Mindy Tsai

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Thymic stromal lymphopoietin contributes to myeloid hyperplasia and increased immunoglobulins, but not epidermal hyperplasia, in RabGEF1-deficient mice
    Mindy Tsai
    Stanford University School of Medicine, Department of Pathology, L 235, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Am J Pathol 177:2411-20. 2010
  2. pmc RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 103:2659-64. 2006
  3. pmc The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis
    Adrian M Piliponsky
    Department of Pathology, Stanford University School of Medicine, California 94305 5324, USA
    Am J Pathol 181:875-86. 2012
  4. pmc Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice
    Jennifer N Lilla
    Department of Pathology, Stanford University School of Medicine, CA 94305 5324, USA
    Blood 118:6930-8. 2011
  5. ncbi request reprint Mast cell-associated TNF promotes dendritic cell migration
    Hajime Suto
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    J Immunol 176:4102-12. 2006
  6. doi request reprint A beneficial role for immunoglobulin E in host defense against honeybee venom
    Thomas Marichal
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Immunity 39:963-75. 2013
  7. ncbi request reprint RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation
    See Ying Tam
    Departments of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Novartis Found Symp 271:115-24; discussion 124-30, 145-51. 2005
  8. ncbi request reprint Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    J Immunol 176:2238-48. 2006
  9. pmc Roles of RabGEF1/Rabex-5 domains in regulating Fc epsilon RI surface expression and Fc epsilon RI-dependent responses in mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Blood 109:5308-17. 2007
  10. pmc Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo
    Michele A Grimbaldeston
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Am J Pathol 167:835-48. 2005

Collaborators

Detail Information

Publications49

  1. pmc Thymic stromal lymphopoietin contributes to myeloid hyperplasia and increased immunoglobulins, but not epidermal hyperplasia, in RabGEF1-deficient mice
    Mindy Tsai
    Stanford University School of Medicine, Department of Pathology, L 235, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Am J Pathol 177:2411-20. 2010
    ....
  2. pmc RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 103:2659-64. 2006
    ..Thus, RabGEF1 plays a critical role in the regulation of SCF/c-Kit-mediated signaling events and biological responses in mast cells...
  3. pmc The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis
    Adrian M Piliponsky
    Department of Pathology, Stanford University School of Medicine, California 94305 5324, USA
    Am J Pathol 181:875-86. 2012
    ..Our findings support the conclusion that mMCP-4 can enhance survival after CLP at least in part by limiting detrimental effects of TNF, and suggest that mast cell chymase may represent an important negative regulator of TNF in vivo...
  4. pmc Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice
    Jennifer N Lilla
    Department of Pathology, Stanford University School of Medicine, CA 94305 5324, USA
    Blood 118:6930-8. 2011
    ....
  5. ncbi request reprint Mast cell-associated TNF promotes dendritic cell migration
    Hajime Suto
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    J Immunol 176:4102-12. 2006
    ..Our findings indicate that mast cell-associated TNF can contribute significantly to the initial stages of FITC-induced migration of cutaneous or airway DCs...
  6. doi request reprint A beneficial role for immunoglobulin E in host defense against honeybee venom
    Thomas Marichal
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Immunity 39:963-75. 2013
    ....
  7. ncbi request reprint RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation
    See Ying Tam
    Departments of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Novartis Found Symp 271:115-24; discussion 124-30, 145-51. 2005
    ....
  8. ncbi request reprint Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    J Immunol 176:2238-48. 2006
    ..These results indicate that the secretion of soluble TNF and direct cell-cell interactions between mast cell OX40L and T cell OX40 contribute to the ability of IgE- and Ag-stimulated mouse mast cells to enhance T cell activation...
  9. pmc Roles of RabGEF1/Rabex-5 domains in regulating Fc epsilon RI surface expression and Fc epsilon RI-dependent responses in mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Blood 109:5308-17. 2007
    ..By contrast, correction of these -/- phenotypes required a functional Vps9 domain. Thus, Fc epsilon RI-mediated mast cell functional activation is dependent on RabGEF1's GEF activity...
  10. pmc Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo
    Michele A Grimbaldeston
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Am J Pathol 167:835-48. 2005
    ..Thus, Kit(W-sh/W-sh) mice represent a useful model for mast cell research, especially for analyzing mast cell function in vivo...
  11. pmc Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice
    Adrian M Piliponsky
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Am J Pathol 176:926-38. 2010
    ..typhimurium...
  12. pmc Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma
    Mang Yu
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5176, USA
    J Clin Invest 121:3133-43. 2011
    ..These findings identify a previously unsuspected IFN-γ/mast cell axis in the pathology of chronic allergic inflammation of the airways in mice...
  13. pmc Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis
    Adrian M Piliponsky
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Med 14:392-8. 2008
    ....
  14. pmc Mast cells can promote the development of multiple features of chronic asthma in mice
    Mang Yu
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    J Clin Invest 116:1633-41. 2006
    ....
  15. ncbi request reprint Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B
    Michele A Grimbaldeston
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5176, USA
    Nat Immunol 8:1095-104. 2007
    ....
  16. ncbi request reprint TNF can contribute to multiple features of ovalbumin-induced allergic inflammation of the airways in mice
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    J Allergy Clin Immunol 119:680-6. 2007
    ..However, studies with TNF-deficient or TNF receptor-deficient mice have not produced a clear picture of the role of TNF in the AHR associated with allergic inflammation in the mouse...
  17. ncbi request reprint Mast cells in the promotion and limitation of chronic inflammation
    Martin Metz
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Immunol Rev 217:304-28. 2007
    ..Such work has confirmed that mast cells can significantly influence multiple features of chronic inflammatory responses, through diverse effects that can either promote or, perhaps more surprisingly, suppress aspects of these responses...
  18. ncbi request reprint Using mast cell knock-in mice to analyze the roles of mast cells in allergic responses in vivo
    Mindy Tsai
    Department of Pathology, Stanford University School of Medicine, Stanford, Calif 94305, USA edu
    Chem Immunol Allergy 87:179-97. 2005
    ....
  19. pmc Mast cell-derived tumor necrosis factor can promote nerve fiber elongation in the skin during contact hypersensitivity in mice
    Maki Kakurai
    Department of Pathology, L 235, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA 94305 5324, USA
    Am J Pathol 169:1713-21. 2006
    ..These observations show that mast cells, and mast cell-derived TNF, can promote the elongation of cutaneous nerve fibers during contact hypersensitivity in the mouse...
  20. pmc Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice
    Beatrix Schäfer
    Department of Pathology, Stanford University School of Medicine, Stanford, Calif 94305 5324, USA
    J Allergy Clin Immunol 131:541-8.e1-9. 2013
    ..However, it is not clear to what extent mast cell expression of C3aR or C5aR influences C3a- or C5a-induced cutaneous responses or IgE-dependent mast cell activation and passive cutaneous anaphylaxis (PCA) in vivo...
  21. ncbi request reprint Mast cells promote homeostasis by limiting endothelin-1-induced toxicity
    Marcus Maurer
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 432:512-6. 2004
    ..These findings identify a new biological function for mast cells: promotion of homeostasis by limiting the toxicity associated with an endogenous mediator...
  22. pmc Rapid desensitization induces internalization of antigen-specific IgE on mouse mast cells
    Tatsuya Oka
    Department of Pathology, Stanford University School of Medicine, Stanford, Calif
    J Allergy Clin Immunol 132:922-32.e1-16. 2013
    ..However, the mechanisms underlying successful rapid desensitization are not fully understood...
  23. ncbi request reprint Mast cells as "tunable" effector and immunoregulatory cells: recent advances
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Annu Rev Immunol 23:749-86. 2005
    ....
  24. ncbi request reprint Mast cells can enhance resistance to snake and honeybee venoms
    Martin Metz
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Science 313:526-30. 2006
    ..These findings identify a new biological function for mast cells in enhancing resistance to the morbidity and mortality induced by animal venoms...
  25. pmc Evidence questioning cromolyn's effectiveness and selectivity as a 'mast cell stabilizer' in mice
    Tatsuya Oka
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Lab Invest 92:1472-82. 2012
    ..These results question cromolyn's effectiveness and selectivity as an inhibitor of mast cell activation and mediator release in the mouse...
  26. ncbi request reprint Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response
    Kentaro Matsuda
    Department of Pathology, Stanford University School of Medicine, CA 94305 5324, USA
    J Allergy Clin Immunol 116:1357-63. 2005
    ..Mouse monoclonal IgE antibodies can promote the survival of mouse bone marrow-derived cultured mast cells and induce the cells to secrete mediators in the absence of known specific antigen...
  27. pmc Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice
    Mitsuteru Akahoshi
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    J Clin Invest 121:4180-91. 2011
    ..Our findings support the notion that mast cells can enhance innate defense by degradation of diverse animal toxins and that release of MCPT4, in addition to CPA3, can contribute to this mast cell function...
  28. pmc Mast cells enhance T cell activation: Importance of mast cell-derived TNF
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5176, USA
    Proc Natl Acad Sci U S A 102:6467-72. 2005
    ..Finally, mast cells also can promote T cell activation by means of soluble factors. These findings identify multiple mechanisms by which mast cells can influence T cell proliferation and cytokine production...
  29. pmc Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice
    Laurent L Reber
    Department of Pathology, Stanford University School of Medicine, Stanford, Calif
    J Allergy Clin Immunol 132:881-8.e1-11. 2013
    ....
  30. pmc Identification of mast cell progenitors in adult mice
    Ching Cheng Chen
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 102:11408-13. 2005
    ....
  31. ncbi request reprint Effector and potential immunoregulatory roles of mast cells in IgE-associated acquired immune responses
    Michele A Grimbaldeston
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Curr Opin Immunol 18:751-60. 2006
    ....
  32. doi request reprint The role of recipient mast cells in acute and chronic cardiac allograft rejection in C57BL/6-KitW-sh/W-sh mice
    Satoshi Itoh
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    J Heart Lung Transplant 29:401-9. 2010
    ..We used C57BL/6-Kit(W-sh/W-sh) mast cell-deficient and corresponding wild-type mice to investigate possible contributions of recipient mast cells to acute or chronic cardiac allograft rejection...
  33. ncbi request reprint Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3)
    Aleena Syed
    Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif
    J Allergy Clin Immunol 133:500-10. 2014
    ..The mechanisms contributing to clinical immune tolerance remain incompletely understood. This study provides evidence for specific immune mechanisms that are associated with a model of operationally defined clinical tolerance...
  34. ncbi request reprint RabGEF1 is a negative regulator of mast cell activation and skin inflammation
    See Ying Tam
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 5:844-52. 2004
    ..Thus, RabGEF1 is a negative regulator of Fc epsilon RI-dependent mast cell activation, and a lack of RabGEF1 results in the development of skin inflammation in vivo...
  35. pmc The development of allergic inflammation
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    Nature 454:445-54. 2008
    ....
  36. pmc Immunomodulatory mast cells: negative, as well as positive, regulators of immunity
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nat Rev Immunol 8:478-86. 2008
    ..Here, we review the evidence that mast cells can have negative, as well as positive, immunomodulatory roles in vivo, and we propose that mast cells can both enhance and later suppress certain features of an immune response...
  37. pmc Evidence that mast cells are not required for healing of splinted cutaneous excisional wounds in mice
    Allison C Nauta
    Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 8:e59167. 2013
    ..These data indicate that mast cells do not play a significant non-redundant role in these features of the healing of splinted full thickness excisional cutaneous wounds in mice...
  38. pmc IgE and mast cells in allergic disease
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, California, USA
    Nat Med 18:693-704. 2012
    ..In this review, we discuss findings supporting the conclusion that IgE and mast cells can have both interdependent and independent roles in the complex immune responses that manifest clinically as asthma and other allergic disorders...
  39. pmc Mast cells: versatile regulators of inflammation, tissue remodeling, host defense and homeostasis
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5176, United States
    J Dermatol Sci 49:7-19. 2008
    ..Through such functions, mast cells can significantly influence inflammation, tissue remodeling, host defense and homeostasis...
  40. ncbi request reprint Mast cells in the development of adaptive immune responses
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nat Immunol 6:135-42. 2005
    ..Thus, mast cells may influence the development, intensity and duration of adaptive immune responses that contribute to host defense, allergy and autoimmunity, rather than simply functioning as effector cells in these settings...
  41. pmc Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Eur J Immunol 40:1843-51. 2010
    ....
  42. pmc Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination
    Rosetta Pedotti
    Department of Neurology and Neurological Science, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 100:1867-72. 2003
    ..The pathogenesis of demyelination must now be viewed as encompassing elements of both Th1 responses and "allergic" responses...
  43. ncbi request reprint Analyzing the roles of mast cells and basophils in host defense and other biological responses
    Stephen J Galli
    Department of Pathology, Stanford University Medical Center, California 94305 5324, USA
    Int J Hematol 75:363-9. 2002
    ..We will also describe briefly some approaches to investigate mast cell and basophil functions in vivo, including the use of mast cells generated directly from embryonic stem cells in vitro...
  44. pmc Transcriptional response of human mast cells stimulated via the Fc(epsilon)RI and identification of mast cells as a source of IL-11
    Koichi Sayama
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    BMC Immunol 3:5. 2002
    ..To search for new mast cell products, we used complementary DNA microarrays to analyze gene expression in human umbilical cord blood-derived mast cells stimulated via the high-affinity IgE receptor (Fc(epsilon)RI)...
  45. pmc Severe anaphylactic reactions to glutamic acid decarboxylase (GAD) self peptides in NOD mice that spontaneously develop autoimmune type 1 diabetes mellitus
    Rosetta Pedotti
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    BMC Immunol 4:2. 2003
    ....
  46. doi request reprint Mast cells and immunoregulation/immunomodulation
    Mindy Tsai
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Adv Exp Med Biol 716:186-211. 2011
    ..We also briefly describe some of the mast-cell functions, products and surface receptors that have the potential to permit mast cells to promote or suppress immune responses that can either enhance host defense or contribute to disease...
  47. pmc Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy
    Yael Gernez
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int Arch Allergy Immunol 154:318-27. 2011
    ..Basophils contribute to anaphylaxis and allergies. We examined the utility of assessing basophil-associated surface antigens (CD11b/CD63/CD123/CD203c/CD294) in characterizing and monitoring subjects with nut allergy...
  48. ncbi request reprint Mast cells: potential positive and negative roles in tumor biology
    Thomas Marichal
    Authors Affiliations Departments of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California
    Cancer Immunol Res 1:269-79. 2013
    ..Finally, we summarize data from studies of human tumors that suggest either beneficial or detrimental roles for mast cells in tumors...
  49. ncbi request reprint Mast cells derived from embryonic stem cells: a model system for studying the effects of genetic manipulations on mast cell development, phenotype, and function in vitro and in vivo
    Mindy Tsai
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Int J Hematol 75:345-9. 2002
    ....