Lei Xing

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. doi request reprint A unified framework for 3D radiation therapy and IMRT planning: plan optimization in the beamlet domain by constraining or regularizing the fluence map variations
    B Meng
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA
    Phys Med Biol 55:N521-31. 2010
  2. ncbi request reprint Automated contour mapping using sparse volume sampling for 4D radiation therapy
    Ming Chao
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5847, USA
    Med Phys 34:4023-9. 2007
  3. doi request reprint Dose reconstruction for volumetric modulated arc therapy (VMAT) using cone-beam CT and dynamic log files
    Jianguo Qian
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Phys Med Biol 55:3597-610. 2010
  4. doi request reprint Intrafraction verification of gated RapidArc by using beam-level kilovoltage X-ray images
    Ruijiang Li
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California
    Int J Radiat Oncol Biol Phys 83:e709-15. 2012
  5. ncbi request reprint Model-based image reconstruction for four-dimensional PET
    Tianfang Li
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5847, USA
    Med Phys 33:1288-98. 2006
  6. doi request reprint Image-guided radiotherapy in near real time with intensity-modulated radiotherapy megavoltage treatment beam imaging
    Weihua Mao
    Department of Radiation Oncology, Stanford University, Palo Alto, CA, USA
    Int J Radiat Oncol Biol Phys 75:603-10. 2009
  7. ncbi request reprint Four-dimensional cone-beam computed tomography using an on-board imager
    Tianfang Li
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
    Med Phys 33:3825-33. 2006
  8. ncbi request reprint Reducing respiratory motion artifacts in positron emission tomography through retrospective stacking
    Brian Thorndyke
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
    Med Phys 33:2632-41. 2006
  9. pmc Four-dimensional inverse treatment planning with inclusion of implanted fiducials in IMRT segmented fields
    Yunzhi Ma
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5847, USA
    Med Phys 36:2215-21. 2009
  10. pmc Scatter correction for cone-beam CT in radiation therapy
    Lei Zhu
    Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA
    Med Phys 36:2258-68. 2009

Research Grants

  1. IMRT Guided by Magnetic Resonance Spectroscopic Imaging
    Lei Xing; Fiscal Year: 2006
  2. IMRT Dose Optimization
    Lei Xing; Fiscal Year: 2007
  3. IMRT Dose Optimization
    Lei Xing; Fiscal Year: 2009
  4. Computational Tools for Adaptive Radiation Therapy
    Lei Xing; Fiscal Year: 2009
  5. Computational Tools for Adaptive Radiation Therapy
    Lei Xing; Fiscal Year: 2010

Collaborators

Detail Information

Publications94

  1. doi request reprint A unified framework for 3D radiation therapy and IMRT planning: plan optimization in the beamlet domain by constraining or regularizing the fluence map variations
    B Meng
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA
    Phys Med Biol 55:N521-31. 2010
    ..The approach provides a unified framework for 3D CRT and IMRT plan optimization...
  2. ncbi request reprint Automated contour mapping using sparse volume sampling for 4D radiation therapy
    Ming Chao
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5847, USA
    Med Phys 34:4023-9. 2007
    ..The robustness and accuracy of this approach make it a valuable tool for the efficient use of the available spatial-tempo information for 4D simulation and treatment...
  3. doi request reprint Dose reconstruction for volumetric modulated arc therapy (VMAT) using cone-beam CT and dynamic log files
    Jianguo Qian
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Phys Med Biol 55:3597-610. 2010
    ..The method reported here affords an objective means for dosimetric evaluation of VMAT delivery and is useful for adaptive VMAT in future...
  4. doi request reprint Intrafraction verification of gated RapidArc by using beam-level kilovoltage X-ray images
    Ruijiang Li
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California
    Int J Radiat Oncol Biol Phys 83:e709-15. 2012
    ..To verify the geometric accuracy of gated RapidArc treatment using kV images acquired during dose delivery...
  5. ncbi request reprint Model-based image reconstruction for four-dimensional PET
    Tianfang Li
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5847, USA
    Med Phys 33:1288-98. 2006
    ..Finally, the 4D PET reconstruction was applied to a patient case...
  6. doi request reprint Image-guided radiotherapy in near real time with intensity-modulated radiotherapy megavoltage treatment beam imaging
    Weihua Mao
    Department of Radiation Oncology, Stanford University, Palo Alto, CA, USA
    Int J Radiat Oncol Biol Phys 75:603-10. 2009
    ....
  7. ncbi request reprint Four-dimensional cone-beam computed tomography using an on-board imager
    Tianfang Li
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
    Med Phys 33:3825-33. 2006
    ....
  8. ncbi request reprint Reducing respiratory motion artifacts in positron emission tomography through retrospective stacking
    Brian Thorndyke
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
    Med Phys 33:2632-41. 2006
    ..These phantom and patient studies demonstrate that RS can correct for lesion motion and deformation, while substantially improving tumor visibility and background noise...
  9. pmc Four-dimensional inverse treatment planning with inclusion of implanted fiducials in IMRT segmented fields
    Yunzhi Ma
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5847, USA
    Med Phys 36:2215-21. 2009
    ..This is a foundation for the authors to use cine MV or combined MV/KV to effectively guide the 4D IMRT delivery...
  10. pmc Scatter correction for cone-beam CT in radiation therapy
    Lei Zhu
    Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA
    Med Phys 36:2258-68. 2009
    ..7% to 5.4%. The proposed method is attractive in applications where a high CBCT image quality is critical, for example, dose calculation in adaptive radiation therapy...
  11. doi request reprint Four-dimensional image registration for image-guided radiotherapy
    Eduard Schreibmann
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5847, USA
    Int J Radiat Oncol Biol Phys 71:578-86. 2008
    ..To use the 4D data acquired under different conditions or using different modalities, an algorithm for registering 4D images must be in place. We developed an automated 4D-4D registration method to take advantage of 4D information...
  12. doi request reprint Auto-propagation of contours for adaptive prostate radiation therapy
    Ming Chao
    Department of Radiation Oncology, Stanford University School of Medicine, 875 Blake Wilbur Drive, Stanford, CA 94305 5847, USA
    Phys Med Biol 53:4533-42. 2008
    ..The proposed approach permits us to take advantage of the regional calculation algorithm yet avoiding the nuisance of rectum/bladder filling and provide a useful tool for adaptive radiotherapy of prostate in the future...
  13. ncbi request reprint Evaluation of on-board kV cone beam CT (CBCT)-based dose calculation
    Yong Yang
    Department of Radiation Oncology, Stanford University School of Medicine, 875 Blake Wilbur Drive, Stanford, CA 94305 5847, USA
    Phys Med Biol 52:685-705. 2007
    ....
  14. doi request reprint Conceptual formulation on four-dimensional inverse planning for intensity modulated radiation therapy
    Louis Lee
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA
    Phys Med Biol 54:N255-66. 2009
    ..Yet there are practical issues to be solved in the 4D RT planning and delivery. The 4D concept in the optimization we have formulated here does provide insight on how the 'time' dimension can be exploited in the 4D optimization process...
  15. pmc Tissue feature-based and segmented deformable image registration for improved modeling of shear movement of lungs
    Yaoqin Xie
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5847, USA
    Int J Radiat Oncol Biol Phys 74:1256-65. 2009
    ..To report a tissue feature-based image registration strategy with explicit inclusion of the differential motions of thoracic structures...
  16. doi request reprint First demonstration of multiplexed X-ray fluorescence computed tomography (XFCT) imaging
    Yu Kuang
    Radiation Oncology Department, Stanford University, Stanford, CA 94305, USA
    IEEE Trans Med Imaging 32:262-7. 2013
    ..In conclusion, XFCT is a promising modality for multiplexed imaging of high atomic number probes...
  17. pmc Automatic prostate tracking and motion assessment in volumetric modulated arc therapy with an electronic portal imaging device
    Juan Diego Azcona
    Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA
    Int J Radiat Oncol Biol Phys 86:762-8. 2013
    ..To assess the prostate intrafraction motion in volumetric modulated arc therapy treatments using cine megavoltage (MV) images acquired with an electronic portal imaging device (EPID)...
  18. doi request reprint An end-to-end examination of geometric accuracy of IGRT using a new digital accelerator equipped with onboard imaging system
    Lei Wang
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA
    Phys Med Biol 57:757-69. 2012
    ..However, increased deviations in spatial and dosimetric accuracy were found when treating lesions smaller than 2 cm or with 15 MV beam...
  19. ncbi request reprint Clinical knowledge-based inverse treatment planning
    Yong Yang
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5847, USA
    Phys Med Biol 49:5101-17. 2004
    ..In particular, we show that the EUD-based optimization is a special case of the general inverse planning formalism described in this paper...
  20. pmc Objective assessment of deformable image registration in radiotherapy: a multi-institution study
    Rojano Kashani
    Department of Radiation Oncology, University of Michigan, Ann Arbor Michigan 48109 0010, USA
    Med Phys 35:5944-53. 2008
    ..Although reasonable accuracy was achieved overall, the variation of error in different regions suggests caution in globally accepting the results from deformable alignment...
  21. ncbi request reprint Investigation of linac-based image-guided hypofractionated prostate radiotherapy
    Todd Pawlicki
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5847, USA
    Med Dosim 32:71-9. 2007
    ..During this study, we have also uncovered opportunities for improvement of the on-board imaging hardware/software implementation that would further enhance performance in this regard...
  22. ncbi request reprint Incorporating model parameter uncertainty into inverse treatment planning
    Jun Lian
    Department of Radiation Oncology, Stanford University School of Medicine, 875 Blake Wilbur Drive, Stanford, California 94305 5847, USA
    Med Phys 31:2711-20. 2004
    ..With the incorporation of the uncertainties, the technique has potential for us to maximally utilize the available radiobiology knowledge for better IMRT treatment...
  23. doi request reprint Dosimetric analysis of organs at risk during expiratory gating in stereotactic body radiation therapy for pancreatic cancer
    Cullen M Taniguchi
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5847, USA
    Int J Radiat Oncol Biol Phys 85:1090-5. 2013
    ..To determine how the respiratory phase impacts dose to normal organs during stereotactic body radiation therapy (SBRT) for pancreatic cancer...
  24. pmc Feature-based rectal contour propagation from planning CT to cone beam CT
    Yaoqin Xie
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5847, USA
    Med Phys 35:4450-9. 2008
    ..The proposed technique provides a powerful tool for adaptive radiotherapy of prostate, rectal, and gynecological cancers in the future...
  25. doi request reprint Beam's-eye-view Dosimetrics-guided inverse planning for aperture-modulated arc therapy
    Yunzhi Ma
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5847, USA
    Int J Radiat Oncol Biol Phys 75:1587-95. 2009
    ..To use angular beam's-eye-view dosimetrics (BEVD) information to improve the computational efficiency and plan quality of inverse planning of aperture-modulated arc therapy (AMAT)...
  26. doi request reprint Using total-variation regularization for intensity modulated radiation therapy inverse planning with field-specific numbers of segments
    Lei Zhu
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA
    Phys Med Biol 53:6653-72. 2008
    ..The head and neck result is also compared to that using an equal number of four segments for each field. The comparison shows that using field-specific numbers of segments achieves a much improved dose distribution...
  27. pmc Development of a QA phantom and automated analysis tool for geometric quality assurance of on-board MV and kV x-ray imaging systems
    Weihua Mao
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
    Med Phys 35:1497-506. 2008
    ..6 mm. The developed tool provides us with a simple, robust, and objective way to probe and monitor the geometric status of an imaging system in a fully automatic process and facilitate routine QA workflow in a clinic...
  28. doi request reprint Individualized gating windows based on four-dimensional CT information for respiration-gated radiotherapy
    Nicole M Wink
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA, USA
    Phys Med Biol 53:165-75. 2008
    ..In conclusion, individualization of gating windows reduces the subjectivity in respiration-gated RT and improves the treatment of moving targets...
  29. doi request reprint Optimized hybrid megavoltage-kilovoltage imaging protocol for volumetric prostate arc therapy
    Wu Liu
    Department of Radiation Oncology, Stanford University School of Medicine, California 94305 5847, USA
    Int J Radiat Oncol Biol Phys 78:595-604. 2010
    ..To develop a real-time prostate position monitoring technique for modern arc radiotherapy through novel use of cine-megavoltage (MV) imaging, together with as-needed kilovoltage (kV) imaging...
  30. pmc Image-based modeling of tumor shrinkage in head and neck radiation therapy
    Ming Chao
    Department of Radiation Oncology, Stanford University School of Medicine, 875 Blake Wilbur Drive, Stanford, California 94305 5847, USA
    Med Phys 37:2351-8. 2010
    ..This article presents a novel framework for image-based modeling of tumor change and demonstrates its performance with synthetic images and clinical cases...
  31. ncbi request reprint Segment-based dose optimization using a genetic algorithm
    Cristian Cotrutz
    Department of Radiation Oncology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5304, USA
    Phys Med Biol 48:2987-98. 2003
    ..Thus the technique may have useful applications in facilitating IMRT treatment planning...
  32. ncbi request reprint Therapeutic treatment plan optimization with probability density-based dose prescription
    Jun Lian
    Department of Radiation Oncology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305 5304, USA
    Med Phys 30:655-66. 2003
    ..The enhanced control over the final plan may greatly facilitate the IMRT treatment planning process...
  33. ncbi request reprint Towards biologically conformal radiation therapy (BCRT): selective IMRT dose escalation under the guidance of spatial biology distribution
    Yong Yang
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5847, USA
    Med Phys 32:1473-84. 2005
    ..The proposed formalism lays a technical foundation for BCRT and allows us to maximally exploit the technical capacity of IMRT to more intelligently escalate the radiation dose...
  34. pmc Noise suppression in scatter correction for cone-beam CT
    Lei Zhu
    Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA
    Med Phys 36:741-52. 2009
    ..6. Significant image quality improvement is also shown in the results on an anthropomorphic phantom, in which the global noise level is reduced and the local streaking artifacts around bones are suppressed...
  35. pmc Development and clinical evaluation of automatic fiducial detection for tumor tracking in cine megavoltage images during volumetric modulated arc therapy
    Juan Diego Azcona
    Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA
    Med Phys 40:031708. 2013
    ..The purpose of this work is to develop a clinically practical autodetection algorithm for motion management during VMAT...
  36. doi request reprint An assessment of PTV margin based on actual accumulated dose for prostate cancer radiotherapy
    Ning Wen
    Department of Radiation Oncology, Henry Ford Health System, Detroit, MI 48202, USA
    Phys Med Biol 58:7733-44. 2013
    ....
  37. doi request reprint Intraoperative imaging of tumors using Cerenkov luminescence endoscopy: a feasibility experimental study
    Hongguang Liu
    Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Canary Center at Stanford for Cancer Early Detection, Stanford University, Stanford, California 94305, USA
    J Nucl Med 53:1579-84. 2012
    ..We developed a prototype customized fiberscopic Cerenkov imaging system to investigate the potential in guiding minimally invasive surgical resection...
  38. pmc Radioluminescent nanophosphors enable multiplexed small-animal imaging
    Colin M Carpenter
    Department of Radiation Oncology, School of Medicine, Stanford University, Stanford, CA 94305, USA
    Opt Express 20:11598-604. 2012
    ..Combined with the high-resolution potential of low-scattering X-ray excitation, this imaging technique may be a promising method to probe molecular processes in living organisms...
  39. doi request reprint Dose optimization with first-order total-variation minimization for dense angularly sampled and sparse intensity modulated radiation therapy (DASSIM-RT)
    Hojin Kim
    Department of Electrical Engineering, Stanford University, Stanford, CA, USA
    Med Phys 39:4316-27. 2012
    ..The purpose of this work is to provide a practical solution to the DASSIM-RT inverse planning problem...
  40. doi request reprint Noise reduction in low-dose x-ray fluoroscopy for image-guided radiation therapy
    Jing Wang
    Department of Radiation Oncology, Stanford University School of Medicine, CA 94305, USA
    Int J Radiat Oncol Biol Phys 74:637-43. 2009
    ..To improve the quality of low-dose X-ray fluoroscopic images using statistics-based restoration algorithm so that the patient fluoroscopy can be performed with reduced radiation dose...
  41. doi request reprint Predicting respiratory tumor motion with multi-dimensional adaptive filters and support vector regression
    Nadeem Riaz
    Department of Radiation Oncology, Stanford University, 875 Blake Wilbur Drive, Stanford, CA 94305 5847, USA
    Phys Med Biol 54:5735-48. 2009
    ..Also, a multi-dimensional adaptive filter framework provides improved performance over single-dimension adaptive filters. Work is underway to combine these two frameworks to improve performance...
  42. doi request reprint Automated contour mapping with a regional deformable model
    Ming Chao
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5847, USA
    Int J Radiat Oncol Biol Phys 70:599-608. 2008
    ..To develop a regional narrow-band algorithm to auto-propagate the contour surface of a region of interest (ROI) from one phase to other phases of four-dimensional computed tomography (4D-CT)...
  43. ncbi request reprint Initial application of a geometric QA tool for integrated MV and kV imaging systems on three image guided radiotherapy systems
    Weihua Mao
    Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas 75390, USA
    Med Phys 38:2335-41. 2011
    ..The purpose of this work is to demonstrate the application of methodology to routine QA across three IGRT-dedicated linac platforms...
  44. pmc Toward truly optimal IMRT dose distribution: inverse planning with voxel-specific penalty
    Pavel Lougovski
    Department of Radiation Oncology, Stanford University School of Medicine, 875 Blake Wilbur Drive, Stanford, CA 94305 5847
    Technol Cancer Res Treat 9:629-36. 2010
    ..To establish an inverse planning framework with adjustable voxel penalty for more conformal IMRT dose distribution as well as improved interactive controllability over the regional dose distribution of the resultant plan...
  45. pmc Dose verification for respiratory-gated volumetric modulated arc therapy
    Jianguo Qian
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Phys Med Biol 56:4827-38. 2011
    ..This methodology affords a useful tool for machine- and patient-specific quality assurance of the newly available respiratory-gated VMAT...
  46. ncbi request reprint Investigation of using a power function as a cost function in inverse planning optimization
    Ping Xia
    Department of Radiation Oncology, University of California San Francisco, San Francisco, California 94143 1708, USA
    Med Phys 32:920-7. 2005
    ..In conclusion, using a power function with exponent greater than 2 as a cost function can effectively achieve homogeneous dose inside the target and/or minimize maximum dose to the critical structures...
  47. pmc Toward real-time Monte Carlo simulation using a commercial cloud computing infrastructure
    Henry Wang
    Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA
    Phys Med Biol 56:N175-81. 2011
    ..In addition to the significant speed up, cloud computing builds a layer of abstraction for high performance parallel computing, which may change the way dose calculations are performed and radiation treatment plans are completed...
  48. ncbi request reprint Inverse treatment planning with adaptively evolving voxel-dependent penalty scheme
    Yong Yang
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5847, USA
    Med Phys 31:2839-44. 2004
    ....
  49. doi request reprint Retrospective IMRT dose reconstruction based on cone-beam CT and MLC log-file
    Louis Lee
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5847, USA
    Int J Radiat Oncol Biol Phys 70:634-44. 2008
    ..The aim of this work is to reconstruct the intensity-modulated radiation therapy dose delivered to an HN patient using the CBCT and multileaf collimator (MLC) log-files...
  50. pmc Clinical implementation of intrafraction cone beam computed tomography imaging during lung tumor stereotactic ablative radiation therapy
    Ruijiang Li
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California
    Int J Radiat Oncol Biol Phys 87:917-23. 2013
    ..To develop and clinically evaluate a volumetric imaging technique for assessing intrafraction geometric and dosimetric accuracy of stereotactic ablative radiation therapy (SABR)...
  51. pmc Monte Carlo simulation of photon migration in a cloud computing environment with MapReduce
    Guillem Pratx
    Stanford University School of Medicine, Department of Radiation Oncology, 875 Blake Wilbur Drive, Stanford, California 94305, USA
    J Biomed Opt 16:125003. 2011
    ..The distributed simulation produced the same output as the original implementation and was resilient to hardware failure: the correctness of the simulation was unaffected by the shutdown of 50% of the nodes...
  52. doi request reprint Improved compressed sensing-based cone-beam CT reconstruction using adaptive prior image constraints
    Ho Lee
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305 5847, USA
    Phys Med Biol 57:2287-307. 2012
    ..Compared to the current CBCT imaging protocols, the APICCS algorithm allows an imaging dose reduction of 10-40 times due to the greatly reduced number of projections and lower x-ray tube current level coming from the low-dose protocol...
  53. doi request reprint Pancreatic tumor motion on a single planning 4D-CT does not correlate with intrafraction tumor motion during treatment
    A Yuriko Minn
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305 5152, USA
    Am J Clin Oncol 32:364-8. 2009
    ....
  54. ncbi request reprint Feasibility study of beam orientation class-solutions for prostate IMRT
    Eduard Schreibmann
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5847, USA
    Med Phys 31:2863-70. 2004
    ..The difference between the plans obtained with class-solutions and patient-specific optimizations was found to be clinically insignificant...
  55. ncbi request reprint In vivo prostate magnetic resonance spectroscopic imaging using two-dimensional J-resolved PRESS at 3 T
    Dong Hyun Kim
    Department of Radiology, Stanford University, CA 94305, USA
    Magn Reson Med 53:1177-82. 2005
    ..Phantom and in vivo data are presented to illustrate the multivoxel 2D J-resolved spiral chemical shift imaging sequence...
  56. pmc Clinical development of a failure detection-based online repositioning strategy for prostate IMRT--experiments, simulation, and dosimetry study
    Wu Liu
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5847, USA
    Med Phys 37:5287-97. 2010
    ..To implement and evaluate clinic-ready adaptive imaging protocols for online patient repositioning (motion tracking) during prostate IMRT using treatment beam imaging supplemented by minimal, as-needed use of on-board kV...
  57. ncbi request reprint Image registration with auto-mapped control volumes
    Eduard Schreibmann
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5847, USA
    Med Phys 33:1165-79. 2006
    ..Patient studies have indicated that the two-step registration technique is fast, reliable, and provides a valuable tool to facilitate both rigid and nonrigid image registrations...
  58. pmc Inverse planning for four-dimensional (4D) volumetric modulated arc therapy
    Yunzhi Ma
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
    Med Phys 37:5627-33. 2010
    ..To develop a 4D volumetric modulated arc therapy (VMAT) inverse planning framework...
  59. doi request reprint A failure detection strategy for intrafraction prostate motion monitoring with on-board imagers for fixed-gantry IMRT
    Wu Liu
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA
    Int J Radiat Oncol Biol Phys 78:904-11. 2010
    ....
  60. ncbi request reprint Computational challenges for image-guided radiation therapy: framework and current research
    Lei Xing
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305 5304, USA
    Semin Radiat Oncol 17:245-57. 2007
    ....
  61. ncbi request reprint CT image registration in sinogram space
    Weihua Mao
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5847, USA
    Med Phys 34:3596-602. 2007
    ..In addition, this algorithm is valuable for dealing with situations where only limited projection data are available, making it appealing for various applications in image guided radiation therapy...
  62. pmc Iterative image reconstruction for CBCT using edge-preserving prior
    Jing Wang
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
    Med Phys 36:252-60. 2009
    ..Compared with conventional isotropic penalty, the PWLS image reconstruction algorithm with anisotropic penalty shows better resolution preservation...
  63. pmc Search for IMRT inverse plans with piecewise constant fluence maps using compressed sensing techniques
    Lei Zhu
    Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA
    Med Phys 36:1895-905. 2009
    ..With the focus on the sparsity of the optimal solution, the proposed method is distinct from the existing beamlet- or segment-based optimization algorithms...
  64. pmc Intrafractional motion of the prostate during hypofractionated radiotherapy
    Yaoqin Xie
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5847, USA
    Int J Radiat Oncol Biol Phys 72:236-46. 2008
    ..To report the characteristics of prostate motion as tracked by the stereoscopic X-ray images of the implanted fiducials during hypofractionated radiotherapy with CyberKnife...
  65. ncbi request reprint Quantitative measurement of MLC leaf displacements using an electronic portal image device
    Yong Yang
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5304, USA
    Phys Med Biol 49:1521-33. 2004
    ..3 mm when the uncertainty is considered. Given its simplicity, efficiency and accuracy, we believe that the technique is ideally suitable for routine MLC leaf positioning QA...
  66. ncbi request reprint Quantitation of the a priori dosimetric capabilities of spatial points in inverse planning and its significant implication in defining IMRT solution space
    Z Shou
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305 5847, USA
    Phys Med Biol 50:1469-82. 2005
    ....
  67. pmc Evaluation of the geometric accuracy of surrogate-based gated VMAT using intrafraction kilovoltage x-ray images
    Ruijiang Li
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305 5847, USA
    Med Phys 39:2686-93. 2012
    ..To evaluate the geometric accuracy of beam targeting in external surrogate-based gated volumetric modulated arc therapy (VMAT) using kilovoltage (kV) x-ray images acquired during dose delivery...
  68. ncbi request reprint Formulating adaptive radiation therapy (ART) treatment planning into a closed-loop control framework
    Adam de la Zerda
    Department of Electrical Engineering, Stanford University, Stanford, CA 94305 9505, USA
    Phys Med Biol 52:4137-53. 2007
    ..We anticipate that improvements in imaging, dose verification and reporting will further increase the importance of adaptive algorithms...
  69. ncbi request reprint Overview of image-guided radiation therapy
    Lei Xing
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5847, USA
    Med Dosim 31:91-112. 2006
    ..We introduce various new IGRT concepts and approaches, and hope to provide the reader with a comprehensive understanding of the emerging clinical IGRT technologies. Some important research topics will also be addressed...
  70. ncbi request reprint Image interpolation in 4D CT using a BSpline deformable registration model
    Eduard Schreibmann
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int J Radiat Oncol Biol Phys 64:1537-50. 2006
    ..To develop a method for deriving the phase-binned four-dimensional computed tomography (4D CT) image sets through interpolation of the images acquired at some known phases...
  71. ncbi request reprint Aperture modulated arc therapy
    S M Crooks
    Department of Radiation Oncology, Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA
    Phys Med Biol 48:1333-44. 2003
    ..19 +/- 6.62%. For a meningioma the coronal plane dose distributions were similar to a value of 4.6 +/- 6.62%. Dose to the isocentre was measured as being within 2% of the planned value in both cases...
  72. ncbi request reprint IMRT dose shaping with regionally variable penalty scheme
    Cristian Cotrutz
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5304, USA
    Med Phys 30:544-51. 2003
    ..Thus introducing the voxel-dependent penalty scheme provides an effective means for IMRT dose distributions painting and sculpting...
  73. ncbi request reprint Stereotactic body radiation therapy in multiple organ sites
    Robert D Timmerman
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9183, USA
    J Clin Oncol 25:947-52. 2007
    ..Stereotactic body radiation therapy (SBRT) uses advanced technology to deliver a potent ablative dose to deep-seated tumors in the lung, liver, spine, pancreas, kidney, and prostate...
  74. doi request reprint A binary image reconstruction technique for accurate determination of the shape and location of metal objects in x-ray computed tomography
    Jing Wang
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5847, USA
    J Xray Sci Technol 18:403-14. 2010
    ..For a hexagonally shaped metal embedded in a water phantom, for example, it is found that the accuracy of metal reconstruction is within sub-millimeter...
  75. pmc The use of EPID-measured leaf sequence files for IMRT dose reconstruction in adaptive radiation therapy
    Louis Lee
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
    Med Phys 35:5019-29. 2008
    ..The approach also allows users who do not have access to MLC log files to probe the actual IMRT delivery and translate the information gained for dose reconstruction in adaptive radiation therapy...
  76. ncbi request reprint Optimizing 4D cone-beam CT acquisition protocol for external beam radiotherapy
    Tianfang Li
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5847, USA
    Int J Radiat Oncol Biol Phys 67:1211-9. 2007
    ..The aim of this study is to optimize the image acquisition on a patient-specific basis while minimizing the scan time and the radiation dose...
  77. ncbi request reprint Incorporating leaf transmission and head scatter corrections into step-and-shoot leaf sequences for IMRT
    Yong Yang
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int J Radiat Oncol Biol Phys 55:1121-34. 2003
    ..The purpose of this article is to propose a reliable algorithm to minimize the dosimetric effects caused by the two factors in step-and-shoot mode...
  78. ncbi request reprint Quality assurance of magnetic resonance spectroscopic imaging-derived metabolic data
    Sandeep Hunjan
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5304, USA
    Int J Radiat Oncol Biol Phys 57:1159-73. 2003
    ..We present a quality assurance procedure for MRSI-derived metabolic data acquired ultimately for guiding conformal radiotherapy...
  79. ncbi request reprint Inverse planning for functional image-guided intensity-modulated radiation therapy
    Lei Xing
    Department of Radiation Oncology, Stanford University School of Medicine, CA 94305 5304, USA
    Phys Med Biol 47:3567-78. 2002
    ..This should enhance our capability to safely and intelligently escalate dose and lays the technical foundation for future clinical studies of the efficacy of functional imaging-guided IMRT...
  80. ncbi request reprint A three-source model for the calculation of head scatter factors
    Yong Yang
    Department of Radiation Oncology, Stanford University, California 94305 5304, USA
    Med Phys 29:2024-33. 2002
    ..4%. The algorithm can also be easily applied to deal with irregular fields shaped by a multileaf collimator that replaces the upper or lower collimator jaws...
  81. ncbi request reprint Examination of the effect of increasing the number of radiation beams on a radiation treatment plan
    Steven M Crooks
    Stanford University Medical Center, Stanford, CA 94305 5304, USA
    Phys Med Biol 47:3485-501. 2002
    ..Results are presented for prostate, spinal and head and neck cases, and the connection to beam-orientation optimization is examined...
  82. pmc A Bayesian approach to real-time 3D tumor localization via monoscopic x-ray imaging during treatment delivery
    Ruijiang Li
    Department of Radiation Oncology, Stanford University School of Medicine, 875 Blake Wilbur Drive, Stanford, California 94305 5847, USA
    Med Phys 38:4205-14. 2011
    ....
  83. pmc Quality assurance of positron emission tomography/computed tomography for radiation therapy
    Lei Xing
    Department of Radiation Oncology, Stanford University, Stanford, CA, USA
    Int J Radiat Oncol Biol Phys 71:S38-42. 2008
    ..This presentation discusses various aspects of nuclide imaging as applied to radiotherapy and describes the QA procedures necessary for the success of biologic image-guided radiation therapy...
  84. ncbi request reprint Point/Counterpoint. Kilovoltage imaging is more suitable than megavoltage imaging for guiding radiation therapy
    Lei Xing
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5847, USA
    Med Phys 34:4563-6. 2007
  85. ncbi request reprint Multiscale image registration
    Dana Paquin
    Department of Mathematics, Stanford University, Stanford, CA 94305 2125
    Math Biosci Eng 3:389-418. 2006
    ..Image registration experiments demonstrate the accuracy and efficiency of the multiscale registration technique, and for all noise levels, the multiscale technique is as accurate as or more accurate than ordinary registration techniques...
  86. doi request reprint Fast and accurate marker-based projective registration method for uncalibrated transmission electron microscope tilt series
    Ho Lee
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305 5847, USA
    Phys Med Biol 55:3417-40. 2010
    ..Experimental results show that our method brings more accurate alignment with less computational cost compared to conventional automatic alignment methods...
  87. ncbi request reprint Indirect MR lymphangiography of the head and neck using conventional gadolinium contrast: a pilot study in humans
    Billy W Loo
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305 5847, USA, and Department of General Surgery, Singapore General Hospital, Singapore
    Int J Radiat Oncol Biol Phys 66:462-8. 2006
    ....
  88. ncbi request reprint Using voxel-dependent importance factors for interactive DVH-based dose optimization
    Cristian Cotrutz
    Department of Radiation Oncology, Stanford University School of Medicine, CA 94305 5304, USA
    Phys Med Biol 47:1659-69. 2002
    ..Thus the technique may have significant practical implications in facilitating the IMRT treatment planning process...
  89. doi request reprint X-ray luminescence computed tomography via selective excitation: a feasibility study
    Guillem Pratx
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    IEEE Trans Med Imaging 29:1992-9. 2010
    ..The molecular and anatomical images are spatially and temporally co-registered, and, if a single-pixel X-ray detector is used, they have matching spatial resolution...
  90. pmc Sinogram preprocessing and binary reconstruction for determination of the shape and location of metal objects in computed tomography (CT)
    Bowen Meng
    Department of Electrical Engineering, Stanford University, Stanford, California 94305, USA
    Med Phys 37:5867-75. 2010
    ..To develop a binary image reconstruction method for the autolocalization of metallic object(s) in CT with sparse projections...
  91. ncbi request reprint Automated detection of junctions structures and tracking of their trajectories in 4D images
    Guanglei Xiong
    Biomedical Informatics Program, Stanford University, Stanford, CA 94305, USA
    Inf Process Med Imaging 22:486-97. 2011
    ..More than 500 junctions in the lung are detected with an average accuracy of greater than 85% and the mean error between the automated and the manual tracking is sub-voxel...
  92. ncbi request reprint The value of PET/CT is being over-sold as a clinical tool in radiation oncology. For the proposition
    Lei Xing
    Stanford University School of Medicine, Department of Radiation Oncology, Stanford, California 94305 5847, USA
    Med Phys 32:1457-8. 2005
  93. ncbi request reprint GPU computing in medical physics: a review
    Guillem Pratx
    Department of Radiation Oncology, Stanford University School of Medicine, 875 Blake Wilbur Drive, Stanford, California 94305, USA
    Med Phys 38:2685-97. 2011
    ....
  94. ncbi request reprint Incorporating prior knowledge into beam orientation optimization in IMRT
    Andrei Pugachev
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int J Radiat Oncol Biol Phys 54:1565-74. 2002
    ....

Research Grants9

  1. IMRT Guided by Magnetic Resonance Spectroscopic Imaging
    Lei Xing; Fiscal Year: 2006
    ..In addition, the dose optimization framework will be equally applicable to biologically-guided IMRT incorporating functional information from other modalities including PET and molecular imaging. ..
  2. IMRT Dose Optimization
    Lei Xing; Fiscal Year: 2007
    ..Thus it will likely result in a measurable improvement in treatment outcome and have a widespread impact on cancer management. ..
  3. IMRT Dose Optimization
    Lei Xing; Fiscal Year: 2009
    ..Thus it will likely result in a measurable improvement in treatment outcome and have a widespread impact on cancer management. ..
  4. Computational Tools for Adaptive Radiation Therapy
    Lei Xing; Fiscal Year: 2009
    ..IGART improves current radiation therapy by adaptively adjusting the beam parameters according to volumetric imaging data acquired with the patient in the actual treatment position. ..
  5. Computational Tools for Adaptive Radiation Therapy
    Lei Xing; Fiscal Year: 2010
    ..IGART improves current radiation therapy by adaptively adjusting the beam parameters according to volumetric imaging data acquired with the patient in the actual treatment position. ..