Chengbiao Wu

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi Nerve growth factor activates persistent Rap1 signaling in endosomes
    C Wu
    Departments of Neurology and Neurological Sciences and of Pediatrics and the Program in Neuroscience, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 21:5406-16. 2001
  2. pmc The coming of age of axonal neurotrophin signaling endosomes
    Chengbiao Wu
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, California 94305 5489, United States
    J Proteomics 72:46-55. 2009
  3. ncbi A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathway
    Chengbiao Wu
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Traffic 8:1503-20. 2007
  4. pmc Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport
    Jia Jia Liu
    Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:2223-8. 2007
  5. ncbi Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport
    Jianqing Ding
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 1201 Welch Road, CA 94305 5489, USA
    Hum Mol Genet 15:1451-63. 2006
  6. pmc BPAG1n4 is essential for retrograde axonal transport in sensory neurons
    Jia Jia Liu
    Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305 5489, USA
    J Cell Biol 163:223-9. 2003
  7. doi Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome
    Pavel V Belichenko
    Department of Neurology and Neurological Sciences, the Center for Research and Treatment of Down Syndrome and Neuroscience Institute at Stanford University, Stanford, California 94305 5489, USA
    J Comp Neurol 512:453-66. 2009
  8. pmc One at a time, live tracking of NGF axonal transport using quantum dots
    Bianxiao Cui
    Department of Physics, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:13666-71. 2007
  9. ncbi Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration
    Ahmad Salehi
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, California 94305, USA
    Neuron 51:29-42. 2006
  10. ncbi NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals
    Jean Dominique Delcroix
    Department of Neurology and Neurological Sciences, Stanford University, Stanford 94305, USA
    Neuron 39:69-84. 2003

Collaborators

Detail Information

Publications15

  1. ncbi Nerve growth factor activates persistent Rap1 signaling in endosomes
    C Wu
    Departments of Neurology and Neurological Sciences and of Pediatrics and the Program in Neuroscience, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 21:5406-16. 2001
    ..We propose that endosomes are a site from which NGF induces the prolonged activation of Rap1 and MAPK...
  2. pmc The coming of age of axonal neurotrophin signaling endosomes
    Chengbiao Wu
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, California 94305 5489, United States
    J Proteomics 72:46-55. 2009
    ..In this review, we summarize current insights that are mainly based on classical hypothesis-driven research, and we emphasize the urgent needs to carry out proteomics to resolve the controversies in the field...
  3. ncbi A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathway
    Chengbiao Wu
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Traffic 8:1503-20. 2007
    ..Dynein- and microtubule-based transport is thus necessary for TrkA signaling to Rap1 and MAPK1/2...
  4. pmc Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport
    Jia Jia Liu
    Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:2223-8. 2007
    ..Our work lays the foundation for understanding fundamental issues of axonal transport and provides insights into the molecular mechanisms underlying human neurodegenerative disorders...
  5. ncbi Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport
    Jianqing Ding
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 1201 Welch Road, CA 94305 5489, USA
    Hum Mol Genet 15:1451-63. 2006
    ..We propose that the axonal transport impairment may be a deleterious consequence of accumulated, toxic MAP8 protein...
  6. pmc BPAG1n4 is essential for retrograde axonal transport in sensory neurons
    Jia Jia Liu
    Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305 5489, USA
    J Cell Biol 163:223-9. 2003
    ..We conclude that BPAG1n4 plays an essential role in retrograde axonal transport in sensory neurons. These findings might advance our understanding of pathogenesis of axonal degeneration and neuronal death...
  7. doi Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome
    Pavel V Belichenko
    Department of Neurology and Neurological Sciences, the Center for Research and Treatment of Down Syndrome and Neuroscience Institute at Stanford University, Stanford, California 94305 5489, USA
    J Comp Neurol 512:453-66. 2009
    ..The results demonstrate a significant alteration of inhibitory synapses in the fascia dentata of Ts65Dn mice...
  8. pmc One at a time, live tracking of NGF axonal transport using quantum dots
    Bianxiao Cui
    Department of Physics, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:13666-71. 2007
    ..Our findings point to the possibility that a single NGF dimer is sufficient to sustain signaling during retrograde axonal transport to the cell body...
  9. ncbi Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration
    Ahmad Salehi
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, California 94305, USA
    Neuron 51:29-42. 2006
    ..Our study thus provides evidence for a pathogenic mechanism for DS in which increased expression of App, in the context of trisomy, causes abnormal transport of NGF and cholinergic neurodegeneration...
  10. ncbi NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals
    Jean Dominique Delcroix
    Department of Neurology and Neurological Sciences, Stanford University, Stanford 94305, USA
    Neuron 39:69-84. 2003
    ..Our results are evidence that signaling endosomes, with the characteristics of early endosomes, convey NGF signals from the target of nociceptive neurons to their cell bodies...
  11. pmc Defective axonal transport of Rab7 GTPase results in dysregulated trophic signaling
    Kai Zhang
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Neurosci 33:7451-62. 2013
    ..5 DRG neurons. We propose that Rab7 mutants induce premature degradation of retrograde NGF-TrkA trophic signaling, which may potentially contribute to the CMT2B disease...
  12. pmc TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology
    Yuki Miyamoto
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:10444-9. 2006
    ..The findings are evidence of a previously uncharacterized mechanism for the activation of Tiam1 and of a role for this effector in neurotrophin-mediated signal transduction leading to changes in cellular morphology...
  13. pmc A novel method for producing mono-biotinylated, biologically active neurotrophic factors: an essential reagent for single molecule study of axonal transport
    Kijung Sung
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA
    J Neurosci Methods 200:121-8. 2011
    ..Finally, by conjugating to quantum-dot streptavidin, mBtNGF was successfully used for single molecule study of axonal NGF trafficking in neurons...
  14. ncbi A novel zinc finger transcription factor with two isoforms that are differentially repressed by estrogen receptor-alpha
    Andrew T Conroy
    Department of Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 277:9326-34. 2002
    ..We conclude that ZER6 is a novel zinc finger transcription factor in which regulation of transcription in hormone-responsive cells can be controlled by the relative level of expression of two distinct isoforms...
  15. doi Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth
    Jun Wan
    Department of Biochemistry, Biotechnology Research Institute and Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    J Neurosci 28:9002-12. 2008
    ..Our observations implicate endophilin B1 as a novel regulator of NGF trafficking, thereby affecting TrkA levels and downstream signaling on endosomes to mediate biological functions of NGF...