Wei Wei

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin
    Wei Wei
    Asian Liver Center, Department of Surgery, 1201 Welch Road, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cancer 10:16. 2011
  2. pmc Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells
    Wei Wei
    Asian Liver Center, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cancer 8:76. 2009
  3. doi request reprint Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo
    Wei Wei
    Asian Liver Center, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305 5655, USA
    Int J Cancer 126:2426-36. 2010
  4. ncbi request reprint Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression
    Moin U Fareed
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1589-97. 2006
  5. ncbi request reprint Degradation of C/EBPbeta in cultured myotubes is calpain-dependent
    Wei Wei
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Cell Physiol 208:386-98. 2006
  6. ncbi request reprint Role of glucocorticoids in the molecular regulation of muscle wasting
    Michael Menconi
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Crit Care Med 35:S602-8. 2007
  7. ncbi request reprint Treatment of cultured myotubes with the proteasome inhibitor beta-lactone increases the expression of the transcription factor C/EBPbeta
    Wei Wei
    Department of Surgery, Beth Israel Deaconess Medical Center, 330 Brookline Avenue ST 919, Boston, MA 02215, USA
    Am J Physiol Cell Physiol 292:C216-26. 2007
  8. ncbi request reprint The gene expression and activity of calpains and the muscle wasting-associated ubiquitin ligases, atrogin-1 and MuRF1, are not altered in patients with primary hyperparathyroidism
    Amy Evenson
    Section of Endocrine Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Mol Med 18:471-5. 2006
  9. ncbi request reprint Dexamethasone-induced protein degradation in cultured myotubes is p300/HAT dependent
    Hongmei Yang
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Physiol Regul Integr Comp Physiol 292:R337-4. 2007
  10. ncbi request reprint Expression and activity of C/EBPbeta and delta are upregulated by dexamethasone in skeletal muscle
    Hongmei Yang
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Cell Physiol 204:219-26. 2005

Collaborators

Detail Information

Publications15

  1. pmc Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin
    Wei Wei
    Asian Liver Center, Department of Surgery, 1201 Welch Road, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cancer 10:16. 2011
    ..Recent studies have identified the Frizzled-7 receptor (FZD7), important for activation of Wnt-mediated signaling, as a potential therapeutic target for HCC and other cancers...
  2. pmc Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells
    Wei Wei
    Asian Liver Center, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cancer 8:76. 2009
    ..Since the Wnt/beta-catenin pathway is essential in HCC carcinogenesis, we studied the inhibition of Wnt-1-mediated signaling as a potential molecular target in HCC...
  3. doi request reprint Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo
    Wei Wei
    Asian Liver Center, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305 5655, USA
    Int J Cancer 126:2426-36. 2010
    ..Our results suggest that these 3 antagonists of the Tcf4/beta-catenin complex are potential chemotherapeutic agents which may offer a pathway specific option for the clinical management of HCC...
  4. ncbi request reprint Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression
    Moin U Fareed
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1589-97. 2006
    ..The present results suggest that treatment with calpain inhibitors may prevent sepsis-induced muscle wasting...
  5. ncbi request reprint Degradation of C/EBPbeta in cultured myotubes is calpain-dependent
    Wei Wei
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Cell Physiol 208:386-98. 2006
    ..The present results suggest that C/EBPbeta is degraded by a calpain-dependent mechanism in skeletal muscle cells and that the role of calpains is specific for C/EBPbeta among different members of the C/EBP transcription factor family...
  6. ncbi request reprint Role of glucocorticoids in the molecular regulation of muscle wasting
    Michael Menconi
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Crit Care Med 35:S602-8. 2007
    ..To review glucocorticoid-regulated molecular mechanisms of muscle wasting...
  7. ncbi request reprint Treatment of cultured myotubes with the proteasome inhibitor beta-lactone increases the expression of the transcription factor C/EBPbeta
    Wei Wei
    Department of Surgery, Beth Israel Deaconess Medical Center, 330 Brookline Avenue ST 919, Boston, MA 02215, USA
    Am J Physiol Cell Physiol 292:C216-26. 2007
    ..The observations are important because they increase the understanding of the complex regulation of the expression and activity of C/EBPbeta in skeletal muscle...
  8. ncbi request reprint The gene expression and activity of calpains and the muscle wasting-associated ubiquitin ligases, atrogin-1 and MuRF1, are not altered in patients with primary hyperparathyroidism
    Amy Evenson
    Section of Endocrine Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Mol Med 18:471-5. 2006
    ..The results suggest that the ubiquitin-proteasome and calpain systems are not activated in skeletal muscle in patients with primary HPT, at least not in patients with moderate hypercalcemia...
  9. ncbi request reprint Dexamethasone-induced protein degradation in cultured myotubes is p300/HAT dependent
    Hongmei Yang
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Physiol Regul Integr Comp Physiol 292:R337-4. 2007
    ..The results also provide evidence that dexamethasone-induced protein degradation in cultured myotubes is, at least in part, regulated by p300/HAT activity...
  10. ncbi request reprint Expression and activity of C/EBPbeta and delta are upregulated by dexamethasone in skeletal muscle
    Hongmei Yang
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Cell Physiol 204:219-26. 2005
    ..The results suggest that glucocorticoids increase C/EBPbeta and delta activity and expression through a direct effect in skeletal muscle...
  11. ncbi request reprint Novel aspects on the regulation of muscle wasting in sepsis
    Per Olof Hasselgren
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Int J Biochem Cell Biol 37:2156-68. 2005
    ....
  12. ncbi request reprint Characterization of the 5'-regulatory regions of the rat and human apelin genes and regulation of breast apelin by USF
    Guiyun Wang
    Department of Surgery, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    FASEB J 20:2639-41. 2006
    ..Together, our findings show that USF exerts a stimulatory role in regulation of breast apelin expression during pregnancy and lactation...
  13. pmc DNA polymerase beta-catalyzed-PCNA independent long patch base excision repair synthesis: a mechanism for repair of oxidatively damaged DNA ends in post-mitotic brain
    Wei Wei
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77555 1220, USA
    J Neurochem 107:734-44. 2008
    ..The differences highlight the physiological relevance of the recently proposed 'Hit and Run' mechanism of alternating cleavage/synthesis steps, in the proliferating cell nuclear antigen-independent LP-BER process...
  14. ncbi request reprint Dexamethasone upregulates the expression of the nuclear cofactor p300 and its interaction with C/EBPbeta in cultured myotubes
    Hongmei Yang
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Cell Biochem 94:1058-67. 2005
    ..Increased expression and activity of p300 may be involved in the regulation of gene transcription in glucocorticoid-dependent muscle wasting...
  15. ncbi request reprint Vasorelaxation induced by vascular endothelial growth factor in the human internal mammary artery and radial artery
    Wei Wei
    Providence Heart and Vascular Institute, Starr Academic Center, Department of Surgery, Oregon Health and Science University, Portland, OR, USA
    Vascul Pharmacol 46:253-9. 2007
    ..The role of nitric oxide (NO), prostacyclin (PGI2), and endothelium-derived hyperpolarizing factor (EDHF) was investigated...