Research Topics
Genomes and GenesSpecies | Irene WapnirSummaryAffiliation: Stanford University Country: USA Publications
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Publications
Immunohistochemical profile of the sodium/iodide symporter in thyroid, breast, and other carcinomas using high density tissue microarrays and conventional sectionsIrene L Wapnir
Department of Surgery, Stanford University School of Medicine, Stanford, California 94305 5655, USA
J Clin Endocrinol Metab 88:1880-8. 2003..Elucidating the regulatory mechanisms that render NIS functional in extrathyroidal carcinomas may make (131)I therapy feasible...
New models and online calculator for predicting non-sentinel lymph node status in sentinel lymph node positive breast cancer patientsHolbrook E Kohrt
Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
BMC Cancer 8:66. 2008..Our goal was to develop new models to quantify the risk of NSLN metastasis in SLN-positive patients and to compare predictive capabilities to another widely used model...
Expression of the Na+/I- symporter (NIS) is markedly decreased or absent in gastric cancer and intestinal metaplastic mucosa of Barrett esophagusAron Altorjay
Department of Surgery, St George University Teaching Hospital H 8000 Székesfehérvár, Hungary
BMC Cancer 7:5. 2007..Whereas NIS expression and regulation have been extensively investigated in healthy and neoplastic thyroid and breast tissues, little is known about NIS expression and function along the healthy and diseased gastrointestinal tract...- Long-term outcomes of invasive ipsilateral breast tumor recurrences after lumpectomy in NSABP B-17 and B-24 randomized clinical trials for DCISIrene L Wapnir
Department of Surgery 300 Pasteur Dr H3625, Stanford University School of Medicine, Stanford, CA 94305 5655
J Natl Cancer Inst 103:478-88. 2011..We evaluated invasive IBTR (I-IBTR) and its influence on survival among participants in two National Surgical Adjuvant Breast and Bowel Project (NSABP) randomized trials for DCIS... - Leiomyosarcoma of the breast in a patient with a 10-year-history of cyclophosphamide exposure: a case reportJennifer De la Pena
300 Pasteur Dr, H3625 Stanford, CA 94305, USA
Cases J 1:301. 2008..Ultrasound guided core biopsy revealed a spindle cell neoplasm characterized on final pathology as a low grade leiomyosarcoma... - Progress on BIG 1-02/IBCSG 27-02/NSABP B-37, a prospective randomized trial evaluating chemotherapy after local therapy for isolated locoregional recurrences of breast cancerIrene L Wapnir
National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistics Center, Pittsburgh, PA, USA
Ann Surg Oncol 15:3227-31. 2008.... 
A randomized clinical trial of adjuvant chemotherapy for radically resected locoregional relapse of breast cancer: IBCSG 27-02, BIG 1-02, and NSABP B-37Irene L Wapnir
National Surgical Adjuvant Breast and Bowel Project Operations Office and Biostatistical Center, Pittsburgh, PA, USA
Clin Breast Cancer 8:287-92. 2008..Although multidrug regimens are preferred, the agents, doses, and use of supportive therapy are at the discretion of the investigator...- The Na+/I- symporter mediates iodide uptake in breast cancer metastases and can be selectively down-regulated in the thyroidIrene L Wapnir
Department of Surgery, Stanford University School of Medicine, Stanford, California, USA
Clin Cancer Res 10:4294-302. 2004..Breast cancer is the only other cancer demonstrating endogenous functional NIS expression. Until now, NIS activity in breast cancer metastases (BCM) was unproven... - Prognosis after ipsilateral breast tumor recurrence and locoregional recurrences in five National Surgical Adjuvant Breast and Bowel Project node-positive adjuvant breast cancer trialsIrene L Wapnir
National Surgical Adjuvant Breast and Bowel Project Operations Office and Biostatistical Center, Pittsburgh, PA, USA
J Clin Oncol 24:2028-37. 2006..Locoregional failure after breast-conserving surgery is associated with increased risk of distant disease and death. The magnitude of this risk in patients receiving chemotherapy has not been adequately characterized... - Prognosis after ipsilateral breast tumor recurrence and locoregional recurrences in patients treated by breast-conserving therapy in five National Surgical Adjuvant Breast and Bowel Project protocols of node-negative breast cancerStewart J Anderson
Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
J Clin Oncol 27:2466-73. 2009..Locoregional failure (LRF) after breast-conserving therapy (BCT) is associated with increased risk of distant disease and death. The magnitude of this risk has not been adequately characterized in patients with lymph node-negative disease... - Breast cancer brain metastases express the sodium iodide symporterCorinne Renier
Department of Surgery, Stanford University School of Medicine, 300 Pasteur Drive H 3625, Stanford, CA 94305 5655, USA
J Neurooncol 96:331-6. 2010..Altogether, these findings indicate that NIS expression is prevalent in breast cancer brain metastases and could have a therapeutic role via the delivery of radioactive iodide and selective ablation of tumor cells... - Endogenous NIS expression in triple-negative breast cancersCorinne Renier
Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
Ann Surg Oncol 16:962-8. 2009..Treatment of triple-negative breast cancers [estrogen/progesterone receptor-negative and HER2-negative (ER-/PR-/HER2-)] is primarily limited to chemotherapy. Our aim was to characterize NIS expression in this subset of tumors... - Timing of breast cancer treatments with oocyte retrieval and embryo cryopreservationJennifer Baynosa
Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
J Am Coll Surg 209:603-7. 2009..In this study, we compared timing of chemotherapy in women who underwent ovarian stimulation/oocyte retrieval (OR) and embryo cryopreservation with those who did not... - Bioluminescent monitoring of NIS-mediated (131)I ablative effects in MCF-7 xenograftsMalavika Ghosh
Stanford University School of Medicine, Stanford, CA 94305, USA
Mol Imaging 5:76-84. 2006..In summary, a pattern of tumor regression occurring over the first three weeks after (131)I administration was observed in NIS-expressing breast cancer xenografts... - The diagnostic value of nipple discharge cytology: breast imaging complements predictive value of nipple discharge cytologyOgori N Kalu
Department of Surgery, Stanford University Medical Center, Stanford, California, USA
J Surg Oncol 106:381-5. 2012..Papilloma is the most common finding associated with pathologic nipple discharge. In the absence of breast imaging abnormalities, the incidence of occult malignancy is <3%... - Metastases to the breast: alveolar soft part sarcoma in adolescentsAndrea Madrigrano
Department of General Surgery, Stanford University and Medical Center, CA 94305 5655, USA
Clin Breast Cancer 8:92-3. 2008..Metastases to the breast comprise 0.5%-2% of breast neoplasms. This is a case report of an 18-year-old woman with an alveolar soft part sarcoma metastatic to the breast... - Resolution of hypoalbuminemia after excision of malignant phyllodes tumorLaila Samiian
Department of Surgery, Stanford University School of Medicine, CA 94305-5655, USA
Clin Breast Cancer 7:411-2. 2006..Final pathology revealed a 22-cm malignant phyllodes tumor. Hypoalbuminemia and alkaline phosphatase quickly resolved after surgical excision without any further treatment... - Egg retrieval with cryopreservation does not delay breast cancer treatmentAndrea Madrigrano
Department of Surgery, Stanford University Medical Center, 300 Pasteur Dr, RM H3625, Stanford, CA 94305 5655, USA
Am J Surg 194:477-81. 2007..Infertility is a concern to young women diagnosed with breast cancer. Advances in fertility technology have made it possible to bank fertilized embryos...