W I Weis

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Cell-surface carbohydrate recognition by animal and viral lectins
    W I Weis
    Department of Structural Biology, Stanford University School of Medicine, CA 94305, USA
    Curr Opin Struct Biol 7:624-30. 1997
  2. ncbi request reprint The C-type lectin superfamily in the immune system
    W I Weis
    Department of Structural Biology, Stanford University School of Medicine, California, USA
    Immunol Rev 163:19-34. 1998
  3. ncbi request reprint Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR
    H Feinberg
    Department of Structural Biology, University School of Medicine, Stanford, CA 94305, USA
    Science 294:2163-6. 2001
  4. ncbi request reprint Self-association of the H3 region of syntaxin 1A. Implications for intermediates in SNARE complex assembly
    K M Misura
    Department of Structural Biology, The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 276:13273-82. 2001
  5. ncbi request reprint The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin
    A H Huber
    Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 105:391-402. 2001
  6. pmc Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex
    K Eklof Spink
    Departments of Structural Biology and of Molecular and Cellular Physiology, Stanford University School of Medicine, 299 Campus Dr West Stanford, CA 94305, USA
    EMBO J 20:6203-12. 2001
  7. ncbi request reprint Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor
    H Feinberg
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 275:21539-48. 2000
  8. ncbi request reprint Crystal structure and biophysical properties of a complex between the N-terminal SNARE region of SNAP25 and syntaxin 1a
    K M Misura
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305 5126, USA
    J Biol Chem 276:41301-9. 2001
  9. ncbi request reprint Ca2+-dependent structural changes in C-type mannose-binding proteins
    K K Ng
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    Biochemistry 37:17965-76. 1998
  10. ncbi request reprint A novel snare N-terminal domain revealed by the crystal structure of Sec22b
    L C Gonzalez
    Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute and the Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 276:24203-11. 2001

Collaborators

  • K Drickamer
  • W J Nelson
  • P Polakis
  • D V Laurents
  • K M Misura
  • A H Huber
  • K K Ng
  • R H Scheller
  • H Feinberg
  • K Eklof Spink
  • L C Gonzalez
  • D L Daniels
  • K E Spink
  • S Pokutta
  • S Park-Snyder
  • A P May
  • D B Stewart
  • S G Fridman
  • D A Mitchell
  • M E Taylor
  • A R Kolatkar
  • C T Heise

Detail Information

Publications21

  1. ncbi request reprint Cell-surface carbohydrate recognition by animal and viral lectins
    W I Weis
    Department of Structural Biology, Stanford University School of Medicine, CA 94305, USA
    Curr Opin Struct Biol 7:624-30. 1997
    ..Recent crystal structures of complexes between these proteins and receptor fragments have provided insights into the recognition of linkage isomers and oligosaccharide conformation...
  2. ncbi request reprint The C-type lectin superfamily in the immune system
    W I Weis
    Department of Structural Biology, Stanford University School of Medicine, California, USA
    Immunol Rev 163:19-34. 1998
    ....
  3. ncbi request reprint Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR
    H Feinberg
    Department of Structural Biology, University School of Medicine, Stanford, CA 94305, USA
    Science 294:2163-6. 2001
    ....
  4. ncbi request reprint Self-association of the H3 region of syntaxin 1A. Implications for intermediates in SNARE complex assembly
    K M Misura
    Department of Structural Biology, The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 276:13273-82. 2001
    ..These results indicate that Phe-216 has a role in preventing formation of stable parallel helical bundles, thus favoring the interaction of the H3 region of syntaxin 1a with other proteins involved in membrane fusion...
  5. ncbi request reprint The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin
    A H Huber
    Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 105:391-402. 2001
    ..APC contains sequences homologous to the phosphorylated region of cadherin, and is likely to bind similarly...
  6. pmc Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex
    K Eklof Spink
    Departments of Structural Biology and of Molecular and Cellular Physiology, Stanford University School of Medicine, 299 Campus Dr West Stanford, CA 94305, USA
    EMBO J 20:6203-12. 2001
    ....
  7. ncbi request reprint Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor
    H Feinberg
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 275:21539-48. 2000
    ..Acid pH-induced removal of this Ca(2+) results in conformational rearrangements of the receptor, rendering it unable to bind carbohydrate ligands...
  8. ncbi request reprint Crystal structure and biophysical properties of a complex between the N-terminal SNARE region of SNAP25 and syntaxin 1a
    K M Misura
    Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305 5126, USA
    J Biol Chem 276:41301-9. 2001
    ..We also demonstrate that the syn1aH3-S25N complex can be disassembled by alpha-SNAP and N-ethylmaleimide-sensitive factor...
  9. ncbi request reprint Ca2+-dependent structural changes in C-type mannose-binding proteins
    K K Ng
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    Biochemistry 37:17965-76. 1998
    ..The highly conserved nature of Ca2+ site 2 suggests that the transitions observed in MBPs are general features of Ca2+ binding in C-type lectins...
  10. ncbi request reprint A novel snare N-terminal domain revealed by the crystal structure of Sec22b
    L C Gonzalez
    Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute and the Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 276:24203-11. 2001
    ..Key residues in this site are distinct in two mammalian Sec22 variants that lack SNARE domains. Finally, sequence analysis indicates that a similar domain is likely present in the endosomal/lysosomal SNARE VAMP7...
  11. ncbi request reprint Coupling of prolyl peptide bond isomerization and Ca2+ binding in a C-type mannose-binding protein
    K K Ng
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    Biochemistry 37:17977-89. 1998
    ..The slow kinetics associated with cis-trans proline isomerization may be exploited by endocytic receptors to facilitate sorting of carbohydrate-bearing ligands from the receptor in the endosome...
  12. ncbi request reprint beta-catenin: molecular plasticity and drug design
    D L Daniels
    Dept of Structural Biology, Stanford University School of Medicine 299 Campus Dr, West Stanford, CA 94305, USA
    Trends Biochem Sci 26:672-8. 2001
    ..Recent structural and biochemical studies have probed the molecular basis of ligand interaction by beta-catenin, and highlighted the possibilities and challenges of designing inhibitors of the beta-catenin-Tcf complex...
  13. ncbi request reprint The cadherin cytoplasmic domain is unstructured in the absence of beta-catenin. A possible mechanism for regulating cadherin turnover
    A H Huber
    Departments of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 276:12301-9. 2001
    ....
  14. ncbi request reprint Structural analysis of monosaccharide recognition by rat liver mannose-binding protein
    K K Ng
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    J Biol Chem 271:663-74. 1996
    ..3 M. These structures explain how MBPs recognize a wide range of monosaccharides and suggest how fine specificity differences between MBP-A and MBP-C may be achieved...
  15. pmc Structural basis of the Axin-adenomatous polyposis coli interaction
    K E Spink
    Department of Structural Biology, Stanford University School of Medicine, 299 Campus Drive West, Stanford, CA 94305, USA
    EMBO J 19:2270-9. 2000
    ..The molecular interactions observed in the Axin-APC complex provide a rationale for the evolutionary conservation seen in both proteins...
  16. ncbi request reprint Structure of the dimerization and beta-catenin-binding region of alpha-catenin
    S Pokutta
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    Mol Cell 5:533-43. 2000
    ..The crystal structure of this chimera reveals the interaction between alpha- and beta-catenin, and provides a basis for understanding adherens junction assembly...
  17. ncbi request reprint Trimeric structure of a C-type mannose-binding protein
    W I Weis
    Department of Structural Biology, Stanford University School of Medicine, CA 94305
    Structure 2:1227-40. 1994
    ..Like most lectins, MBPs display weak intrinsic affinity for monovalent sugar ligands, but bind avidly to multivalent ligands...
  18. ncbi request reprint Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex
    K M Misura
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    Nature 404:355-62. 2000
    ..The structure also indicates mechanisms that might couple the action of upstream effector proteins to conformational changes in syntaxin 1a and nSec1 that lead to core complex formation and membrane fusion...
  19. ncbi request reprint Three-dimensional structure of the armadillo repeat region of beta-catenin
    A H Huber
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    Cell 90:871-82. 1997
    ..Although unrelated in sequence, the beta-catenin binding regions of cadherins, Tcfs, and APC are acidic and are proposed to interact with this groove...
  20. ncbi request reprint Structure of the calcium-dependent lectin domain from a rat mannose-binding protein determined by MAD phasing
    W I Weis
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032
    Science 254:1608-15. 1991
    ..The strong anomalous scattering observed at the Ho LIII edge demonstrates that traditional heavy atom complexes will be generally amenable to the MAD phasing method...
  21. ncbi request reprint Structure of a C-type mannose-binding protein complexed with an oligosaccharide
    W I Weis
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032
    Nature 360:127-34. 1992
    ..Two branches of the oligosaccharide crosslink neighbouring carbohydrate-recognition domains in the crystal, enabling multivalent binding to a single oligosaccharide chain to be visualized directly...