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Species | P A UnderhillSummaryAffiliation: Stanford University Country: USA Publications
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Publications
Y chromosome sequence variation and the history of human populationsP A Underhill
Department of Genetics, Stanford University, Stanford, California
Nat Genet 26:358-61. 2000..A minority of contemporary East Africans and Khoisan represent the descendants of the most ancestral patrilineages of anatomically modern humans that left Africa between 35,000 and 89,000 years ago...
Y-chromosomal evidence of a pastoralist migration through Tanzania to southern AfricaBrenna M Henn
Department of Anthropology, Stanford University, Stanford, CA 94035 2117, USA
Proc Natl Acad Sci U S A 105:10693-8. 2008..Our Y-chromosomal evidence supports a demic diffusion model of pastoralism from eastern to southern Africa approximately 2,000 years ago...- Saudi Arabian Y-Chromosome diversity and its relationship with nearby regionsKhaled K Abu-Amero
Molecular Genetics Laboratory, College of Medicine, King Saud University, Riyadh 11411, Saudi Arabia
BMC Genet 10:59. 2009..In addition, haplotypic diversity for its most prominent J1-M267 lineage was estimated using a set of 17 Y-specific STR loci... - The coming of the Greeks to Provence and Corsica: Y-chromosome models of archaic Greek colonization of the western MediterraneanRoy J King
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305, USA
BMC Evol Biol 11:69. 2011.... - The phylogeography of Y chromosome binary haplotypes and the origins of modern human populationsP A Underhill
Department of Genetics, Stanford University, CA 94305 5120, USA
Ann Hum Genet 65:43-62. 2001.... - Separating the post-Glacial coancestry of European and Asian Y chromosomes within haplogroup R1aPeter A Underhill
Division of Child and Adolescent Psychiatry and Child Development, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94304 5485, USA
Eur J Hum Genet 18:479-84. 2010..Importantly, the virtual absence of M458 chromosomes outside Europe speaks against substantial patrilineal gene flow from East Europe to Asia, including to India, at least since the mid-Holocene... - Use of y chromosome and mitochondrial DNA population structure in tracing human migrationsPeter A Underhill
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
Annu Rev Genet 41:539-64. 2007..We introduce new results concerning Y chromosome founder haplogroups C, DE, and F that resolve their previous trifurcation and improve the harmony with the mtDNA recapitulation of the out-of-Africa migration... - Maori origins, Y-chromosome haplotypes and implications for human history in the PacificP A Underhill
Department of Genetics, Stanford University, Stanford, California 94305 5120, USA
Hum Mutat 17:271-80. 2001..The Y-chromosome data highlight a distinctive gender-modulated pattern of differential gene flow in the history of Polynesia... - Detection of numerous Y chromosome biallelic polymorphisms by denaturing high-performance liquid chromatographyP A Underhill
Department of Genetics, Stanford University, Stanford, California 94305 5120, USA
Genome Res 7:996-1005. 1997..It provides evidence of an ancient bottleneck event. It is now possible to anticipate the inevitable detailed reconstruction of human Y chromosome genealogy based on several tens to even hundreds of these important polymorphisms... - The Werner syndrome gene and global sequence variationG Passarino
Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
Genomics 71:118-22. 2001..The resulting global nucleotide diversity was 5.226 x 10(-4), with a slight difference between coding and noncoding regions... 
Differential Y-chromosome Anatolian influences on the Greek and Cretan NeolithicR J King
Department of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, Stanford, CA 94305 5722, USA
Ann Hum Genet 72:205-14. 2008....- Y chromosome binary markers to study the high prevalence of males in Sardinian centenarians and the genetic structure of the Sardinian populationG Passarino
Department of Genetics, Stanford University, Stanford, CA, USA
Hum Hered 52:136-9. 2001..These findings set the stage for future studies on longevity and other complex traits in Sardinia... - Inferring human history: clues from Y-chromosome haplotypesP A Underhill
Department of Genetics, Stanford University School of Medicine, Stanford, California 94305-5120, USA
Cold Spring Harb Symp Quant Biol 68:487-93. 2003 - Population genetic implications from sequence variation in four Y chromosome genesP Shen
Stanford DNA Sequencing and Technology Center, 855 California Avenue, Palo Alto, CA 94304, USA
Proc Natl Acad Sci U S A 97:7354-9. 2000..Pairwise nucleotide mismatch distributions date the occurrence of population expansion to approximately 28,000 years ago. This estimate is in accord with the spread of Aurignacian technology and the disappearance of the Neanderthals... - SNPSTRs: empirically derived, rapidly typed, autosomal haplotypes for inference of population history and mutational processesJoanna L Mountain
Department of Anthropological Sciences, Stanford, California 94305, USA
Genome Res 12:1766-72. 2002..Here, we illustrate the approach with two SNPSTR systems. Although even one system provides insight into population history, the power of the approach lies in combining results from multiple SNPSTR systems... - African Y chromosome and mtDNA divergence provides insight into the history of click languagesAlec Knight
Department of Anthropological Sciences, Stanford University, Stanford, CA 94305, USA
Curr Biol 13:464-73. 2003..Intriguingly, the language of the Hadzabe of eastern Africa, although not closely related to any other language, shares click consonants and accompaniments with languages of Khwe and San... - Excavating Y-chromosome haplotype strata in AnatoliaCengiz Cinnioglu
Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5120, USA
Hum Genet 114:127-48. 2004..The variety of Turkish haplotypes is witness to Turkey being both an important source and recipient of gene flow... - Immunology: hepatitis A virus link to atopic diseaseJennifer J McIntire
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California 94305-5208, USA
Nature 425:576. 2003 - Molecular variation of human HSP90alpha and HSP90beta genes in CaucasiansGiuseppe Passarino
Department of Genetics, Stanford University School of Medicine, Stanford, California, USA
Hum Mutat 21:554-5. 2003..Only three of the observed mutations altered the genic product. Interestingly, one of the variations observed was a missense mutation leading to the impairment of the hsp90alpha protein... - Melanesian and Asian origins of Polynesians: mtDNA and Y chromosome gradients across the PacificManfred Kayser
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
Mol Biol Evol 23:2234-44. 2006..We also demonstrate that Fiji played a pivotal role in the history of Polynesia: humans probably first migrated to Fiji, and subsequent settlement of Polynesia probably came from Fiji... - Difference between evolutionarily effective and germ line mutation rate due to stochastically varying haplogroup sizeLev A Zhivotovsky
N I Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia
Mol Biol Evol 23:2268-70. 2006.... - A counter-clockwise northern route of the Y-chromosome haplogroup N from Southeast Asia towards EuropeSiiri Rootsi
Department of Evolutionary Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
Eur J Hum Genet 15:204-11. 2007..These phylogeographic patterns provide evidence consistent with male-mediated counter-clockwise late Pleistocene-Holocene migratory trajectories toward Northwestern Europe from an ancestral East Asian source of Paleolithic heritage... - Paleolithic Y-haplogroup heritage predominates in a Cretan highland plateauLaisel Martinez
Department of Biological Sciences, Florida International University, Miami, FL 33199, USA
Eur J Hum Genet 15:485-93. 2007..In contrast, Cretan R1b microsatellite-defined haplotypes displayed more resemblance to those from Northeast Italy than to those from Turkey and the Balkans... - The dual origin and Siberian affinities of Native American Y chromosomesJeffrey T Lell
Center for Molecular Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Hum Genet 70:192-206. 2002..This migration event contributed to the modern genetic pool of the Na-Dene and Amerinds of North and Central America... - Revealing the prehistoric settlement of Australia by Y chromosome and mtDNA analysisGeorgi Hudjashov
Estonian Biocentre and Tartu University, Department of Evolutionary Biology, Riia 23, 51010 Tartu, Estonia
Proc Natl Acad Sci U S A 104:8726-30. 2007.... - Y-chromosome short tandem repeat DYS458.2 non-consensus alleles occur independently in both binary haplogroups J1-M267 and R1b3-M405Natalie M Myres
Sorenson Molecular Genealogy Foundation, Salt Lake City, Utah, USA
Croat Med J 48:450-9. 2007..2 short tandem repeat alleles and evaluate their phylogenetic substructure and frequency in representative samples from the Middle East, Europe, and Pakistan... - Y-chromosome diversity characterizes the Gulf of OmanAlicia M Cadenas
Department of Biological Sciences, Florida International University, Miami, FL 33199, USA
Eur J Hum Genet 16:374-86. 2008..Elevated rates of consanguinity may have had an impact in Yemen and Qatar, which experience significant heterozygote deficiencies at various hypervariable autosomal STR loci... - Ethiopians and Khoisan share the deepest clades of the human Y-chromosome phylogenyOrnella Semino
Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
Am J Hum Genet 70:265-8. 2002..The first observation confirms the ancestral affinity between the Ethiopians and the Khoisan, which has previously been suggested by both archaeological and genetic findings... - The Himalayas as a directional barrier to gene flowTenzin Gayden
Department of Biological Sciences, Florida International University, Miami, FL 33199, USA
Am J Hum Genet 80:884-94. 2007..Yet the presence of haplogroup O3a5-M134 representatives in Nepal indicates that the Himalayas have been permeable to dispersals from the east. These genetic patterns suggest that this cordillera has been a biased bidirectional barrier... - Molecular dissection of the Y chromosome haplogroup E-M78 (E3b1a): a posteriori evaluation of a microsatellite-network-based approach through six new biallelic markersFulvio Cruciani
Dipartimento di Genetica e Biologia Molecolare, , Rome, Italy
Hum Mutat 27:831-2. 2006.... - Detection of novel Y SNPs provides further insights into Y chromosomal variation in PakistanAisha Mohyuddin
Biomedical and Genetic Engineering Laboratories, G. P. O Box 2891, 44000, Islamabad, Pakistan
J Hum Genet 51:375-8. 2006..BATWING analysis gave an estimate of between 2,500 and 7,300 YBP for population expansion in Pakistan which coincides with the period of the Indus Valley civilizations... - A Y chromosome census of the British IslesCristian Capelli
Department of Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
Curr Biol 13:979-84. 2003.... - Accelerated evolution of the pituitary adenylate cyclase-activating polypeptide precursor gene during human originYin Qiu Wang
Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Yunnan
Genetics 170:801-6. 2005..Our data suggested that the PACAP precursor gene underwent adaptive changes during human origin and may have contributed to the formation of human cognition... - Origin, diffusion, and differentiation of Y-chromosome haplogroups E and J: inferences on the neolithization of Europe and later migratory events in the Mediterranean areaOrnella Semino
Dipartimento di Genetica e Microbiologia, Universita di Pavia, 27100 Pavia, Italy
Am J Hum Genet 74:1023-34. 2004..A 7%-22% contribution of Y chromosomes from Greece to southern Italy was estimated by admixture analysis... - A back migration from Asia to sub-Saharan Africa is supported by high-resolution analysis of human Y-chromosome haplotypesFulvio Cruciani
Dipartimenti di Genetica e Biologia Molecolare, Universita La Sapienza, Rome, Italy
Am J Hum Genet 70:1197-214. 2002..Haplogroup IX Y chromosomes appear to have been involved in such a migration, the traces of which can now be observed mostly in northern Cameroon... - Phylogeography of Y-chromosome haplogroup I reveals distinct domains of prehistoric gene flow in europeSiiri Rootsi
Department of Evolutionary Biology, University of Tartu and Estonian Biocentre, Riia, Tartu, Estonia
Am J Hum Genet 75:128-37. 2004..In contrast, I1b2 most likely arose in southern France/Iberia. Similarly to the other subclades, it underwent a postglacial expansion and marked the human colonization of Sardinia approximately 9,000 years ago... - Reduced genetic structure of the Iberian peninsula revealed by Y-chromosome analysis: implications for population demographyCarlos Flores
Departamento de Genetica, Universidad de La Laguna, Tenerife E 38271, Spain
Eur J Hum Genet 12:855-63. 2004..These results indicate that neither old or recent Levantine expansions nor North African contacts have influenced the current Iberian Y-chromosome diversity so that geographical patterns can be identified... - Genetic affinities of the Andaman Islanders, a vanishing human populationKumarasamy Thangaraj
Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, 440 006, Nagpur, India
Curr Biol 13:86-93. 2003..In contrast, the Nicobarese have genetic affinities to groups widely distributed throughout Asia today, presumably descended from Neolithic agriculturalists... - Y-chromosomal evidence for a limited Greek contribution to the Pathan population of PakistanSadaf Firasat
Biomedical and Genetic Engineering Division, Dr AQ Khan Research Laboratories, Islamabad, Pakistan
Eur J Hum Genet 15:121-6. 2007..Although based on only a few unrelated descendants, this provides strong evidence for a European origin for a small proportion of the Pathan Y chromosomes... - Y-chromosome lineages from Portugal, Madeira and Açores record elements of Sephardim and Berber ancestryRita Goncalves
Human Genetics Laboratory, University of Madeira, Campus of Penteada, 9000 390 Funchal, Portugal
Ann Hum Genet 69:443-54. 2005.... - Y-chromosome evidence of southern origin of the East Asian-specific haplogroup O3-M122Hong Shi
Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Kunming, China
Am J Hum Genet 77:408-19. 2005..It was estimated that the early northward migration of the O3-M122 lineages in East Asia occurred approximately 25,000-30,000 years ago, consistent with the fossil records of modern humans in East Asia... - The role of selection in the evolution of human mitochondrial genomesToomas Kivisild
Department of Human and Clinical Genetics, Leiden University Medical Center, 2333 AL Leiden, The Netherlands
Genetics 172:373-87. 2006..We introduce a new calibration method of the mutation rate of synonymous transitions to estimate the coalescent times of mtDNA haplogroups... - Polarity and temporality of high-resolution y-chromosome distributions in India identify both indigenous and exogenous expansions and reveal minor genetic influence of Central Asian pastoralistsSanghamitra Sengupta
Human Genetics Unit, Indian Statistical Institute, Kolkata, India
Am J Hum Genet 78:202-21. 2006..Our reappraisal indicates that pre-Holocene and Holocene-era--not Indo-European--expansions have shaped the distinctive South Asian Y-chromosome landscape... - Different genetic components in the Norwegian population revealed by the analysis of mtDNA and Y chromosome polymorphismsGiuseppe Passarino
Dipartimento di Biologia Cellulare, Universita della Calabria, Ponte Pietro Bucci c da Arcavacata, 87030 Rende, Italy
Eur J Hum Genet 10:521-9. 2002..Other minor genetic influences on the Norwegian population from Uralic speakers and Mediterranean populations were also highlighted... - DNA mutation detection using denaturing high-performance liquid chromatography (DHPLC)Bing Yu
Department of Molecular and Clinical Genetics, Central Clinical School and SUPAMAC The University of Sydney, New South Wales, Australia
Curr Protoc Hum Genet . 2006..The method exploits the differential retention of homoduplex and heteroduplex DNA species under conditions of partial thermal denaturation. DHPLC provides a useful platform for high-throughput mutation detection and SNP discovery... - Toward resolution of the debate regarding purported crypto-Jews in a Spanish-American population: evidence from the Y chromosomeWesley K Sutton
Department of Anthropology, New York University, New York 10003, USA
Ann Hum Biol 33:100-11. 2006..Despite ethnographic criticisms, the notion of substantial crypto-Jewish ancestry among Spanish-Americans persists... - The effective mutation rate at Y chromosome short tandem repeats, with application to human population-divergence timeLev A Zhivotovsky
N I Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia
Am J Hum Genet 74:50-61. 2004..This value is used to estimate the times of the African Bantu expansion, the divergence of Polynesian populations (the Maoris, Cook Islanders, and Samoans), and the origin of Gypsy populations from Bulgaria... - Co-introgression of Y-chromosome haplogroups and the sickle cell gene across Africa's SahelRihab E Bereir
Institute of Endemic Diseases, Medical Campus, University of Khartoum, Khartoum, Sudan
Eur J Hum Genet 15:1183-5. 2007..We discuss the possible dynamics of the process and give estimates of the age of the introduction of the S allele into eastern Sahel... - On the evolutionary mutation rate at Y-chromosome STRs: comments on paper by Di Giacomo et al. (2004)Lev A Zhivotovsky
Hum Genet 116:529-32. 2005 - The enigma of the San Lesmes (response to Langdon, 2002)Geoffrey K Chambers
Hum Mutat 19:181-2. 2002 - New binary polymorphisms reshape and increase resolution of the human Y chromosomal haplogroup treeTatiana M Karafet
ARL Division of Biotechnology, University of Arizona, Tucson, Arizona 85721, USA
Genome Res 18:830-8. 2008..Several changes in the tree topology have important implications for studies of human ancestry. We also present demography-independent age estimates for 11 of the major clades in the new Y chromosome tree...