Research Topics
Genomes and Genes
| Chengbiao WuSummaryAffiliation: Stanford University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Nerve growth factor activates persistent Rap1 signaling in endosomesC Wu
Departments of Neurology and Neurological Sciences and of Pediatrics and the Program in Neuroscience, Stanford University School of Medicine, Stanford, California 94305, USA
J Neurosci 21:5406-16. 2001..We propose that endosomes are a site from which NGF induces the prolonged activation of Rap1 and MAPK...
The coming of age of axonal neurotrophin signaling endosomesChengbiao Wu
Department of Neurology and Neurological Sciences, Stanford University, Stanford, California 94305 5489, United States
J Proteomics 72:46-55. 2009..In this review, we summarize current insights that are mainly based on classical hypothesis-driven research, and we emphasize the urgent needs to carry out proteomics to resolve the controversies in the field...- A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathwayChengbiao Wu
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
Traffic 8:1503-20. 2007..Dynein- and microtubule-based transport is thus necessary for TrkA signaling to Rap1 and MAPK1/2... - Retrolinkin, a membrane protein, plays an important role in retrograde axonal transportJia Jia Liu
Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 104:2223-8. 2007..Our work lays the foundation for understanding fundamental issues of axonal transport and provides insights into the molecular mechanisms underlying human neurodegenerative disorders... - Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transportJianqing Ding
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 1201 Welch Road, CA 94305 5489, USA
Hum Mol Genet 15:1451-63. 2006..We propose that the axonal transport impairment may be a deleterious consequence of accumulated, toxic MAP8 protein... - BPAG1n4 is essential for retrograde axonal transport in sensory neuronsJia Jia Liu
Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305 5489, USA
J Cell Biol 163:223-9. 2003..We conclude that BPAG1n4 plays an essential role in retrograde axonal transport in sensory neurons. These findings might advance our understanding of pathogenesis of axonal degeneration and neuronal death... 
Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndromePavel V Belichenko
Department of Neurology and Neurological Sciences, the Center for Research and Treatment of Down Syndrome and Neuroscience Institute at Stanford University, Stanford, California 94305 5489, USA
J Comp Neurol 512:453-66. 2009..The results demonstrate a significant alteration of inhibitory synapses in the fascia dentata of Ts65Dn mice...- Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degenerationAhmad Salehi
Department of Neurology and Neurological Sciences, Stanford University, Stanford, California 94305, USA
Neuron 51:29-42. 2006..Our study thus provides evidence for a pathogenic mechanism for DS in which increased expression of App, in the context of trisomy, causes abnormal transport of NGF and cholinergic neurodegeneration... - One at a time, live tracking of NGF axonal transport using quantum dotsBianxiao Cui
Department of Physics, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 104:13666-71. 2007..Our findings point to the possibility that a single NGF dimer is sufficient to sustain signaling during retrograde axonal transport to the cell body... - NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signalsJean Dominique Delcroix
Department of Neurology and Neurological Sciences, Stanford University, Stanford 94305, USA
Neuron 39:69-84. 2003..Our results are evidence that signaling endosomes, with the characteristics of early endosomes, convey NGF signals from the target of nociceptive neurons to their cell bodies... - TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphologyYuki Miyamoto
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 103:10444-9. 2006..The findings are evidence of a previously uncharacterized mechanism for the activation of Tiam1 and of a role for this effector in neurotrophin-mediated signal transduction leading to changes in cellular morphology... - A novel method for producing mono-biotinylated, biologically active neurotrophic factors: an essential reagent for single molecule study of axonal transportKijung Sung
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA
J Neurosci Methods 200:121-8. 2011..Finally, by conjugating to quantum-dot streptavidin, mBtNGF was successfully used for single molecule study of axonal NGF trafficking in neurons... - A novel zinc finger transcription factor with two isoforms that are differentially repressed by estrogen receptor-alphaAndrew T Conroy
Department of Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
J Biol Chem 277:9326-34. 2002..We conclude that ZER6 is a novel zinc finger transcription factor in which regulation of transcription in hormone-responsive cells can be controlled by the relative level of expression of two distinct isoforms... - Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowthJun Wan
Department of Biochemistry, Biotechnology Research Institute and Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
J Neurosci 28:9002-12. 2008..Our observations implicate endophilin B1 as a novel regulator of NGF trafficking, thereby affecting TrkA levels and downstream signaling on endosomes to mediate biological functions of NGF...