Research Topics
Genomes and Genes
| IRVING LERNER WEISSMANSummaryAffiliation: Stanford University Country: USA Publications
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Detail Information
Publications
Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cellsChance John Luckey
Joslin Diabetes Center, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 103:3304-9. 2006..These observations provide evidence that the shared phenotype of self-renewal in the hematopoietic system is linked at the molecular level...- The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseasesIrving L Weissman
Stanford Institute of Stem Cell Biology and Regenerative Medicine, Stanford, CA 94304 1334, USA
Blood 112:3543-53. 2008..Here we review the steps, from our viewpoint, that led to HSC isolation and its importance in self-nonself immune recognition... 
Stem cell therapies could change medicine... if they get the chanceIrving Weissman
Institute of Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA
Cell Stem Cell 10:663-5. 2012..Stem cell therapies have the potential to revolutionize the way we practice medicine. However, in the current climate several barriers and false assumptions stand in the way of achieving that goal...- Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cellsR C Allsopp
Beckman Center, Pathology Department, Stanford University School of Medicine, Stanford University, Stanford, California 94305, USA
J Exp Med 193:917-24. 2001..Together, these data show that telomeres shorten during division of HSCs in vivo, and are consistent with the hypothesis that telomere shortening may limit the replicative capacity of HSCs... 
Stem cells, cancer, and cancer stem cellsT Reya
Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Palo Alto, California 94305, USA
Nature 414:105-11. 2001....- The E. Donnall Thomas lecture: normal and neoplastic stem cellsIrving L Weissman
Stanford University School of Medicine, Stanford, California 94305, USA
Biol Blood Marrow Transplant 14:849-58. 2008..The following text is a modified transcribed version of the presentation made by Dr. Weissman... - Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiationsI L Weissman
B257 Beckman Center, Stanford University School of Medicine Stanford, California 94305 5323, USA
Annu Rev Cell Dev Biol 17:387-403. 2001..It is interesting that in the hematopoietic system the only long-term self-renewing cells in the stem and progenitors pool are the hematopoietic stem cells. This fact is discussed in the context of normal and leukemic hematopoiesis... - Stem cell research: paths to cancer therapies and regenerative medicineIrving Weissman
Institute of Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, Calif, USA
JAMA 294:1359-66. 2005.... - Determinants of skeletal muscle contributions from circulating cells, bone marrow cells, and hematopoietic stem cellsRichard I Sherwood
Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California, USA
Stem Cells 22:1292-304. 2004..It is not yet clear whether such events represent a normal myogenic pathway or a pathological response to muscle damage... - Common lymphoid progenitors rapidly engraft and protect against lethal murine cytomegalovirus infection after hematopoietic stem cell transplantationCaroline Arber
Department of Medicine, Division of Bone Marrow Transplantation, Stanford University Medical Center, Stanford, CA, USA
Blood 102:421-8. 2003..These data support the potential for composing grafts with committed progenitors to reduce susceptibility to viral infection following HCT... - Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host diseaseMiriam Merad
Department of Pathology, Stanford University School of Medicine, Palo Alto, California 94304, USA
Nat Med 10:510-7. 2004.... - Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitmentToshihiro Miyamoto
Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Palo Alto, CA 94305, USA
Dev Cell 3:137-47. 2002..Thus, the accessibility for multiple myeloid or lymphoid programs promiscuously may allow flexibility in fate commitments at these multipotent stages... - Stepwise development of committed progenitors in the bone marrow that generate functional T cells in the absence of the thymusMarcos E Garcia-Ojeda
Department of Medicine, Stanford University School of Medicine, CA 94305, USA
J Immunol 175:4363-73. 2005..In conclusion, CTPs in wild-type bone marrow can generate functional T cells via an extrathymic pathway in athymic nu/nu mice... - Evaluation of the long-term reconstituting subset of hematopoietic stem cells with CD150Peter Papathanasiou
Institute of Stem Cell Biology and Regenerative Medicine and Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
Stem Cells 27:2498-508. 2009..This is important for the clarification of lineage relationships and the identification of bona fide regulators of stem cell self-renewal and differentiation both in normal and neoplastic tissues... - Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene familyPatrick Viatour
Department of Pediatrics, Stanford Medical School, Stanford, CA 94305, USA
Cell Stem Cell 3:416-28. 2008..The presence of a single p107 allele is sufficient to largely rescue these defects. Thus, Rb family members collectively maintain HSC quiescence and the balance between lymphoid and myeloid cell fates in the hematopoietic system... - MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in miceChi Wai So
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cancer Cell 3:161-71. 2003..This experimental modeling of ABL in mice highlights its origin from multipotential progenitors that arrest at a bipotential stage specifically targeted or induced by MLL oncogenes... - Differential expression of alpha2 integrin separates long-term and short-term reconstituting Lin-/loThy1.1(lo)c-kit+ Sca-1+ hematopoietic stem cellsAmy J Wagers
Department of Pathology, Stanford University School of Medicine, California, USA
Stem Cells 24:1087-94. 2006.... - Flk2+ common lymphoid progenitors possess equivalent differentiation potential for the B and T lineagesHolger Karsunky
Institute of Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University School of Medicine, CA, USA
Blood 111:5562-70. 2008..Thus, Flk2 expression defines a homogeneous, readily obtainable subset of bone marrow CLP that is completely lymphoid-committed and can differentiate equivalently well into both B and T lineages... - Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardiumLeora B Balsam
Departments of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 428:668-73. 2004..1(lo) Lin- Sca-1+ long-term reconstituting haematopoietic stem cells adopt only traditional haematopoietic fates... - Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitorsAntonio Cozzio
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Genes Dev 17:3029-35. 2003.... - The effect of bleeding on hematopoietic stem cell cycling and self-renewalSamuel H Cheshier
Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA
Stem Cells Dev 16:707-17. 2007..This response was suppressed when red blood cells, but not when white blood cells, were transferred after bleeding. Thus, regulators of HSC proliferation can sense and respond to red blood cell levels... - Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytesFeng Cao
Department of Radiology, Stanford University School of Medicine, Stanford, California, United States of America
PLoS ONE 3:e3474. 2008.... - Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesisThomas Serwold
Stanford Institute of Stem Cell Biology and Regenerative Medicine, CA, USA
Blood 113:807-15. 2009..These results identify CLPs as the major source of thymocyte progenitors within the BM... - Efficient transplantation via antibody-based clearance of hematopoietic stem cell nichesAgnieszka Czechowicz
Institute of Stem Cell Biology and Regenerative Medicine, Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Science 318:1296-9. 2007..Subsequent transplantation of these mice with donor HSCs led to chimerism levels of up to 90%. Extrapolation of these methods to humans may enable mild but effective conditioning regimens for transplantation... - Shifting foci of hematopoiesis during reconstitution from single stem cellsYu-An Cao
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 101:221-6. 2004.... - Hematopoietic stem and progenitor cells and the inflammatory responseSiddhartha Jaiswal
Ludwig Center at Stanford, Stanford Cancer Center, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Ann N Y Acad Sci 1174:118-21. 2009..How the HSPCs remain immune to destruction in a toxic inflammatory milieu is unknown... - B-cell development fails in the absence of the Pbx1 proto-oncogeneMrinmoy Sanyal
Department of Pathology, Stanford University, School of Medicine, Stanford, CA 94305, USA
Blood 109:4191-9. 2007..Thus, Pbx1 critically functions at a stage between hematopoietic stem cell development and B-cell commitment and, therefore, is one of the earliest-acting transcription factors that regulate de novo B-lineage lymphopoiesis... - In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac deliveryFeng Cao
Department of Radiology, Bio-X Program, Stanford University School of Medicine, Stanford, CA 94305-5344, USA
Circulation 113:1005-14. 2006..This versatile imaging platform should have broad applications for basic research and clinical studies on stem cell therapy... - Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscleRichard I Sherwood
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 119:543-54. 2004..Together, these studies describe the clonal isolation of functional adult myogenic progenitors and demonstrate that these cells do not arise from hematopoietic or other bone marrow or circulating precursors... - Bmi-1-green fluorescent protein-knock-in mice reveal the dynamic regulation of bmi-1 expression in normal and leukemic hematopoietic cellsNaoki Hosen
Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
Stem Cells 25:1635-44. 2007..Disclosure of potential conflicts of interest is found at the end of this article... - Functional and transcriptional characterization of human embryonic stem cell-derived endothelial cells for treatment of myocardial infarctionZongjin Li
Department of Radiology and Molecular Imaging Program at Stanford MIPS, Stanford University School of Medicine, Stanford, California, USA
PLoS ONE 4:e8443. 2009..Moreover, to fully understand the beneficial effects of stem cell therapy, investigators must be able to track the functional biology and physiology of transplanted cells in living subjects over time... - Distinguishing mast cell and granulocyte differentiation at the single-cell levelChristopher B Franco
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell Stem Cell 6:361-8. 2010..Our data provide criteria for the prospective isolation of SL-CMP and SL-GMP and support the conclusion that mast cells are specified during hematopoiesis earlier than and independently from granulocytes... - Rejuvenation of aged progenitor cells by exposure to a young systemic environmentIrina M Conboy
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 433:760-4. 2005..These results suggest that the age-related decline of progenitor cell activity can be modulated by systemic factors that change with age... - Gene expression analysis of purified hematopoietic stem cells and committed progenitorsAlexey V Terskikh
Department Pathology and Developm, ental Biology, Stanford University School of Medicine, Stanford, CA, USA
Blood 102:94-101. 2003.... - Circulation and chemotaxis of fetal hematopoietic stem cellsJulie L Christensen
Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
PLoS Biol 2:E75. 2004..This finding indicates the importance of the combined effects of SLF and SDF-1alpha in the migration of fetal HSCs, and is, to our knowledge, the first demonstration of a synergistic effect of two chemoattractive agents on HSCs... - Frizzled 9 knock-out mice have abnormal B-cell developmentErik A Ranheim
Departments of Pathology and Genetics, Stanford University School of Medicine, Stanford, CA, USA
Blood 105:2487-94. 2005..Mature B cells are present in normal numbers in lymph node and spleen. These findings suggest a role for Fzd9 signaling in lymphoid development, particularly at points where B cells undergo self-renewal prior to further differentiation... - Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cellsMichael F Clarke
Stanford University School of Medicine, Stanford, California, USA
Cancer Res 66:9339-44. 2006 - Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with ageDerrick J Rossi
Department of Pathology, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 447:725-9. 2007..These data are consistent with DNA damage accrual being a physiological mechanism of stem cell ageing that may contribute to the diminished capacity of aged tissues to return to homeostasis after exposure to acute stress or injury... - Lineage infidelity in myeloid cells with TCR gene rearrangement: a latent developmental potential of proT cells revealed by ectopic cytokine receptor signalingAngela G King
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 99:4508-13. 2002..In addition, Dbeta1 and Dbeta2 DJ rearrangement of the TCRbeta gene may be differentially regulated and thus serve as markers for distinct proT cell maturational stages... - Stem cells are units of natural selection in a colonial ascidianDiana J Laird
Department of Biological Sciences, Departments of Pathology and Developmental Biology, Stanford University Medical Center, Stanford, CA 94305, USA
Cell 123:1351-60. 2005.... - Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitorsYu An Cao
Departments of Pediatrics, Stanford University School of Medicine, CA, USA
Blood 112:4494-502. 2008..Control of stem cell stress response by HO-1 presents opportunities for metabolic manipulation of stem cell-based therapies... - fester, A candidate allorecognition receptor from a primitive chordateSpencer V Nyholm
Department of Pathology, Stanford University School of Medicine, California 94305, USA
Immunity 25:163-73. 2006..The genetic and somatic diversity, coupled to the expression and functional data, suggests that fester is a receptor involved in histocompatibility... - CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemiaNaoki Hosen
Department of Pathology, Institute of Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA 94305 5323, USA
Proc Natl Acad Sci U S A 104:11008-13. 2007..These results demonstrate that CD96 is a cell surface marker present on many AML-LSC and may serve as an LSC-specific therapeutic target... - Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9Chi Wai So
Department of Pathology, Stanford University School of Medicine, Stanford 94305, USA
Blood 103:3192-9. 2004.... - Identification of mast cell progenitors in adult miceChing-Cheng Chen
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305-5324, USA
Proc Natl Acad Sci U S A 102:11408-13. 2005.... - Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CMLCatriona H M Jamieson
Division of Hematology, Stanford University School of Medicine, Stanford, Calif 94305-5323, USA
N Engl J Med 351:657-67. 2004..CONCLUSIONS: Activation of beta-catenin in CML granulocyte-macrophage progenitors appears to enhance the self-renewal activity and leukemic potential of these cells... - The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular developmentJason Beliakoff
Departments of Urology and Genetics, S287, Grant Building, Stanford University School of Medicine, Stanford, CA 94305 5118, USA
Mol Cell Biol 28:282-92. 2008..Using fra-1 promoter/reporter constructs, we further demonstrate the regulatory role of Zimp10 on the transcription of Fra-1. This study provides evidence to demonstrate a crucial role for Zimp10 in vasculogenesis... - A neurosurgeon's guide to stem cells, cancer stem cells, and brain tumor stem cellsSamuel H Cheshier
Stanford Institute of Stem Cell Biology and Regenerative Medicine, Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA
Neurosurgery 65:237-49; discussion 249-50; quiz N6. 2009..Herein, we provide a brief review of stem cell and cancer stem cell biology and highlight the scientific and clinical implications of recent findings regarding the presence of cancer-forming stem cells in brain tumors... - Expression of AA4.1 marks lymphohematopoietic progenitors in early mouse developmentToshiyuki Yamane
Department of Pathology, Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 106:8953-8. 2009..These data suggest that AA4.1 is a cell surface marker that can identify the earliest lymphohematopoietic progenitors in mouse development... - Developmental plasticity of lymphoid progenitorsSusan S Prohaska
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Semin Immunol 14:377-84. 2002.... - Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosisStanley J Tamaki
StemCells, Inc, Palo Alto, CA 94304, USA
Cell Stem Cell 5:310-9. 2009..These data provide the experimental basis for human clinical trials with these banked hCNS-SCns... - Isolation of human fetal liver progenitors and their enhanced proliferation by three-dimensional coculture with endothelial cellsAnming Xiong
Department of Surgery, Stanford University, Stanford, California, USA
Tissue Eng Part A 14:995-1006. 2008..This coculture methodology offers a novel coculture system that could be applied for the development of engineered liver tissues... - Telomerase maintained in self-renewing tissues during serial regeneration of the urochordate Botryllus schlosseriDiana J Laird
Department of Biological Sciences, Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950, USA
Dev Biol 273:185-94. 2004.... - Hematopoietic cells maintain hematopoietic fates upon entering the brainMei Massengale
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Exp Med 201:1579-89. 2005..These data strongly suggest that HSCs and their progeny maintain lineage fidelity in the brain and do not adopt neural cell fates with any measurable frequency... - Self-renewal of the long-term reconstituting subset of hematopoietic stem cells is regulated by IkarosPeter Papathanasiou
Institute of Stem Cell Biology and Regenerative Medicine, and Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
Stem Cells 27:3082-92. 2009.... - Prospective isolation of human clonogenic common myeloid progenitorsMarkus G Manz
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 99:11872-7. 2002..The isolation of highly purified hematopoietic intermediates provides tools to better understand developmental programs underlying normal and leukemic hematopoiesis... - Wnt proteins are lipid-modified and can act as stem cell growth factorsKarl Willert
Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 423:448-52. 2003..The purified Wnt3a protein induces self-renewal of haematopoietic stem cells, signifying its potential use in tissue engineering... - Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine gliomaMichelle Monje
Department of Neurology, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 108:4453-8. 2011..Together, these findings provide a foundation for understanding the cellular and molecular origins of DIPG, and suggest that the Hh pathway represents a potential therapeutic target in this devastating pediatric tumor... - Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-SThanyaphong Na Nakorn
Department of Pathology and Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
J Clin Invest 109:1579-85. 2002.... - Replicative senescence of hematopoietic stem cells during serial transplantation: does telomere shortening play a role?Richard C Allsopp
Department of Pathology, Stanford University School of Medicine, Stanford, California, CA 94305, USA
Oncogene 21:3270-3. 2002.... - Construction and characterization of large-insert genomic libraries (BAC and fosmid) from the Ascidian Botryllus schlosseri and initial physical mapping of a histocompatibility locusAnthony W De Tomaso
Department of Pathology, Stanford University School of Medicine, Stanford CA 94305, and Hopkins Marine Station, Pacific Grove, CA 93950, USA
Mar Biotechnol (NY) 5:103-15. 2003..schlosseri genome, and the techniques adapted to make them are suitable for use on other organisms in which high molecular weight DNA is difficult to purify... - Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivoHolger Karsunky
Institute for Research in Biomedicine IRB, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
J Exp Med 198:305-13. 2003.... - Hematopoietic stem and progenitor cells: clinical and preclinical regeneration of the hematolymphoid systemJudith A Shizuru
Division of Blood and Marrow Transplantation, Stanford University Medical Center, California 94305, USA
Annu Rev Med 56:509-38. 2005.... - Human Acute Myelogenous Leukemia Stem Cells Revisited: There's More Than Meets the EyeRavindra Majeti
Department of Internal Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA Institute for Stem Cell Biology and Regenerative Medicine, Cancer Center, and Ludwig Center, Stanford University School of Medicine, Stanford, CA 94305, USA
Cancer Cell 19:9-10. 2011..These findings have implications for therapeutic targeting of these cells... - Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47Mark P Chao
Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, and Ludwig Center at Stanford, Stanford, CA 94305, USA
Sci Transl Med 2:63ra94. 2010.... - Isolation and characterization of a protochordate histocompatibility locusAnthony W De Tomaso
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 438:454-9. 2005..This is the first non-vertebrate histocompatibility gene described, and may provide insights into the evolution of vertebrate adaptive immunity... - Striving for normality: whole body regeneration through a series of abnormal generationsAyelet Voskoboynik
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
FASEB J 21:1335-44. 2007..It presents a powerful model for studying the specification of the same body plan by different developmental programs... - CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosisSiddhartha Jaiswal
Ludwig Center at Stanford, Stanford Cancer Center, Department of Pathology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 138:271-85. 2009..We conclude that CD47 upregulation is an important mechanism that provides protection to normal HSCs during inflammation-mediated mobilization, and that leukemic progenitors co-opt this ability in order to evade macrophage killing... - Langerhans cells renew in the skin throughout life under steady-state conditionsMiriam Merad
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94304, USA
Nat Immunol 3:1135-41. 2002..These data indicate that under steady-state conditions, LCs are maintained locally, but inflammatory changes in the skin result in their replacement by blood-borne LC progenitors... - A genetic determinant that specifically regulates the frequency of hematopoietic stem cellsSean J Morrison
Howard Hughes Medical Institute and Departments of Internal Medicine and Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 168:635-42. 2002..This suggests that to affect HSC frequencies, the product(s) of this locus likely depend on interactions with unlinked modifying loci... - Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchyCornelis J H Pronk
Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, BMC I13, 221 84 Lund, Sweden Immunology Unit, Institution for Experimental Medical Science, Lund University, BMC I13, 221 84 Lund, Sweden
Cell Stem Cell 1:428-42. 2007.... - Differential gene expression profiling of adult murine hematopoietic stem cellsIn-Kyung Park
University of Michigan, Department of Internal Medicine, Ann Arbor, USA
Blood 99:488-98. 2002..A large number of genes that were differentially expressed by enriched populations of HSCs and MPP cells were identified. These included transcription factors, signaling molecules, and previously unknown genes... - Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growthSusanna Purhonen
Academy of Finland Center of Excellence in Cancer Biology and Molecular Cancer Biology Laboratory, Molecular Cancer Biology Research Program, University of Helsinki, P O Box 63, 00014, Helsinki, Finland
Proc Natl Acad Sci U S A 105:6620-5. 2008..Endothelial differentiation is not a typical in vivo function of normal BM-derived stem cells in adults, and it has to be an extremely rare event if it occurs at all... - Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cellsRichard C Allsopp
Nat Med 9:369-71. 2003 - Biology of hematopoietic stem cells and progenitors: implications for clinical applicationMotonari Kondo
Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
Annu Rev Immunol 21:759-806. 2003.... - Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cellsIn Kyung Park
Division of Hematology Oncology, Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
Nature 423:302-5. 2003..Expression of p16Ink4a and p19Arf in normal HSCs resulted in proliferative arrest and p53-dependent cell death, respectively. Our results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs... - Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation. 1982Eugene C Butcher
J Immunol 175:1363-72. 2005 - Differential amplification of murine bipotent megakaryocytic/erythroid progenitor and precursor cells during recovery from acute and chronic erythroid stressMassimo Sanchez
Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
Stem Cells 24:337-48. 2006..A model describing the relationship between MEP, PEM, and common myeloid progenitor cells is presented... - Enforced expression of Bcl-2 restores the number of NK cells, but does not rescue the impaired development of NKT cells or intraepithelial lymphocytes, in IL-2/IL-15 receptor beta-chain-deficient miceMasahiro Minagawa
Department of Dermatology, Niigata University School of Medicine, 1 757 Asahimachi dori, Niigata 951 8510, Japan
J Immunol 169:4153-60. 2002..These results indicate an essential role of IL-2/IL-15R-mediated survival signals in the development of NK cells, but they also show that additional nonsurvival signals from IL-2/IL-15R are necessary for innate lymphocyte development... - Identification of a novel gene involved in asexual organogenesis in the budding ascidian Botryllus schlosseriDiana J Laird
Department of Biological Sciences, Hopkins Marine Station of Stanford University, Pacific Grove, California, USA
Dev Dyn 234:997-1005. 2005..As genetic intervention in this organism has not been possible, this study establishes the use of RNAi and morpholinos in Botryllus as well as describing the knockdown phenotype of a new gene... - Antagonistic effect of CCAAT enhancer-binding protein-alpha and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitorsChia Lin Hsu
Department of Immunology, Duke University Medical Center, DUMC 3010, Research Drive, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 103:672-7. 2006..Furthermore, complete loss of Pax5 expression triggered by up-regulation of C/EBPalpha is a critical event for lineage conversion from lymphoid to myeloid lineage in CLPs and proB cells... - The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiationCatriona H M Jamieson
Department of Medicine and Moores Cancer Center, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 103:6224-9. 2006..The JAK2 V617F mutation was detectable within HSC and their progeny in PV. Moreover, the aberrant erythroid potential of PV HSC was potently inhibited with a JAK2 inhibitor, AG490... - A cell-surface molecule involved in organ-specific homing of lymphocytes. 1983W Michael Gallatin
J Immunol 177:5-9. 2006 - Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cellsMarta Serafini
Stem Cell Institute and Cancer Center and Department of Pediatrics, Division of Hematology, Oncology, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
J Exp Med 204:129-39. 2007..Because GFP+ host-derived CD45.1+ cells were not observed, fusion is not likely to account for the generation of HSCs by MAPCs... - Reversal of autoimmune disease in lupus-prone New Zealand black/New Zealand white mice by nonmyeloablative transplantation of purified allogeneic hematopoietic stem cellsStephanie Smith Berdan
Cellerant Therapeutics, San Carlos, CA 94070, USA
Blood 110:1370-8. 2007..Induction of durable mixed chimerism by transplantation of purified allogeneic HSCs after nonmyeloablative conditioning has the potential to reverse symptoms of established NZBW lupus... - Pioneer factor interactions and unmethylated CpG dinucleotides mark silent tissue-specific enhancers in embryonic stem cellsJian Xu
Howard Hughes Medical Institute, Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 104:12377-82. 2007..The enhancer marks may therefore represent important features of the pluripotent state... - Transcriptional instability is not a universal attribute of agingLuigi A Warren
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Aging Cell 6:775-82. 2007..We conclude that large-scale regulatory destabilization is not a universal concomitant of aging, and may be of significance as an aging mechanism primarily in nonrenewing tissues... - Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populationsMathew C Easterday
Interdepartmental Program for Neuroscience, UCLA, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Dev Biol 264:309-22. 2003..Taken together, these studies identify many genes not previously associated with neural progenitor cell biology and also provide a rational scheme for stratification of microarray data for functional analysis...
Research Grants
- HSC Diversity: Regulation by Clonal Selection vs Epigenetic InductionIRVING LERNER WEISSMAN; Fiscal Year: 2010..Understanding the basis of this increased susceptibility is the first step to developing targeted therapies to prevent and/or reverse these public health issues. ..
- Stem Cell Lineage Selectionin ProtochordateIrving Weissman; Fiscal Year: 2006....
- BIOLOGY AND TRANSPLANTATION OF CLPIrving Weissman; Fiscal Year: 2005....
- GENETICS OF ALLOGENEIC RECOGNITION IN A PROTOCHORDATEIrving Weissman; Fiscal Year: 2003..We shall test the relation of 1) to 2), and hope eventually to understand how Fu/HC self/nonself recognition works, and whether it has homologues in vertebrates. ..
- MOLECULAR CHARACTERIZATION OF ACUTE MYELOID LEUKEMIAIrving Weissman; Fiscal Year: 2004..Eventually, human AMLs will be screened for homologous gene defects. ..
- HEMATOPOIETIC STEM CELL--BIOLOGY, PRECURSORS, AND PROGENIrving Weissman; Fiscal Year: 2004..1, Flk2/Flt3, SCL) as well as others recently identified as being stem cell specific in their expression (e.g., a new serpin gene cloned in this laboratory). ..
- THYMIC LYMPHOCYTE DEVELOPMENTIrving Weissman; Fiscal Year: 2004..abstract_text> ..
- Molecular Mechanisms of Protochordate AllorecognitionIrving Weissman; Fiscal Year: 2004..Given the close phylogenetic relationship between the protochordates and vertebrates, Fu/HC-based allorecognition may represent the ancestral MHC, or a completely novel innate allorecognition system. ..
- HOMING RECEPTOR DETERMINANTS ON HSCIrving Weissman; Fiscal Year: 2006..abstract_text> ..
- BD Biosciences FACSAria Benchtop Cell SorterIrving Weissman; Fiscal Year: 2006..Each of the projects described herein requires multi-parameter sorting capability to fulfill one or more of its aims. Thus, we feel the request for purchase of this essential equipment is well justified. ..
- Cellular and molecular mechanisms of aging and regeneration in colonial chordateIRVING LERNER WEISSMAN; Fiscal Year: 2010..Thus the Botryllus model organism is a powerful tool to elucidate the role of stem cell aging on aging and regeneration processes. ..
- Homing Receptor Determinants of HSCIRVING LERNER WEISSMAN; Fiscal Year: 2010....
- Homing Receptor Determinants of HSCIrving Weissman; Fiscal Year: 2009....
- Hematopoietic Stem Cell: Biology, Precursors, and ProgenyIrving Weissman; Fiscal Year: 2009..This concurrent examination of the purification, development and biology of HSC along with their preclinical utility is the theme that drives the basic research of this grant. ..
- MOLECULAR CHARACTERIZATION OF ACUTE MYELOID LEUKEMIAIrving Weissman; Fiscal Year: 2009..It is the goal of these studies to provide further confirmation of the cancer/leukemia stem cell hypothesis, and to provide insight into the leukemogenic process and potential therapies. ..
- MOLECULAR CHARACTERIZATION OF ACUTE MYELOID LEUKEMIAIrving Weissman; Fiscal Year: 2007..It is the goal of these studies to provide further confirmation of the cancer/leukemia stem cell hypothesis, and to provide insight into the leukemogenic process and potential therapies. ..
- STEM CELL LINEAGE SELECTION IN A PROTOCHORDATEIrving Weissman; Fiscal Year: 2004..These experiments will serve as a prelude to develop an understanding of the phylogeny of stem cells, the genetic bases for their functions, and the eventual identification of the human homologues of these Botryllus genes. ..
- HOMING RECEPTOR DETERMINANTS ON HSCIrving Weissman; Fiscal Year: 2001..Because MPB stem cells are currently used for autologous and allogeneic transplants in man, the results of these experiments could impact on clinical protocols. ..