Research Topics
Genomes and Genes | Patrick ViatourSummaryAffiliation: Stanford University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Newly identified aspects of tumor suppression by RBPatrick Viatour
Department of Genetics, Stanford University, Stanford, CA 94305, USA
Dis Model Mech 4:581-5. 2011..In particular, we discuss the pro- and anti-tumorigenic roles of RB during the early stages of cancer, as well as the importance of the RB pathway in stem cells and cell fate decisions...
Regulation of RB transcription in vivo by RB family membersDeborah L Burkhart
Department of Pediatrics, Stanford Medical School, 269 Campus Drive, CCSR1215, Stanford, CA 94305, USA
Mol Cell Biol 30:1729-45. 2010..These experiments identify novel regulatory feedback mechanisms within the RB pathway in mammalian cells...
Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathwayPatrick Viatour
Department of Genetics, Department of Pediatrics, Stanford University, Stanford, CA, USA Department of Medical Chemistry, University of Liege, B 4000 Liege, Belgium
J Exp Med 208:1963-76. 2011..The level of Notch activity is also able to predict survival of HCC patients, suggesting novel means to diagnose and treat HCC...
G1 arrest and differentiation can occur independently of Rb family functionStacey E Wirt
Department of Pediatrics, Stanford Medical School, Stanford, CA 94305, USA
J Cell Biol 191:809-25. 2010....
Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene familyPatrick Viatour
Department of Pediatrics, Stanford Medical School, Stanford, CA 94305, USA
Cell Stem Cell 3:416-28. 2008..The presence of a single p107 allele is sufficient to largely rescue these defects. Thus, Rb family members collectively maintain HSC quiescence and the balance between lymphoid and myeloid cell fates in the hematopoietic system...
GFP reporter mice for the retinoblastoma-related cell cycle regulator p107Deborah L Burkhart
Department of Pediatrics and Genetics, Cancer Biology Program, Stanford Medical School, Stanford, California, USA
Cell Cycle 7:2544-52. 2008..Thus, p107 BAC-eGFP transgenic mice serve as a useful tool to identify distinct cell types in which p107 is expressed and may have key functions in vivo, and to characterize changes in cellular networks accompanying Rb deficiency...
MicroRNA programs in normal and aberrant stem and progenitor cellsChristopher P Arnold
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
Genome Res 21:798-810. 2011..Together, these analyses reveal the miRNA programs that may control key processes in normal and aberrant stem and progenitor cells, setting the foundations for dissecting post-transcriptional regulatory networks in stem cells...
