Robert West

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Detection of long non-coding RNA in archival tissue: correlation with polycomb protein expression in primary and metastatic breast carcinoma
    Karen M Chisholm
    Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 7:e47998. 2012
  2. pmc A compact VEGF signature associated with distant metastases and poor outcomes
    Zhiyuan Hu
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    BMC Med 7:9. 2009
  3. pmc Inter-observer reproducibility of HER2 immunohistochemical assessment and concordance with fluorescent in situ hybridization (FISH): pathologist assessment compared to quantitative image analysis
    Gulisa Turashvili
    Molecular Oncology and Breast Cancer Program, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    BMC Cancer 9:165. 2009
  4. doi request reprint Expression profiling in soft tissue sarcomas with emphasis on synovial sarcoma, gastrointestinal stromal tumor, and leiomyosarcoma
    Robert B West
    Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA
    Adv Anat Pathol 17:366-73. 2010
  5. pmc MYB expression and translocation in adenoid cystic carcinomas and other salivary gland tumors with clinicopathologic correlation
    Robert B West
    Department of Pathology, Stanford University Medical Center, CA, USA
    Am J Surg Pathol 35:92-9. 2011
  6. ncbi request reprint Experimental approaches to the study of cancer-stroma interactions: recent findings suggest a pivotal role for stroma in carcinogenesis
    Robert B West
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Lab Invest 87:967-70. 2007
  7. pmc Variations in stromal signatures in breast and colorectal cancer metastases
    Jonathan A Webster
    Department of Pathology, Stanford University Medical Center, Stanford, CA, USA
    J Pathol 222:158-65. 2010
  8. pmc Coordinate expression of colony-stimulating factor-1 and colony-stimulating factor-1-related proteins is associated with poor prognosis in gynecological and nongynecological leiomyosarcoma
    Inigo Espinosa
    Dept of Pathology, L 235, Stanford University Medical Center, 300 Pasteur Dr, Stanford, CA 94305, USA
    Am J Pathol 174:2347-56. 2009
  9. pmc LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor
    Lihua Ying
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Sci 122:1441-51. 2009
  10. pmc Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation
    Julie B Sneddon
    Department of Biochemistry, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:14842-7. 2006

Research Grants

Collaborators

Detail Information

Publications37

  1. pmc Detection of long non-coding RNA in archival tissue: correlation with polycomb protein expression in primary and metastatic breast carcinoma
    Karen M Chisholm
    Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 7:e47998. 2012
    ..This approach offers a method to make observations on lncRNAs that may influence the cancer epigenome in a tissue-based technique...
  2. pmc A compact VEGF signature associated with distant metastases and poor outcomes
    Zhiyuan Hu
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    BMC Med 7:9. 2009
    ..Tumor metastases pose the greatest threat to a patient's survival, and thus, understanding the biology of disseminated cancer cells is critical for developing effective therapies...
  3. pmc Inter-observer reproducibility of HER2 immunohistochemical assessment and concordance with fluorescent in situ hybridization (FISH): pathologist assessment compared to quantitative image analysis
    Gulisa Turashvili
    Molecular Oncology and Breast Cancer Program, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    BMC Cancer 9:165. 2009
    ..Our study compares HER2 scoring by histopathologists with automated quantitation of staining, and determines the concordance of IHC scores with FISH results...
  4. doi request reprint Expression profiling in soft tissue sarcomas with emphasis on synovial sarcoma, gastrointestinal stromal tumor, and leiomyosarcoma
    Robert B West
    Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA
    Adv Anat Pathol 17:366-73. 2010
    ..This review details gene expression studies done in 3 sarcomas, synovial sarcoma, gastrointestinal stromal tumor, and leiomyosarcoma...
  5. pmc MYB expression and translocation in adenoid cystic carcinomas and other salivary gland tumors with clinicopathologic correlation
    Robert B West
    Department of Pathology, Stanford University Medical Center, CA, USA
    Am J Surg Pathol 35:92-9. 2011
    ..A chromosomal translocation involving the genes encoding the transcription factors, MYB and NFIB, has been recently discovered in these tumors...
  6. ncbi request reprint Experimental approaches to the study of cancer-stroma interactions: recent findings suggest a pivotal role for stroma in carcinogenesis
    Robert B West
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Lab Invest 87:967-70. 2007
    ..Major hurdles in the study of the cancer stroma revolve around the cellular complexity of the tumor microenvironment, both in modeling the microenvironment and discovering/isolating pure populations of stromal cell types...
  7. pmc Variations in stromal signatures in breast and colorectal cancer metastases
    Jonathan A Webster
    Department of Pathology, Stanford University Medical Center, Stanford, CA, USA
    J Pathol 222:158-65. 2010
    ..The preservation of the CSF1 macrophage response pattern in metastases lends support to targeting the CSF1 pathway in cancer...
  8. pmc Coordinate expression of colony-stimulating factor-1 and colony-stimulating factor-1-related proteins is associated with poor prognosis in gynecological and nongynecological leiomyosarcoma
    Inigo Espinosa
    Dept of Pathology, L 235, Stanford University Medical Center, 300 Pasteur Dr, Stanford, CA 94305, USA
    Am J Pathol 174:2347-56. 2009
    ..2; 95% CI, 1.12 to 16; P = 0.03). Our findings indicate that CSF1 may play an important role in the clinical behavior of LMS that may open a window for new therapeutic reagents...
  9. pmc LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor
    Lihua Ying
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Sci 122:1441-51. 2009
    ..Expression profiling of soft tissue tumors revealed increased expression of both LC3 and CTGF in some locally invasive tumor types...
  10. pmc Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation
    Julie B Sneddon
    Department of Biochemistry, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:14842-7. 2006
    ..Our data suggest that BMP antagonists may be important constituents of tumor stroma, providing a favorable microenvironment for cancer cell survival and expansion in many cancers...
  11. ncbi request reprint Chest wall leiomyosarcoma after breast-conservative therapy for early-stage breast cancer in a young woman with Li-Fraumeni syndrome
    Eve Henry
    Department of Medicine, Stanford University, Stanford, California, USA
    J Natl Compr Canc Netw 10:939-42. 2012
    ....
  12. doi request reprint Characterization of a novel anti-fatty acid synthase (FASN) antiserum in breast tissue
    Kristin C Jensen
    Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA
    Mod Pathol 21:1413-20. 2008
    ..In addition, FASN expression is described in apocrine metaplasia, columnar cell lesions, and flat epithelial atypia...
  13. doi request reprint The fibromatosis signature defines a robust stromal response in breast carcinoma
    Andrew H Beck
    Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA
    Lab Invest 88:591-601. 2008
    ..Our data demonstrate that the DTF core gene set is a robust descriptor of a distinct stromal response that is associated with improved clinical outcome in breast cancer patients...
  14. pmc The Stanford Tissue Microarray Database
    Robert J Marinelli
    Department of Biochemistry, Stanford University School of Medicine, Howard Hughes Medical Institute, Stanford, CA, USA
    Nucleic Acids Res 36:D871-7. 2008
    ..The production server uses the Apache HTTP Server, Oracle Database and Perl application code. Source code is available to interested researchers under a no-cost license...
  15. ncbi request reprint Expression of CD163 (hemoglobin scavenger receptor) in normal tissues, lymphomas, carcinomas, and sarcomas is largely restricted to the monocyte/macrophage lineage
    TuDung T Nguyen
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5243, USA
    Am J Surg Pathol 29:617-24. 2005
    ....
  16. ncbi request reprint MOC-31 exhibits superior reactivity compared with Ber-EP4 in invasive lobular and ductal carcinoma of the breast: a tissue microarray study
    Reetesh K Pai
    Department of Pathology, Stanford University, Stanford, CA 94305, USA
    Appl Immunohistochem Mol Morphol 17:202-6. 2009
    ..MOC-31 and Ber-EP4 exhibited identical staining with all other carcinoma types. Our findings indicate that MOC-31 is superior to Ber-EP4 in detecting both invasive lobular and ductal carcinoma of the breast...
  17. pmc Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors
    Norman L Lehman
    Department of Pathology, MC5324, Stanford University, Stanford, CA, USA
    Am J Pathol 170:1793-805. 2007
    ..This profile of misregulated mitotic APC/C substrates and regulators in malignant tumors suggests that analysis of this pathway may be diagnostically useful and represent a potentially important therapeutic target...
  18. doi request reprint Gene expression profiling identifies p63 as a diagnostic marker for giant cell tumor of the bone
    Cheng Han Lee
    Department of Pathology, Stanford University, Stanford, CA, USA
    Mod Pathol 21:531-9. 2008
    ..These findings altogether show that p63 can be used as a diagnostic marker to aid the clinical diagnosis of GCTOB...
  19. pmc Determination of stromal signatures in breast carcinoma
    Robert B West
    Department of Pathology, Stanford University Medical Center, Stanford, California, USA
    PLoS Biol 3:e187. 2005
    ..Our findings suggest that the host stromal response varies significantly among carcinomas and that gene expression patterns characteristic of soft tissue tumors can be used to discover new markers for normal connective tissue cells...
  20. ncbi request reprint The gene expression profile of extraskeletal myxoid chondrosarcoma
    Subbaya Subramanian
    Department of Pathology, Stanford University Medical Center, Stanford, CA 94035, USA
    J Pathol 206:433-44. 2005
    ..Small molecule inhibitors for PPARG exist and PPARG could be a potential therapeutic target for EMC...
  21. doi request reprint Microtubule-associated protein-2 is a sensitive marker of primary and metastatic neuroblastoma
    Chandra Krishnan
    Department of Pathology, Stanford University, Stanford, CA 94205, USA
    Am J Surg Pathol 33:1695-704. 2009
    ..We examined the diagnostic utility of MAP-2 as a marker of neuroblastoma and attempted to characterize the expression of this protein in other tumors in the morphologic differential diagnosis of neuroblastoma...
  22. doi request reprint Gene expression profiling for the investigation of soft tissue sarcoma pathogenesis and the identification of diagnostic, prognostic, and predictive biomarkers
    Andrew H Beck
    Pathology Department, Stanford University Medical Center, Stanford, CA 94305, USA
    Virchows Arch 456:141-51. 2010
    ..Lastly, we conclude with a discussion of strategies to further optimize the translation of gene expression data into a greater understanding of sarcoma pathogenesis and improved clinical outcomes for sarcoma patients...
  23. pmc The macrophage colony-stimulating factor 1 response signature in breast carcinoma
    Andrew H Beck
    Department of Pathology, Stanford University Medical Center, Stanford, California 94305, USA
    Clin Cancer Res 15:778-87. 2009
    ..The purpose of this study was to define a novel CSF1 response signature and to evaluate its clinical and biological significance in breast cancer...
  24. doi request reprint A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors
    Inigo Espinosa
    Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA
    Am J Surg Pathol 32:210-8. 2008
    ..5%) synovial sarcomas among the 935 soft tissue tumors examined showed positive immunostaining for DOG1.1. In addition, DOG1.1 immunoreactivity was seen in fewer cases of carcinoma, melanoma, and seminoma as compared with KIT...
  25. ncbi request reprint Translocation and expression of CSF1 in pigmented villonodular synovitis, tenosynovial giant cell tumor, rheumatoid arthritis and other reactive synovitides
    John S Cupp
    Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA
    Am J Surg Pathol 31:970-6. 2007
    ....
  26. pmc The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status
    Robert B West
    Department of Pathology, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA
    Am J Pathol 165:107-13. 2004
    ..Reactivity for DOG1 may aid in the diagnosis of GISTs, including PDGFRA mutants that fail to express KIT antigen, and lead to appropriate treatment with imatinib mesylate, an inhibitor of the KIT tyrosine kinase...
  27. ncbi request reprint Apo D in soft tissue tumors: a novel marker for dermatofibrosarcoma protuberans
    Robert B West
    Department of Pathology, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA
    Am J Surg Pathol 28:1063-9. 2004
    ..stanford.edu/tma_portal/apod/). We conclude that Apo D is strongly expressed in DFSPs and neural lesions and may be useful in differentiating DFSP from fibrous histiocytoma...
  28. pmc Breast Angiosarcoma: Case Series and Expression of Vascular Endothelial Growth Factor
    Rondeep Brar
    Department of Internal Medicine, Stanford University Medical Center, Stanford, Calif, USA
    Case Rep Oncol 2:242-250. 2009
    ..CONCLUSION: Angiosarcoma of the breast is an aggressive malignancy with a propensity for both local recurrence and distant metastases. Angiogenesis inhibition may represent a novel therapeutic modality in this rare, vascular malignancy...
  29. doi request reprint Diagnostic implications of podoplanin expression in peripheral nerve sheath neoplasms
    Chris H Jokinen
    Department of Pathology, University of Washington, Seattle, USA
    Am J Clin Pathol 129:886-93. 2008
    ..These results suggest diffuse podoplanin expression or coexpression of podoplanin and S-100 is limited to schwannoma and EMPNST and may be useful in the evaluation of these neoplasms...
  30. ncbi request reprint Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles
    Subbaya Subramanian
    Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA
    Oncogene 23:7780-90. 2004
    ..These gene products could serve as highly selective therapeutic targets in GISTs containing the KIT or PDGFRA mutational types with which they are associated...
  31. pmc 3'-end sequencing for expression quantification (3SEQ) from archival tumor samples
    Andrew H Beck
    Department of Pathology, Stanford University Medical Center, Stanford, California, United States of America
    PLoS ONE 5:e8768. 2010
    ..These findings demonstrate that 3SEQ is an effective technique for gene expression profiling from archival tumor samples and may facilitate significant advances in translational cancer research...
  32. pmc A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells
    Robert B West
    Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:690-5. 2006
    ....
  33. ncbi request reprint Evaluation of Her-2/neu status in carcinomas with amplified chromosome 17 centromere locus
    Megan L Troxell
    Department of Pathology, Oregon Health and Science University, Portland, OR 97239, USA
    Am J Clin Pathol 126:709-16. 2006
    ..Such additional data, correlated with immunohistochemical analysis, may help guide therapy in patients with breast carcinoma...
  34. ncbi request reprint The usefulness of immunohistochemistry in the diagnosis of follicular lymphoma in bone marrow biopsy specimens
    Robert B West
    Department of Pathology, Stanford University Medical Center, CA 94305 5302, USA
    Am J Clin Pathol 117:636-43. 2002
    ..bcl-6 often was expressed in both neoplastic and nonneoplastic aggregates and, thus, poorly discriminated between these processes. We studied the expression of CD10 and bcl-6 in selected lymph nodes in some cases...
  35. ncbi request reprint TMA-Combiner, a simple software tool to permit analysis of replicate cores on tissue microarrays
    Chih Long Liu
    Biological and Biomedical Sciences Program, Division of Medical Sciences, Harvard Medical School, Cambridge, MA 02138, USA
    Mod Pathol 18:1641-8. 2005
    ..This greatly facilitates analysis of tissue microarrays, particularly for users with large repositories of data, and may facilitate discovery of biological trends and help refine diagnostic accuracy of tissue markers in clinical samples...
  36. ncbi request reprint Nuclear beta-catenin in mesenchymal tumors
    Tony L Ng
    Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Mod Pathol 18:68-74. 2005
    ..High-level nuclear beta-catenin staining serves as a useful diagnostic tool, as it is specific to a small subset of mesenchymal tumors...
  37. pmc Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology
    Torsten O Nielsen
    Department of Pathology and Genetic Pathology Evaluation Centre, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Pathol 163:1449-56. 2003
    ..Digital images from over 2500 immunostained cores analyzed in this study were captured and are made accessible through the accompanying website: http://microarray-pubs.stanford.edu/tma_portal/synsarc...

Research Grants3

  1. Discovery of Gene Expression Signatures in Cancer Stroma
    Robert B West; Fiscal Year: 2010
    ..The fact that different carcinomas share expression of these targets would mean that large groups of patients suffering from a variety of tumors could benefit. ..
  2. Discovery of Gene Expression Signatures in Cancer Stroma
    Robert West; Fiscal Year: 2009
    ..The fact that different carcinomas share expression of these targets would mean that large groups of patients suffering from a variety of tumors could benefit. ..