecretion of extracellular matrix, we hypothesized that keloid fibroblasts (KFs) may have enhanced activation of the UPR compared with normal fibroblasts (NFs)...
  5. ncbi request reprint The angiogenic factor Del1 prevents apoptosis of endothelial cells through integrin binding
    Zhen Wang
    Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Surgery 151:296-305. 2012
    ..We were interested in the specific effects of del1 on endothelial cell biology to gain insight into its biologic role during angiogenesis...
  6. pmc Use of organotypic coculture to study keloid biology
    Paris D Butler
    Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Am J Surg 195:144-8. 2008
    ..The lack of an animal model for keloid formation has hampered study. We developed an in vitro organotypic skin model to simulate normal keloid biology, which may allow us to study keloid formation without an animal model...
  7. ncbi request reprint Increased transcriptional response to mechanical strain in keloid fibroblasts due to increased focal adhesion complex formation
    Zhen Wang
    Department of Surgery, Stanford University Medical School, Stanford 94305, and Palo Alto VA Health Care System, California, USA
    J Cell Physiol 206:510-7. 2006
    ..This may be one molecular mechanism for the development of keloids...
  8. ncbi request reprint Increased rate of hair regrowth in mice with constitutive overexpression of Del1
    Gloria P Hsu
    Department of Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    J Surg Res 146:73-80. 2008
    ..We hypothesized that increased expression of an angiogenic factor would lead to enhanced wound healing...
  9. pmc Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271
    Alexander D Boiko
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94304 5542, USA
    Nature 466:133-7. 2010
    ....
  10. ncbi request reprint P38 MAP kinase mediates transforming growth factor-beta2 transcription in human keloid fibroblasts
    Wei Xia
    Department of Surgery, Stanford University Medical School, California, USA
    Am J Physiol Regul Integr Comp Physiol 290:R501-8. 2006
    ..This suggests the mechanism of keloid pathogenesis may be due in part to an inherent difference in how the fibroblasts respond to wounding...
  11. ncbi request reprint Complex epithelial-mesenchymal interactions modulate transforming growth factor-beta expression in keloid-derived cells
    Wei Xia
    Department of Surgery, Stanford University Medical School, 257 Campus Drive, Stanford, CA 94305, USA
    Wound Repair Regen 12:546-56. 2004
    ..These data suggest that keloid pathogenesis may result from both an increased TGF-beta production and activation by the keloid keratinocyte, and elevated TGF-beta expression, utilization, and signaling in keloid fibroblasts...
  12. doi request reprint Current progress in keloid research and treatment
    Paris D Butler
    Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305 5148, USA
    J Am Coll Surg 206:731-41. 2008
  13. ncbi request reprint Phase II study to assess the efficacy of conventionally fractionated radiotherapy followed by a stereotactic radiosurgery boost in patients with locally advanced pancreatic cancer
    Albert C Koong
    Department of Radiation Oncology, Stanford University School of Medicine, 269 Campus Drive West, Stanford, CA 94305
    Int J Radiat Oncol Biol Phys 63:320-3. 2005
    ..To determine the efficacy of concurrent 5-fluorouracil (5-FU) and intensity-modulated radiotherapy (IMRT) followed by body stereotactic radiosurgery (SRS) in patients with locally advanced pancreatic cancer...
  14. ncbi request reprint Functions of vitamin D, retinoic acid, and dexamethasone in mouse adipose-derived mesenchymal cells
    Preeti Malladi
    Children s Surgical Research Program, Department of Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    Tissue Eng 12:2031-40. 2006
    ..In summary, we show in vitro that vitamin D and RA are potential candidates to serve as enhancers of osteogenesis of AMCs and may be incorporated into future cell-based strategies for bone tissue engineering...
  15. pmc Engineered epidermal growth factor mutants with faster binding on-rates correlate with enhanced receptor activation
    Jennifer L Lahti
    Department of Bioengineering, Cancer Center, Bio X Program, Stanford University, Stanford, CA 94305, USA
    FEBS Lett 585:1135-9. 2011
    ..We found that EGF mutants with faster kinetic on-rates stimulate increased EGFR activation compared to wild-type EGF. These findings support previous predictions that faster association rates correlate with enhanced receptor activity...
  16. doi request reprint Gemcitabine chemotherapy and single-fraction stereotactic body radiotherapy for locally advanced pancreatic cancer
    Devin Schellenberg
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA
    Int J Radiat Oncol Biol Phys 72:678-86. 2008
    ..This prospective trial evaluated the efficacy of a single fraction of 25 Gy stereotactic body radiotherapy (SBRT) delivered between Cycle 1 and 2 of gemcitabine chemotherapy...
  17. pmc The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth
    Kevin L Bennewith
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA
    Cancer Res 69:775-84. 2009
    ....
  18. ncbi request reprint Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling
    Yijun Chen
    Department of Radiation Oncology, Center for Clinical Sciences Research, Department of Surgery, Palo Alto VA Health Care System, Palo Alto, CA, USA
    Cancer Res 64:7302-10. 2004
    ..These data suggest that IKKbeta is a novel endogenous marker of tumor hypoxia and may represent a new target for anticancer therapy...
  19. doi request reprint Comparative healing of rat fascia following incision with three surgical instruments
    Edward I Chang
    Department of Surgery, Division of Plastic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    J Surg Res 167:e47-54. 2011
    ..We hypothesize that incisions made with the pulsed radiofrequency energy device will result in a superior fascial healing profile compared with conventional electrosurgery...
  20. ncbi request reprint Surgical application of cDNA microarray technique
    David E Sahar
    Department of Surgery, University of California San Francisco East Bay, Oakland, CA 94611, USA
    Surgery 138:399-403. 2005
  21. ncbi request reprint Tissue engineering and regenerative medicine
    D Denison Jenkins
    The Department of Surgery, Stanford University School of Medicine, 257 Campus Drive, Stanford, CA 94305 5148, USA
    Clin Plast Surg 30:581-8. 2003
    ..As these advances occur, physicians and surgeons of the twenty-first century will possess ever more powerful tools to restore form and function...
  22. pmc Treatment of oesophageal ulcerations using endoscopic transplantation of tissue-engineered autologous oral mucosal epithelial cell sheets in a canine model
    George P Yang
    Department of Surgery, Stanford University School of Medicine, Stanford, CA 94304, USA
    Gut 56:313-4. 2007
  23. ncbi request reprint Stereotactic body radiotherapy for unresectable pancreatic cancer
    Stephanie T Chang
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Front Radiat Ther Oncol 40:386-94. 2007
    ..SBRT is an effective method of treating patients resulting in excellent local control. Current research is aimed at defining the optimal method of combining this treatment with other cancer therapies...

Research Grants2

  1. Differential Gene Expression in Keloids
    George Yang; Fiscal Year: 2007
    ..The institution has every resource needed to carry out this project in addition to a number of experts in the field to provide advice. ..