Amy J Wagers

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Changes in integrin expression are associated with altered homing properties of Lin(-/lo)Thy1.1(lo)Sca-1(+)c-kit(+) hematopoietic stem cells following mobilization by cyclophosphamide/granulocyte colony-stimulating factor
    Amy J Wagers
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Exp Hematol 30:176-85. 2002
  2. ncbi request reprint Little evidence for developmental plasticity of adult hematopoietic stem cells
    Amy J Wagers
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 297:2256-9. 2002
  3. ncbi request reprint Plasticity of adult stem cells
    Amy J Wagers
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 116:639-48. 2004
  4. ncbi request reprint Determinants of skeletal muscle contributions from circulating cells, bone marrow cells, and hematopoietic stem cells
    Richard I Sherwood
    Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California, USA
    Stem Cells 22:1292-304. 2004
  5. pmc Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates
    Emmanuelle Passegue
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 202:1599-611. 2005
  6. ncbi request reprint Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle
    Richard I Sherwood
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 119:543-54. 2004
  7. pmc Cell intrinsic alterations underlie hematopoietic stem cell aging
    Derrick J Rossi
    Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 102:9194-9. 2005
  8. pmc Circulation and chemotaxis of fetal hematopoietic stem cells
    Julie L Christensen
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Biol 2:E75. 2004
  9. ncbi request reprint Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
    Leora B Balsam
    Departments of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 428:668-73. 2004
  10. ncbi request reprint Rejuvenation of aged progenitor cells by exposure to a young systemic environment
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 433:760-4. 2005

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Changes in integrin expression are associated with altered homing properties of Lin(-/lo)Thy1.1(lo)Sca-1(+)c-kit(+) hematopoietic stem cells following mobilization by cyclophosphamide/granulocyte colony-stimulating factor
    Amy J Wagers
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Exp Hematol 30:176-85. 2002
    ....
  2. ncbi request reprint Little evidence for developmental plasticity of adult hematopoietic stem cells
    Amy J Wagers
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 297:2256-9. 2002
    ..These data indicate that "transdifferentiation" of circulating HSCs and/or their progeny is an extremely rare event, if it occurs at all...
  3. ncbi request reprint Plasticity of adult stem cells
    Amy J Wagers
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 116:639-48. 2004
    ....
  4. ncbi request reprint Determinants of skeletal muscle contributions from circulating cells, bone marrow cells, and hematopoietic stem cells
    Richard I Sherwood
    Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California, USA
    Stem Cells 22:1292-304. 2004
    ..It is not yet clear whether such events represent a normal myogenic pathway or a pathological response to muscle damage...
  5. pmc Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates
    Emmanuelle Passegue
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 202:1599-611. 2005
    ....
  6. ncbi request reprint Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle
    Richard I Sherwood
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 119:543-54. 2004
    ..Together, these studies describe the clonal isolation of functional adult myogenic progenitors and demonstrate that these cells do not arise from hematopoietic or other bone marrow or circulating precursors...
  7. pmc Cell intrinsic alterations underlie hematopoietic stem cell aging
    Derrick J Rossi
    Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 102:9194-9. 2005
    ....
  8. pmc Circulation and chemotaxis of fetal hematopoietic stem cells
    Julie L Christensen
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Biol 2:E75. 2004
    ..This finding indicates the importance of the combined effects of SLF and SDF-1alpha in the migration of fetal HSCs, and is, to our knowledge, the first demonstration of a synergistic effect of two chemoattractive agents on HSCs...
  9. ncbi request reprint Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
    Leora B Balsam
    Departments of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 428:668-73. 2004
    ..1(lo) Lin- Sca-1+ long-term reconstituting haematopoietic stem cells adopt only traditional haematopoietic fates...
  10. ncbi request reprint Rejuvenation of aged progenitor cells by exposure to a young systemic environment
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 433:760-4. 2005
    ..These results suggest that the age-related decline of progenitor cell activity can be modulated by systemic factors that change with age...
  11. ncbi request reprint Differential expression of alpha2 integrin separates long-term and short-term reconstituting Lin-/loThy1.1(lo)c-kit+ Sca-1+ hematopoietic stem cells
    Amy J Wagers
    Department of Pathology, Stanford University School of Medicine, California, USA
    Stem Cells 24:1087-94. 2006
    ....
  12. pmc Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors
    Yu An Cao
    Departments of Pediatrics, Stanford University School of Medicine, CA, USA
    Blood 112:4494-502. 2008
    ..Control of stem cell stress response by HO-1 presents opportunities for metabolic manipulation of stem cell-based therapies...
  13. pmc Shifting foci of hematopoiesis during reconstitution from single stem cells
    Yu An Cao
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 101:221-6. 2004
    ....
  14. pmc Use of the parabiotic model in studies of cutaneous wound healing to define the participation of circulating cells
    Guodong Song
    Division of Plastic Surgery, Brigham and Women s Hospital, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Wound Repair Regen 18:426-32. 2010
    ..Application of this approach enables further investigation into the contribution of peripheral blood in normal and abnormal healing responses...
  15. pmc Hematopoietic cells maintain hematopoietic fates upon entering the brain
    Mei Massengale
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 201:1579-89. 2005
    ..These data strongly suggest that HSCs and their progeny maintain lineage fidelity in the brain and do not adopt neural cell fates with any measurable frequency...
  16. pmc Hematopoietic stem cells are uniquely selective in their migratory response to chemokines
    Douglas E Wright
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 195:1145-54. 2002
    ..The sharply restricted chemotactic responsiveness of HSC is unique among leukocytes and may be necessary for the specific homing of circulating HSC to bone marrow, as well as for the maintenance of HSC in hematopoietic microenvironments...
  17. ncbi request reprint Simple and efficient isolation of hematopoietic stem cells from H2K-zFP transgenic mice
    Didier Surdez
    Department of Life Science, Swiss Federal Institute of Technology, Lausanne, Switzerland
    Stem Cells 23:1617-25. 2005
    ..This approach will greatly facilitate gene transfer, including short interfering RNA for gene knockdown, into HSCs and, consequently, into all other hematopoietic lineages...
  18. pmc Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells
    David T Breault
    Divisions of Endocrinology and Gastroenterology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:10420-5. 2008
    ....
  19. pmc Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles
    Massimiliano Cerletti
    Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02115, USA
    Cell 134:37-47. 2008
    ..Together, these studies indicate the presence in adult skeletal muscle of prospectively isolatable muscle-forming stem cells and directly demonstrate the efficacy of myogenic stem cell transplant for treating muscle degenerative disease...
  20. ncbi request reprint Biology of hematopoietic stem cells and progenitors: implications for clinical application
    Motonari Kondo
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Immunol 21:759-806. 2003
    ....
  21. pmc Osteolineage niche cells initiate hematopoietic stem cell mobilization
    Shane R Mayack
    Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, Department of Stem Cell and Regenerative Biology, Harvard University, and Harvard Stem Cell Institute, Boston, MA 02215, USA
    Blood 112:519-31. 2008
    ..This work also establishes that direct interaction with osteolineage niche cells, in the absence of additional environmental inputs, is sufficient to modulate stem cell activity...
  22. doi request reprint The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells
    Irene M Min
    Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, Boston, MA 02115, USA
    Cell Stem Cell 2:380-91. 2008
    ..The ability of this single factor to regulate both proliferation and mobilization of HSCs suggests that EGR1 commands a genetic program that coordinates stem cell division and migration to maintain appropriate HSC number and function...
  23. ncbi request reprint Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations
    Claudia Jakubzick
    Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 180:3019-27. 2008
    ..Overall, these data demonstrate that the two circulating subsets of monocytes give rise to distinct tissue DC populations...
  24. ncbi request reprint No place like home: anatomy and function of the stem cell niche
    D Leanne Jones
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Nat Rev Mol Cell Biol 9:11-21. 2008
    ....
  25. pmc Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues
    Steffen Massberg
    Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Cell 131:994-1008. 2007
    ..Thus, HSPCs can survey peripheral organs and can foster the local production of tissue-resident innate immune cells under both steady-state conditions and in response to inflammatory signals...
  26. ncbi request reprint Ovulated oocytes in adult mice derive from non-circulating germ cells
    Kevin Eggan
    The Stowers Medical Institute, Harvard Stem Cell Institute and The Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 441:1109-14. 2006
    ..Instead, cells that travelled to the ovary through the bloodstream exhibited properties characteristic of committed blood leukocytes...
  27. ncbi request reprint Stem cell grand SLAM
    Amy J Wagers
    Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Cell 121:967-70. 2005
    ....
  28. ncbi request reprint Cellular and molecular signatures of muscle regeneration: current concepts and controversies in adult myogenesis
    Amy J Wagers
    Joslin Diabetes Center and Department of Pathology Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell 122:659-67. 2005
    ....
  29. doi request reprint Stem cell trafficking in tissue development, growth, and disease
    Diana J Laird
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10058, USA
    Cell 132:612-30. 2008
    ....
  30. pmc Circulating C3 is necessary and sufficient for induction of autoantibody-mediated arthritis in a mouse model
    Paul A Monach
    Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 56:2968-74. 2007
    ..The aim of this study was to test, in a mouse model of rheumatoid arthritis, whether C3 synthesized within the synovium is important in promoting inflammation...
  31. ncbi request reprint Regulating quiescence: new insights into hematopoietic stem cell biology
    Emmanuelle Passegue
    Developmental and Stem Cell Biology Program, University of California, San Francisco, 94143, USA
    Dev Cell 10:415-7. 2006
    ....
  32. ncbi request reprint The Immunological Genome Project: networks of gene expression in immune cells
    Tracy S P Heng
    Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Nat Immunol 9:1091-4. 2008
    ..The Immunological Genome Project combines immunology and computational biology laboratories in an effort to establish a complete 'road map' of gene-expression and regulatory networks in all immune cells...
  33. ncbi request reprint Harnessing the potential of myogenic satellite cells
    Richard I Sherwood
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Trends Mol Med 12:189-92. 2006
    ..A recent study from Montarras and colleagues has provided new insights into the requirements for efficient muscle engraftment from purified muscle satellite cells, suggesting possible strategies to enhance their therapeutic potential...