Y Wen

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Phospholipase A(2) and cyclooxygenase gene expression in human preimplantation embryos
    Hongbo Wang
    Department of Gynecology and Obstetrics, Polan Laboratory, Stanford University School of Medicine, 300 Pasteur Drive, Room HH333, Stanford, CA 94305, USA
    J Clin Endocrinol Metab 87:2629-34. 2002
  2. ncbi request reprint Do extracellular matrix protein expressions change with cyclic reproductive hormones in pelvic connective tissue from women with stress urinary incontinence?
    Yan Wen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Hum Reprod 21:1266-73. 2006
  3. pmc Reprogramming of fibroblasts from older women with pelvic floor disorders alters cellular behavior associated with donor age
    Yan Wen
    Department of Obstetrics Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    Stem Cells Transl Med 2:118-28. 2013
  4. pmc Identification of protein marker in vaginal wall tissues of women with stress urinary incontinence by protein chip array
    Yan Wen
    Department of Obstetrics and Gynecology Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Obstet Gynaecol Res 38:89-96. 2012
  5. ncbi request reprint Expression of CD9 in frozen-thawed mouse oocytes: preliminary experience
    Yan Wen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    Fertil Steril 88:526-9. 2007
  6. ncbi request reprint Is alpha2-macroglobulin important in female stress urinary incontinence?
    Y Wen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, H333 Stanford, CA 94305, USA
    Hum Reprod 23:387-93. 2008
  7. doi request reprint Effect of relaxin on TGF-beta1 expression in cultured vaginal fibroblasts from women with stress urinary incontinence
    Yan Wen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305, USA
    Reprod Sci 15:312-20. 2008
  8. doi request reprint Expression of apoptotic factors in vaginal tissues from women with urogenital prolapse
    Yan Wen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA
    Neurourol Urodyn 30:1627-32. 2011
  9. ncbi request reprint Quantitative gonadotropin-releasing hormone gene expression and immunohistochemical localization in human endometrium throughout the menstrual cycle
    F Raga
    Department of Gynecology and Obstetrics, Reproductive Immunology Laboratory, Stanford University School of Medicine, Stanford, California 94305, USA
    Biol Reprod 59:661-9. 1998
  10. ncbi request reprint Interleukin (IL)-1beta regulation of IL-1beta and IL-1 receptor antagonist expression in cultured human endometrial stromal cells
    H Y Huang
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, California 94305, USA
    J Clin Endocrinol Metab 86:1387-93. 2001

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Phospholipase A(2) and cyclooxygenase gene expression in human preimplantation embryos
    Hongbo Wang
    Department of Gynecology and Obstetrics, Polan Laboratory, Stanford University School of Medicine, 300 Pasteur Drive, Room HH333, Stanford, CA 94305, USA
    J Clin Endocrinol Metab 87:2629-34. 2002
    ..COX-1 and COX-2 are differentially expressed, with COX-2 being primarily expressed by trophectoderm in late-stage human preimplantation embryos, which may promote embryonic differentiation and implantation...
  2. ncbi request reprint Do extracellular matrix protein expressions change with cyclic reproductive hormones in pelvic connective tissue from women with stress urinary incontinence?
    Yan Wen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Hum Reprod 21:1266-73. 2006
    ....
  3. pmc Reprogramming of fibroblasts from older women with pelvic floor disorders alters cellular behavior associated with donor age
    Yan Wen
    Department of Obstetrics Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    Stem Cells Transl Med 2:118-28. 2013
    ..Donor age differences were not observed in these iPSCs using standard senescence markers, and donor age did not appear to affect cell mitotic activity in fibroblasts redifferentiated from iPSCs...
  4. pmc Identification of protein marker in vaginal wall tissues of women with stress urinary incontinence by protein chip array
    Yan Wen
    Department of Obstetrics and Gynecology Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Obstet Gynaecol Res 38:89-96. 2012
    ....
  5. ncbi request reprint Expression of CD9 in frozen-thawed mouse oocytes: preliminary experience
    Yan Wen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    Fertil Steril 88:526-9. 2007
    ..The expression levels of both CD9 mRNA and protein in the frozen oocytes were significantly lower than those found in the fresh oocytes...
  6. ncbi request reprint Is alpha2-macroglobulin important in female stress urinary incontinence?
    Y Wen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, H333 Stanford, CA 94305, USA
    Hum Reprod 23:387-93. 2008
    ..The vaginal wall is the main supporting tissue for pelvic organs and changes in components of supporting tissues are known to be involved in the pathophysiology of SUI...
  7. doi request reprint Effect of relaxin on TGF-beta1 expression in cultured vaginal fibroblasts from women with stress urinary incontinence
    Yan Wen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305, USA
    Reprod Sci 15:312-20. 2008
    ..05) in the supernatant, cells and ECM of both women with SUI and controls. Relaxin decreased the levels of total and active TGF-beta1 in the ECM isolated from SUI vaginal fibroblasts...
  8. doi request reprint Expression of apoptotic factors in vaginal tissues from women with urogenital prolapse
    Yan Wen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA
    Neurourol Urodyn 30:1627-32. 2011
    ..We evaluated expression of apoptotic factors (Bcl-2 family) in vaginal tissues from women with pelvic organ prolapse (POP) and how these factors correlate with severity of prolapse...
  9. ncbi request reprint Quantitative gonadotropin-releasing hormone gene expression and immunohistochemical localization in human endometrium throughout the menstrual cycle
    F Raga
    Department of Gynecology and Obstetrics, Reproductive Immunology Laboratory, Stanford University School of Medicine, Stanford, California 94305, USA
    Biol Reprod 59:661-9. 1998
    ..On the basis of these data, we suggest that during reproductive life, endometrial GnRH may play a paracrine/autocrine role in the early stages of implantation by modulating embryonic trophoblastic secretion of hCG...
  10. ncbi request reprint Interleukin (IL)-1beta regulation of IL-1beta and IL-1 receptor antagonist expression in cultured human endometrial stromal cells
    H Y Huang
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, California 94305, USA
    J Clin Endocrinol Metab 86:1387-93. 2001
    ..These results suggest that IL-1 may play a crucial role in embryo-maternal interaction by regulating stromal cell expression of IL-1beta and IL-1ra, resulting in an appropriate ratio during the process of embryonic implantation...
  11. ncbi request reprint Independent regulation of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 (TIMP-1), and TIMP-3 in human endometrial stromal cells by gonadotropin-releasing hormone: implications in early human implantation
    F Raga
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305, USA
    J Clin Endocrinol Metab 84:636-42. 1999
    ..Our results provide evidence that trophoblastic GnRH may play an important role in placental tissue organization and in the early embryo-maternal dialogue by enhancing trophoblast invasion through the specific inhibition of TIMPs...
  12. ncbi request reprint Differences in mRNA and protein expression of small proteoglycans in vaginal wall tissue from women with and without stress urinary incontinence
    Y Wen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, USA
    Hum Reprod 22:1718-24. 2007
    ..To investigate changes in mRNA and protein levels of biglycan (BGN), decorin (DCN) and fibromodulin (FMOD) in vaginal wall tissue from women with stress urinary incontinence (SUI) compared to menstrual-cycle matched continent women...
  13. ncbi request reprint Distinctive proliferative phase differences in gene expression in human myometrium and leiomyomata
    Hongbo Wang
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA
    Fertil Steril 80:266-76. 2003
    ..To gain a comprehensive view of the gene expression and regulation involved in uterine leiomyomata and matched normal myometrium using oligonucleotide microarray-based hybridization analysis...
  14. ncbi request reprint Immunoreactive gonadotropin-releasing hormone expression in cycling human endometrium of fertile patients
    E M CasaƱ
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California, USA
    Fertil Steril 70:102-6. 1998
    ..To investigate the protein expression of GnRH in the endometrium of fertile patients throughout the menstrual cycle...
  15. ncbi request reprint Single blastomeres within human preimplantation embryos express different amounts of messenger ribonucleic acid for beta-actin and interleukin-1 receptor type I
    J S Krussel
    Department of Gynecology and Obstetrics, Reproductive Immunology Laboratory, Stanford University School of Medicine, Palo Alto, California 94305, USA
    J Clin Endocrinol Metab 83:953-9. 1998
    ..Our results suggest that the mRNA pattern of an embryo cannot be reliably quantitated from the mRNA pattern of a single blastomere and therefore imply limitations for the use of this method for preimplantation diagnosis...
  16. ncbi request reprint Interleukin-1beta regulates urokinase plasminogen activator (u-PA), u-PA receptor, soluble u-PA receptor, and plasminogen activator inhibitor-1 messenger ribonucleic acid expression in cultured human endometrial stromal cells
    H W Chung
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305 5317, USA
    J Clin Endocrinol Metab 86:1332-40. 2001
    ..u-PA mRNA expression was not dependent on IL-1beta. These results suggest that IL-1 may be important in regulating PAI-1 and u-PAR during stromal cell decidualization before implantation...
  17. ncbi request reprint Collagen metabolism and turnover in women with stress urinary incontinence and pelvic prolapse
    B H Chen
    Department of Gynecology and Obstetrics, Stanford University Medical School, California 94305 5317, USA
    Int Urogynecol J Pelvic Floor Dysfunct 13:80-7; discussion 87. 2002
    ..Both these findings are consistent with increased collagen breakdown as a pathologic etiology of incontinence...
  18. ncbi request reprint Different pattern of interleukin-1 beta-(IL-1 beta), interleukin-1 receptor antagonist- (IL-1ra) and interleukin-1 receptor type I- (IL-1R tI) mRNA-expression in single preimplantation mouse embryos at various developmental stages
    J S Kruessel
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, Palo Alto, California 94304, USA
    J Reprod Immunol 34:103-20. 1997
    ..IL-1ra mRNA seems to be expressed in a very high percentage (74%) of embryos near the time of implantation, whereas the percentage of IL-1 beta-mRNA positive embryos is surprisingly low (19%)...
  19. ncbi request reprint Menstrual phase-dependent gene expression differences in periurethral vaginal tissue from women with stress incontinence
    Bertha Chen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Am J Obstet Gynecol 189:89-97. 2003
    ....
  20. pmc Relaxin increases elastase activity and protease inhibitors in smooth muscle cells from the myometrium compared with cells from leiomyomas
    Bertha Chen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA
    Fertil Steril 91:1351-4. 2009
    ..Relaxin increases elastase activity and protease inhibitor expressions in myometrial smooth muscle cells, but no effect was observed in leiomyoma cells...
  21. ncbi request reprint Increased expression of latent TGF-beta binding protein-1 and fibrillin-1 in human uterine leiomyomata
    Yangyu Zhao
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, USA
    Mol Hum Reprod 13:343-9. 2007
    ..Estrogen may be involved in LTBP-1 and FBN-1 expression in leiomyomata. Extracellular matrix metabolism may be different in medium-sized leiomyoma...
  22. ncbi request reprint Follicle development in grafted mouse ovaries after cryopreservation and subcutaneous transplantation
    Hongbo Wang
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, CA 94305, USA
    Am J Obstet Gynecol 187:370-4. 2002
    ..Our aim was to determine the impact of freezing, thawing, and subcutaneous transplantation on follicular development in grafted mouse ovaries...
  23. ncbi request reprint The role of neutrophil elastase in elastin metabolism of pelvic tissues from women with stress urinary incontinence
    Bertha Chen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Neurourol Urodyn 26:274-9. 2007
    ..Altered elastin metabolism is implicated in pelvic floor disorders. We studied neutrophil elastase (NE) and matrix metalloproteinase (MMP) activities in vaginal tissues from premenopausal women with stress urinary incontinence (SUI)...
  24. ncbi request reprint Microarray analysis of differentially expressed genes in vaginal tissues from women with stress urinary incontinence compared with asymptomatic women
    Bertha Chen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Hum Reprod 21:22-9. 2006
    ..We sought to identify differentially expressed genes involved in extracellular matrix (ECM) metabolism in vaginal tissues from women with SUI in the secretory phase of menses compared with asymptomatic women...
  25. ncbi request reprint Matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression in human preimplantation embryos
    Hongbo Wang
    Reproductive Immunology Laboratory, Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, California 94305, USA
    Fertil Steril 80:736-42. 2003
    ..To examine human embryos at various stages of preimplantation development for simultaneous expression of matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinases (TIMPs)...
  26. ncbi request reprint Elastin metabolism in pelvic tissues: is it modulated by reproductive hormones?
    Bertha Chen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Calif 94305 5317, USA
    Am J Obstet Gynecol 192:1605-13. 2005
    ..The purpose of this study was to investigate the effect of relaxin on extracellular matrix protein expression in pelvic fibroblasts that were cultured from women with stress urinary incontinence compared with asymptomatic control subjects...
  27. ncbi request reprint Differences in estrogen modulation of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-1 expression in cultured fibroblasts from continent and incontinent women
    Bertha Chen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA
    Am J Obstet Gynecol 189:59-65. 2003
    ....
  28. pmc Preliminary experience with low concentration of granulocyte-macrophage colony-stimulating factor: a potential regulator in preimplantation mouse embryo development and apoptosis
    Barry Behr
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA
    J Assist Reprod Genet 22:25-32. 2005
    ..To investigate the effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) on the development of preimplantation mouse embryos...
  29. ncbi request reprint Elastolytic activity in women with stress urinary incontinence and pelvic organ prolapse
    Bertha Chen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    Neurourol Urodyn 23:119-26. 2004
    ....
  30. ncbi request reprint The role of gonadotropin-releasing hormone in murine preimplantation embryonic development
    F Raga
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California, USA
    Endocrinology 140:3705-12. 1999
    ..The deleterious effect of GnRH antagonist on embryo development was reversed by increasing concentrations of the agonist, as determined by the number of embryos reaching the blastocyst stage...
  31. ncbi request reprint Expression of vascular endothelial growth factor mRNA in human preimplantation embryos derived from tripronuclear zygotes
    J Krussel
    Reproductive Immunology Laboratory, Department of Gynecology and Obstetrics, Stanford University Medical Center, California, Palo Alto, USA
    Fertil Steril 74:1220-6. 2000
    ..To detect the expression of vascular endothelial growth factor (VEGF) mRNA and/or secretion of VEGF protein by human preimplantation embryos...
  32. pmc Is lysyl oxidase-like protein-1, alpha-1 antitrypsin, and neutrophil elastase site specific in pelvic organ prolapse?
    Weng Chi Man
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, HH 333, Stanford, CA 94305 5317, USA
    Int Urogynecol J Pelvic Floor Dysfunct 20:1423-9. 2009
    ..We investigated whether the expression of alpha-1 antitrypsin (ATT), neutrophil elastase (NE), and lysyl oxidase-like protein 1 (LOXL-1) vary within the vagina in subjects with pelvic organ prolapse (POP)...
  33. ncbi request reprint Bench to bedside: clinical opportunities for microarray analysis
    Mary Lake Polan
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA
    Fertil Steril 80:291-2. 2003
  34. pmc Transforming growth interacting factor expression in leiomyoma compared with myometrium
    Jason Yen-Ping Ho
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    Fertil Steril 94:1078-83. 2010
    ..To investigate the expression of transforming growth interacting factor (TGIF), a Smad transcriptional corepressor, in leiomyoma and matched myometrial tissue samples and the effect of TGIF overexpression in myometrial cells...
  35. ncbi request reprint Lipocortin V may function as a signaling protein for vascular endothelial growth factor receptor-2/Flk-1
    Y Wen
    Membrane Biology Laboratory, Department of Medicine, West, Los Angeles VA Medical Center and UCLA, Los Angeles, California, 90073, USA
    Biochem Biophys Res Commun 258:713-21. 1999
    ....
  36. ncbi request reprint Two functional forms of vascular endothelial growth factor receptor-2/Flk-1 mRNA are expressed in normal rat retina
    Y Wen
    Department of Medicine, West Los Angeles VA Medical Center, California, USA
    J Biol Chem 273:2090-7. 1998
    ....
  37. ncbi request reprint Interleukin-1beta regulation of gonadotropin-releasing hormone messenger ribonucleic acid in cultured human endometrial stromal cells
    Hong Yuan Huang
    Department of Obstetrics and Gynecology, Lin Kou Medical Center, Chang Gung Memorial Hospital, Tao Yuan, Taiwan
    Fertil Steril 79:399-406. 2003
    ..To investigate the role of interleukin-1beta (IL-1beta) in regulating GnRH mRNA expression in cultured human endometrial stromal cells using a modified semiquantitative competitive reverse transcription and polymerase chain reaction (PCR)...
  38. ncbi request reprint Matrix metalloproteinase-2, membranous type 1 matrix metalloproteinase, and tissue inhibitor of metalloproteinase-2 expression in ectopic and eutopic endometrium
    Hye Won Chung
    Department of Obstetrics and Gynecology, Ewha Womans University School of Medicine, Seoul, Korea
    Fertil Steril 78:787-95. 2002
    ....
  39. ncbi request reprint Exogenous granulocyte-macrophage colony-stimulating factor promotes follicular development in the newborn rat in vivo
    Hongbo Wang
    Huntington Reproductive Center, Westlake Village, CA 91361, USA
    Hum Reprod 20:2749-56. 2005
    ....
  40. ncbi request reprint Regulation of cyclooxygenase activity in cultured endometrial stromal cells by granulocyte-macrophage colony-stimulating factor
    Hongbo Wang
    Huntington Reproductive Center, Westlake Village, California 91361, USA
    Fertil Steril 85:1118-24. 2006
    ....