P A Underhill

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Y chromosome sequence variation and the history of human populations
    P A Underhill
    Department of Genetics, Stanford University, Stanford, California
    Nat Genet 26:358-61. 2000
  2. pmc Y-chromosomal evidence of a pastoralist migration through Tanzania to southern Africa
    Brenna M Henn
    Department of Anthropology, Stanford University, Stanford, CA 94035 2117, USA
    Proc Natl Acad Sci U S A 105:10693-8. 2008
  3. pmc Saudi Arabian Y-Chromosome diversity and its relationship with nearby regions
    Khaled K Abu-Amero
    Molecular Genetics Laboratory, College of Medicine, King Saud University, Riyadh 11411, Saudi Arabia
    BMC Genet 10:59. 2009
  4. pmc The coming of the Greeks to Provence and Corsica: Y-chromosome models of archaic Greek colonization of the western Mediterranean
    Roy J King
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305, USA
    BMC Evol Biol 11:69. 2011
  5. ncbi request reprint The phylogeography of Y chromosome binary haplotypes and the origins of modern human populations
    P A Underhill
    Department of Genetics, Stanford University, CA 94305 5120, USA
    Ann Hum Genet 65:43-62. 2001
  6. pmc Separating the post-Glacial coancestry of European and Asian Y chromosomes within haplogroup R1a
    Peter A Underhill
    Division of Child and Adolescent Psychiatry and Child Development, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94304 5485, USA
    Eur J Hum Genet 18:479-84. 2010
  7. ncbi request reprint Use of y chromosome and mitochondrial DNA population structure in tracing human migrations
    Peter A Underhill
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Annu Rev Genet 41:539-64. 2007
  8. ncbi request reprint Maori origins, Y-chromosome haplotypes and implications for human history in the Pacific
    P A Underhill
    Department of Genetics, Stanford University, Stanford, California 94305 5120, USA
    Hum Mutat 17:271-80. 2001
  9. pmc Detection of numerous Y chromosome biallelic polymorphisms by denaturing high-performance liquid chromatography
    P A Underhill
    Department of Genetics, Stanford University, Stanford, California 94305 5120, USA
    Genome Res 7:996-1005. 1997
  10. ncbi request reprint The Werner syndrome gene and global sequence variation
    G Passarino
    Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    Genomics 71:118-22. 2001

Detail Information

Publications51

  1. ncbi request reprint Y chromosome sequence variation and the history of human populations
    P A Underhill
    Department of Genetics, Stanford University, Stanford, California
    Nat Genet 26:358-61. 2000
    ..A minority of contemporary East Africans and Khoisan represent the descendants of the most ancestral patrilineages of anatomically modern humans that left Africa between 35,000 and 89,000 years ago...
  2. pmc Y-chromosomal evidence of a pastoralist migration through Tanzania to southern Africa
    Brenna M Henn
    Department of Anthropology, Stanford University, Stanford, CA 94035 2117, USA
    Proc Natl Acad Sci U S A 105:10693-8. 2008
    ..Our Y-chromosomal evidence supports a demic diffusion model of pastoralism from eastern to southern Africa approximately 2,000 years ago...
  3. pmc Saudi Arabian Y-Chromosome diversity and its relationship with nearby regions
    Khaled K Abu-Amero
    Molecular Genetics Laboratory, College of Medicine, King Saud University, Riyadh 11411, Saudi Arabia
    BMC Genet 10:59. 2009
    ..In addition, haplotypic diversity for its most prominent J1-M267 lineage was estimated using a set of 17 Y-specific STR loci...
  4. pmc The coming of the Greeks to Provence and Corsica: Y-chromosome models of archaic Greek colonization of the western Mediterranean
    Roy J King
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305, USA
    BMC Evol Biol 11:69. 2011
    ....
  5. ncbi request reprint The phylogeography of Y chromosome binary haplotypes and the origins of modern human populations
    P A Underhill
    Department of Genetics, Stanford University, CA 94305 5120, USA
    Ann Hum Genet 65:43-62. 2001
    ....
  6. pmc Separating the post-Glacial coancestry of European and Asian Y chromosomes within haplogroup R1a
    Peter A Underhill
    Division of Child and Adolescent Psychiatry and Child Development, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94304 5485, USA
    Eur J Hum Genet 18:479-84. 2010
    ..Importantly, the virtual absence of M458 chromosomes outside Europe speaks against substantial patrilineal gene flow from East Europe to Asia, including to India, at least since the mid-Holocene...
  7. ncbi request reprint Use of y chromosome and mitochondrial DNA population structure in tracing human migrations
    Peter A Underhill
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Annu Rev Genet 41:539-64. 2007
    ..We introduce new results concerning Y chromosome founder haplogroups C, DE, and F that resolve their previous trifurcation and improve the harmony with the mtDNA recapitulation of the out-of-Africa migration...
  8. ncbi request reprint Maori origins, Y-chromosome haplotypes and implications for human history in the Pacific
    P A Underhill
    Department of Genetics, Stanford University, Stanford, California 94305 5120, USA
    Hum Mutat 17:271-80. 2001
    ..The Y-chromosome data highlight a distinctive gender-modulated pattern of differential gene flow in the history of Polynesia...
  9. pmc Detection of numerous Y chromosome biallelic polymorphisms by denaturing high-performance liquid chromatography
    P A Underhill
    Department of Genetics, Stanford University, Stanford, California 94305 5120, USA
    Genome Res 7:996-1005. 1997
    ..It provides evidence of an ancient bottleneck event. It is now possible to anticipate the inevitable detailed reconstruction of human Y chromosome genealogy based on several tens to even hundreds of these important polymorphisms...
  10. ncbi request reprint The Werner syndrome gene and global sequence variation
    G Passarino
    Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    Genomics 71:118-22. 2001
    ..The resulting global nucleotide diversity was 5.226 x 10(-4), with a slight difference between coding and noncoding regions...
  11. doi request reprint Differential Y-chromosome Anatolian influences on the Greek and Cretan Neolithic
    R J King
    Department of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, Stanford, CA 94305 5722, USA
    Ann Hum Genet 72:205-14. 2008
    ....
  12. ncbi request reprint Y chromosome binary markers to study the high prevalence of males in Sardinian centenarians and the genetic structure of the Sardinian population
    G Passarino
    Department of Genetics, Stanford University, Stanford, CA, USA
    Hum Hered 52:136-9. 2001
    ..These findings set the stage for future studies on longevity and other complex traits in Sardinia...
  13. ncbi request reprint Inferring human history: clues from Y-chromosome haplotypes
    P A Underhill
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    Cold Spring Harb Symp Quant Biol 68:487-93. 2003
  14. pmc Population genetic implications from sequence variation in four Y chromosome genes
    P Shen
    Stanford DNA Sequencing and Technology Center, 855 California Avenue, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 97:7354-9. 2000
    ..Pairwise nucleotide mismatch distributions date the occurrence of population expansion to approximately 28,000 years ago. This estimate is in accord with the spread of Aurignacian technology and the disappearance of the Neanderthals...
  15. pmc SNPSTRs: empirically derived, rapidly typed, autosomal haplotypes for inference of population history and mutational processes
    Joanna L Mountain
    Department of Anthropological Sciences, Stanford, California 94305, USA
    Genome Res 12:1766-72. 2002
    ..Here, we illustrate the approach with two SNPSTR systems. Although even one system provides insight into population history, the power of the approach lies in combining results from multiple SNPSTR systems...
  16. ncbi request reprint African Y chromosome and mtDNA divergence provides insight into the history of click languages
    Alec Knight
    Department of Anthropological Sciences, Stanford University, Stanford, CA 94305, USA
    Curr Biol 13:464-73. 2003
    ..Intriguingly, the language of the Hadzabe of eastern Africa, although not closely related to any other language, shares click consonants and accompaniments with languages of Khwe and San...
  17. ncbi request reprint Excavating Y-chromosome haplotype strata in Anatolia
    Cengiz Cinnioglu
    Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5120, USA
    Hum Genet 114:127-48. 2004
    ..The variety of Turkish haplotypes is witness to Turkey being both an important source and recipient of gene flow...
  18. ncbi request reprint Immunology: hepatitis A virus link to atopic disease
    Jennifer J McIntire
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California 94305 5208, USA
    Nature 425:576. 2003
  19. ncbi request reprint Molecular variation of human HSP90alpha and HSP90beta genes in Caucasians
    Giuseppe Passarino
    Department of Genetics, Stanford University School of Medicine, Stanford, California, USA
    Hum Mutat 21:554-5. 2003
    ..Only three of the observed mutations altered the genic product. Interestingly, one of the variations observed was a missense mutation leading to the impairment of the hsp90alpha protein...
  20. ncbi request reprint Melanesian and Asian origins of Polynesians: mtDNA and Y chromosome gradients across the Pacific
    Manfred Kayser
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 23:2234-44. 2006
    ..We also demonstrate that Fiji played a pivotal role in the history of Polynesia: humans probably first migrated to Fiji, and subsequent settlement of Polynesia probably came from Fiji...
  21. ncbi request reprint Difference between evolutionarily effective and germ line mutation rate due to stochastically varying haplogroup size
    Lev A Zhivotovsky
    N I Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia
    Mol Biol Evol 23:2268-70. 2006
    ....
  22. ncbi request reprint A counter-clockwise northern route of the Y-chromosome haplogroup N from Southeast Asia towards Europe
    Siiri Rootsi
    Department of Evolutionary Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
    Eur J Hum Genet 15:204-11. 2007
    ..These phylogeographic patterns provide evidence consistent with male-mediated counter-clockwise late Pleistocene-Holocene migratory trajectories toward Northwestern Europe from an ancestral East Asian source of Paleolithic heritage...
  23. ncbi request reprint Paleolithic Y-haplogroup heritage predominates in a Cretan highland plateau
    Laisel Martinez
    Department of Biological Sciences, Florida International University, Miami, FL 33199, USA
    Eur J Hum Genet 15:485-93. 2007
    ..In contrast, Cretan R1b microsatellite-defined haplotypes displayed more resemblance to those from Northeast Italy than to those from Turkey and the Balkans...
  24. pmc The dual origin and Siberian affinities of Native American Y chromosomes
    Jeffrey T Lell
    Center for Molecular Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Hum Genet 70:192-206. 2002
    ..This migration event contributed to the modern genetic pool of the Na-Dene and Amerinds of North and Central America...
  25. pmc Revealing the prehistoric settlement of Australia by Y chromosome and mtDNA analysis
    Georgi Hudjashov
    Estonian Biocentre and Tartu University, Department of Evolutionary Biology, Riia 23, 51010 Tartu, Estonia
    Proc Natl Acad Sci U S A 104:8726-30. 2007
    ....
  26. pmc Y-chromosome short tandem repeat DYS458.2 non-consensus alleles occur independently in both binary haplogroups J1-M267 and R1b3-M405
    Natalie M Myres
    Sorenson Molecular Genealogy Foundation, Salt Lake City, Utah, USA
    Croat Med J 48:450-9. 2007
    ..2 short tandem repeat alleles and evaluate their phylogenetic substructure and frequency in representative samples from the Middle East, Europe, and Pakistan...
  27. ncbi request reprint Y-chromosome diversity characterizes the Gulf of Oman
    Alicia M Cadenas
    Department of Biological Sciences, Florida International University, Miami, FL 33199, USA
    Eur J Hum Genet 16:374-86. 2008
    ..Elevated rates of consanguinity may have had an impact in Yemen and Qatar, which experience significant heterozygote deficiencies at various hypervariable autosomal STR loci...
  28. pmc Ethiopians and Khoisan share the deepest clades of the human Y-chromosome phylogeny
    Ornella Semino
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
    Am J Hum Genet 70:265-8. 2002
    ..The first observation confirms the ancestral affinity between the Ethiopians and the Khoisan, which has previously been suggested by both archaeological and genetic findings...
  29. pmc The Himalayas as a directional barrier to gene flow
    Tenzin Gayden
    Department of Biological Sciences, Florida International University, Miami, FL 33199, USA
    Am J Hum Genet 80:884-94. 2007
    ..Yet the presence of haplogroup O3a5-M134 representatives in Nepal indicates that the Himalayas have been permeable to dispersals from the east. These genetic patterns suggest that this cordillera has been a biased bidirectional barrier...
  30. ncbi request reprint Molecular dissection of the Y chromosome haplogroup E-M78 (E3b1a): a posteriori evaluation of a microsatellite-network-based approach through six new biallelic markers
    Fulvio Cruciani
    Dipartimento di Genetica e Biologia Molecolare, Universita La Sapienza, Rome, Italy
    Hum Mutat 27:831-2. 2006
    ....
  31. ncbi request reprint Detection of novel Y SNPs provides further insights into Y chromosomal variation in Pakistan
    Aisha Mohyuddin
    Biomedical and Genetic Engineering Laboratories, G P O Box 2891, 44000, Islamabad, Pakistan
    J Hum Genet 51:375-8. 2006
    ..BATWING analysis gave an estimate of between 2,500 and 7,300 YBP for population expansion in Pakistan which coincides with the period of the Indus Valley civilizations...
  32. ncbi request reprint A Y chromosome census of the British Isles
    Cristian Capelli
    Department of Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Curr Biol 13:979-84. 2003
    ....
  33. pmc Accelerated evolution of the pituitary adenylate cyclase-activating polypeptide precursor gene during human origin
    Yin Qiu Wang
    Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Yunnan
    Genetics 170:801-6. 2005
    ..Our data suggested that the PACAP precursor gene underwent adaptive changes during human origin and may have contributed to the formation of human cognition...
  34. pmc Origin, diffusion, and differentiation of Y-chromosome haplogroups E and J: inferences on the neolithization of Europe and later migratory events in the Mediterranean area
    Ornella Semino
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, 27100 Pavia, Italy
    Am J Hum Genet 74:1023-34. 2004
    ..A 7%-22% contribution of Y chromosomes from Greece to southern Italy was estimated by admixture analysis...
  35. pmc A back migration from Asia to sub-Saharan Africa is supported by high-resolution analysis of human Y-chromosome haplotypes
    Fulvio Cruciani
    Dipartimenti di Genetica e Biologia Molecolare, Universita La Sapienza, Rome, Italy
    Am J Hum Genet 70:1197-214. 2002
    ..Haplogroup IX Y chromosomes appear to have been involved in such a migration, the traces of which can now be observed mostly in northern Cameroon...
  36. pmc Phylogeography of Y-chromosome haplogroup I reveals distinct domains of prehistoric gene flow in europe
    Siiri Rootsi
    Department of Evolutionary Biology, University of Tartu and Estonian Biocentre, Riia, Tartu, Estonia
    Am J Hum Genet 75:128-37. 2004
    ..In contrast, I1b2 most likely arose in southern France/Iberia. Similarly to the other subclades, it underwent a postglacial expansion and marked the human colonization of Sardinia approximately 9,000 years ago...
  37. ncbi request reprint Reduced genetic structure of the Iberian peninsula revealed by Y-chromosome analysis: implications for population demography
    Carlos Flores
    Departamento de Genetica, Universidad de La Laguna, Tenerife E 38271, Spain
    Eur J Hum Genet 12:855-63. 2004
    ..These results indicate that neither old or recent Levantine expansions nor North African contacts have influenced the current Iberian Y-chromosome diversity so that geographical patterns can be identified...
  38. ncbi request reprint Genetic affinities of the Andaman Islanders, a vanishing human population
    Kumarasamy Thangaraj
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, 440 006, Nagpur, India
    Curr Biol 13:86-93. 2003
    ..However, it is generally believed that they descend from the early Australo-Melanesian settlers of Southeast Asia and that their resemblance to some Africans is due to adaptation to a similar environment, rather than shared origins...
  39. pmc Y-chromosomal evidence for a limited Greek contribution to the Pathan population of Pakistan
    Sadaf Firasat
    Biomedical and Genetic Engineering Division, Dr AQ Khan Research Laboratories, Islamabad, Pakistan
    Eur J Hum Genet 15:121-6. 2007
    ..Although based on only a few unrelated descendants, this provides strong evidence for a European origin for a small proportion of the Pathan Y chromosomes...
  40. ncbi request reprint Y-chromosome lineages from Portugal, Madeira and Açores record elements of Sephardim and Berber ancestry
    Rita Goncalves
    Human Genetics Laboratory, University of Madeira, Campus of Penteada, 9000 390 Funchal, Portugal
    Ann Hum Genet 69:443-54. 2005
    ....
  41. pmc Y-chromosome evidence of southern origin of the East Asian-specific haplogroup O3-M122
    Hong Shi
    Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Kunming, China
    Am J Hum Genet 77:408-19. 2005
    ..It was estimated that the early northward migration of the O3-M122 lineages in East Asia occurred approximately 25,000-30,000 years ago, consistent with the fossil records of modern humans in East Asia...
  42. pmc The role of selection in the evolution of human mitochondrial genomes
    Toomas Kivisild
    Department of Human and Clinical Genetics, Leiden University Medical Center, 2333 AL Leiden, The Netherlands
    Genetics 172:373-87. 2006
    ..We introduce a new calibration method of the mutation rate of synonymous transitions to estimate the coalescent times of mtDNA haplogroups...
  43. pmc Polarity and temporality of high-resolution y-chromosome distributions in India identify both indigenous and exogenous expansions and reveal minor genetic influence of Central Asian pastoralists
    Sanghamitra Sengupta
    Human Genetics Unit, Indian Statistical Institute, Kolkata, India
    Am J Hum Genet 78:202-21. 2006
    ..Our reappraisal indicates that pre-Holocene and Holocene-era--not Indo-European--expansions have shaped the distinctive South Asian Y-chromosome landscape...
  44. ncbi request reprint Different genetic components in the Norwegian population revealed by the analysis of mtDNA and Y chromosome polymorphisms
    Giuseppe Passarino
    Dipartimento di Biologia Cellulare, Universita della Calabria, Ponte Pietro Bucci c da Arcavacata, 87030 Rende, Italy
    Eur J Hum Genet 10:521-9. 2002
    ..Other minor genetic influences on the Norwegian population from Uralic speakers and Mediterranean populations were also highlighted...
  45. doi request reprint DNA mutation detection using denaturing high-performance liquid chromatography (DHPLC)
    Bing Yu
    Department of Molecular and Clinical Genetics, Central Clinical School and SUPAMAC The University of Sydney, New South Wales, Australia
    Curr Protoc Hum Genet . 2006
    ..The method exploits the differential retention of homoduplex and heteroduplex DNA species under conditions of partial thermal denaturation. DHPLC provides a useful platform for high-throughput mutation detection and SNP discovery...
  46. ncbi request reprint Toward resolution of the debate regarding purported crypto-Jews in a Spanish-American population: evidence from the Y chromosome
    Wesley K Sutton
    Department of Anthropology, New York University, New York 10003, USA
    Ann Hum Biol 33:100-11. 2006
    ..Despite ethnographic criticisms, the notion of substantial crypto-Jewish ancestry among Spanish-Americans persists...
  47. pmc The effective mutation rate at Y chromosome short tandem repeats, with application to human population-divergence time
    Lev A Zhivotovsky
    N I Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia
    Am J Hum Genet 74:50-61. 2004
    ..This value is used to estimate the times of the African Bantu expansion, the divergence of Polynesian populations (the Maoris, Cook Islanders, and Samoans), and the origin of Gypsy populations from Bulgaria...
  48. ncbi request reprint Co-introgression of Y-chromosome haplogroups and the sickle cell gene across Africa's Sahel
    Rihab E Bereir
    Institute of Endemic Diseases, Medical Campus, University of Khartoum, Khartoum, Sudan
    Eur J Hum Genet 15:1183-5. 2007
    ..We discuss the possible dynamics of the process and give estimates of the age of the introduction of the S allele into eastern Sahel...
  49. ncbi request reprint On the evolutionary mutation rate at Y-chromosome STRs: comments on paper by Di Giacomo et al. (2004)
    Lev A Zhivotovsky
    Hum Genet 116:529-32. 2005
  50. ncbi request reprint The enigma of the San Lesmes (response to Langdon, 2002)
    Geoffrey K Chambers
    Hum Mutat 19:181-2. 2002
  51. pmc New binary polymorphisms reshape and increase resolution of the human Y chromosomal haplogroup tree
    Tatiana M Karafet
    ARL Division of Biotechnology, University of Arizona, Tucson, Arizona 85721, USA
    Genome Res 18:830-8. 2008
    ..Several changes in the tree topology have important implications for studies of human ancestry. We also present demography-independent age estimates for 11 of the major clades in the new Y chromosome tree...