P A Wender

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Synthesis and PKC binding of a new class of a-ring diversifiable bryostatin analogues utilizing a double asymmetric hydrogenation and cross-coupling strategy
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 8:4581-4. 2006
  2. ncbi request reprint An efficient, scalable synthesis of the molecular transporter octaarginine via a segment doubling strategy
    P A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 3:3229-32. 2001
  3. ncbi request reprint A new class of simplified phorbol ester analogues: synthesis and binding to PKC and eta PKC-C1B (eta PKC-CRD2)
    P A Wender
    Department of Chemistry, Stanford University, California 94305, USA
    Org Lett 1:1009-12. 1999
  4. ncbi request reprint Asymmetric total synthesis of (+)-aphanamol I based on the transition metal catalyzed [5 + 2] cycloaddition of allenes and vinylcyclopropanes
    P A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 2:2323-6. 2000
  5. pmc The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters
    P A Wender
    Departments of Chemistry and Neurology, Stanford University, Stanford, CA 94305 5080, USA
    Proc Natl Acad Sci U S A 97:13003-8. 2000
  6. ncbi request reprint Asymmetric synthesis of the tricyclic core of NGF-inducing cyathane diterpenes via a transition-metal-catalyzed [5 + 2] cycloaddition
    P A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 3:2105-8. 2001
  7. ncbi request reprint Molecular transporters for peptides: delivery of a cardioprotective epsilonPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7)
    L Chen
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA
    Chem Biol 8:1123-9. 2001
  8. pmc The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1
    P A Wender
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Proc Natl Acad Sci U S A 95:6624-9. 1998
  9. pmc Single-molecule motions of oligoarginine transporter conjugates on the plasma membrane of Chinese hamster ovary cells
    H L Lee
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Am Chem Soc 130:9364-70. 2008
  10. ncbi request reprint Pharmacophore mapping in the laulimalide series: total synthesis of a vinylogue for a late-stage metathesis diversification strategy
    Paul A Wender
    Departments of Chemistry and Molecular Pharmacology, Stanford University, Stanford, CA 94305 5080, USA
    Org Lett 8:4105-8. 2006

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Synthesis and PKC binding of a new class of a-ring diversifiable bryostatin analogues utilizing a double asymmetric hydrogenation and cross-coupling strategy
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 8:4581-4. 2006
    ..An aryl bromide diversification site is incorporated allowing access to systematically varied analogues. The new analogues all exhibit potent, nanomolar affinity to PKC...
  2. ncbi request reprint An efficient, scalable synthesis of the molecular transporter octaarginine via a segment doubling strategy
    P A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 3:3229-32. 2001
    ....
  3. ncbi request reprint A new class of simplified phorbol ester analogues: synthesis and binding to PKC and eta PKC-C1B (eta PKC-CRD2)
    P A Wender
    Department of Chemistry, Stanford University, California 94305, USA
    Org Lett 1:1009-12. 1999
    ..The binding of these analogues to protein kinase C (PKC) and the truncated peptide eta PKC-C1B (eta PKC-CRD2) is also reported...
  4. ncbi request reprint Asymmetric total synthesis of (+)-aphanamol I based on the transition metal catalyzed [5 + 2] cycloaddition of allenes and vinylcyclopropanes
    P A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 2:2323-6. 2000
    ..The metal-catalyzed [5 + 2] cycloaddition of this precursor proceeds with complete chemo, endo/exo, and diastereoselectivity in 93% yield, representing an effective general route to bicyclo[5.3.0]decane derivatives...
  5. pmc The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters
    P A Wender
    Departments of Chemistry and Neurology, Stanford University, Stanford, CA 94305 5080, USA
    Proc Natl Acad Sci U S A 97:13003-8. 2000
    ..Overall, a transporter has been developed that is superior to Tat(49-57), protease resistant, and more readily and economically prepared...
  6. ncbi request reprint Asymmetric synthesis of the tricyclic core of NGF-inducing cyathane diterpenes via a transition-metal-catalyzed [5 + 2] cycloaddition
    P A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 3:2105-8. 2001
    ..This strategy provides efficient access (14 steps and 13% overall yield) to potential analogues as well as precursors of nerve growth factor (NGF)-inducing diterpenes...
  7. ncbi request reprint Molecular transporters for peptides: delivery of a cardioprotective epsilonPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7)
    L Chen
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA
    Chem Biol 8:1123-9. 2001
    ..CONCLUSIONS: Our data suggest that R(7) converts a peptide lead into a potential therapeutic agent for the ischemic heart...
  8. pmc The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1
    P A Wender
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Proc Natl Acad Sci U S A 95:6624-9. 1998
    ..8-170 ng/ml) against several human cancer cell lines, providing an important step toward the development of simplified, synthetically accessible analogs of the bryostatins...
  9. pmc Single-molecule motions of oligoarginine transporter conjugates on the plasma membrane of Chinese hamster ovary cells
    H L Lee
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Am Chem Soc 130:9364-70. 2008
    ....
  10. ncbi request reprint Pharmacophore mapping in the laulimalide series: total synthesis of a vinylogue for a late-stage metathesis diversification strategy
    Paul A Wender
    Departments of Chemistry and Molecular Pharmacology, Stanford University, Stanford, CA 94305 5080, USA
    Org Lett 8:4105-8. 2006
    ..This step-economical strategy enables the rapid synthesis of new analogues using alkenes as an inexpensive, abundantly available diversification feedstock...
  11. ncbi request reprint Molecular transporters: synthesis of oligoguanidinium transporters and their application to drug delivery and real-time imaging
    Elena A Goun
    Stanford University, Department of Chemistry Stanford, CA 94305, USA
    Chembiochem 7:1497-515. 2006
  12. ncbi request reprint Total synthesis and initial biological evaluation of new B-ring-modified bryostatin analogs
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 8:5299-302. 2006
    ..The resulting new analogs exhibit potent nanomolar or picomolar affinity to protein kinase C (PKC), comparable to or better than that found for bryostatin...
  13. ncbi request reprint Studies on oxidopyrylium [5+2] cycloadditions: toward a general synthetic route to the C12-hydroxydaphnetoxins
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 8:5373-6. 2006
    ..Depending on the choice of protecting groups and solvent, the oxidopyrylium-alkene [5+2] cycloaddition originating from A provides cycloadduct diastereomer B or C with good to excellent selectivity...
  14. ncbi request reprint Laulimalide and synthetic laulimalide analogues are synergistic with paclitaxel and 2-methoxyestradiol
    Erin A Clark
    Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, San Antonio, Texas 78227, USA
    Mol Pharm 3:457-67. 2006
    ..These important findings suggest that specific combinations of microtubule-targeting agents should be considered for clinical utilities as they have excellent potential to improve clinical response...
  15. ncbi request reprint Releasable luciferin-transporter conjugates: tools for the real-time analysis of cellular uptake and release
    Lisa R Jones
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 128:6526-7. 2006
    ..The process provides a method to assay uptake and release of free luciferin as a function of variations in the releasable linker and in the transporter...
  16. ncbi request reprint Intracellular cargo delivery by an octaarginine transporter adapted to target prostate cancer cells through cell surface protease activation
    Elena A Goun
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    Bioconjug Chem 17:787-96. 2006
    ..These APTD peptide-based molecules may facilitate targeted delivery of therapeutics or imaging agents to PSA-expressing prostate cancers...
  17. ncbi request reprint Asymmetric catalysis of the [5 + 2] cycloaddition reaction of vinylcyclopropanes and pi-systems
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Am Chem Soc 128:6302-3. 2006
    ..A predictive model for the selectivity is also presented...
  18. ncbi request reprint RhI-catalyzed C-C bond activation: seven-membered ring synthesis by a [6+1] carbonylative ring-expansion reaction of allenylcyclobutanes
    Paul A Wender
    Department of Chemistry, Department of Molecular Pharmacology, Stanford University, Stanford, CA 94305 5080, USA
    Angew Chem Int Ed Engl 45:3957-60. 2006
  19. ncbi request reprint Design, synthesis, and biological evaluation of a potent, PKC selective, B-ring analog of bryostatin
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 8:1893-6. 2006
    ..This analog exhibits potent, single-digit nanomolar affinity to PKC and selectively translocates novel PKC isozymes...
  20. ncbi request reprint Total synthesis and biological evaluation of 11-desmethyllaulimalide, a highly potent simplified laulimalide analogue
    Paul A Wender
    Departments of Chemistry and Molecular Pharmacology, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 8:1507-10. 2006
    ..This new lead retains the anticancer function of laulimalide...
  21. ncbi request reprint Cyclopentadienone synthesis by rhodium(I)-catalyzed [3 + 2] cycloaddition reactions of cyclopropenones and alkynes
    Paul A Wender
    Departments of Chemistry and of Molecular Pharmacology, Stanford University, Stanford, CA 94305 5080, USA
    J Am Chem Soc 128:14814-5. 2006
    ..The reaction is readily scalable to produce gram quantities of cycloadduct and provides a unique and versatile route to CPDs that would be otherwise difficult to obtain...
  22. ncbi request reprint Isolation, structure determination, and anti-cancer activity of apoptolidin D
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 9:691-4. 2007
    ..Its equilibration with isoapoptolidin D and characterization of the latter are also described. [structure: see text]...
  23. pmc Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters
    Elena A Dubikovskaya
    Department of Chemistry and Chemical and Systems Biology, Stanford University, Stanford, CA 94305 5080, USA
    Proc Natl Acad Sci U S A 105:12128-33. 2008
    ....
  24. pmc The design, synthesis, and evaluation of C7 diversified bryostatin analogs reveals a hot spot for PKC affinity
    Paul A Wender
    Department of Chemistry, Department of Chemical and Systems Biology, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 10:3331-4. 2008
    ..Several analogs exhibit single-digit nanomolar affinity to PKC and display superior activity compared to bryostatin against the leukemia cell line K562...
  25. pmc Efficient synthetic access to a new family of highly potent bryostatin analogues via a Prins-driven macrocyclization strategy
    Paul A Wender
    Departments of Chemistry and Chemical and Systems Biology, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 130:6658-9. 2008
    ..These tetrahydropyranyl B-ring analogues are among our most potent and efficacious analogues to date, exhibiting nanomolar and picomolar activities in protein kinase C affinity assays as well as in cellular antiproliferation assays...
  26. pmc Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV
    Paul A Wender
    Department of Chemistry, Stanford University, 337 Campus Drive, Stanford, CA 94305, USA
    Science 320:649-52. 2008
    ..This synthesis reliably supplies gram quantities of the therapeutically promising natural products, hitherto available only in low and variable amounts from natural sources, and opens access to a variety of new analogs...
  27. doi request reprint Substituent effects, reactant preorganization, and ligand exchange control the reactivity in Rh(I)-catalyzed (5+2) cycloadditions between vinylcyclopropanes and alkynes
    Peng Liu
    Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095 1569, USA
    Angew Chem Int Ed Engl 47:3939-41. 2008
  28. doi request reprint Origins of differences in reactivities of alkenes, alkynes, and allenes in [Rh(CO)2Cl]2-catalyzed (5 + 2) cycloaddition reactions with vinylcyclopropanes
    Zhi Xiang Yu
    Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry, Peking University, Beijing 100871, PR China
    J Am Chem Soc 130:2378-9. 2008
  29. pmc The design of guanidinium-rich transporters and their internalization mechanisms
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    Adv Drug Deliv Rev 60:452-72. 2008
    ..Some GRT drug conjugates have been advanced into clinical trials. This review will provide an overview of recent work pertinent to the design and mechanism of uptake of GRTs...
  30. ncbi request reprint Function-oriented synthesis, step economy, and drug design
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Acc Chem Res 41:40-9. 2008
    ..This approach enables the development of synthetically innovative strategies while targeting therapeutically novel structures...
  31. ncbi request reprint Nickel(0)-catalyzed [2 + 2 + 2 + 2] cycloadditions of terminal diynes for the synthesis of substituted cyclooctatetraenes
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    J Am Chem Soc 129:13402-3. 2007
  32. ncbi request reprint A computationally designed Rh(I)-catalyzed two-component [5+2+1] cycloaddition of ene-vinylcyclopropanes and CO for the synthesis of cyclooctenones
    Yuanyuan Wang
    Beijing National Laboratory for Molecular Sciences BNLMS, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China
    J Am Chem Soc 129:10060-1. 2007
  33. pmc Real-time analysis of uptake and bioactivatable cleavage of luciferin-transporter conjugates in transgenic reporter mice
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Proc Natl Acad Sci U S A 104:10340-5. 2007
    ....
  34. ncbi request reprint Function-oriented synthesis: studies aimed at the synthesis and mode of action of 1alpha-alkyldaphnane analogues
    Paul A Wender
    Department of Chemistry and Department of Chemical and Systems Biology, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 9:1829-32. 2007
    ..A completely diastereoselective palladium-catalyzed enyne cyclization was then employed to establish the A-ring with a C1 appendage...
  35. ncbi request reprint Metal-catalyzed [2+2+1] cycloadditions of 1,3-dienes, allenes, and CO
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Angew Chem Int Ed Engl 45:2459-62. 2006
  36. ncbi request reprint Function oriented synthesis: the design, synthesis, PKC binding and translocation activity of a new bryostatin analog
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    Curr Drug Discov Technol 1:1-11. 2004
    ....
  37. pmc Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 8:589-92. 2006
    ..Potent F(0)F(1)-ATPase inhibition was not a sufficient determinant of antiproliferative activity for several analogues, suggesting the existence of a secondary biological target or more complex mode of action for apoptolidin...
  38. ncbi request reprint Synthesis and biological evaluation of (-)-laulimalide analogues
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    Org Lett 5:3507-9. 2003
    ..Significantly, like laulimalide, these analogues are poor substrates for the drug transport protein P-glycoprotein (Pgp) and are thus effective against Taxol-resistant cell lines...
  39. ncbi request reprint Arginine-based molecular transporters: the synthesis and chemical evaluation of releasable taxol-transporter conjugates
    Thorsten A Kirschberg
    CellGate, Inc, 552 Del Rey Avenue, Sunnyvale, California 95085, USA
    Org Lett 5:3459-62. 2003
    ..The resultant taxol-transporter conjugates are highly water soluble and release free taxol with half-lives of minutes to hours depending on the pH and the linker structure...
  40. ncbi request reprint Gene transfer via reversible plasmid condensation with cysteine-flanked, internally spaced arginine-rich peptides
    Zurab Siprashvili
    VA Palo Alto Healthcare System, Palo Alto, CA 94305, USA
    Hum Gene Ther 14:1225-33. 2003
    ..Thus, cysteine-flanked, internally spaced arginine-rich (CFIS-R) peptides represent a new approach to efficient nonviral plasmid delivery using rationally designed protein transduction domains...
  41. ncbi request reprint Facile synthetic access to and biological evaluation of the macrocyclic core of apoptolidin
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    Org Lett 5:2299-302. 2003
    ..The ability of compounds derived from this cleavage to inhibit mitochondrial F(0)F(1)-ATPase is reported. [structure: see text]..
  42. ncbi request reprint Guanidinium rich peptide transporters and drug delivery
    Lee R Wright
    Department of Chemistry, Stanford University, Stanford, California 95304, USA
    Curr Protein Pept Sci 4:105-24. 2003
    ..Lead conjugates in this area are currently in clinical trials...
  43. ncbi request reprint Isoapoptolidin: structure and activity of the ring-expanded isomer of apoptolidin
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 4:3819-22. 2002
    ..Isoapoptolidin's ability to inhibit mitochondrial F0F1-ATPase is over 10-fold less than that of apoptolidin...
  44. ncbi request reprint Toward a structure-activity relationship for apoptolidin: selective functionalization of the hydroxyl group array
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, California, 94305 5080, USA
    Org Lett 5:487-90. 2003
    ..The syntheses of these derivatives and their ability to inhibit F(0)F(1)-ATPase are reported...
  45. ncbi request reprint A concise, selective synthesis of the polyketide spacer domain of a potent bryostatin analogue
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 5:277-9. 2003
    ..The spacer domain 1 is obtained in 10 steps with a 25% overall yield and is readily incorporated into the synthesis of 2...
  46. ncbi request reprint The practical synthesis of a novel and highly potent analogue of bryostatin
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 124:13648-9. 2002
    ..Macrocycle 1 can be generated in clinically required amounts by chemical synthesis in only 19 steps (LLS) and represents a new clinical lead for the treatment of cancer...
  47. ncbi request reprint Oligocarbamate molecular transporters: design, synthesis, and biological evaluation of a new class of transporters for drug delivery
    Paul A Wender
    Department of Chemistry, Stanford University, California 94305 5080, USA
    J Am Chem Soc 124:13382-3. 2002
    ..Significantly, this new family of transporters also enables uptake into the formidable skin barrier of a probe molecule that by itself does not penetrate skin...
  48. ncbi request reprint Arginine-rich molecular transporters for drug delivery: role of backbone spacing in cellular uptake
    Jonathan B Rothbard
    CellGate Inc, 552 Del Rey Avenue, Sunnyvale, California 94085, USA
    J Med Chem 45:3612-8. 2002
    ..This study led to the identification of a new series of highly efficient molecular transporters...
  49. ncbi request reprint A new synthetic approach to the C ring of known as well as novel bryostatin analogues
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 5:4549-52. 2003
    ..The convergent approach, illustrated above, requires fewer steps and offers greater flexibility in rapidly accessing diverse C ring analogues...
  50. pmc Microtubule-stabilizing agents based on designed laulimalide analogues
    Susan L Mooberry
    Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, 7620 Northwest Loop 410, San Antonio, TX 78227, USA
    Proc Natl Acad Sci U S A 101:8803-8. 2004
    ..In summary, analogues of laulimalide designed to minimize or eliminate its intrinsic instability have been synthesized, and some have been found to retain the unique biological activities of laulimalide...
  51. ncbi request reprint Total synthesis of (-)-laulimalide
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 124:4956-7. 2002
    ..Laulimalide was synthesized in 25 steps (longest linear; 36 overall) in 3.5% overall yield, providing a uniquely short and efficient route to 1 and its analogues...
  52. ncbi request reprint Actin is the primary cellular receptor of bistramide A
    Alexander V Statsuk
    Department of Chemistry, University of Chicago, Chicago, Illinois 60637, USA
    Nat Chem Biol 1:383-8. 2005
    ....
  53. ncbi request reprint Dendrimeric molecular transporters: synthesis and evaluation of tunable polyguanidino dendrimers that facilitate cellular uptake
    Paul A Wender
    Department of Chemistry and Department of Molecular Pharmacology, Stanford University, California 94305 5080, USA
    Org Lett 7:4815-8. 2005
    ..While the dendrimers varied significantly in their ability to enter a human lymphocyte cell line, the best transporters out-performed an oligoarginine reference standard...
  54. pmc Apoptolidins B and C: isolation, structure determination, and biological activity
    Paul A Wender
    Department of Chemistry, Stanford University, California 94305 5080, USA
    Org Lett 7:3025-8. 2005
    ..These new agents are found to have antiproliferative activity on par with or better than apoptolidin itself in an assay with H292 lung cancer cells...
  55. ncbi request reprint Role of the A-ring of bryostatin analogues in PKC binding: synthesis and initial biological evaluation of new A-ring-modified bryologs
    Paul A Wender
    Department of Chemistry, Stanford University, California 94305 5080, USA
    Org Lett 7:1995-8. 2005
    ..All three analogues exhibit potent, single-digit nanomolar affinity to protein kinase C...
  56. ncbi request reprint Identification of a tunable site in bryostatin analogs: C20 Bryologs through late stage diversification
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Org Lett 7:1177-80. 2005
    ..The use of this site in a late-stage diversification strategy has enabled the facile synthesis of a variety of new C20 analogs, all of which retain nanomolar affinity for PKC, in agreement with our pharmacophore hypothesis...
  57. ncbi request reprint Adaptive translocation: the role of hydrogen bonding and membrane potential in the uptake of guanidinium-rich transporters into cells
    Jonathan B Rothbard
    Department of Chemistry, Stanford University, Stanford CA 94305, USA
    Adv Drug Deliv Rev 57:495-504. 2005
    ..This mechanism could also be involved in the translocation of guanidinium-rich molecules that are endocytosed due to their size or the conditions of the assay, across the endosomal membrane...
  58. ncbi request reprint Late-stage intermolecular CH activation for lead diversification: a highly chemoselective oxyfunctionalization of the C-9 position of potent bryostatin analogues
    Paul A Wender
    Department of Chemistry, Stanford University, Stanford, California 94305 8050, USA
    Org Lett 7:79-82. 2005
    ..Complete selectivity for C-9 hydroxylation was restored upon acylation of the C-26 secondary alcohol...
  59. ncbi request reprint Effect of serum and antioxidants on the immunogenicity of protein kinase C-activated chronic lymphocytic leukemia cells
    Caitlin Hammond
    Division of Molecular and Cellular Biology, Research Institute, Sunnybrook and Women s College Health Sciences Center, 2075 Bayview Avenue, Toronto, Canada M4N 3M5
    J Immunother 28:28-39. 2005
    ..The observation that CLL cells can acquire features of dendritic cells that promote type 1 immunity may find clinical application in immunotherapeutic strategies for this disease...
  60. ncbi request reprint Synthetic bryostatin analogues activate the RasGRP1 signaling pathway
    James C Stone
    Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Med Chem 47:6638-44. 2004
    ..In addition to sharing potential anticancer properties with bryostatin 1, compounds 1 and 2 might be clinically useful as modulators of the immune system...
  61. ncbi request reprint Simplified analogs of bryostatin with anticancer activity display greater potency for translocation of PKCdelta-GFP
    Jeremy L Baryza
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    Chem Biol 11:1261-7. 2004
    ....
  62. ncbi request reprint Role of membrane potential and hydrogen bonding in the mechanism of translocation of guanidinium-rich peptides into cells
    Jonathan B Rothbard
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Am Chem Soc 126:9506-7. 2004
    ..The complex dissociates on the inner leaf of the membrane, and the transporter enters the cytosol. This hypothesis does not preclude uptake by other mechanisms, including endocytosis, which is likely to dominate with large cargos...
  63. ncbi request reprint Photoinduced cleavage of DNA by bromofluoroacetophenone-pyrrolecarboxamide conjugates
    Paul A Wender
    Department of Chemistry, Stanford University, CA 94305, USA
    Bioorg Med Chem Lett 13:1763-6. 2003
    ..The DNA cleaving activities of 2'-bromo-4'-fluoroacetophenone derivatives were larger than those of 4'-bromo-2'-fluoroacetophenone derivatives...
  64. ncbi request reprint Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into Mammalian cells
    Nadine Wong Shi Kam
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Am Chem Soc 126:6850-1. 2004
    ..The biocompatibility and unique physical, electrical, optical, and mechanical properties of nanotubes provide the basis for new classes of materials for drug, protein, and gene delivery applications...