WILLIAM WEIS

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc AlphaE-catenin regulates actin dynamics independently of cadherin-mediated cell-cell adhesion
    Jacqueline M Benjamin
    Cancer Biology Program, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 189:339-52. 2010
  2. pmc Trimeric structure of langerin
    Hadar Feinberg
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94306, USA
    J Biol Chem 285:13285-93. 2010
  3. pmc Structural basis for langerin recognition of diverse pathogen and mammalian glycans through a single binding site
    Hadar Feinberg
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA
    J Mol Biol 405:1027-39. 2011
  4. pmc Segmented helical structure of the neck region of the glycan-binding receptor DC-SIGNR
    Hadar Feinberg
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Mol Biol 394:613-20. 2009
  5. pmc Structural insights into G-protein-coupled receptor activation
    William I Weis
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, USA
    Curr Opin Struct Biol 18:734-40. 2008
  6. pmc Re-solving the cadherin-catenin-actin conundrum
    William I Weis
    Department of Structural Biology, Stanford University, Stanford, California 94305, USA
    J Biol Chem 281:35593-7. 2006
  7. pmc Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly
    Frauke Drees
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 123:903-15. 2005
  8. pmc Deconstructing the cadherin-catenin-actin complex
    Soichiro Yamada
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 123:889-901. 2005
  9. pmc Catenins: playing both sides of the synapse
    Adam V Kwiatkowski
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, United States
    Curr Opin Cell Biol 19:551-6. 2007
  10. pmc Biochemical and structural analysis of alpha-catenin in cell-cell contacts
    Sabine Pokutta
    Department of Structural Biology, D100 Fairchild Science Building, Stanford University School of Medicine, Stanford, CA 94305 5126, U S A
    Biochem Soc Trans 36:141-7. 2008

Research Grants

Collaborators

  • WILLIAM J NELSON
  • B K Kobilka
  • Maureen E Taylor
  • Soichiro Yamada
  • Kurt Drickamer
  • AXEL BRUNGER
  • Tatyana Svitkina
  • Leonardo Pardo
  • Yoshimi Takai
  • Changsong Yang
  • Daniel A Mitchell
  • G F Schertler
  • KATHLEEN JANEE GREEN
  • Venkata R P Ratnala
  • Hadar Feinberg
  • Hee Jung Choi
  • Sabine Pokutta
  • Adam V Kwiatkowski
  • Søren G F Rasmussen
  • Tong Sun Kobilka
  • Daniel M Rosenbaum
  • Jacqueline M Benjamin
  • Frauke Drees
  • Danette L Daniels
  • Foon Sun Thian
  • Douglas A Hattendorf
  • Jason M Davies
  • Yuan Guo
  • Michael P Bokoch
  • Juan Jose Fung
  • Pawel Burkhardt
  • Peter W Day
  • Xiao Jie Yao
  • Zsuzsa A Hamburger
  • Tracie Y Hudson
  • Nam Chul Ha
  • Shaun Park-Snyder
  • Kira M S Misura
  • Kenneth K S Ng
  • Yuriy A Knirel
  • Sarah A Graham
  • Ryan McBride
  • Nahid Razi
  • Yaozhong Zou
  • Alex S Powlesland
  • Jeff Hardin
  • R Scott Prosser
  • Joseph D Puglisi
  • Rie Nygaard
  • Allison M Lynch
  • Farida Korobova
  • Corey W Liu
  • Stephanie L Maiden
  • Luciano Mueller
  • Cynthia K W Tso
  • Julia C Gross
  • Dirk Fasshauer
  • Raymond C Stevens
  • Charles Parnot
  • Manfred Burghammer
  • Robert F Fischetti
  • Patrick J Brennwald
  • Patricia C Edwards
  • Akanksha Gangar
  • Asna Masood
  • Michael A Hanson
  • Riccardo Castelli
  • Ruslan Sanishvili
  • Peter H Seeberger
  • Anna Andreeva
  • Vadim Cherezov
  • Daniel K Rohrer
  • Agnes E Hamburger
  • Anthony P West
  • Andrew H Huber
  • Richard Alvarez
  • Arthur C Huen
  • Luca Borradori
  • Lionel Fontao
  • Jennifer L Stamos
  • Edward Conroy
  • Takashi Tonozuka
  • Lisa M Godsel
  • Ola Blixt
  • Joost C M Uitdehaag
  • Russell Wallis
  • Anand R Kolatkar
  • Damon A Clark
  • Lauren T Pascoe
  • Lino C Gonzalez

Detail Information

Publications40

  1. pmc AlphaE-catenin regulates actin dynamics independently of cadherin-mediated cell-cell adhesion
    Jacqueline M Benjamin
    Cancer Biology Program, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 189:339-52. 2010
    ..In contrast, sequestration of cytosolic alphaE-catenin to the plasma membrane reduces membrane dynamics. These results demonstrate that the cytosolic pool of alphaE-catenin regulates actin dynamics independently of cell-cell adhesion...
  2. pmc Trimeric structure of langerin
    Hadar Feinberg
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94306, USA
    J Biol Chem 285:13285-93. 2010
    ..The fixed orientation of the sugar-binding sites in the trimer is likely to place constraints on the ligands that can be bound by langerin...
  3. pmc Structural basis for langerin recognition of diverse pathogen and mammalian glycans through a single binding site
    Hadar Feinberg
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA
    J Mol Biol 405:1027-39. 2011
    ..Salt bridges between the sulfate group and two lysine residues appear to compensate for the nonoptimal binding of galactose at this site...
  4. pmc Segmented helical structure of the neck region of the glycan-binding receptor DC-SIGNR
    Hadar Feinberg
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Mol Biol 394:613-20. 2009
    ..The organization of the neck suggests how CRDs may be disposed differently in DC-SIGN compared with DC-SIGNR and in variant forms of DC-SIGNR assembled from polypeptides with different numbers of repeats in the neck domain...
  5. pmc Structural insights into G-protein-coupled receptor activation
    William I Weis
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, USA
    Curr Opin Struct Biol 18:734-40. 2008
    ..Crystallographic and spectroscopic studies of the visual pigment rhodopsin and two beta-adrenergic receptors have defined some of the conformational changes associated with activation...
  6. pmc Re-solving the cadherin-catenin-actin conundrum
    William I Weis
    Department of Structural Biology, Stanford University, Stanford, California 94305, USA
    J Biol Chem 281:35593-7. 2006
  7. pmc Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly
    Frauke Drees
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 123:903-15. 2005
    ..These results indicate a new role for alpha-catenin in local regulation of actin assembly and organization at sites of cadherin-mediated cell-cell adhesion...
  8. pmc Deconstructing the cadherin-catenin-actin complex
    Soichiro Yamada
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 123:889-901. 2005
    ..These results suggest that the linkage between the cadherin-catenin complex and actin filaments is more dynamic than previously appreciated...
  9. pmc Catenins: playing both sides of the synapse
    Adam V Kwiatkowski
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, United States
    Curr Opin Cell Biol 19:551-6. 2007
    ..Here we review the role of catenins in regulating the development of pre- and postsynaptic compartments and function in synaptic plasticity, with particular focus on their role in regulating the actin cytoskeleton...
  10. pmc Biochemical and structural analysis of alpha-catenin in cell-cell contacts
    Sabine Pokutta
    Department of Structural Biology, D100 Fairchild Science Building, Stanford University School of Medicine, Stanford, CA 94305 5126, U S A
    Biochem Soc Trans 36:141-7. 2008
    ..Thus alpha-catenin appears to play a central role in cell-cell contact formation...
  11. pmc X-ray structure determination at low resolution
    Axel T Brunger
    Howard Hughes Medical Institute, Stanford University, USA
    Acta Crystallogr D Biol Crystallogr 65:128-33. 2009
    ..It is concluded that de novo model building is problematic at low resolution and refinement should start from high-resolution crystal structures whenever possible...
  12. ncbi request reprint The cytoplasmic face of cell contact sites
    Sabine Pokutta
    Department of Structural Biology, Stanford University School of Medicine, 299 Campus Drive West, Stanford, California 94305, USA
    Curr Opin Struct Biol 12:255-62. 2002
    ....
  13. pmc In vitro and in vivo reconstitution of the cadherin-catenin-actin complex from Caenorhabditis elegans
    Adam V Kwiatkowski
    Department of Biology, Stanford University, 318 Campus Drive, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:14591-6. 2010
    ..Our study defines evolutionarily conserved properties of alpha-catenin and suggests that multiple mechanisms regulate alpha-catenin binding to F-actin...
  14. ncbi request reprint Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation
    Nam Chul Ha
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94043, USA
    Mol Cell 15:511-21. 2004
    ..Phosphorylated APC and axin bind to the same surface of, and compete directly for, beta-catenin. The structural and biochemical data suggest a novel model for how APC functions in beta-catenin degradation...
  15. pmc Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2
    Hadar Feinberg
    Departments of Structural Biology and of Molecular and Cellular Physiology, Stanford University School of Medicine, 299 Campus Drive West, CA 94305 5126, USA
    EMBO J 22:2348-59. 2003
    ..A model of the full six-domain structure and its interaction with MBPs suggests mechanisms by which binding to a target cell transmits conformational changes from MBP to MASP that allow activation of its protease activity...
  16. ncbi request reprint ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules
    Danette L Daniels
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cell 10:573-84. 2002
    ..The C-terminal armadillo repeats of beta-catenin may be an attractive target for compounds designed to disrupt aberrant beta-catenin-mediated transcription associated with various cancers...
  17. pmc Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes
    Hee Jung Choi
    Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305 5126, USA
    J Biol Chem 284:31776-88. 2009
    ..Using purified proteins, we show that desmosomal cadherins and alpha-catenin compete directly for binding to plakoglobin, consistent with the absence of alpha-catenin in desmosomes...
  18. ncbi request reprint Crystal structure of the human beta2 adrenergic G-protein-coupled receptor
    Søren G F Rasmussen
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, Palo Alto, California 94305, USA
    Nature 450:383-7. 2007
    ..These differences may be responsible for the relatively high basal activity and structural instability of the beta2AR, and contribute to the challenges in obtaining diffraction-quality crystals of non-rhodopsin GPCRs...
  19. ncbi request reprint A monoclonal antibody for G protein-coupled receptor crystallography
    Peter W Day
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, Palo Alto, California 94305, USA
    Nat Methods 4:927-9. 2007
    ..We describe the generation of a monoclonal antibody that recognizes the third intracellular loop (IL3) of the native human beta(2) adrenergic (beta(2)AR) receptor; this antibody was critical for acquiring diffraction-quality crystals...
  20. doi request reprint Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change
    Jason M Davies
    Department of Structural Biology, Stanford University, Stanford, CA 94305 5432, USA
    Structure 16:715-26. 2008
    ....
  21. ncbi request reprint Structure and mechanism of cadherins and catenins in cell-cell contacts
    Sabine Pokutta
    Department of Structural Biology and Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Annu Rev Cell Dev Biol 23:237-61. 2007
    ....
  22. pmc Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis(x) by a novel mechanism
    Hadar Feinberg
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94306, USA
    J Biol Chem 282:17250-8. 2007
    ..Crystals of the human receptor lacking bound calcium ions reveal an alternative conformation in which a glycan ligand would be released during receptor-mediated endocytosis...
  23. ncbi request reprint Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure
    Hee Jung Choi
    Department of Structural Biology, Stanford University School of Medicine, 299 Campus Drive West, Stanford, California 94305, USA
    Nat Struct Biol 9:612-20. 2002
    ..In contrast to the elongated structures formed by other kinds of repeat motifs, the plakin repeats form a globular structure with a unique fold. A conserved basic groove found on the domain may represent an IF-binding site...
  24. ncbi request reprint Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation
    Danette L Daniels
    Department of Structural Biology, Stanford University School of Medicine, Stanford University School of Medicine, 299 Campus Drive West, Stanford, California 94305 5126, USA
    Nat Struct Mol Biol 12:364-71. 2005
    ....
  25. ncbi request reprint Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity
    Hee Jung Choi
    Department of Structural Biology, Stanford University School of Medicine, CA 94305 5126, USA
    J Biol Chem 281:1027-38. 2006
    ..However, the beta-catenin C-terminal tail was found to decrease the affinity for the weaker ligands APC and axin, suggesting that this region may have a regulatory role in beta-catenin degradation...
  26. pmc Three-dimensional structure of the amino-terminal domain of syntaxin 6, a SNAP-25 C homolog
    Kira M S Misura
    Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305
    Proc Natl Acad Sci U S A 99:9184-9. 2002
    ....
  27. pmc Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin
    Sabine Pokutta
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 277:18868-74. 2002
    ..alpha-Catenin and the actin-binding protein vinculin share sequence and most likely structural similarity within their actin-binding domains. Despite this homology, actin binding requires additional sequences adjacent to this region...
  28. ncbi request reprint Crystal structure of the S.cerevisiae exocyst component Exo70p
    Zsuzsa A Hamburger
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305 5126, USA
    J Mol Biol 356:9-21. 2006
    ..The structure provides a first view of the Exo70 protein family and provides a framework to study the molecular function of this exocyst component...
  29. pmc Multiple modes of binding enhance the affinity of DC-SIGN for high mannose N-linked glycans found on viral glycoproteins
    Hadar Feinberg
    Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 282:4202-9. 2007
    ....
  30. ncbi request reprint Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism
    Douglas A Hattendorf
    Department of Structural Biology, Stanford University School of Medicine, 299 Campus Drive West, Stanford, California 94305 5126, USA
    Nature 446:567-71. 2007
    ..Sequence alignments indicate that lethal giant larvae and tomosyn have a two-beta-propeller fold similar to that of Sro7, but only tomosyn appears to retain the regulatory tail...
  31. ncbi request reprint Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR
    Hadar Feinberg
    Departments of Structural Biology and of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 280:1327-35. 2005
    ....
  32. pmc Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
    Michael P Bokoch
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 463:108-12. 2010
    ..Moreover, these studies provide a new insight into the dynamic behaviour of GPCRs not addressable by static, inactive-state crystal structures...
  33. ncbi request reprint Orientation of bound ligands in mannose-binding proteins. Implications for multivalent ligand recognition
    Kenneth K S Ng
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 277:16088-95. 2002
    ..A lateral association of trimers in the cross-linked crystals may reflect interactions within higher oligomers of MBP-A that are stabilized by multivalent ligands...
  34. ncbi request reprint Structure of the armadillo repeat domain of plakophilin 1
    Hee Jung Choi
    Department of Structural Biology, Stanford University School of Medicine, 299 Campus Drive West, Stanford, CA 94305 5126, USA
    J Mol Biol 346:367-76. 2005
    ..A prominent basic patch on the surface of the protein may serve as a binding site for partners of these proteins...
  35. ncbi request reprint GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function
    Daniel M Rosenbaum
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 318:1266-73. 2007
    ..Amino acids known to regulate receptor function are linked through packing interactions and a network of hydrogen bonds, suggesting a conformational pathway from the ligand-binding pocket to regions that interact with G proteins...
  36. ncbi request reprint Cell biology: how to build a cell junction
    William I Weis
    Nature 430:513-5. 2004
  37. ncbi request reprint Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR
    Yuan Guo
    Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
    Nat Struct Mol Biol 11:591-8. 2004
    ..Thus, whereas DC-SIGN has dual ligand-binding properties and functions both in adhesion and in endocytosis of pathogens, DC-SIGNR binds a restricted set of ligands and has only the properties of an adhesion receptor...
  38. pmc Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide
    Pawel Burkhardt
    Research Group Structural Biochemistry, Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    EMBO J 27:923-33. 2008
    ..This suggests that Munc18a controls the accessibility of syntaxin 1a to its partners, a role that might be common to all SM proteins...
  39. ncbi request reprint In vitro methods for investigating desmoplakin-intermediate filament interactions and their role in adhesive strength
    Tracie Y Hudson
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Methods Cell Biol 78:757-86. 2004

Research Grants42

  1. CATENINS, CADHERINS AND THEIR INTERACTIONS
    William I Weis; Fiscal Year: 2010
    ..This basic research project seeks to understand the molecular assemblies responsible for these processes. ..
  2. CATENINS, CADHERINS AND THEIR INTERACTIONS
    WILLIAM WEIS; Fiscal Year: 2003
    ..The structure of a ternary complex of beta-catenin, the transcription factor LEF-1, and a cognate DNA sequence will be determined. ..
  3. CELL SURFACE CARBOHYDRATE RECOGNITION BY C-TYPE LECTINS
    WILLIAM WEIS; Fiscal Year: 2003
    ..The structures of MBP/selectin chimeras that mimic the binding of selectins will be determined in complex with selectin ligands, as will the structure of an L-selectin fragment containing the lectin and EGF-like domains. ..
  4. Structural Studies of SNARE Regulation and Disassembly
    WILLIAM WEIS; Fiscal Year: 2004
    ..The conformational changes induced in NSF by ATP hydrolysis and release will be studied using a combination of small-angle x-ray scattering and crystallography. ..
  5. CATENINS, CADHERINS AND THEIR INTERACTIONS
    WILLIAM WEIS; Fiscal Year: 2004
    ..The structure of a ternary complex of beta-catenin, the transcription factor LEF-1, and a cognate DNA sequence will be determined. ..
  6. CELL SURFACE CARBOHYDRATE RECOGNITION BY C-TYPE LECTINS
    WILLIAM WEIS; Fiscal Year: 2004
    ..The structures of strongly binding peptides bound to DC-SIGN will be determined. ..
  7. Structural Studies of SNARE Regulation and Disassembly
    WILLIAM WEIS; Fiscal Year: 2005
    ..The conformational changes induced in NSF by ATP hydrolysis and release will be studied using a combination of small-angle x-ray scattering and crystallography. ..
  8. CATENINS, CADHERINS AND THEIR INTERACTIONS
    WILLIAM WEIS; Fiscal Year: 2005
    ..4. The higher-order transcriptional assemblies of beta-catenin will be examined, as well as the molecular mechanism by which beta-catenin changes Tcf/Lef-family transcription factors from co-repressors to co-activators. ..
  9. CELL SURFACE CARBOHYDRATE RECOGNITION BY C-TYPE LECTINS
    WILLIAM WEIS; Fiscal Year: 2006
    ..The structures of strongly binding peptides bound to DC-SIGN will be determined. ..
  10. CATENINS, CADHERINS AND THEIR INTERACTIONS
    WILLIAM WEIS; Fiscal Year: 2006
    ..4. The higher-order transcriptional assemblies of beta-catenin will be examined, as well as the molecular mechanism by which beta-catenin changes Tcf/Lef-family transcription factors from co-repressors to co-activators. ..
  11. MOLECULAR BIOPHYSICS TRAINING PROGRAM
    WILLIAM WEIS; Fiscal Year: 2007
    ....
  12. Biochemical and structural basis of regulated snare assembly and disassembly
    WILLIAM WEIS; Fiscal Year: 2007
    ..The conformational changes produced by nucleotide hydrolysis by NSF and the related ATPase p97 will be investigated by small-angle x-ray scattering and x-ray crystallography. ..
  13. Biochemical and structural basis of regulated snare assembly and disassembly
    WILLIAM WEIS; Fiscal Year: 2009
    ..The conformational changes produced by nucleotide hydrolysis by NSF and the related ATPase p97 will be investigated by small-angle x-ray scattering and x-ray crystallography. ..
  14. CATENINS, CADHERINS AND THEIR INTERACTIONS
    WILLIAM WEIS; Fiscal Year: 2009
    ..This basic research project seeks to understand the molecular assemblies responsible for these processes. ..
  15. Biochemical and structural basis of regulated snare assembly and disassembly
    William I Weis; Fiscal Year: 2010
    ..The conformational changes produced by nucleotide hydrolysis by NSF and the related ATPase p97 will be investigated by small-angle x-ray scattering and x-ray crystallography. ..
  16. Structural Studies of SNARE Regulation and Disassembly
    WILLIAM WEIS; Fiscal Year: 2003
    ..The conformational changes induced in NSF by ATP hydrolysis and release will be studied using a combination of small-angle x-ray scattering and crystallography. ..
  17. Structural Studies of SNARE Regulation and Disassembly
    WILLIAM WEIS; Fiscal Year: 2002
    ..The conformational changes induced in NSF by ATP hydrolysis and release will be studied using a combination of small-angle x-ray scattering and crystallography. ..
  18. CELL SURFACE CARBOHYDRATE RECOGNITION BY C-TYPE LECTINS
    WILLIAM WEIS; Fiscal Year: 1999
    ..The structures of MBP/selectin chimeras that mimic the binding of selectins will be determined in complex with selectin ligands, as will the structure of an L-selectin fragment containing the lectin and EGF-like domains. ..
  19. STRUCTURAL STUDIES OF SYNTAXIN AND ITS INTERACTIONS
    WILLIAM WEIS; Fiscal Year: 1999
    ....
  20. CELL SURFACE CARBOHYDRATE RECOGNITION BY C-TYPE LECTINS
    WILLIAM WEIS; Fiscal Year: 2000
    ..The structures of MBP/selectin chimeras that mimic the binding of selectins will be determined in complex with selectin ligands, as will the structure of an L-selectin fragment containing the lectin and EGF-like domains. ..
  21. CELL SURFACE CARBOHYDRATE RECOGNITION BY C-TYPE LECTINS
    WILLIAM WEIS; Fiscal Year: 2001
    ..The structures of MBP/selectin chimeras that mimic the binding of selectins will be determined in complex with selectin ligands, as will the structure of an L-selectin fragment containing the lectin and EGF-like domains. ..
  22. CATENINS, CADHERINS AND THEIR INTERACTIONS
    WILLIAM WEIS; Fiscal Year: 2000
    ....
  23. CATENINS, CADHERINS AND THEIR INTERACTIONS
    WILLIAM WEIS; Fiscal Year: 2002
    ..The structure of a ternary complex of beta-catenin, the transcription factor LEF-1, and a cognate DNA sequence will be determined. ..
  24. CELL SURFACE CARBOHYDRATE RECOGNITION BY C-TYPE LECTINS
    WILLIAM WEIS; Fiscal Year: 2003
    ..The structures of strongly binding peptides bound to DC-SIGN will be determined. ..
  25. Structural Studies of SNARE Regulation and Disassembly
    WILLIAM WEIS; Fiscal Year: 2001
    ..The conformational changes induced in NSF by ATP hydrolysis and release will be studied using a combination of small-angle x-ray scattering and crystallography. ..
  26. CATENINS, CADHERINS AND THEIR INTERACTIONS
    WILLIAM WEIS; Fiscal Year: 2001
    ..The structure of a ternary complex of beta-catenin, the transcription factor LEF-1, and a cognate DNA sequence will be determined. ..
  27. CELL SURFACE CARBOHYDRATE RECOGNITION BY C-TYPE LECTINS
    WILLIAM WEIS; Fiscal Year: 2002
    ..The structures of MBP/selectin chimeras that mimic the binding of selectins will be determined in complex with selectin ligands, as will the structure of an L-selectin fragment containing the lectin and EGF-like domains. ..
  28. CATENINS, CADHERINS AND THEIR INTERACTIONS
    WILLIAM WEIS; Fiscal Year: 1999
    ....
  29. STRUCTURAL STUDIES OF SYNTAXIN AND ITS INTERACTIONS
    WILLIAM WEIS; Fiscal Year: 2000
    ....
  30. CELL SURFACE CARBOHYDRATE RECOGNITION BY C-TYPE LECTINS
    WILLIAM WEIS; Fiscal Year: 2005
    ..The structures of strongly binding peptides bound to DC-SIGN will be determined. ..
  31. CATENINS, CADHERINS AND THEIR INTERACTIONS
    WILLIAM WEIS; Fiscal Year: 2007
    ..4. The higher-order transcriptional assemblies of beta-catenin will be examined, as well as the molecular mechanism by which beta-catenin changes Tcf/Lef-family transcription factors from co-repressors to co-activators. ..
  32. CATENINS, CADHERINS AND THEIR INTERACTIONS
    William I Weis; Fiscal Year: 2010
    ..This basic research project seeks to understand the molecular assemblies responsible for these processes. ..