Genomes and Genes
Affiliation: Stanford University
- DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritisLan Shao
Department of Medicine, Immunology and Rheumatology, Stanford University, Stanford, CA, USA
EMBO Mol Med 2:415-27. 2010..Therapeutic blockade of the DNA-PK-dependent cell-death machinery may rejuvenate the immune system in RA...
- Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cellsZhen Yang
Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305
J Exp Med 210:2119-34. 2013....
- The immunopathology of giant cell arteritis: diagnostic and therapeutic implicationsCornelia M Weyand
Department of Medicine, and the Byers Eye Institute at Stanford, Stanford University, Stanford, CA, USA
J Neuroophthalmol 32:259-65. 2012..Expansion of the therapeutic armamentarium for GCA needs to focus on approaches that mitigate the impact of the aging artery and adapt to the needs of the immunosenescent host...
- IFN-γ and IL-17: the two faces of T-cell pathology in giant cell arteritisCornelia M Weyand
Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305 5166, USA
Curr Opin Rheumatol 23:43-9. 2011..Recent data demonstrate that at least two separate lineages of CD4 T cells participate in vascular inflammation, providing an important clue that multiple disease instigators may initiate pathogenic immunity...
- Giant cell arteritis: immune and vascular aging as disease risk factorsShalini V Mohan
Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305 5166, USA
Arthritis Res Ther 13:231. 2011..Thus, the aging process impacts the two major biologic systems that liaise to promote giant cell arteritis; the immune system and the vessel wall niche...
- Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitisKisha Piggott
Lowance Center for Human Immunology and Rheumatology, Emory University, Atlanta, GA, USA
Circulation 123:309-18. 2011....
- Th17 and Th1 T-cell responses in giant cell arteritisJiusheng Deng
Division of Immunology and Rheumatology, Stanford University School of Medicine, 269 W Campus Dr, Stanford, CA 94305, USA
Circulation 121:906-15. 2010..The effects of glucocorticoids on the systemic and vascular components of GCA are not understood...
- IMMUNOPATHWAYS IN ACUTE CORONARY SYNDROMESCornelia Weyand; Fiscal Year: 2005..abstract_text> ..
- CD8 T Cells in Rheumatoid ArthritisCornelia M Weyand; Fiscal Year: 2010..The goal of this proposal is to understand how such anti-inflammatory lymphocytes function and how they can be harnessed as novel therapeutic reagents in RA. ..