Thomas D Wang

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Functional imaging of colonic mucosa with a fibered confocal microscope for real-time in vivo pathology
    Thomas D Wang
    Division of Gastroenterology, Stanford University School of Medicine, Stanford, California, USA
    Clin Gastroenterol Hepatol 5:1300-5. 2007
  2. pmc Dual-axis confocal microscope for high-resolution in vivo imaging
    Thomas D Wang
    Stanford University School of Medicine, 269 Campus Drive, Stanford, California 94305 5187, USA
    Opt Lett 28:414-6. 2003
  3. pmc Dual-axes confocal microscopy with post-objective scanning and low-coherence heterodyne detection
    Thomas D Wang
    Stanford University School of Medicine, Stanford, California 94305, USA
    Opt Lett 28:1915-7. 2003
  4. pmc Confocal fluorescence microscope with dual-axis architecture and biaxial postobjective scanning
    Thomas D Wang
    Stanford University School of Medicine, Stanford, California 94305, USA
    J Biomed Opt 9:735-42. 2004
  5. pmc Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy
    Pei Lin Hsiung
    Department of Pediatrics, Radiology and Microbiology and Immunology, Stanford University School of Medicine, 318 Campus Dr, Rm E 150, Stanford, California 94305, USA
    Nat Med 14:454-8. 2008
  6. pmc Three-dimensional in vivo imaging by a handheld dual-axes confocal microscope
    Hyejun Ra
    Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA
    Opt Express 16:7224-32. 2008
  7. pmc In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract
    Wibool Piyawattanametha
    Stanford University, James H Clark Center for Biomedical Engineering and Sciences, Department of Pediatrics, Stanford, California 94305, USA
    J Biomed Opt 17:021102. 2012
  8. pmc Dual-axes confocal reflectance microscope for distinguishing colonic neoplasia
    Jonathan T C Liu
    Ginzton Laboratory, Stanford University, Stanford, California 94305, USA
    J Biomed Opt 11:054019. 2006
  9. pmc In vivo targeting of colonic dysplasia on fluorescence endoscopy with near-infrared octapeptide
    Zhongyao Liu
    Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA
    Gut 62:395-403. 2013
  10. doi request reprint Efficient rejection of scattered light enables deep optical sectioning in turbid media with low-numerical-aperture optics in a dual-axis confocal architecture
    Jonathan T C Liu
    Stanford University, Department of Electrical Engineering, Ginzton Laboratory, and School of Medicine, James H Clark Center for Biomedical Engineering and Science, Stanford, California 94305, USA
    J Biomed Opt 13:034020. 2008

Collaborators

Detail Information

Publications22

  1. pmc Functional imaging of colonic mucosa with a fibered confocal microscope for real-time in vivo pathology
    Thomas D Wang
    Division of Gastroenterology, Stanford University School of Medicine, Stanford, California, USA
    Clin Gastroenterol Hepatol 5:1300-5. 2007
    ..The aim of this study was to show the use of functional optical imaging of viable mucosa for quantitative evaluation of colonic neoplasia in real time...
  2. pmc Dual-axis confocal microscope for high-resolution in vivo imaging
    Thomas D Wang
    Stanford University School of Medicine, 269 Campus Drive, Stanford, California 94305 5187, USA
    Opt Lett 28:414-6. 2003
    ..3 and 2.1 microm, respectively, in free space, and confirm subcellular resolution in excised esophageal mucosa. The optics may be scaled to millimeter dimensions and fiber coupled for collection of high-resolution images in vivo...
  3. pmc Dual-axes confocal microscopy with post-objective scanning and low-coherence heterodyne detection
    Thomas D Wang
    Stanford University School of Medicine, Stanford, California 94305, USA
    Opt Lett 28:1915-7. 2003
    ..This architecture can be scaled down to millimeter dimensions with microelectromechanical systems technology for performance of in vivo optical biopsy...
  4. pmc Confocal fluorescence microscope with dual-axis architecture and biaxial postobjective scanning
    Thomas D Wang
    Stanford University School of Medicine, Stanford, California 94305, USA
    J Biomed Opt 9:735-42. 2004
    ..Furthermore, the scanning mechanism produces only small differences in aberrations over the image FOV. These results demonstrate proof of concept of the dual-axis confocal architecture for in vivo molecular and cellular imaging...
  5. pmc Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy
    Pei Lin Hsiung
    Department of Pediatrics, Radiology and Microbiology and Immunology, Stanford University School of Medicine, 318 Campus Dr, Rm E 150, Stanford, California 94305, USA
    Nat Med 14:454-8. 2008
    ..This methodology represents a promising diagnostic imaging approach for the early detection of colorectal cancer and potentially of other epithelial malignancies...
  6. pmc Three-dimensional in vivo imaging by a handheld dual-axes confocal microscope
    Hyejun Ra
    Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA
    Opt Express 16:7224-32. 2008
    ..The transverse and axial resolutions of the handheld probe are 1.7 microm and 5.8 microm, respectively. Capability to perform real time small animal imaging is demonstrated in vivo in transgenic mice...
  7. pmc In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract
    Wibool Piyawattanametha
    Stanford University, James H Clark Center for Biomedical Engineering and Sciences, Department of Pediatrics, Stanford, California 94305, USA
    J Biomed Opt 17:021102. 2012
    ..These results suggest that DAC microendoscopy may have utility for visualizing the anatomical and, perhaps, functional changes associated with colorectal pathology for the early detection of colorectal cancer...
  8. pmc Dual-axes confocal reflectance microscope for distinguishing colonic neoplasia
    Jonathan T C Liu
    Ginzton Laboratory, Stanford University, Stanford, California 94305, USA
    J Biomed Opt 11:054019. 2006
    ..This design is scalable to millimeter dimensions, and the results demonstrate the potential for a miniature instrument to detect precancerous tissues, and hence to perform in vivo histopathology...
  9. pmc In vivo targeting of colonic dysplasia on fluorescence endoscopy with near-infrared octapeptide
    Zhongyao Liu
    Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA
    Gut 62:395-403. 2013
    ..To demonstrate a near-infrared (NIR) peptide that is highly specific for colonic adenomas on fluorescence endoscopy in vivo...
  10. doi request reprint Efficient rejection of scattered light enables deep optical sectioning in turbid media with low-numerical-aperture optics in a dual-axis confocal architecture
    Jonathan T C Liu
    Stanford University, Department of Electrical Engineering, Ginzton Laboratory, and School of Medicine, James H Clark Center for Biomedical Engineering and Science, Stanford, California 94305, USA
    J Biomed Opt 13:034020. 2008
    ..Our results demonstrate efficient rejection of scattered light in a DACM, which enables deep optical sectioning in tissue with subcellular resolution that can distinguish between normal and premalignant pathologies...
  11. pmc Use of an endoscope-compatible probe to detect colonic dysplasia with Fourier transform infrared spectroscopy
    Mark A Mackanos
    Stanford Medical Center, Department of Pediatrics, E 150 Clark Center, 318 Campus Drive, Stanford, California 94305, USA
    J Biomed Opt 14:044006. 2009
    ....
  12. pmc Miniature near-infrared dual-axes confocal microscope utilizing a two-dimensional microelectromechanical systems scanner
    Jonathan T C Liu
    Edward L Ginzton Laboratory, Stanford University, Stanford, California 94305, USA
    Opt Lett 32:256-8. 2007
    ..Reflectance and fluorescence images are obtained with a laser source at 785 nm, demonstrating the ability to perform real-time optical biopsy...
  13. pmc Detection of endogenous biomolecules in Barrett's esophagus by Fourier transform infrared spectroscopy
    Thomas D Wang
    Division of Gastroenterology, Stanford University School of Medicine, Palo Alto Veterans Affairs Health Care System, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 104:15864-9. 2007
    ....
  14. pmc Near-infrared-labeled peptide multimer functions as phage mimic for high affinity, specific targeting of colonic adenomas in vivo (with videos)
    Bishnu P Joshi
    Department of Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Gastrointest Endosc 76:1197-206.e1-5. 2012
    ..Fluorescent-labeled peptides are being developed to improve the endoscopic detection of colonic dysplasia...
  15. pmc Targeted detection of murine colonic dysplasia in vivo with flexible multispectral scanning fiber endoscopy
    Sharon J Miller
    University of Michigan, Department of Internal Medicine, Division of Gastroenterology, 109 Zina Pitcher Pl BSRB 1522, Ann Arbor, Michigan 48109 2200, USA
    J Biomed Opt 17:021103. 2012
    ..Specific binding of two or more peptides can be distinguished in vivo using a novel multispectral endoscope to localize colonic dysplasia on real-time wide-field imaging...
  16. pmc Improved rejection of multiply scattered photons in confocal microscopy using dual-axes architecture
    Larry K Wong
    Stanford University, CA 94305, USA
    Opt Lett 32:1674-6. 2007
    ....
  17. doi request reprint Fibered confocal microscopy of bladder tumors: an ex vivo study
    Geoffrey A Sonn
    Department of Urology, Stanford University School of Medicine, Stanford, California 94305 5118, USA
    J Endourol 23:197-201. 2009
    ..We report the initial use of this technology to visualize tumors in the human bladder...
  18. doi request reprint Targeted imaging of esophageal neoplasia with a fluorescently labeled peptide: first-in-human results
    Matthew B Sturm
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Sci Transl Med 5:184ra61. 2013
    ....
  19. pmc Optical biopsy: a new frontier in endoscopic detection and diagnosis
    Thomas D Wang
    Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, CA 94305, USA
    Clin Gastroenterol Hepatol 2:744-53. 2004
    ..This review describes the basic biophysics of light-tissue interactions, assesses the strengths and weaknesses of each method, and examines clinical and preclinical evidence for each approach...
  20. pmc Confocal microscopy from the bench to the bedside
    Thomas D Wang
    Gastrointest Endosc 62:696-7. 2005
  21. ncbi request reprint Autofluorescence imaging: have we finally seen the light?
    Thomas D Wang
    Gastrointest Endosc 61:686-8. 2005
  22. ncbi request reprint Detection of high-grade dysplasia in Barrett's esophagus by spectroscopy measurement of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence
    Stephan Brand
    Gastrointestinal Unit, Wellman Laboratories of Photomedicine, Boston, Massachusetts, USA
    Gastrointest Endosc 56:479-87. 2002
    ..This study used quantitative methods to determine whether aminolevulinic acid-induced protoporphyrin IX fluorescence can differentiate between Barrett's mucosa with and without dysplasia...