Alice Whittemore

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Oral contraceptive use and ovarian cancer risk among carriers of BRCA1 or BRCA2 mutations
    A S Whittemore
    Department of Health Research and Policy, Stanford University School of Medicine, HRP Redwood Building, Stanford, CA 94305 5405, USA
    Br J Cancer 91:1911-5. 2004
  2. pmc Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families
    Joan E Bailey-Wilson
    Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA
    BMC Med Genet 13:46. 2012
  3. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
  4. pmc Variants in estrogen-biosynthesis genes CYP17 and CYP19 and breast cancer risk: a family-based genetic association study
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Breast Cancer Res 7:R71-81. 2005
  5. pmc The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer
    Esther M John
    Clinical and Genetic Epidemiology Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA
    Breast Cancer Res 6:R375-89. 2004
  6. ncbi request reprint Prostate specific antigen levels in young adulthood predict prostate cancer risk: results from a cohort of Black and White Americans
    Alice S Whittemore
    Department of Health Research and Policy, Stanford University School of Medicine, California 94305 5405, USA
    J Urol 174:872-6; discussion 876. 2005
  7. pmc No evidence of familial correlation in breast cancer metastasis
    Alice S Whittemore
    Department of Health Research and Policy, Stanford University School of Medicine, Redwood Building, Room T204, Stanford, CA, 94305 5405, USA
    Breast Cancer Res Treat 118:575-81. 2009
  8. ncbi request reprint Assessing environmental modifiers of disease risk associated with rare mutations
    Alice S Whittemore
    Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305 5405, USA
    Hum Hered 63:134-43. 2007
  9. ncbi request reprint Covariate adjustment in family-based association studies
    Alice S Whittemore
    Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA
    Genet Epidemiol 28:244-55. 2005
  10. pmc Evaluating health risk models
    Alice S Whittemore
    Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305 5405, USA
    Stat Med 29:2438-52. 2010

Research Grants

  1. GENETIC EPIDEMIOLOGY OF PROSTATE CANCER
    Alice Whittemore; Fiscal Year: 2006
  2. GENETIC EPIDEMIOLOGY OF PROSTATE CANCER
    Alice Whittemore; Fiscal Year: 2007
  3. "Statistical Methods for Genetic Epidemiology"
    Alice Whittemore; Fiscal Year: 2007
  4. Cancer Risks in Multi-ethnic Carriers of Unclassified BRCA1 Variants
    Alice Whittemore; Fiscal Year: 2007
  5. "Statistical Methods for Genetic Epidemiology"
    Alice Whittemore; Fiscal Year: 2009
  6. STATISTICAL METHODS FOR GENETIC EPIDEMIOLOGY
    Alice Whittemore; Fiscal Year: 2006
  7. GENETIC EPIDEMIOLOGY OF PROSTATE CANCER
    Alice Whittemore; Fiscal Year: 2005
  8. STATISTICAL METHODS FOR GENETIC EPIDEMIOLOGY
    Alice Whittemore; Fiscal Year: 2002
  9. STATISTICAL METHODS FOR GENETIC EPIDEMIOLOGY
    Alice Whittemore; Fiscal Year: 2003
  10. Breast Cancer Risk Modifiers in BRCA Mutation Carriers
    Alice Whittemore; Fiscal Year: 2003

Detail Information

Publications81

  1. pmc Oral contraceptive use and ovarian cancer risk among carriers of BRCA1 or BRCA2 mutations
    A S Whittemore
    Department of Health Research and Policy, Stanford University School of Medicine, HRP Redwood Building, Stanford, CA 94305 5405, USA
    Br J Cancer 91:1911-5. 2004
    ..Use for 6 or more years was associated with an odds-ratio of 0.62 (0.35-1.09). These data support the hypothesis that long-term oral contraceptive use reduces the risk of ovarian cancer among women who carry mutations of BRCA1 or BRCA2...
  2. pmc Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families
    Joan E Bailey-Wilson
    Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA
    BMC Med Genet 13:46. 2012
    ..Current evidence suggests that genetic linkage to prostate cancer has been found on several chromosomes including the X; however, identification of causative genes has been elusive...
  3. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
    ....
  4. pmc Variants in estrogen-biosynthesis genes CYP17 and CYP19 and breast cancer risk: a family-based genetic association study
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Breast Cancer Res 7:R71-81. 2005
    ....
  5. pmc The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer
    Esther M John
    Clinical and Genetic Epidemiology Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA
    Breast Cancer Res 6:R375-89. 2004
    ....
  6. ncbi request reprint Prostate specific antigen levels in young adulthood predict prostate cancer risk: results from a cohort of Black and White Americans
    Alice S Whittemore
    Department of Health Research and Policy, Stanford University School of Medicine, California 94305 5405, USA
    J Urol 174:872-6; discussion 876. 2005
    ..Little is known about PSA distribution in young adulthood, when benign and malignant prostatic diseases are rare, or about how PSA within the normal range in youth relates to subsequent prostate cancer risk...
  7. pmc No evidence of familial correlation in breast cancer metastasis
    Alice S Whittemore
    Department of Health Research and Policy, Stanford University School of Medicine, Redwood Building, Room T204, Stanford, CA, 94305 5405, USA
    Breast Cancer Res Treat 118:575-81. 2009
    ..03 (95% confidence interval -0.11 to 0.06). These findings suggest that a family history of metastatic breast cancer does not contribute substantially to risk of metastasis for breast cancer patients...
  8. ncbi request reprint Assessing environmental modifiers of disease risk associated with rare mutations
    Alice S Whittemore
    Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305 5405, USA
    Hum Hered 63:134-43. 2007
    ..Such assessment is difficult when the mutations are rare and evaluating them in large population samples is costly...
  9. ncbi request reprint Covariate adjustment in family-based association studies
    Alice S Whittemore
    Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA
    Genet Epidemiol 28:244-55. 2005
    ..e., data for which multiple logistic regression of matched sibships would have little power. Software for performing the covariate-adjusted tests is available at http://www.stanford.edu/dept/HRP/epidemiology/COVTDT...
  10. pmc Evaluating health risk models
    Alice S Whittemore
    Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305 5405, USA
    Stat Med 29:2438-52. 2010
    ..We propose new ways to identify these subgroups and to quantify how much they gain by measuring the additional covariates. Those with largest gains could be targeted for cost-efficient covariate assessment...
  11. ncbi request reprint Prevalence of BRCA1 mutation carriers among U.S. non-Hispanic Whites
    Alice S Whittemore
    Department of Health Research and Policy, Stanford University School of Medicine, Redwood Building, Room T204, Stanford, CA 94503 5405, USA
    Cancer Epidemiol Biomarkers Prev 13:2078-83. 2004
    ..S. Whites (506,206 non-Ashkenazim and 44,307 Ashkenazim) carry germ line BRCA1 mutations. These estimates may be useful in guiding resource allocation for genetic testing and genetic counseling and in planning preventive interventions...
  12. ncbi request reprint Observational studies and randomized trials of hormone replacement therapy: what can we learn from them?
    Alice S Whittemore
    Department of Health Research and Policy, Stanford University School of Medicine, CA 94305, USA
    Epidemiology 14:8-10. 2003
  13. pmc Breast cancer in Marin County
    Alice S Whittemore
    Stanford University School of Medicine, Stanford, California, USA
    Breast Cancer Res 5:232-4. 2003
    ..I discuss possible causes for such cancer 'clusters', and conclude with some thoughts about the future...
  14. pmc Breast cancer risk for noncarriers of family-specific BRCA1 and BRCA2 mutations: findings from the Breast Cancer Family Registry
    Allison W Kurian
    Stanford University School of Medicine, Stanford, CA 94305, USA
    J Clin Oncol 29:4505-9. 2011
    ..We estimated breast cancer risks for noncarriers by using a population-based sample of patients with breast cancer and their female first-degree relatives (FDRs)...
  15. pmc Stage at diagnosis and survival in a multiethnic cohort of prostate cancer patients
    Ingrid Oakley-Girvan
    Stanford University School of Medicine, Stanford, California 94305 5405, USA
    Am J Public Health 93:1753-9. 2003
    ..We evaluated the effects of socioeconomic status and comorbidity on stage of disease and survival among 1509 population-based prostate cancer patients...
  16. ncbi request reprint Breast and ovarian cancer in relatives of cancer patients, with and without BRCA mutations
    Jennifer S Lee
    Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, HRP Redwood Building, Stanford, California 94305 5405, USA
    Cancer Epidemiol Biomarkers Prev 15:359-63. 2006
    ..Little is known about how their risks vary with the patient's cancer site, carrier status for predisposing genetic mutations, or age at cancer diagnosis...
  17. ncbi request reprint Tests for genetic association using family data
    Mei Chiung Shih
    Department of Health Research and Policy, Stanford University, Stanford, California 94305, USA
    Genet Epidemiol 22:128-45. 2002
    ..The software program FGAP for computing test statistics is available at http://www.stanford.edu/dept/HRP/epidemiology/FGAP...
  18. pmc Performance of prediction models for BRCA mutation carriage in three racial/ethnic groups: findings from the Northern California Breast Cancer Family Registry
    Allison W Kurian
    Stanford University School of Medicine, Department of Health Research and Policy, Stanford, CA 94305 5405, USA
    Cancer Epidemiol Biomarkers Prev 18:1084-91. 2009
    ..Two widely used models, BRCAPRO and BOADICEA, were developed using data from non-Hispanic Whites (NHW), but their accuracies have not been evaluated in other racial/ethnic populations...
  19. ncbi request reprint Risk of early-onset prostate cancer in relation to germ line polymorphisms of the vitamin D receptor
    Ingrid Oakley-Girvan
    Department of Health Research and Policy, Stanford University School of Medicine, HRP Redwood Building, T204, Stanford, CA 94305 5405, USA
    Cancer Epidemiol Biomarkers Prev 13:1325-30. 2004
    ..S. Whites. If the FokI association noted here were causal, this difference could account for some of the disease burden among African Americans and some of the excess risk in African Americans compared with Whites...
  20. ncbi request reprint Segregation analysis of prostate cancer in 1,719 white, African-American and Asian-American families in the United States and Canada
    Gail Gong
    Stanford University School of Medicine, Department of Health Research and Policy, CA 94305 5405, USA
    Cancer Causes Control 13:471-82. 2002
    ..However, higher observed frequencies in brothers than fathers may merely reflect the strong temporal changes in US incidence rates...
  21. ncbi request reprint Optimal designs for estimating penetrance of rare mutations of a disease-susceptibility gene
    Gail Gong
    Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California 94305 5405, USA
    Genet Epidemiol 24:173-80. 2003
    ..Rough variance calculations suggest that clinic-based designs give more accurate estimates because they include more identified mutation carriers...
  22. ncbi request reprint Incidence of small bowel cancer in the United States and worldwide: geographic, temporal, and racial differences
    Tmirah Haselkorn
    Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cancer Causes Control 16:781-7. 2005
    ..To examine the demographic and geographic patterns of small bowel cancer incidence in the United States and worldwide...
  23. pmc Estimating gene penetrance from family data
    Gail Gong
    Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA
    Genet Epidemiol 34:373-81. 2010
    ....
  24. ncbi request reprint Survival among U.S. women with invasive epithelial ovarian cancer
    Valerie McGuire
    Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California 94305 5405, USA
    Gynecol Oncol 84:399-403. 2002
    ..S. women of different race/ethnicities. To investigate this issue, we evaluated pathological characteristics and death rates due to invasive epithelial ovarian cancer in a population-based sample of patients from six racial/ethnic groups...
  25. ncbi request reprint Imputation of missing ages in pedigree data
    Raymond R Balise
    Department of Health Research and Policy, Stanford University, Stanford, CA, USA
    Hum Hered 63:168-74. 2007
    ..In particular, there is little information about the level of agreement between imputed and actual values of temporal data and their effects on inferences...
  26. ncbi request reprint Breast cancer followed by corpus cancer: is there a higher risk for aggressive histologic subtypes?
    John K Chan
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Stanford University Medical Center, Stanford Cancer Center 875 Blake Wilbur Drive, MC 5827, Stanford, CA 94305, USA
    Gynecol Oncol 102:508-12. 2006
    ..To analyze corpus cancer patients with a breast cancer history for risk of developing aggressive uterine histologic types...
  27. ncbi request reprint Race, epithelial ovarian cancer survival, and membership in a large health maintenance organization
    Valerie McGuire
    Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305 5405, USA
    Epidemiology 13:231-4. 2002
    ..African-American ovarian cancer patients present with more advanced disease and have poorer survival than do white patients...
  28. ncbi request reprint Patterns and progress in ovarian cancer over 14 years
    John K Chan
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford Cancer Center, Stanford, California 94305, USA
    Obstet Gynecol 108:521-8. 2006
    ..To estimate the change in survival rates of women with ovarian cancer during the past 14 years...
  29. ncbi request reprint Sex steroid hormones in young manhood and the risk of subsequent prostate cancer: a longitudinal study in African-Americans and Caucasians (United States)
    Chiaojung J Tsai
    Department of Health Research and Policy, Stanford University School of Medicine, HRP Redwood Building, Room T204, Stanford, CA 94305 5405, USA
    Cancer Causes Control 17:1237-44. 2006
    ..To investigate the relation of sex hormone levels in young adults to subsequent prostate cancer risk...
  30. ncbi request reprint No increased risk of breast cancer associated with alcohol consumption among carriers of BRCA1 and BRCA2 mutations ages <50 years
    Valerie McGuire
    Department of Health Research and Policy, Stanford University School of Medicine, Health Research and Stanford, CA 94305 5405, USA
    Cancer Epidemiol Biomarkers Prev 15:1565-7. 2006
  31. pmc Performance of BRCA1/2 mutation prediction models in Asian Americans
    Allison W Kurian
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5405, USA
    J Clin Oncol 26:4752-8. 2008
    ..We compared the performance in Asian and white individuals of two widely used BRCA1/2 mutation prediction models, BRCAPRO and Myriad II...
  32. ncbi request reprint Logistic regression of family data from retrospective study designs
    Alice S Whittemore
    Stanford University School of Medicine, Stanford, CA 94305, USA
    Genet Epidemiol 25:177-89. 2003
    ..stanford.edu/dept/HRP/epidemiology. We illustrate these pros and cons by application to data on the effects of parity on ovarian cancer risk in mother/daughter pairs, and use simulations to study the performance of the estimates...
  33. ncbi request reprint Histologic types of epithelial ovarian cancer: have they different risk factors?
    Allison W Kurian
    Department of Medicine, Division of Oncology, Stanford University School of Medicine, 875 Blake Wilbur Drive, Stanford, CA 94305 5820, USA
    Gynecol Oncol 96:520-30. 2005
    ..The goals of the current study were to characterize further the relation of histologic-specific ovarian cancer risks to reproductive and lifestyle attributes...
  34. doi request reprint Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer
    Celeste Leigh Pearce
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA, USA
    Cancer Epidemiol Biomarkers Prev 22:880-90. 2013
    ..However, the interplay between such risk factors and susceptibility loci has not been studied...
  35. doi request reprint Oral contraceptives, postmenopausal hormones, and risk of asynchronous bilateral breast cancer: the WECARE Study Group
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    J Clin Oncol 26:1411-8. 2008
    ..To investigate whether oral contraceptive (OC) use and postmenopausal hormones (PMH) are associated with an increased risk of developing asynchronous bilateral breast cancer among women diagnosed with breast cancer younger than 55 years...
  36. ncbi request reprint Improved survival of Asians with corpus cancer compared with whites: an analysis of underlying factors
    Mallory M Zhang
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Stanford Cancer Center, Stanford University School of Medicine, CA 94305, USA
    Obstet Gynecol 107:329-35. 2006
    ..To compare the clinicopathologic prognosticators and survival of Asians and whites with corpus cancer...
  37. pmc Common variants on chromosome 6p22.1 are associated with schizophrenia
    Jianxin Shi
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94304, USA
    Nature 460:753-7. 2009
    ..These results demonstrate that common schizophrenia susceptibility alleles can be detected. The characterization of these signals will suggest important directions for research on susceptibility mechanisms...
  38. pmc Significance levels for studies with correlated test statistics
    Jianxin Shi
    Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Stanford, CA 94305, USA
    Biostatistics 9:458-66. 2008
    ..We justify this conditioning using the conditionality principle described by Cox and Hinkley (1974). Application of the method to gene expression data illustrates the circumstances when conditional significance levels are needed...
  39. ncbi request reprint Role of ethnicity in risk for hepatocellular carcinoma in patients with chronic hepatitis C and cirrhosis
    Mindie H Nguyen
    Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, CA 94305, USA
    Clin Gastroenterol Hepatol 2:820-4. 2004
    ..Our study examined ethnicity as a potential risk factor for HCC among patients with chronic hepatitis C...
  40. ncbi request reprint Getting more from digital SNP data
    Noureddine El Karoui
    Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA
    Stat Med 25:3124-33. 2006
    ..We propose an alternative classification scheme based on the false discovery rate, and show that it outperforms the SPRT when applied to Digital SNP data...
  41. ncbi request reprint Genetic association tests for family data with missing parental genotypes: a comparison
    Alice S Whittemore
    Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California 94305, USA
    Genet Epidemiol 25:80-91. 2003
    ..However, its utility is limited by the lack of a simple algorithm to apply it to families with varying structures and phenotypes...
  42. ncbi request reprint Nonparametric linkage analysis using person-specific covariates
    Alice S Whittemore
    Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California 94305 5405, USA
    Genet Epidemiol 30:369-79. 2006
    ..We have developed a modified version of GENEHUNTER that allows inclusion of person-specific weights in the nonparametric analyses. This program is freely available at http://med.stanford.edu/epidemiology/statisticalSoftware/weightedKAC...
  43. ncbi request reprint Genetic association studies: time for a new paradigm?
    Alice S Whittemore
    Department of Health Research and Policy, Stanford University School of Medicine, California, USA
    Cancer Epidemiol Biomarkers Prev 14:1359-60. 2005
  44. ncbi request reprint Disengagement and social support moderate distress among women with a family history of breast cancer
    Julie M Turner-Cobb
    Psychiatry and Behavioral Sciences and Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA
    Breast J 12:7-15. 2006
    ....
  45. doi request reprint Ovarian cancer rates after hysterectomy with and without salpingo-oophorectomy
    John K Chan
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, Helen Diller Family Comprehensive Cancer Center, and the Division of Gynecology, Department of Obstetrics and Gynecology and Reproductive Sciences, University of California, San Francisco School of Medicine, San Francisco, The Division of Research, Kaiser Permanente, Oakland, The Division of Medical Oncology, Chao Comprehensive Cancer Center, University of California, Irvine Medical Center, Chao Family Comprehensive Cancer Center, Orange, and the Division of Epidemiology, Stanford Cancer Center, Stanford University School of Medicine, Stanford, California
    Obstet Gynecol 123:65-72. 2014
    ..To estimate ovarian and peritoneal cancer rates after hysterectomy with and without salpingo-oophorectomy for benign conditions...
  46. ncbi request reprint Short-term chloral hydrate administration and cancer in humans
    Tmirah Haselkorn
    Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA
    Drug Saf 29:67-77. 2006
    ..Chloral hydrate, used as a hypnosedative in adults and children, has been shown to be genotoxic and carcinogenic in animal studies. We investigated the potential causal association between chloral hydrate exposure and cancer risk in humans...
  47. ncbi request reprint Increasing colorectal cancer incidence rates in Japan
    Hoi Yan Yiu
    Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA
    Int J Cancer 109:777-81. 2004
    ..Similar patterns are evident for women. The current trends suggest that colorectal cancer will become a major source of morbidity and mortality in Japan, as these young Japanese age and their risks increase...
  48. doi request reprint Facility factors dominate the ability to achieve target haemoglobin levels in haemodialysis patients
    Kevin E Chan
    Division of Nephrology, Stanford University School of Medicine, 300 Pasteur Drive, S161, Stanford, CA 94305 5114, USA
    Nephrol Dial Transplant 23:2948-56. 2008
    ..Our objective was to determine whether patient factors, processes of care and measures of erythropoietin (EPO) responsiveness were associated with successful anemia management at the individual patient level...
  49. ncbi request reprint Prediagnostic C-peptide and risk of prostate cancer
    Marilyn J Borugian
    Cancer Control Research, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia, Canada V5Z 1L3
    Cancer Epidemiol Biomarkers Prev 16:2164-5. 2007
  50. doi request reprint The effects of common genetic variants in oncogenes on ovarian cancer survival
    Lydia Quaye
    Gynaecological Cancer Research Laboratory, UCL EGA Institute for Women s Health, University College London, London, United Kingdom
    Clin Cancer Res 14:5833-9. 2008
    ..The aim of this study was to evaluate associations between common germline genetic variants in the oncogenes BRAF, ERBB2, KRAS, NMI, and PIK3CA, and survival after a diagnosis of epithelial ovarian cancer...
  51. pmc Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation set
    Jonathan Beesley
    Queensland Institute of Medical Research, Herston, Queensland, Australia
    Cancer Epidemiol Biomarkers Prev 16:2557-65. 2007
    ..Further analyses of SNPs in this gene are therefore warranted to determine whether SRD5A2 plays a role in ovarian cancer predisposition...
  52. ncbi request reprint Prevalence of pathogenic BRCA1 mutation carriers in 5 US racial/ethnic groups
    Esther M John
    Northern California Cancer Center, Fremont, CA 94538 2334, USA
    JAMA 298:2869-76. 2007
    ..Information on the prevalence of pathogenic BRCA1 mutation carriers in racial/ethnic minority populations is limited...
  53. pmc Multiple loci with different cancer specificities within the 8q24 gene desert
    Maya Ghoussaini
    Cancer Research UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, CB1 8RN, Cambridge, UK
    J Natl Cancer Inst 100:962-6. 2008
    ..We conclude that there are at least five separate functional variants in this region...
  54. doi request reprint Prostate cancer risk in relation to insulin-like growth factor (IGF)-I and IGF-binding protein-3: a prospective multiethnic study
    Marilyn J Borugian
    Cancer Control Research, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia, Canada
    Cancer Epidemiol Biomarkers Prev 17:252-4. 2008
  55. pmc Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival
    Honglin Song
    CR UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, United Kingdom
    Clin Cancer Res 14:1090-5. 2008
    ..Of particular interest are genes involved in cell cycle pathways, which regulate cell division and could plausibly influence clinical characteristics of multiple tumors types...
  56. pmc Consortium analysis of 7 candidate SNPs for ovarian cancer
    Susan J Ramus
    Translational Research Laboratory, University College London EGA Institute for Women s Health, London, United Kingdom
    Int J Cancer 123:380-8. 2008
    ..These null results for SNPs identified from relatively large initial studies shows the importance of replicating associations by a consortium approach...
  57. ncbi request reprint Contribution of BRCA1 and BRCA2 mutations to inherited ovarian cancer
    Susan J Ramus
    Translational Research Laboratory, University College London UCL, Elizabeth Garrett Anderson EGA Institute for Women s Health, University College London, London, United Kingdom
    Hum Mutat 28:1207-15. 2007
    ..Finally, it is likely that these data will be of clinical importance for individuals in families with a history of epithelial ovarian cancer, in providing accurate estimates of their disease risks...
  58. ncbi request reprint Ovarian cysts and breast cancer: results from the Women's Contraceptive and Reproductive Experiences Study
    Julia A Knight
    Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street, Box 18, Toronto, ON, Canada, M5T 3L9
    Breast Cancer Res Treat 109:157-64. 2008
    ..Additional studies are required to determine the specific cyst type(s) responsible for the observed relationship...
  59. ncbi request reprint UDP-Glucuronosyltransferase 1A1 gene polymorphisms and total bilirubin levels in an ethnically diverse cohort of women
    Andrew L Hong
    Department of Medicine, Section of Hematology Oncology, University of Chicago, 5841 S Maryland Ave, MC 2115, Chicago, IL 60637, USA
    Drug Metab Dispos 35:1254-61. 2007
    ..These data have implications for the design of epidemiologic studies of cancer susceptibility and pharmacogenetic studies for adverse drug reactions in populations of African ancestry...
  60. ncbi request reprint Polymorphisms in DNA repair genes and epithelial ovarian cancer risk
    Annika Auranen
    CR UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory
    Int J Cancer 117:611-8. 2005
    ..8 (0.7-0.9) and 0.9 (0.7-1.2), respectively. In our study, some polymorphisms in XRCC2 and XRCC3 genes were associated with EOC risk. Further research on the role of these genes on epithelial ovarian cancer is warranted...
  61. ncbi request reprint Re: Reason for late-stage breast cancer: absence of screening or detection, or breakdown in follow-up?
    Alice S Whittemore
    J Natl Cancer Inst 97:400; author reply 400-1. 2005
  62. ncbi request reprint Oral contraceptive use and risk of early-onset breast cancer in carriers and noncarriers of BRCA1 and BRCA2 mutations
    Roger L Milne
    Centre for Genetic Epidemiology, The University of Melbourne, Level 2, 723 Swanston Street, Carlton, Victoria 3053, Australia
    Cancer Epidemiol Biomarkers Prev 14:350-6. 2005
    ..Recent oral contraceptive use has been associated with a small increase in breast cancer risk and a substantial decrease in ovarian cancer risk. The effects on risks for women with germ line mutations in BRCA1 or BRCA2 are unclear...
  63. ncbi request reprint Breast cancer risks for BRCA1/2 carriers
    Douglas F Easton
    Science 306:2187-91; author reply 2187-91. 2004
  64. ncbi request reprint STK15 polymorphisms and association with risk of invasive ovarian cancer
    Richard A Dicioccio
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 13:1589-94. 2004
    ..These results suggest a model of dominant inheritance of ovarian cancer risk by the I31 allele of F31I and that the I31 allele may be a common ovarian cancer susceptibility allele of low penetrance...
  65. ncbi request reprint The effects of BRCA1 missense variants V1804D and M1628T on transcriptional activity
    Kimberly Laskie Ostrow
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Genet Cytogenet 153:177-80. 2004
    ..M1628T had the same transcriptional activity as wild-type BRCA1 but V1804D and the empty vector control showed a 60% reduction. This indicates that V1804D is deleterious but M1628T is not...
  66. ncbi request reprint A family-based genetic association study of variants in estrogen-metabolism genes COMT and CYP1B1 and breast cancer risk
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Breast Cancer Res Treat 85:121-31. 2004
    ....
  67. ncbi request reprint Histopathology, FIGO stage, and BRCA mutation status of ovarian cancers from the Gilda Radner Familial Ovarian Cancer Registry
    Bruce A Werness
    Department of Pathology, Inova Fair Oaks Hospital, Fairfax, Virginia 22033, USA
    Int J Gynecol Pathol 23:29-34. 2004
    ..Borderline and mucinous tumors do not appear to be part of the phenotype of families with germline mutations in the BRCA genes...
  68. ncbi request reprint BRCA1/2 mutation status influences somatic genetic progression in inherited and sporadic epithelial ovarian cancer cases
    Susan J Ramus
    Department of Oncology, Strangeways Research Laboratories, Cambridge, United Kingdom
    Cancer Res 63:417-23. 2003
    ....
  69. ncbi request reprint An inverse association between ovarian cysts and breast cancer in the breast cancer family registry
    Julia A Knight
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Int J Cancer 118:197-202. 2006
    ..Further study of ovarian cysts may increase our understanding of hormonal and other mechanisms of breast cancer etiology...
  70. ncbi request reprint The CHEK2*1100delC allelic variant and risk of breast cancer: screening results from the Breast Cancer Family Registry
    Jonine L Bernstein
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 3rd Floor, 307 East 63rd Street, New York, New York 10021, USA
    Cancer Epidemiol Biomarkers Prev 15:348-52. 2006
    ..63; 95% CI, 1.25-10.52). These data supporting the biological relevance of CHEK2 in breast carcinogenesis suggest that further studies examining the joint roles of CHEK2*1100delC carrier status and radiation exposure may be warranted...
  71. pmc A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Hum Genet 77:219-29. 2005
    ....
  72. pmc Multiple regions within 8q24 independently affect risk for prostate cancer
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Nat Genet 39:638-44. 2007
    ..None of the prostate cancer risk variants aligns to a known gene or alters the coding sequence of an encoded protein...
  73. ncbi request reprint Screening for the BRCA1-ins6kbEx13 mutation: potential for misdiagnosis. Mutation in brief #964. Online
    Susan J Ramus
    Translational Research Laboratory, Institute for Women s Health, University College London, United Kingdom
    Hum Mutat 28:525-6. 2007
    ....
  74. ncbi request reprint Medical radiation exposure and breast cancer risk: findings from the Breast Cancer Family Registry
    Esther M John
    Northern California Cancer Center, Fremont, CA 94538, USA
    Int J Cancer 121:386-94. 2007
    ..Given the widespread and increasing use of medical diagnostic radiation, continued surveillance of breast cancer risk is warranted, particularly in women at specific genetic risk, such as those carrying mutations in BRCA1 or BRCA2...
  75. ncbi request reprint BRCA2 mutation-associated breast cancers exhibit a distinguishing phenotype based on morphology and molecular profiles from tissue microarrays
    Anita L Bane
    Department of Pathology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario, Canada
    Am J Surg Pathol 31:121-8. 2007
    ....
  76. ncbi request reprint Common variants in RB1 gene and risk of invasive ovarian cancer
    Honglin Song
    Cancer Research UK Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom
    Cancer Res 66:10220-6. 2006
    ..The possible associations of rs2854344 and rs4151620 with ovarian cancer risk warrant confirmation in independent case-control studies before studies on their biological mode of action...
  77. ncbi request reprint BRCA1 and BRCA2 mutation carriers, oral contraceptive use, and breast cancer before age 50
    Robert W Haile
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, MS 9175, Los Angeles, CA 90089 9175, USA
    Cancer Epidemiol Biomarkers Prev 15:1863-70. 2006
    ..Understanding the effect of oral contraceptives on risk of breast cancer in BRCA1 or BRCA2 mutation carriers is important because oral contraceptive use is a common, modifiable practice...
  78. pmc Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men
    Matthew L Freedman
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:14068-73. 2006
    ..Thus, admixture mapping indicates a major, still-unidentified risk gene for prostate cancer at 8q24, motivating intense work to find it...
  79. ncbi request reprint Pooled genome linkage scan of aggressive prostate cancer: results from the International Consortium for Prostate Cancer Genetics
    Daniel J Schaid
    Harwick 7, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hum Genet 120:471-85. 2006
    ..This provides a basis for attempts to identify these genes, with potential clinical utility for men with aggressive prostate cancer and their relatives...
  80. ncbi request reprint Common variants in mismatch repair genes and risk of invasive ovarian cancer
    Honglin Song
    CR UK Department of Oncology, University of Cambridge Strangeways Research Laboratory, Cambridge, UK
    Carcinogenesis 27:2235-42. 2006
    ..The observed association of PMS2 rs7797466 with ovarian cancer warrants confirmation in an independent study...
  81. ncbi request reprint Re: On the use of familial aggregation in population-based case probands for calculating penetrance
    Alice S Whittemore
    J Natl Cancer Inst 95:76-7; author reply 77-8. 2003

Research Grants20

  1. GENETIC EPIDEMIOLOGY OF PROSTATE CANCER
    Alice Whittemore; Fiscal Year: 2006
    ..As members of the ICPCG, our long-term aim is to pursue with this group any promising leads identified in this project. ..
  2. GENETIC EPIDEMIOLOGY OF PROSTATE CANCER
    Alice Whittemore; Fiscal Year: 2007
    ..As members of the ICPCG, our long-term aim is to pursue with this group any promising leads identified in this project. ..
  3. "Statistical Methods for Genetic Epidemiology"
    Alice Whittemore; Fiscal Year: 2007
    ..The goals of this research are to develop such methods, and thereby to help generate new knowledge useful for cancer prevention and treatment. ..
  4. Cancer Risks in Multi-ethnic Carriers of Unclassified BRCA1 Variants
    Alice Whittemore; Fiscal Year: 2007
    ..This study will examine the feasibility of adding new information about these risks using cancer data from relatives of variant carriers. ..
  5. "Statistical Methods for Genetic Epidemiology"
    Alice Whittemore; Fiscal Year: 2009
    ..The goals of this research are to develop such methods, and thereby to help generate new knowledge useful for cancer prevention and treatment. ..
  6. STATISTICAL METHODS FOR GENETIC EPIDEMIOLOGY
    Alice Whittemore; Fiscal Year: 2006
    ..A major thrust of the work will be the development of user-friendly software to allow epidemiologists to apply the methods to their data...
  7. GENETIC EPIDEMIOLOGY OF PROSTATE CANCER
    Alice Whittemore; Fiscal Year: 2005
    ..As members of the ICPCG, our long-term aim is to pursue with this group any promising leads identified in this project. ..
  8. STATISTICAL METHODS FOR GENETIC EPIDEMIOLOGY
    Alice Whittemore; Fiscal Year: 2002
    ..A major thrust of the work will be the development of user-friendly software to allow epidemiologists to apply the methods to their data...
  9. STATISTICAL METHODS FOR GENETIC EPIDEMIOLOGY
    Alice Whittemore; Fiscal Year: 2003
    ..A major thrust of the work will be the development of user-friendly software to allow epidemiologists to apply the methods to their data...
  10. Breast Cancer Risk Modifiers in BRCA Mutation Carriers
    Alice Whittemore; Fiscal Year: 2003
    ..The proposed analysis will provide new information on alternatives to mastectomy as a preventive strategy for these women. ..
  11. STATISTICAL METHODS FOR GENETIC EPIDEMIOLOGY
    Alice Whittemore; Fiscal Year: 2004
    ..A major thrust of the work will be the development of user-friendly software to allow epidemiologists to apply the methods to their data...
  12. Breast Cancer Risk Modifiers in BRCA Mutation Carriers
    Alice Whittemore; Fiscal Year: 2004
    ..The proposed analysis will provide new information on alternatives to mastectomy as a preventive strategy for these women. ..
  13. Protein Expression in Tissue of Ovarian Cancer Patients
    Alice Whittemore; Fiscal Year: 2004
    ..Such detection also may advance our understanding of the pathogenesis of ovarian cancer. ..
  14. STATISTICAL METHODS FOR GENETIC EPIDEMIOLOGY
    Alice Whittemore; Fiscal Year: 2005
    ..A major thrust of the work will be the development of user-friendly software to allow epidemiologists to apply the methods to their data...
  15. "Statistical Methods for Genetic Epidemiology"
    Alice Whittemore; Fiscal Year: 2010
    ..The goals of this research are to develop such methods, and thereby to help generate new knowledge useful for cancer prevention and treatment. ..