Michael R Verneris
Affiliation: Stanford University
- Studies of ex vivo activated and expanded CD8+ NK-T cells in humans and miceMichael R Verneris
Division of Pediatric Hematology Oncology, and Bone Marrow Transplantation, Stanford, California 94305, USA
J Clin Immunol 22:131-6. 2002..We conclude that expanded CD8+ NK-T cells are a promising form of cellular therapy in the allogeneic setting...
- Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cellsMobin Karimi
Division of Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 175:7819-28. 2005..These studies demonstrated the importance of NKG2D, DAP10, and DAP12 in human effector cell function...
- Revealing lymphoma growth and the efficacy of immune cell therapies using in vivo bioluminescence imagingMatthias Edinger
Division of Bone Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, CA, USA
Blood 101:640-8. 2003..The complex cellular processes in bone marrow transplantation and antitumor immunotherapy, previously inaccessible to investigation, can now be revealed in real time in living animals...
- Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cellsMichael R Verneris
Division of Pediatric Blood and Marrow Diseases, University of Minnesota, Minneapolis, MN 55455, USA
Blood 103:3065-72. 2004..Collectively these results establish that NKG2D triggering accounts for the majority of major histocompatibility complex (MHC)-unrestricted cytotoxicity of activated and expanded CD8+ T cells, likely through DAP10-mediated signaling...
- Coordinated acquisition of inhibitory and activating receptors and functional properties by developing human natural killer cellsBartosz Grzywacz
Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, 425 E River Rd, Suite 660, Minneapolis, MN 55455, USA
Blood 108:3824-33. 2006..The identified stages of NK-cell differentiation provide evidence for coordinated acquisition of HLA-specific inhibitory receptors (ie, CD94/NKG2A) and function in developing human NK cells...
- iTRAQ is a useful method to screen for membrane-bound proteins differentially expressed in human natural killer cell typesTroy C Lund
Department of Medicine, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, 670 CCRB, 425 East River Road, Minneapolis, MN 55455, USA
J Proteome Res 6:644-53. 2007..This is the first demonstration and verification using iTRAQ to screen for membrane-bound protein differences in human NK cells and represents a powerful new tool in the field of proteomics...
- Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCTJeffery S Miller
Divisions of Adult and Pediatric Hematology, Oncology and Transplantation, University of Minnesota Cancer Center, Harvard Street at East River Road, Minneapolis, MN 55455, USA
Blood 109:5058-61. 2007..58, 95% CI 1.13-2.22; P = .008). These data support a genetically determined role for NK cells following unrelated HCT in myeloid leukemia...
- The unexpected effect of cyclosporin A on CD56+CD16- and CD56+CD16+ natural killer cell subpopulationsHongbo Wang
Department of Pediatrics, Cancer Center, University of Minnesota, Minneapolis, USA
Blood 110:1530-9. 2007..Collectively, these studies show that CSA influences NK-cell function and phenotype, which may have important implications for graft-versus-leukemia effects...
- Use of natural killer cells as immunotherapy for leukaemiaBartosz Grzywacz
Division of Blood and Marrow Transplantation, University of Minnesota, MN, USA
Best Pract Res Clin Haematol 21:467-83. 2008..Future modifications to improve NK cell adoptive immunotherapy by means of increasing target recognition and reducing inhibitory signalling are being explored...