IRVING LERNER WEISSMAN

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations
    I L Weissman
    B257 Beckman Center, Stanford University School of Medicine Stanford, California 94305 5323, USA
    Annu Rev Cell Dev Biol 17:387-403. 2001
  2. ncbi request reprint Stem cells, cancer, and cancer stem cells
    T Reya
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Palo Alto, California 94305, USA
    Nature 414:105-11. 2001
  3. ncbi request reprint Stem cell research: paths to cancer therapies and regenerative medicine
    Irving Weissman
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, Calif, USA
    JAMA 294:1359-66. 2005
  4. pmc Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells
    Chance John Luckey
    Joslin Diabetes Center, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 103:3304-9. 2006
  5. pmc The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases
    Irving L Weissman
    Stanford Institute of Stem Cell Biology and Regenerative Medicine, Stanford, CA 94304 1334, USA
    Blood 112:3543-53. 2008
  6. doi request reprint Stem cell therapies could change medicine... if they get the chance
    Irving Weissman
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA
    Cell Stem Cell 10:663-5. 2012
  7. pmc Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells
    R C Allsopp
    Beckman Center, Pathology Department, Stanford University School of Medicine, Stanford University, Stanford, California 94305, USA
    J Exp Med 193:917-24. 2001
  8. pmc The E. Donnall Thomas lecture: normal and neoplastic stem cells
    Irving L Weissman
    Stanford University School of Medicine, Stanford, California 94305, USA
    Biol Blood Marrow Transplant 14:849-58. 2008
  9. ncbi request reprint Determinants of skeletal muscle contributions from circulating cells, bone marrow cells, and hematopoietic stem cells
    Richard I Sherwood
    Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California, USA
    Stem Cells 22:1292-304. 2004
  10. ncbi request reprint Common lymphoid progenitors rapidly engraft and protect against lethal murine cytomegalovirus infection after hematopoietic stem cell transplantation
    Caroline Arber
    Department of Medicine, Division of Bone Marrow Transplantation, Stanford University Medical Center, Stanford, CA, USA
    Blood 102:421-8. 2003

Research Grants

  1. HSC Diversity: Regulation by Clonal Selection vs Epigenetic Induction
    IRVING LERNER WEISSMAN; Fiscal Year: 2010
  2. Stem Cell Lineage Selectionin Protochordate
    Irving Weissman; Fiscal Year: 2006
  3. BIOLOGY AND TRANSPLANTATION OF CLP
    Irving Weissman; Fiscal Year: 2005
  4. GENETICS OF ALLOGENEIC RECOGNITION IN A PROTOCHORDATE
    Irving Weissman; Fiscal Year: 2003
  5. MOLECULAR CHARACTERIZATION OF ACUTE MYELOID LEUKEMIA
    Irving Weissman; Fiscal Year: 2004
  6. HEMATOPOIETIC STEM CELL--BIOLOGY, PRECURSORS, AND PROGEN
    Irving Weissman; Fiscal Year: 2004
  7. THYMIC LYMPHOCYTE DEVELOPMENT
    Irving Weissman; Fiscal Year: 2004
  8. Molecular Mechanisms of Protochordate Allorecognition
    Irving Weissman; Fiscal Year: 2004
  9. HOMING RECEPTOR DETERMINANTS ON HSC
    Irving Weissman; Fiscal Year: 2006
  10. BD Biosciences FACSAria Benchtop Cell Sorter
    Irving Weissman; Fiscal Year: 2006

Detail Information

Publications88

  1. ncbi request reprint Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations
    I L Weissman
    B257 Beckman Center, Stanford University School of Medicine Stanford, California 94305 5323, USA
    Annu Rev Cell Dev Biol 17:387-403. 2001
    ..It is interesting that in the hematopoietic system the only long-term self-renewing cells in the stem and progenitors pool are the hematopoietic stem cells. This fact is discussed in the context of normal and leukemic hematopoiesis...
  2. ncbi request reprint Stem cells, cancer, and cancer stem cells
    T Reya
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Palo Alto, California 94305, USA
    Nature 414:105-11. 2001
    ....
  3. ncbi request reprint Stem cell research: paths to cancer therapies and regenerative medicine
    Irving Weissman
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, Calif, USA
    JAMA 294:1359-66. 2005
    ....
  4. pmc Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells
    Chance John Luckey
    Joslin Diabetes Center, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 103:3304-9. 2006
    ..These observations provide evidence that the shared phenotype of self-renewal in the hematopoietic system is linked at the molecular level...
  5. pmc The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases
    Irving L Weissman
    Stanford Institute of Stem Cell Biology and Regenerative Medicine, Stanford, CA 94304 1334, USA
    Blood 112:3543-53. 2008
    ..Here we review the steps, from our viewpoint, that led to HSC isolation and its importance in self-nonself immune recognition...
  6. doi request reprint Stem cell therapies could change medicine... if they get the chance
    Irving Weissman
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA
    Cell Stem Cell 10:663-5. 2012
    ..Stem cell therapies have the potential to revolutionize the way we practice medicine. However, in the current climate several barriers and false assumptions stand in the way of achieving that goal...
  7. pmc Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells
    R C Allsopp
    Beckman Center, Pathology Department, Stanford University School of Medicine, Stanford University, Stanford, California 94305, USA
    J Exp Med 193:917-24. 2001
    ..Together, these data show that telomeres shorten during division of HSCs in vivo, and are consistent with the hypothesis that telomere shortening may limit the replicative capacity of HSCs...
  8. pmc The E. Donnall Thomas lecture: normal and neoplastic stem cells
    Irving L Weissman
    Stanford University School of Medicine, Stanford, California 94305, USA
    Biol Blood Marrow Transplant 14:849-58. 2008
    ..The following text is a modified transcribed version of the presentation made by Dr. Weissman...
  9. ncbi request reprint Determinants of skeletal muscle contributions from circulating cells, bone marrow cells, and hematopoietic stem cells
    Richard I Sherwood
    Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California, USA
    Stem Cells 22:1292-304. 2004
    ..It is not yet clear whether such events represent a normal myogenic pathway or a pathological response to muscle damage...
  10. ncbi request reprint Common lymphoid progenitors rapidly engraft and protect against lethal murine cytomegalovirus infection after hematopoietic stem cell transplantation
    Caroline Arber
    Department of Medicine, Division of Bone Marrow Transplantation, Stanford University Medical Center, Stanford, CA, USA
    Blood 102:421-8. 2003
    ..These data support the potential for composing grafts with committed progenitors to reduce susceptibility to viral infection following HCT...
  11. ncbi request reprint Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease
    Miriam Merad
    Department of Pathology, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Nat Med 10:510-7. 2004
    ....
  12. ncbi request reprint Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment
    Toshihiro Miyamoto
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Palo Alto, CA 94305, USA
    Dev Cell 3:137-47. 2002
    ..Thus, the accessibility for multiple myeloid or lymphoid programs promiscuously may allow flexibility in fate commitments at these multipotent stages...
  13. ncbi request reprint Stepwise development of committed progenitors in the bone marrow that generate functional T cells in the absence of the thymus
    Marcos E Garcia-Ojeda
    Department of Medicine, Stanford University School of Medicine, CA 94305, USA
    J Immunol 175:4363-73. 2005
    ..In conclusion, CTPs in wild-type bone marrow can generate functional T cells via an extrathymic pathway in athymic nu/nu mice...
  14. pmc Evaluation of the long-term reconstituting subset of hematopoietic stem cells with CD150
    Peter Papathanasiou
    Institute of Stem Cell Biology and Regenerative Medicine and Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Stem Cells 27:2498-508. 2009
    ..This is important for the clarification of lineage relationships and the identification of bona fide regulators of stem cell self-renewal and differentiation both in normal and neoplastic tissues...
  15. pmc Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family
    Patrick Viatour
    Department of Pediatrics, Stanford Medical School, Stanford, CA 94305, USA
    Cell Stem Cell 3:416-28. 2008
    ..The presence of a single p107 allele is sufficient to largely rescue these defects. Thus, Rb family members collectively maintain HSC quiescence and the balance between lymphoid and myeloid cell fates in the hematopoietic system...
  16. ncbi request reprint MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice
    Chi Wai So
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cancer Cell 3:161-71. 2003
    ..This experimental modeling of ABL in mice highlights its origin from multipotential progenitors that arrest at a bipotential stage specifically targeted or induced by MLL oncogenes...
  17. ncbi request reprint Differential expression of alpha2 integrin separates long-term and short-term reconstituting Lin-/loThy1.1(lo)c-kit+ Sca-1+ hematopoietic stem cells
    Amy J Wagers
    Department of Pathology, Stanford University School of Medicine, California, USA
    Stem Cells 24:1087-94. 2006
    ....
  18. pmc Flk2+ common lymphoid progenitors possess equivalent differentiation potential for the B and T lineages
    Holger Karsunky
    Institute of Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University School of Medicine, CA, USA
    Blood 111:5562-70. 2008
    ..Thus, Flk2 expression defines a homogeneous, readily obtainable subset of bone marrow CLP that is completely lymphoid-committed and can differentiate equivalently well into both B and T lineages...
  19. ncbi request reprint Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
    Leora B Balsam
    Departments of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 428:668-73. 2004
    ..1(lo) Lin- Sca-1+ long-term reconstituting haematopoietic stem cells adopt only traditional haematopoietic fates...
  20. pmc Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
    Antonio Cozzio
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Genes Dev 17:3029-35. 2003
    ....
  21. ncbi request reprint The effect of bleeding on hematopoietic stem cell cycling and self-renewal
    Samuel H Cheshier
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Stem Cells Dev 16:707-17. 2007
    ..This response was suppressed when red blood cells, but not when white blood cells, were transferred after bleeding. Thus, regulators of HSC proliferation can sense and respond to red blood cell levels...
  22. pmc Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes
    Feng Cao
    Department of Radiology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 3:e3474. 2008
    ....
  23. doi request reprint Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis
    Thomas Serwold
    Stanford Institute of Stem Cell Biology and Regenerative Medicine, CA, USA
    Blood 113:807-15. 2009
    ..These results identify CLPs as the major source of thymocyte progenitors within the BM...
  24. pmc Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches
    Agnieszka Czechowicz
    Institute of Stem Cell Biology and Regenerative Medicine, Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 318:1296-9. 2007
    ..Subsequent transplantation of these mice with donor HSCs led to chimerism levels of up to 90%. Extrapolation of these methods to humans may enable mild but effective conditioning regimens for transplantation...
  25. pmc Shifting foci of hematopoiesis during reconstitution from single stem cells
    Yu An Cao
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 101:221-6. 2004
    ....
  26. doi request reprint Hematopoietic stem and progenitor cells and the inflammatory response
    Siddhartha Jaiswal
    Ludwig Center at Stanford, Stanford Cancer Center, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Ann N Y Acad Sci 1174:118-21. 2009
    ..How the HSPCs remain immune to destruction in a toxic inflammatory milieu is unknown...
  27. pmc B-cell development fails in the absence of the Pbx1 proto-oncogene
    Mrinmoy Sanyal
    Department of Pathology, Stanford University, School of Medicine, Stanford, CA 94305, USA
    Blood 109:4191-9. 2007
    ..Thus, Pbx1 critically functions at a stage between hematopoietic stem cell development and B-cell commitment and, therefore, is one of the earliest-acting transcription factors that regulate de novo B-lineage lymphopoiesis...
  28. ncbi request reprint In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery
    Feng Cao
    Department of Radiology, Bio X Program, Stanford University School of Medicine, Stanford, CA 94305 5344, USA
    Circulation 113:1005-14. 2006
    ..Recent studies have shown that stem cell therapy can promote tissue regeneration; however, monitoring stem cells in vivo remains problematic owing to limitations of conventional histological assays and imaging modalities...
  29. ncbi request reprint Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle
    Richard I Sherwood
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 119:543-54. 2004
    ..Together, these studies describe the clonal isolation of functional adult myogenic progenitors and demonstrate that these cells do not arise from hematopoietic or other bone marrow or circulating precursors...
  30. ncbi request reprint Bmi-1-green fluorescent protein-knock-in mice reveal the dynamic regulation of bmi-1 expression in normal and leukemic hematopoietic cells
    Naoki Hosen
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Stem Cells 25:1635-44. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  31. pmc Functional and transcriptional characterization of human embryonic stem cell-derived endothelial cells for treatment of myocardial infarction
    Zongjin Li
    Department of Radiology and Molecular Imaging Program at Stanford MIPS, Stanford University School of Medicine, Stanford, California, USA
    PLoS ONE 4:e8443. 2009
    ..Moreover, to fully understand the beneficial effects of stem cell therapy, investigators must be able to track the functional biology and physiology of transplanted cells in living subjects over time...
  32. pmc Distinguishing mast cell and granulocyte differentiation at the single-cell level
    Christopher B Franco
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Stem Cell 6:361-8. 2010
    ..Our data provide criteria for the prospective isolation of SL-CMP and SL-GMP and support the conclusion that mast cells are specified during hematopoiesis earlier than and independently from granulocytes...
  33. ncbi request reprint Rejuvenation of aged progenitor cells by exposure to a young systemic environment
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 433:760-4. 2005
    ..These results suggest that the age-related decline of progenitor cell activity can be modulated by systemic factors that change with age...
  34. ncbi request reprint Gene expression analysis of purified hematopoietic stem cells and committed progenitors
    Alexey V Terskikh
    Department Pathology and Developm, ental Biology, Stanford University School of Medicine, Stanford, CA, USA
    Blood 102:94-101. 2003
    ....
  35. pmc Circulation and chemotaxis of fetal hematopoietic stem cells
    Julie L Christensen
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Biol 2:E75. 2004
    ..This finding indicates the importance of the combined effects of SLF and SDF-1alpha in the migration of fetal HSCs, and is, to our knowledge, the first demonstration of a synergistic effect of two chemoattractive agents on HSCs...
  36. ncbi request reprint Frizzled 9 knock-out mice have abnormal B-cell development
    Erik A Ranheim
    Departments of Pathology and Genetics, Stanford University School of Medicine, Stanford, CA, USA
    Blood 105:2487-94. 2005
    ..Mature B cells are present in normal numbers in lymph node and spleen. These findings suggest a role for Fzd9 signaling in lymphoid development, particularly at points where B cells undergo self-renewal prior to further differentiation...
  37. ncbi request reprint Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells
    Michael F Clarke
    Stanford University School of Medicine, Stanford, California, USA
    Cancer Res 66:9339-44. 2006
  38. ncbi request reprint Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
    Derrick J Rossi
    Department of Pathology, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 447:725-9. 2007
    ..These data are consistent with DNA damage accrual being a physiological mechanism of stem cell ageing that may contribute to the diminished capacity of aged tissues to return to homeostasis after exposure to acute stress or injury...
  39. pmc Lineage infidelity in myeloid cells with TCR gene rearrangement: a latent developmental potential of proT cells revealed by ectopic cytokine receptor signaling
    Angela G King
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:4508-13. 2002
    ..In addition, Dbeta1 and Dbeta2 DJ rearrangement of the TCRbeta gene may be differentially regulated and thus serve as markers for distinct proT cell maturational stages...
  40. ncbi request reprint Stem cells are units of natural selection in a colonial ascidian
    Diana J Laird
    Department of Biological Sciences, Departments of Pathology and Developmental Biology, Stanford University Medical Center, Stanford, CA 94305, USA
    Cell 123:1351-60. 2005
    ....
  41. pmc Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors
    Yu An Cao
    Departments of Pediatrics, Stanford University School of Medicine, CA, USA
    Blood 112:4494-502. 2008
    ..Control of stem cell stress response by HO-1 presents opportunities for metabolic manipulation of stem cell-based therapies...
  42. ncbi request reprint fester, A candidate allorecognition receptor from a primitive chordate
    Spencer V Nyholm
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Immunity 25:163-73. 2006
    ..The genetic and somatic diversity, coupled to the expression and functional data, suggests that fester is a receptor involved in histocompatibility...
  43. pmc CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia
    Naoki Hosen
    Department of Pathology, Institute of Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA 94305 5323, USA
    Proc Natl Acad Sci U S A 104:11008-13. 2007
    ..These results demonstrate that CD96 is a cell surface marker present on many AML-LSC and may serve as an LSC-specific therapeutic target...
  44. ncbi request reprint Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9
    Chi Wai So
    Department of Pathology, Stanford University School of Medicine, Stanford 94305, USA
    Blood 103:3192-9. 2004
    ....
  45. pmc Identification of mast cell progenitors in adult mice
    Ching Cheng Chen
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 102:11408-13. 2005
    ....
  46. ncbi request reprint Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
    Catriona H M Jamieson
    Division of Hematology, Stanford University School of Medicine, Stanford, Calif 94305 5323, USA
    N Engl J Med 351:657-67. 2004
    ..In normal mouse hematopoietic stem cells, the process of self-renewal involves the beta-catenin-signaling pathway. We investigated whether leukemic stem cells in CML also use the beta-catenin pathway for self-renewal...
  47. pmc The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development
    Jason Beliakoff
    Departments of Urology and Genetics, S287, Grant Building, Stanford University School of Medicine, Stanford, CA 94305 5118, USA
    Mol Cell Biol 28:282-92. 2008
    ..Using fra-1 promoter/reporter constructs, we further demonstrate the regulatory role of Zimp10 on the transcription of Fra-1. This study provides evidence to demonstrate a crucial role for Zimp10 in vasculogenesis...
  48. doi request reprint A neurosurgeon's guide to stem cells, cancer stem cells, and brain tumor stem cells
    Samuel H Cheshier
    Stanford Institute of Stem Cell Biology and Regenerative Medicine, Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA
    Neurosurgery 65:237-49; discussion 249-50; quiz N6. 2009
    ..Herein, we provide a brief review of stem cell and cancer stem cell biology and highlight the scientific and clinical implications of recent findings regarding the presence of cancer-forming stem cells in brain tumors...
  49. pmc Expression of AA4.1 marks lymphohematopoietic progenitors in early mouse development
    Toshiyuki Yamane
    Department of Pathology, Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 106:8953-8. 2009
    ..These data suggest that AA4.1 is a cell surface marker that can identify the earliest lymphohematopoietic progenitors in mouse development...
  50. ncbi request reprint Developmental plasticity of lymphoid progenitors
    Susan S Prohaska
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Semin Immunol 14:377-84. 2002
    ....
  51. doi request reprint Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis
    Stanley J Tamaki
    StemCells, Inc, Palo Alto, CA 94304, USA
    Cell Stem Cell 5:310-9. 2009
    ..These data provide the experimental basis for human clinical trials with these banked hCNS-SCns...
  52. pmc Isolation of human fetal liver progenitors and their enhanced proliferation by three-dimensional coculture with endothelial cells
    Anming Xiong
    Department of Surgery, Stanford University, Stanford, California, USA
    Tissue Eng Part A 14:995-1006. 2008
    ..This coculture methodology offers a novel coculture system that could be applied for the development of engineered liver tissues...
  53. ncbi request reprint Telomerase maintained in self-renewing tissues during serial regeneration of the urochordate Botryllus schlosseri
    Diana J Laird
    Department of Biological Sciences, Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950, USA
    Dev Biol 273:185-94. 2004
    ....
  54. pmc Hematopoietic cells maintain hematopoietic fates upon entering the brain
    Mei Massengale
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 201:1579-89. 2005
    ..These data strongly suggest that HSCs and their progeny maintain lineage fidelity in the brain and do not adopt neural cell fates with any measurable frequency...
  55. pmc Self-renewal of the long-term reconstituting subset of hematopoietic stem cells is regulated by Ikaros
    Peter Papathanasiou
    Institute of Stem Cell Biology and Regenerative Medicine, and Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Stem Cells 27:3082-92. 2009
    ....
  56. pmc Prospective isolation of human clonogenic common myeloid progenitors
    Markus G Manz
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:11872-7. 2002
    ..The isolation of highly purified hematopoietic intermediates provides tools to better understand developmental programs underlying normal and leukemic hematopoiesis...
  57. ncbi request reprint Wnt proteins are lipid-modified and can act as stem cell growth factors
    Karl Willert
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 423:448-52. 2003
    ..The purified Wnt3a protein induces self-renewal of haematopoietic stem cells, signifying its potential use in tissue engineering...
  58. pmc Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma
    Michelle Monje
    Department of Neurology, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 108:4453-8. 2011
    ..Together, these findings provide a foundation for understanding the cellular and molecular origins of DIPG, and suggest that the Hh pathway represents a potential therapeutic target in this devastating pediatric tumor...
  59. pmc Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S
    Thanyaphong Na Nakorn
    Department of Pathology and Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Clin Invest 109:1579-85. 2002
    ....
  60. ncbi request reprint Replicative senescence of hematopoietic stem cells during serial transplantation: does telomere shortening play a role?
    Richard C Allsopp
    Department of Pathology, Stanford University School of Medicine, Stanford, California, CA 94305, USA
    Oncogene 21:3270-3. 2002
    ....
  61. ncbi request reprint Construction and characterization of large-insert genomic libraries (BAC and fosmid) from the Ascidian Botryllus schlosseri and initial physical mapping of a histocompatibility locus
    Anthony W De Tomaso
    Department of Pathology, Stanford University School of Medicine, Stanford CA 94305, and Hopkins Marine Station, Pacific Grove, CA 93950, USA
    Mar Biotechnol (NY) 5:103-15. 2003
    ..schlosseri genome, and the techniques adapted to make them are suitable for use on other organisms in which high molecular weight DNA is difficult to purify...
  62. pmc Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo
    Holger Karsunky
    Institute for Research in Biomedicine IRB, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    J Exp Med 198:305-13. 2003
    ....
  63. ncbi request reprint Hematopoietic stem and progenitor cells: clinical and preclinical regeneration of the hematolymphoid system
    Judith A Shizuru
    Division of Blood and Marrow Transplantation, Stanford University Medical Center, California 94305, USA
    Annu Rev Med 56:509-38. 2005
    ....
  64. pmc Human Acute Myelogenous Leukemia Stem Cells Revisited: There's More Than Meets the Eye
    Ravindra Majeti
    Department of Internal Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA Institute for Stem Cell Biology and Regenerative Medicine, Cancer Center, and Ludwig Center, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cancer Cell 19:9-10. 2011
    ..These findings have implications for therapeutic targeting of these cells...
  65. doi request reprint Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47
    Mark P Chao
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, and Ludwig Center at Stanford, Stanford, CA 94305, USA
    Sci Transl Med 2:63ra94. 2010
    ....
  66. pmc Isolation and characterization of a protochordate histocompatibility locus
    Anthony W De Tomaso
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 438:454-9. 2005
    ..This is the first non-vertebrate histocompatibility gene described, and may provide insights into the evolution of vertebrate adaptive immunity...
  67. ncbi request reprint Striving for normality: whole body regeneration through a series of abnormal generations
    Ayelet Voskoboynik
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    FASEB J 21:1335-44. 2007
    ..It presents a powerful model for studying the specification of the same body plan by different developmental programs...
  68. pmc CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis
    Siddhartha Jaiswal
    Ludwig Center at Stanford, Stanford Cancer Center, Department of Pathology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 138:271-85. 2009
    ..We conclude that CD47 upregulation is an important mechanism that provides protection to normal HSCs during inflammation-mediated mobilization, and that leukemic progenitors co-opt this ability in order to evade macrophage killing...
  69. ncbi request reprint Langerhans cells renew in the skin throughout life under steady-state conditions
    Miriam Merad
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94304, USA
    Nat Immunol 3:1135-41. 2002
    ..These data indicate that under steady-state conditions, LCs are maintained locally, but inflammatory changes in the skin result in their replacement by blood-borne LC progenitors...
  70. ncbi request reprint A genetic determinant that specifically regulates the frequency of hematopoietic stem cells
    Sean J Morrison
    Howard Hughes Medical Institute and Departments of Internal Medicine and Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 168:635-42. 2002
    ..This suggests that to affect HSC frequencies, the product(s) of this locus likely depend on interactions with unlinked modifying loci...
  71. ncbi request reprint Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy
    Cornelis J H Pronk
    Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, BMC I13, 221 84 Lund, Sweden Immunology Unit, Institution for Experimental Medical Science, Lund University, BMC I13, 221 84 Lund, Sweden
    Cell Stem Cell 1:428-42. 2007
    ....
  72. ncbi request reprint Differential gene expression profiling of adult murine hematopoietic stem cells
    In Kyung Park
    University of Michigan, Department of Internal Medicine, Ann Arbor, USA
    Blood 99:488-98. 2002
    ..A large number of genes that were differentially expressed by enriched populations of HSCs and MPP cells were identified. These included transcription factors, signaling molecules, and previously unknown genes...
  73. pmc Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth
    Susanna Purhonen
    Academy of Finland Center of Excellence in Cancer Biology and Molecular Cancer Biology Laboratory, Molecular Cancer Biology Research Program, University of Helsinki, P O Box 63, 00014, Helsinki, Finland
    Proc Natl Acad Sci U S A 105:6620-5. 2008
    ..Endothelial differentiation is not a typical in vivo function of normal BM-derived stem cells in adults, and it has to be an extremely rare event if it occurs at all...
  74. ncbi request reprint Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells
    Richard C Allsopp
    Nat Med 9:369-71. 2003
  75. ncbi request reprint Biology of hematopoietic stem cells and progenitors: implications for clinical application
    Motonari Kondo
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Immunol 21:759-806. 2003
    ....
  76. ncbi request reprint Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    In Kyung Park
    Division of Hematology Oncology, Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 423:302-5. 2003
    ..Expression of p16Ink4a and p19Arf in normal HSCs resulted in proliferative arrest and p53-dependent cell death, respectively. Our results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs...
  77. ncbi request reprint Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation. 1982
    Eugene C Butcher
    J Immunol 175:1363-72. 2005
  78. ncbi request reprint Differential amplification of murine bipotent megakaryocytic/erythroid progenitor and precursor cells during recovery from acute and chronic erythroid stress
    Massimo Sanchez
    Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Stem Cells 24:337-48. 2006
    ..A model describing the relationship between MEP, PEM, and common myeloid progenitor cells is presented...
  79. ncbi request reprint Enforced expression of Bcl-2 restores the number of NK cells, but does not rescue the impaired development of NKT cells or intraepithelial lymphocytes, in IL-2/IL-15 receptor beta-chain-deficient mice
    Masahiro Minagawa
    Department of Dermatology, Niigata University School of Medicine, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    J Immunol 169:4153-60. 2002
    ..These results indicate an essential role of IL-2/IL-15R-mediated survival signals in the development of NK cells, but they also show that additional nonsurvival signals from IL-2/IL-15R are necessary for innate lymphocyte development...
  80. pmc Identification of a novel gene involved in asexual organogenesis in the budding ascidian Botryllus schlosseri
    Diana J Laird
    Department of Biological Sciences, Hopkins Marine Station of Stanford University, Pacific Grove, California, USA
    Dev Dyn 234:997-1005. 2005
    ..As genetic intervention in this organism has not been possible, this study establishes the use of RNAi and morpholinos in Botryllus as well as describing the knockdown phenotype of a new gene...
  81. pmc Antagonistic effect of CCAAT enhancer-binding protein-alpha and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors
    Chia Lin Hsu
    Department of Immunology, Duke University Medical Center, DUMC 3010, Research Drive, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:672-7. 2006
    ..Furthermore, complete loss of Pax5 expression triggered by up-regulation of C/EBPalpha is a critical event for lineage conversion from lymphoid to myeloid lineage in CLPs and proB cells...
  82. pmc The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation
    Catriona H M Jamieson
    Department of Medicine and Moores Cancer Center, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 103:6224-9. 2006
    ..The JAK2 V617F mutation was detectable within HSC and their progeny in PV. Moreover, the aberrant erythroid potential of PV HSC was potently inhibited with a JAK2 inhibitor, AG490...
  83. ncbi request reprint A cell-surface molecule involved in organ-specific homing of lymphocytes. 1983
    W Michael Gallatin
    J Immunol 177:5-9. 2006
  84. pmc Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells
    Marta Serafini
    Stem Cell Institute and Cancer Center and Department of Pediatrics, Division of Hematology, Oncology, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 204:129-39. 2007
    ..Because GFP+ host-derived CD45.1+ cells were not observed, fusion is not likely to account for the generation of HSCs by MAPCs...
  85. ncbi request reprint Reversal of autoimmune disease in lupus-prone New Zealand black/New Zealand white mice by nonmyeloablative transplantation of purified allogeneic hematopoietic stem cells
    Stephanie Smith-Berdan
    Cellerant Therapeutics, San Carlos, CA 94070, USA
    Blood 110:1370-8. 2007
    ..Induction of durable mixed chimerism by transplantation of purified allogeneic HSCs after nonmyeloablative conditioning has the potential to reverse symptoms of established NZBW lupus...
  86. pmc Pioneer factor interactions and unmethylated CpG dinucleotides mark silent tissue-specific enhancers in embryonic stem cells
    Jian Xu
    Howard Hughes Medical Institute, Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:12377-82. 2007
    ..The enhancer marks may therefore represent important features of the pluripotent state...
  87. ncbi request reprint Transcriptional instability is not a universal attribute of aging
    Luigi A Warren
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Aging Cell 6:775-82. 2007
    ..We conclude that large-scale regulatory destabilization is not a universal concomitant of aging, and may be of significance as an aging mechanism primarily in nonrenewing tissues...
  88. ncbi request reprint Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations
    Mathew C Easterday
    Interdepartmental Program for Neuroscience, UCLA, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Dev Biol 264:309-22. 2003
    ..Taken together, these studies identify many genes not previously associated with neural progenitor cell biology and also provide a rational scheme for stratification of microarray data for functional analysis...

Research Grants53

  1. HSC Diversity: Regulation by Clonal Selection vs Epigenetic Induction
    IRVING LERNER WEISSMAN; Fiscal Year: 2010
    ..Understanding the basis of this increased susceptibility is the first step to developing targeted therapies to prevent and/or reverse these public health issues. ..
  2. Stem Cell Lineage Selectionin Protochordate
    Irving Weissman; Fiscal Year: 2006
    ....
  3. BIOLOGY AND TRANSPLANTATION OF CLP
    Irving Weissman; Fiscal Year: 2005
    ....
  4. GENETICS OF ALLOGENEIC RECOGNITION IN A PROTOCHORDATE
    Irving Weissman; Fiscal Year: 2003
    ..We shall test the relation of 1) to 2), and hope eventually to understand how Fu/HC self/nonself recognition works, and whether it has homologues in vertebrates. ..
  5. MOLECULAR CHARACTERIZATION OF ACUTE MYELOID LEUKEMIA
    Irving Weissman; Fiscal Year: 2004
    ..Eventually, human AMLs will be screened for homologous gene defects. ..
  6. HEMATOPOIETIC STEM CELL--BIOLOGY, PRECURSORS, AND PROGEN
    Irving Weissman; Fiscal Year: 2004
    ..1, Flk2/Flt3, SCL) as well as others recently identified as being stem cell specific in their expression (e.g., a new serpin gene cloned in this laboratory). ..
  7. THYMIC LYMPHOCYTE DEVELOPMENT
    Irving Weissman; Fiscal Year: 2004
    ..abstract_text> ..
  8. Molecular Mechanisms of Protochordate Allorecognition
    Irving Weissman; Fiscal Year: 2004
    ..Given the close phylogenetic relationship between the protochordates and vertebrates, Fu/HC-based allorecognition may represent the ancestral MHC, or a completely novel innate allorecognition system. ..
  9. HOMING RECEPTOR DETERMINANTS ON HSC
    Irving Weissman; Fiscal Year: 2006
    ..abstract_text> ..
  10. BD Biosciences FACSAria Benchtop Cell Sorter
    Irving Weissman; Fiscal Year: 2006
    ..Each of the projects described herein requires multi-parameter sorting capability to fulfill one or more of its aims. Thus, we feel the request for purchase of this essential equipment is well justified. ..
  11. Cellular and molecular mechanisms of aging and regeneration in colonial chordate
    IRVING LERNER WEISSMAN; Fiscal Year: 2010
    ..Thus the Botryllus model organism is a powerful tool to elucidate the role of stem cell aging on aging and regeneration processes. ..
  12. Homing Receptor Determinants of HSC
    IRVING LERNER WEISSMAN; Fiscal Year: 2010
    ....
  13. Homing Receptor Determinants of HSC
    Irving Weissman; Fiscal Year: 2009
    ....
  14. Hematopoietic Stem Cell: Biology, Precursors, and Progeny
    Irving Weissman; Fiscal Year: 2009
    ..This concurrent examination of the purification, development and biology of HSC along with their preclinical utility is the theme that drives the basic research of this grant. ..
  15. MOLECULAR CHARACTERIZATION OF ACUTE MYELOID LEUKEMIA
    Irving Weissman; Fiscal Year: 2009
    ..It is the goal of these studies to provide further confirmation of the cancer/leukemia stem cell hypothesis, and to provide insight into the leukemogenic process and potential therapies. ..
  16. MOLECULAR CHARACTERIZATION OF ACUTE MYELOID LEUKEMIA
    Irving Weissman; Fiscal Year: 2007
    ..It is the goal of these studies to provide further confirmation of the cancer/leukemia stem cell hypothesis, and to provide insight into the leukemogenic process and potential therapies. ..
  17. STEM CELL LINEAGE SELECTION IN A PROTOCHORDATE
    Irving Weissman; Fiscal Year: 2004
    ..These experiments will serve as a prelude to develop an understanding of the phylogeny of stem cells, the genetic bases for their functions, and the eventual identification of the human homologues of these Botryllus genes. ..
  18. HOMING RECEPTOR DETERMINANTS ON HSC
    Irving Weissman; Fiscal Year: 2001
    ..Because MPB stem cells are currently used for autologous and allogeneic transplants in man, the results of these experiments could impact on clinical protocols. ..