DOUGLAS E VOLLRATH

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Loss-of-function mutations in the LIM-homeodomain gene, LMX1B, in nail-patella syndrome
    D Vollrath
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Hum Mol Genet 7:1091-8. 1998
  2. pmc A sequence-ready BAC clone contig of a 2.2-Mb segment of human chromosome 1q24
    D Vollrath
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 USA
    Genome Res 9:150-7. 1999
  3. pmc Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk
    D Vollrath
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Proc Natl Acad Sci U S A 98:12584-9. 2001
  4. ncbi request reprint Temperature sensitive secretion of mutant myocilins
    Douglas Vollrath
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Exp Eye Res 82:1030-6. 2006
  5. ncbi request reprint Reversal of mutant myocilin non-secretion and cell killing: implications for glaucoma
    Yuhui Liu
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Hum Mol Genet 13:1193-204. 2004
  6. ncbi request reprint A novel His158Arg mutation in TIMP3 causes a late-onset form of Sorsby fundus dystrophy
    Ruth J Lin
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    Am J Ophthalmol 142:839-48. 2006
  7. ncbi request reprint Mertk triggers uptake of photoreceptor outer segments during phagocytosis by cultured retinal pigment epithelial cells
    Wei Feng
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    J Biol Chem 277:17016-22. 2002
  8. ncbi request reprint phiC31 integrase confers genomic integration and long-term transgene expression in rat retina
    Thomas W Chalberg
    Department of Genetics, Stanford University School of Medicine, CA 94305, USA
    Invest Ophthalmol Vis Sci 46:2140-6. 2005
  9. doi request reprint Mertk drives myosin II redistribution during retinal pigment epithelial phagocytosis
    David J Strick
    Department of Genetics, Stanford University, Stanford, California 94305 5120, USA
    Invest Ophthalmol Vis Sci 50:2427-35. 2009

Research Grants

  1. Genetic model of retinal pigment epithelium degeneration
    Douglas Vollrath; Fiscal Year: 2005
  2. MOLECULAR GENETICS OF OPEN ANGLE GLAUCOMA
    Douglas Vollrath; Fiscal Year: 2007

Collaborators

  • M A Kay
  • P R Lichter
  • M M LaVail
  • I McIntosh
  • Wei Feng
  • David J Strick
  • Ruth J Lin
  • Thomas W Chalberg
  • Yuhui Liu
  • Jonathan Binkley
  • Kathy Wu
  • Mark S Blumenkranz
  • Hilary L Genise
  • Michele P Calos
  • Michael T Matthes
  • Douglas Yasumura

Detail Information

Publications9

  1. ncbi request reprint Loss-of-function mutations in the LIM-homeodomain gene, LMX1B, in nail-patella syndrome
    D Vollrath
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Hum Mol Genet 7:1091-8. 1998
    ..The results further suggest that the NPS and OAG phenotypes in the families studied result from mutations in a single gene, LMX1B...
  2. pmc A sequence-ready BAC clone contig of a 2.2-Mb segment of human chromosome 1q24
    D Vollrath
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 USA
    Genome Res 9:150-7. 1999
    ..The gene order and content of the region provide insight into ancient duplication events that have occurred on proximal 1q. The stage is now set for further elucidation of this interesting region through large-scale sequencing...
  3. pmc Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk
    D Vollrath
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Proc Natl Acad Sci U S A 98:12584-9. 2001
    ..These results, together with the recent discovery of MERTK mutations in individuals with retinitis pigmentosa, emphasize the importance of the RCS rat as a model for gene therapy of diseases that arise from RPE dysfunction...
  4. ncbi request reprint Temperature sensitive secretion of mutant myocilins
    Douglas Vollrath
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Exp Eye Res 82:1030-6. 2006
    ..These results support the hypothesis that myocilin-induced glaucoma is a protein conformational disease. Facilitating mutant protein folding could be a new approach to development of therapies for this disease...
  5. ncbi request reprint Reversal of mutant myocilin non-secretion and cell killing: implications for glaucoma
    Yuhui Liu
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Hum Mol Genet 13:1193-204. 2004
    ..The beneficial effects of facilitating folding and secretion of mutant myocilin suggest a new type of treatment for this form of glaucoma...
  6. ncbi request reprint A novel His158Arg mutation in TIMP3 causes a late-onset form of Sorsby fundus dystrophy
    Ruth J Lin
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    Am J Ophthalmol 142:839-48. 2006
    ..To describe the phenotype and genotype of a family with suspected Sorsby fundus dystrophy (SFD)...
  7. ncbi request reprint Mertk triggers uptake of photoreceptor outer segments during phagocytosis by cultured retinal pigment epithelial cells
    Wei Feng
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    J Biol Chem 277:17016-22. 2002
    ..We conclude that Mertk likely functions directly in the RPE phagocytic process as a signaling molecule triggering outer segment ingestion...
  8. ncbi request reprint phiC31 integrase confers genomic integration and long-term transgene expression in rat retina
    Thomas W Chalberg
    Department of Genetics, Stanford University School of Medicine, CA 94305, USA
    Invest Ophthalmol Vis Sci 46:2140-6. 2005
    ....
  9. doi request reprint Mertk drives myosin II redistribution during retinal pigment epithelial phagocytosis
    David J Strick
    Department of Genetics, Stanford University, Stanford, California 94305 5120, USA
    Invest Ophthalmol Vis Sci 50:2427-35. 2009
    ..To address this, the authors sought proteins that associated with Mertk during OS phagocytosis...

Research Grants2

  1. Genetic model of retinal pigment epithelium degeneration
    Douglas Vollrath; Fiscal Year: 2005
    ....
  2. MOLECULAR GENETICS OF OPEN ANGLE GLAUCOMA
    Douglas Vollrath; Fiscal Year: 2007
    ....